Publications by authors named "Oren J Becher"

50Publications

Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models.

J Clin Invest 2020 Sep 29. Epub 2020 Sep 29.

Department of Radiation Oncology, Duke University, Durham, United States of America.

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http://dx.doi.org/10.1172/JCI142158DOI Listing
September 2020

Convection-Enhanced Delivery of Enhancer of Zeste Homolog-2 (EZH2) Inhibitor for the Treatment of Diffuse Intrinsic Pontine Glioma.

Neurosurgery 2020 Jul 16. Epub 2020 Jul 16.

Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1093/neuros/nyaa301DOI Listing
July 2020

Epigenetic reprogramming and chromatin accessibility in pediatric diffuse intrinsic pontine gliomas: a neural developmental disease.

Neuro Oncol 2020 02;22(2):195-206

Department of Cell and Developmental Biology and Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan.

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http://dx.doi.org/10.1093/neuonc/noz218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032633PMC
February 2020

HDAC inhibitors to the rescue in sonic hedgehog medulloblastoma.

Authors:
Oren J Becher

Neuro Oncol 2019 Sep;21(9):1091-1092

Division of Hematology, Oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1093/neuonc/noz115DOI Listing
September 2019

CDK4/6 and diffuse intrinsic pontine glioma - Evaluate at diagnosis?

Authors:
Oren J Becher

EBioMedicine 2019 06 13;44:16-17. Epub 2019 May 13.

Division of Hematology, Oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA; Malnati Brain Tumor Center and Lurie Cancer Center, Northwestern University, Chicago, IL, USA; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604365PMC
June 2019

CDK4/6 and PDGFRA Signaling as Therapeutic Targets in Diffuse Intrinsic Pontine Glioma.

Front Oncol 2018 31;8:191. Epub 2018 May 31.

Department of Pediatrics, Northwestern University, Chicago, IL, United States.

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http://dx.doi.org/10.3389/fonc.2018.00191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990603PMC
May 2018

Histone H3.3K27M Represses to Accelerate Gliomagenesis in a Murine Model of DIPG.

Mol Cancer Res 2017 09 18;15(9):1243-1254. Epub 2017 May 18.

Division of Hematology-Oncology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-16-0389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581686PMC
September 2017

A phase I study of perifosine with temsirolimus for recurrent pediatric solid tumors.

Pediatr Blood Cancer 2017 Jul 30;64(7). Epub 2016 Dec 30.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/pbc.26409DOI Listing
July 2017

Pediatric Neuro-Oncology: Time to Go Molecular.

Authors:
Oren J Becher

Oncology (Williston Park) 2016 May;30(5):424-5

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May 2016

ABCG2 and ABCB1 Limit the Efficacy of Dasatinib in a PDGF-B-Driven Brainstem Glioma Model.

Mol Cancer Ther 2016 05 16;15(5):819-29. Epub 2016 Feb 16.

Department of Pediatrics, Duke University, Durham, North Carolina. Department of Pathology, Duke University, Durham, North Carolina. Preston Robert Tisch Brain Tumor Center, Durham, North Carolina.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873451PMC
May 2016

A Novel Mouse Model of Diffuse Intrinsic Pontine Glioma Initiated in Pax3-Expressing Cells.

Neoplasia 2016 Jan;18(1):60-70

Division of Pediatric Hematology-Oncology, Duke University Medical Center, Durham, NC; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC; Department of Pathology, Duke University Medical Center, Durham, NC. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2015.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735629PMC
January 2016

Glioma Stem-like Cells Keep Their H3.3 Variant Levels at Bay.

Cancer Cell 2015 Dec;28(6):679-680

Division of Human Biology, Solid Tumor and Translational Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Alvord Brain Tumor Center, University of Washington, Seattle, WA 98104, USA. Electronic address:

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http://www.cell.com/cancer-cell/pdf/S1535-6108(15)00432-8.pd
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http://linkinghub.elsevier.com/retrieve/pii/S153561081500432
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http://dx.doi.org/10.1016/j.ccell.2015.12.001DOI Listing
December 2015

Diffuse Intrinsic Pontine Glioma: Time for Cautious Optimism.

J Child Neurol 2016 10 14;31(12):1377-85. Epub 2015 Sep 14.

Department of Pediatrics Duke University Medical Center, Durham, NC, USA Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA Department of Pathology, Duke University Medical Center, Durham, NC, USA

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http://dx.doi.org/10.1177/0883073815601495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025797PMC
October 2016

Pre-Clinical Models of Diffuse Intrinsic Pontine Glioma.

Front Oncol 2015 24;5:172. Epub 2015 Jul 24.

Department of Pediatrics, Division of Hematology-Oncology, Duke University Medical Center , Durham, NC , USA ; Department of Pathology, Duke University Medical Center , Durham, NC , USA.

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http://dx.doi.org/10.3389/fonc.2015.00172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513210PMC
August 2015

A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent.

PLoS One 2015 6;10(3):e0118926. Epub 2015 Mar 6.

Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America; Department of Pathology, Duke University Medical Center, Durham, NC, United States of America; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118926PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352073PMC
February 2016

Cancer. For pediatric glioma, leave no histone unturned.

Science 2014 Dec;346(6216):1458-9

Tumor Initiation & Maintenance Program, NCI-Designated Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1126/science.aaa3814DOI Listing
December 2014

Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma.

Acta Neuropathol Commun 2014 Oct 21;2:134. Epub 2014 Oct 21.

Division of Pediatric Hematology-Oncology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1186/s40478-014-0134-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210596PMC
October 2014

Sox2, a marker for stem-like tumor cells in skin squamous cell carcinoma and hedgehog subgroup medulloblastoma.

EMBO J 2014 Sep 24;33(18):1984-6. Epub 2014 Jul 24.

Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Alvord Brain Tumor Center, University of Washington, Seattle, WA, USA.

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http://emboj.embopress.org/cgi/doi/10.15252/embj.201489479
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http://dx.doi.org/10.15252/embj.201489479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195767PMC
September 2014

Children are not just little adults: recent advances in understanding of diffuse intrinsic pontine glioma biology.

Pediatr Res 2014 Jan 5;75(1-2):205-9. Epub 2013 Nov 5.

1] Department of Pediatrics, Duke University, Durham, North Carolina [2] Department of Pathology, Duke University, Durham, North Carolina.

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http://www.nature.com/articles/pr2013194
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http://dx.doi.org/10.1038/pr.2013.194DOI Listing
January 2014

PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma.

PLoS One 2013 2;8(10):e77639. Epub 2013 Oct 2.

Department of Pediatrics, Duke University, Durham, North Carolina, United States of America ; Preston Robert Tisch Brain Tumor Center, Duke University, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077639PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788718PMC
April 2014

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.

Science 2013 May 28;340(6134):857-61. Epub 2013 Mar 28.

Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.1232245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951439PMC
May 2013

Disease control and ototoxicity using intensity-modulated radiation therapy tumor-bed boost for medulloblastoma.

Int J Radiat Oncol Biol Phys 2011 Nov 12;81(3):e15-20. Epub 2011 Apr 12.

Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2010.11.081DOI Listing
November 2011

Evidence for and against regional differences in neural stem and progenitor cells of the CNS.

Genes Dev 2010 Oct;24(20):2233-8

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1101/gad.1988010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956202PMC
October 2010

Modeling Adult Gliomas Using RCAS/t-va Technology.

Transl Oncol 2009 May;2(2):89-95

Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670576PMC
http://dx.doi.org/10.1593/tlo.09100DOI Listing
May 2009

Large congenital melanotic nevi in an extremity with neurocutaneous melanocytosis.

Pediatr Dermatol 2009 Jan-Feb;26(1):79-82

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, USA.

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http://dx.doi.org/10.1111/j.1525-1470.2008.00828.xDOI Listing
May 2009

IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK.

J Child Neurol 2008 Oct;23(10):1205-13

Center for Cancer and Immunology Research, Children's Research Institute, Washington, DC 20010, USA.

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http://dx.doi.org/10.1177/0883073808321766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674842PMC
October 2008

Cancer stem cells and survival pathways.

Cell Cycle 2008 May 19;7(10):1371-8. Epub 2008 Mar 19.

Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.4161/cc.7.10.5954DOI Listing
May 2008

Genetically engineered models have advantages over xenografts for preclinical studies.

Cancer Res 2006 Apr;66(7):3355-8, discussion 3358-9

Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-3827DOI Listing
April 2006