Publications by authors named "Oreste Acuto"

61Publications

Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles.

Nat Commun 2020 10 15;11(1):5189. Epub 2020 Oct 15.

HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR.

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http://dx.doi.org/10.1038/s41467-020-19028-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564011PMC
October 2020

Molecular Dynamics Simulations Reveal Canonical Conformations in Different pMHC/TCR Interactions.

Cells 2020 04 10;9(4). Epub 2020 Apr 10.

Department of Chemistry, University of Rome Sapienza, P.le A.Moro 5-00185 Rome, Italy.

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http://dx.doi.org/10.3390/cells9040942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226950PMC
April 2020

Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity.

Sci Signal 2018 06 12;11(534). Epub 2018 Jun 12.

Laboratory of Immunobiology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scisignal.aan8799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393939PMC
June 2018

The T cell IFT20 interactome reveals new players in immune synapse assembly.

J Cell Sci 2017 03 2;130(6):1110-1121. Epub 2017 Feb 2.

Department of Life Sciences, University of Siena, Siena 53100, Italy

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http://dx.doi.org/10.1242/jcs.200006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358343PMC
March 2017

TCR Signal Strength and T Cell Development.

Annu Rev Cell Dev Biol 2016 10;32:327-348

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, and Immunology Program, National University of Singapore, Singapore 11759; email:

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http://dx.doi.org/10.1146/annurev-cellbio-111315-125324DOI Listing
October 2016

SHP1-ing thymic selection.

Eur J Immunol 2016 09;46(9):2091-4

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/eji.201646582DOI Listing
September 2016

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination.

Proc Natl Acad Sci U S A 2016 09 29;113(37):E5454-63. Epub 2016 Aug 29.

European Molecular Biology Laboratory (EMBL) Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, Sydney, NSW 2052, Australia;

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http://dx.doi.org/10.1073/pnas.1607436113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027455PMC
September 2016

Expanding the yeast protein arginine methylome.

Proteomics 2015 Sep 2;15(18):3232-43. Epub 2015 Jul 2.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/pmic.201500032DOI Listing
September 2015

Comprehensive identification of arginine methylation in primary T cells reveals regulatory roles in cell signalling.

Nat Commun 2015 Apr 7;6:6758. Epub 2015 Apr 7.

Laboratory of T cell signalling, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

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http://www.nature.com/articles/ncomms7758
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http://dx.doi.org/10.1038/ncomms7758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396391PMC
April 2015

THEMIS: a critical TCR signal regulator for ligand discrimination.

Curr Opin Immunol 2015 Apr 18;33:86-92. Epub 2015 Feb 18.

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2015.01.020DOI Listing
April 2015

Membrane nanodomains in T-cell antigen receptor signalling.

Essays Biochem 2015 ;57:165-75

T Cell Signalling Laboratory, Sir William Dunn School of Pathology University of Oxford, South Parks Road, Oxford OX1 3RE, U.K.

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http://dx.doi.org/10.1042/bse0570165DOI Listing
October 2015

The late endosomal transporter CD222 directs the spatial distribution and activity of Lck.

J Immunol 2014 Sep 15;193(6):2718-32. Epub 2014 Aug 15.

Molecular Immunology Unit, Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna A-1090, Austria; Laboratory of Molecular Immunology, Institute of Molecular Biology, Slovak Academy of Sciences, 84551 Bratislava, Slovak Republic

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http://dx.doi.org/10.4049/jimmunol.1303349DOI Listing
September 2014

Fine-tuning T cell receptor signaling to control T cell development.

Trends Immunol 2014 Jul 17;35(7):311-8. Epub 2014 Jun 17.

Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597. Electronic address:

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http://dx.doi.org/10.1016/j.it.2014.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119814PMC
July 2014

Themis sets the signal threshold for positive and negative selection in T-cell development.

Nature 2013 Dec 13;504(7480):441-5. Epub 2013 Nov 13.

1] Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA [2] Department of Microbiology, Yong Loo Lin School of Medicine and Immunology Programme, National University of Singapore, 5 Science Drive 2, Singapore 117545.

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http://dx.doi.org/10.1038/nature12718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977001PMC
December 2013

Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells.

J Immunol 2013 Mar 28;190(5):1927-35. Epub 2013 Jan 28.

Department of Molecular Immunology, Institute of Biology III, Faculty of Biology, University of Freiburg and Max Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany.

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http://dx.doi.org/10.4049/jimmunol.1200653DOI Listing
March 2013

Quantitative dynamics of phosphoproteome: the devil is in the details.

Anal Chem 2012 Oct 4;84(20):8431-6. Epub 2012 Oct 4.

T cell Signaling Laboratory, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom.

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http://dx.doi.org/10.1021/ac301833kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477822PMC
October 2012

A method for large-scale identification of protein arginine methylation.

Mol Cell Proteomics 2012 Nov 3;11(11):1489-99. Epub 2012 Aug 3.

T Cell Signalling Laboratory, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://www.mcponline.org/content/early/2012/08/03/mcp.M112.0
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http://www.mcponline.org/cgi/doi/10.1074/mcp.M112.020743
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http://dx.doi.org/10.1074/mcp.M112.020743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494207PMC
November 2012

A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulation.

Biochem Biophys Res Commun 2012 Jun 30;423(2):301-7. Epub 2012 May 30.

Department of Microbiology and Immunology, McGill University, Montréal, Canada.

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http://dx.doi.org/10.1016/j.bbrc.2012.05.116DOI Listing
June 2012

Lymphocyte signaling: a Tuscan affair.

Nat Immunol 2011 Dec 16;13(1):3-6. Epub 2011 Dec 16.

Department of Evolutionary Biology, University of Siena, Siena, Italy.

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http://www.nature.com/ni/journal/v13/n1/pdf/ni.2185.pdf%3FWT
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http://www.nature.com/doifinder/10.1038/ni.2185
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http://dx.doi.org/10.1038/ni.2185DOI Listing
December 2011

Comparative evaluation of label-free SINQ normalized spectral index quantitation in the central proteomics facilities pipeline.

Proteomics 2011 Jul 8;11(14):2790-7. Epub 2011 Jun 8.

Central Proteomics Facility, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/pmic.201000800DOI Listing
July 2011

Molecular T cell biology -- basic and translational challenges in the twenty-first century.

Front Immunol 2011 7;2. Epub 2011 Feb 7.

Laboratory of Immunobiology, Dana Farber Cancer Institute Boston, MA, USA.

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http://dx.doi.org/10.3389/fimmu.2011.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342379PMC
August 2012

T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component.

J Biol Chem 2011 Mar 28;286(9):7535-47. Epub 2010 Dec 28.

T Cell Signalling Laboratory, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.201236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045008PMC
March 2011

Proteomic characterization of plasma membrane-proximal T cell activation responses.

J Biol Chem 2011 Feb 2;286(6):4072-80. Epub 2010 Dec 2.

Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.165415
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http://dx.doi.org/10.1074/jbc.M110.165415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039341PMC
February 2011

CPFP: a central proteomics facilities pipeline.

Bioinformatics 2010 Apr 25;26(8):1131-2. Epub 2010 Feb 25.

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1093/bioinformatics/btq081DOI Listing
April 2010

Tailoring T-cell receptor signals by proximal negative feedback mechanisms.

Nat Rev Immunol 2008 Sep;8(9):699-712

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1038/nri2397DOI Listing
September 2008

Protein arginine methylation: a new frontier in T cell signal transduction.

Adv Exp Med Biol 2006 ;584:189-206

Molecular Immunology Unit, Institut Pasteur, Paris 75015, France.

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http://dx.doi.org/10.1007/0-387-34132-3_14DOI Listing
October 2006

Protein arginine methylation in lymphocyte signaling.

Curr Opin Immunol 2006 Jun 17;18(3):321-8. Epub 2006 Apr 17.

Molecular Immunology Unit, Institut Pasteur, Paris 75015, France.

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http://dx.doi.org/10.1016/j.coi.2006.03.001DOI Listing
June 2006

CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.

J Immunol 2005 Dec;175(11):7388-97

Molecular Immunology Unit, Department of Immunology, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.4049/jimmunol.175.11.7388DOI Listing
December 2005

CD28 costimulatory signal induces protein arginine methylation in T cells.

J Exp Med 2005 Aug;202(3):371-7

Molecular Immunology Unit, Institut Pasteur, Paris 75015, Cedex 15, France.

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http://dx.doi.org/10.1084/jem.20050176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213083PMC
August 2005

Antigen receptor signaling: the Tuscan chronicles.

Nat Immunol 2005 Jan;6(1):3-5

Department of Evolutionary Biology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1038/ni0105-3DOI Listing
January 2005

Large-scale screening for genes involved in T-cell signaling: do we know all the players now?

Trends Immunol 2004 Aug;25(8):399-402

Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25 Rue du Docteur Roux, F-75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1016/j.it.2004.06.001DOI Listing
August 2004

Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.

J Leukoc Biol 2004 Jun 24;75(6):1036-44. Epub 2004 Feb 24.

INSERM U396, Institut des Cordeliers, 75006 Paris, France.

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http://dx.doi.org/10.1189/jlb.0703356DOI Listing
June 2004

Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis.

J Biol Chem 2004 Apr 16;279(15):15550-60. Epub 2004 Jan 16.

Institut National de la Santé et de la Recherche Médicale Unité 576, Hôpital de l'Archet, Cedex 3, 06202 Nice, France.

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http://dx.doi.org/10.1074/jbc.M312659200DOI Listing
April 2004

CD28-mediated co-stimulation: a quantitative support for TCR signalling.

Nat Rev Immunol 2003 Dec;3(12):939-51

Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25 Rue du Dr Roux, Cedex 15, 75724 Paris, France.

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http://dx.doi.org/10.1038/nri1248DOI Listing
December 2003

Proximal changes in signal transduction that modify CD8+ T cell responsiveness in vivo.

Eur J Immunol 2003 Sep;33(9):2551-6

INSERM U591, Institut Necker, Paris, France.

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http://dx.doi.org/10.1002/eji.200324196DOI Listing
September 2003

T cell-dendritic cell interaction in vivo: random encounters favor development of long-lasting ties.

Authors:
Oreste Acuto

Sci STKE 2003 Jul 22;2003(192):PE28. Epub 2003 Jul 22.

Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris, Cedex 15, France.

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http://dx.doi.org/10.1126/stke.2003.192.pe28DOI Listing
July 2003

Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor.

Immunol Rev 2003 Apr;192:21-31

Molecular Immunology Unit, Department of Immunology, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1034/j.1600-065x.2003.00034.xDOI Listing
April 2003

Mammalian actin binding protein 1 is essential for endocytosis but not lamellipodia formation: functional analysis by RNA interference.

Biochem Biophys Res Commun 2003 Feb;301(3):704-10

Department of Immunology, Molecular Immunology Unit, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1016/s0006-291x(02)02972-8DOI Listing
February 2003

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling.

Nat Immunol 2003 Feb 23;4(2):189-97. Epub 2002 Dec 23.

Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1038/ni877DOI Listing
February 2003

Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction.

Blood 2002 Oct;100(8):2874-81

Institut National de la Santé et de la Recherche Médicale (INSERM) U487 and Unité des Thérapies innovantes, Institut Gustave Roussy, and Institut Andre Lwoff-CNRS, Hôpital Paul Brousse, Villejuif, France.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-02-06
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http://dx.doi.org/10.1182/blood-2002-02-0643DOI Listing
October 2002

CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?

Sci STKE 2002 Aug 6;2002(144):pe35. Epub 2002 Aug 6.

Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris, Cedex 15, France.

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http://dx.doi.org/10.1126/stke.2002.144.pe35DOI Listing
August 2002

Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor.

Eur J Immunol 2002 02;32(2):568-75

Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25 Rue du Docteur Roux, F-75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1002/1521-4141(200202)32:2<568::AID-IMMU568>3.0.CO;2-QDOI Listing
February 2002

Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.

Eur J Immunol 2002 02;32(2):447-56

Department of Cellular and Developmental Biology, University of Rome La Sapienza, Via del Sardi 70, I-00185 Rome, Italy.

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http://dx.doi.org/10.1002/1521-4141(200202)32:2<447::AID-IMMU447>3.0.CO;2-5DOI Listing
February 2002