Publications by authors named "Oriol Casanovas"

52Publications

EVI1 as a Prognostic and Predictive Biomarker of Clear Cell Renal Cell Carcinoma.

Cancers (Basel) 2020 Jan 28;12(2). Epub 2020 Jan 28.

ProCURE, Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona 08908, Catalonia, Spain.

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http://dx.doi.org/10.3390/cancers12020300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072453PMC
January 2020

Antitumor Effects of Anti-Semaphorin 4D Antibody Unravel a Novel Proinvasive Mechanism of Vascular-Targeting Agents.

Cancer Res 2019 Oct 25;79(20):5328-5341. Epub 2019 Jun 25.

Tumor Angiogenesis Group, ProCURE Research Program, Catalan Institute of Oncology, OncoBell Program, IDIBELL, Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3436DOI Listing
October 2019

Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?

Cancers (Basel) 2019 Jun 17;11(6). Epub 2019 Jun 17.

Medical Oncology Department, Catalan Institute of Cancer (ICO), IDIBELL-OncoBell, Hospitalet de Llobregat, 08908 Barcelona, Spain.

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http://dx.doi.org/10.3390/cancers11060834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627065PMC
June 2019

Quantification of gold nanoparticle accumulation in tissue by two-photon luminescence microscopy.

Nanoscale 2019 Jun;11(23):11331-11339

ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels (Barcelona), Spain.

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http://xlink.rsc.org/?DOI=C9NR01198F
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http://dx.doi.org/10.1039/c9nr01198fDOI Listing
June 2019

Unraveling the Role of Angiogenesis in Cancer Ecosystems.

Front Oncol 2018 2;8:248. Epub 2018 Jul 2.

Tumor Angiogenesis Group, ProCURE, Catalan Institute of Oncology - IDIBELL, Barcelona, Spain.

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http://dx.doi.org/10.3389/fonc.2018.00248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036108PMC
July 2018

ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K Activation.

Arterioscler Thromb Vasc Biol 2018 05 15;38(5):1216-1229. Epub 2018 Feb 15.

From the Program Against Cancer Therapeutic Resistance, Institut Català d'Oncologia, Hospital Duran i Reynals (E.A.-S., Y.G.-I., A.M.F., C.R.-D., A.F., O.C., M.A.P., M.G., F.V.)

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http://dx.doi.org/10.1161/ATVBAHA.118.310760DOI Listing
May 2018

A Role for CXCR4 in Peritoneal and Hematogenous Ovarian Cancer Dissemination.

Mol Cancer Ther 2018 02 16;17(2):532-543. Epub 2017 Nov 16.

Program Against Cancer Therapeutic Resistance (ProCURE), Institut Català d'Oncologia, Hospital Duran i Reynals, Barcelona, Spain.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0643DOI Listing
February 2018

Angiogenesis and Metabolism: Entwined for Therapy Resistance.

Trends Cancer 2017 01 26;3(1):10-18. Epub 2016 Dec 26.

Tumor Angiogenesis Group, ProCURE, Catalan Institute of Oncology (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2016.11.007DOI Listing
January 2017

Pre-clinical longitudinal monitoring of hemodynamic response to anti-vascular chemotherapy by hybrid diffuse optics.

Biomed Opt Express 2017 May 19;8(5):2563-2582. Epub 2017 Apr 19.

ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Sciences and Technology, 08860, Castelldefels (Barcelona), Spain.

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http://dx.doi.org/10.1364/BOE.8.002563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480498PMC
May 2017

Sprouting strategies and dead ends in anti-angiogenic targeting of NETs.

J Mol Endocrinol 2017 07 3;59(1):R77-R91. Epub 2017 May 3.

Tumor Angiogenesis GroupProCURE, Catalan Institute of Oncology - IDIBELL, Barcelona, Spain.

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http://dx.doi.org/10.1530/JME-17-0029DOI Listing
July 2017

Antiangiogenic resistance via metabolic symbiosis.

Mol Cell Oncol 2016 14;3(5):e1211979. Epub 2016 Jul 14.

Tumor Angiogenesis Group, ProCURE, Catalan Institute of Oncology - IDIBELL , Barcelona, Spain.

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http://dx.doi.org/10.1080/23723556.2016.1211979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068180PMC
July 2016

Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors.

Clin Cancer Res 2016 Dec 25;22(23):5805-5817. Epub 2016 May 25.

Vascular Signaling Laboratory, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-3051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338478PMC
December 2016

The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels.

Int J Cancer 2016 10 25;139(8):1894-903. Epub 2016 Jun 25.

Program Against Cancer Therapeutic Resistance (ProCURE), Institut Català D'Oncologia (ICO), Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1002/ijc.30233DOI Listing
October 2016

Scanning, non-contact, hybrid broadband diffuse optical spectroscopy and diffuse correlation spectroscopy system.

Biomed Opt Express 2016 Feb 15;7(2):481-98. Epub 2016 Jan 15.

ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Sciences and Technology, 08860, Castelldefels (Barcelona), Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08015 Barcelona, Spain.

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http://dx.doi.org/10.1364/BOE.7.000481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771466PMC
February 2016

Antiangiogenic Resistance: Novel Angiogenesis Axes Uncovered by Antiangiogenic Therapies Research.

Curr Drug Targets 2016 ;17(15):1728-1734

Tumor Angiogenesis Group, Catalan Institute of Oncology-IDIBELL, Av. Gran Via de l'Hospitalet 199- 203 (3rd floor), E-08908 L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.2174/1389450117666160301101425DOI Listing
August 2017

A novel role for an RCAN3-derived peptide as a tumor suppressor in breast cancer.

Carcinogenesis 2015 Jul 26;36(7):792-9. Epub 2015 Apr 26.

Cellular Signaling Unit, Human Molecular Genetics Group, Bellvitge Biomedical Research Institute - IDIBELL. L'Hospitalet de Llobregat 08908 Barcelona, Spain,

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http://dx.doi.org/10.1093/carcin/bgv056DOI Listing
July 2015

Multi-target angiokinase inhibitors to fight resistance.

Cell Cycle 2014 ;13(17):2649-50

a Tumor Angiogenesis Group ; Catalan Institute of Oncology (ICO)-Bellvitge Biomedical Research Institute ; Barcelona , Spain.

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http://dx.doi.org/10.4161/15384101.2014.954216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613648PMC
June 2016

Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis.

Nat Commun 2014 Oct 1;5:5054. Epub 2014 Oct 1.

Centre for Tumour Biology, Barts Cancer Institute-a Cancer Research UK Centre of Excellence, Queen Mary, University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.

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http://www.nature.com/articles/ncomms6054
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http://dx.doi.org/10.1038/ncomms6054DOI Listing
October 2014

Antiangiogenic therapies: going beyond their limits.

Cancer Discov 2014 Jan 19;4(1):31-41. Epub 2013 Dec 19.

Tumor Angiogenesis Group, Catalan Institute of Oncology-IDIBELL, Av Gran Via de l'Hospitalet, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0199DOI Listing
January 2014

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.

J Exp Med 2013 Sep 16;210(10):1937-45. Epub 2013 Sep 16.

Vascular Signaling Laboratory; and 2 Translational Research Laboratory, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), 08907 L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1084/jem.20121571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782054PMC
September 2013

Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors.

BMC Cancer 2013 Aug 10;13:382. Epub 2013 Aug 10.

Laboratori de Recerca Translacional, Institut Català d'Oncologia, Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, 08908, Spain.

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http://dx.doi.org/10.1186/1471-2407-13-382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751347PMC
August 2013

Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells.

Int J Cancer 2013 Nov 4;133(10):2464-72. Epub 2013 Jun 4.

Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1002/ijc.28259DOI Listing
November 2013

Relevance of angiogenesis in neuroendocrine tumors.

Target Oncol 2012 Jun 17;7(2):93-8. Epub 2012 May 17.

Hereditary Cancer Program, Catalan Institute of Oncology-IDIBELL, Barcelona, Spain.

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http://dx.doi.org/10.1007/s11523-012-0217-xDOI Listing
June 2012

Cancer: Limitations of therapies exposed.

Authors:
Oriol Casanovas

Nature 2012 Apr 4;484(7392):44-6. Epub 2012 Apr 4.

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http://dx.doi.org/10.1038/484044aDOI Listing
April 2012

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.

Nature 2012 Mar 18;484(7392):110-4. Epub 2012 Mar 18.

Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, D-48149 Münster, Germany.

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http://dx.doi.org/10.1038/nature10908DOI Listing
March 2012

Exploiting pleiotropic activities of semaphorins as multi-target therapies for cancer.

EMBO Mol Med 2012 Mar 10;4(3):168-70. Epub 2012 Feb 10.

Tumor Angiogenesis Group, Catalan Institute of Oncology - IDIBELL, L'Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1002/emmm.201200206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376851PMC
March 2012

The adaptive stroma joining the antiangiogenic resistance front.

Authors:
Oriol Casanovas

J Clin Invest 2011 Apr 23;121(4):1244-7. Epub 2011 Mar 23.

Tumor Angiogenesis Group, Translational Research Laboratory, Catalan Institute of Oncology - IDIBELL, L'Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1172/JCI46430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069791PMC
April 2011

Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model.

Mol Cancer Ther 2008 Mar;7(3):638-47

Laboratori de Recerca Translacional, Institut Català d'Oncologia-IDIBELL, Hospital Duran i Reynals, L'Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-2122DOI Listing
March 2008

Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors.

Cancer Cell 2005 Oct;8(4):299-309

Department of Biochemistry and Biophysics, Comprehensive Cancer Center, and Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.09.005DOI Listing
October 2005

Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis.

Oncogene 2005 Oct;24(44):6597-604

Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California-San Francisco, 94143, USA.

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http://dx.doi.org/10.1038/sj.onc.1208823DOI Listing
October 2005

P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation.

Oncogene 2004 Sep;23(45):7537-44

Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Casanova 143, 08036, Spain.

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http://dx.doi.org/10.1038/sj.onc.1208040DOI Listing
September 2004

The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers.

Hepatology 2002 May;35(5):1063-71

Department of Cell Biology and Pathology, Faculty of Medicine, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1053/jhep.2002.32678DOI Listing
May 2002