Ophir D Klein

Ophir D Klein

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Ophir D Klein

Publications by authors named "Ophir D Klein"

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Use of organoids to study regenerative responses to intestinal damage.

Am J Physiol Gastrointest Liver Physiol 2019 Oct 7. Epub 2019 Oct 7.

Baylor College of Medicine.

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http://dx.doi.org/10.1152/ajpgi.00346.2018DOI Listing
October 2019

A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage.

Nat Cell Biol 2019 Sep 2;21(9):1102-1112. Epub 2019 Sep 2.

Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41556-019-0378-2DOI Listing
September 2019

Case Report of Floating-Harbor Syndrome With Bilateral Cleft Lip.

Cleft Palate Craniofac J 2019 Jun 27:1055665619858257. Epub 2019 Jun 27.

1 Program in Craniofacial Biology and Division of Craniofacial Anomalies, Department of Orofacial Sciences, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1177/1055665619858257DOI Listing
June 2019

The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting.

Am J Med Genet A 2019 May 22;179(5):864-869. Epub 2019 Feb 22.

Stowers Institute for Medical Research, Kansas City, Missouri.

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http://dx.doi.org/10.1002/ajmg.a.61090DOI Listing
May 2019

Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development.

Int J Mol Sci 2019 May 8;20(9). Epub 2019 May 8.

Department of Oral Biochemistry, Sahlgrenska Academy at the University of Gothenburg, SE-40530 Göteborg, Sweden.

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http://dx.doi.org/10.3390/ijms20092275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540044PMC
May 2019

Feedback regulation of RTK signaling in development.

Dev Biol 2019 03 26;447(1):71-89. Epub 2017 Oct 26.

Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco 94143, USA; Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, San Francisco 94143, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00121606173037
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http://dx.doi.org/10.1016/j.ydbio.2017.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920792PMC
March 2019

Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila.

Am J Physiol Gastrointest Liver Physiol 2019 Mar 13;316(3):G313-G322. Epub 2018 Dec 13.

Program in Craniofacial Biology and Department of Orofacial Sciences, University of California , San Francisco, California.

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http://dx.doi.org/10.1152/ajpgi.00353.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415738PMC
March 2019

Introduction to themed series on intestinal stem cells and the NIDDK Intestinal Stem Cell Consortium.

Am J Physiol Gastrointest Liver Physiol 2019 Feb 14;316(2):G247-G250. Epub 2018 Dec 14.

Department of Diabetes and Cancer Discovery Science, City of Hope Comprehensive Cancer Center, Duarte, California.

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http://dx.doi.org/10.1152/ajpgi.00146.2018DOI Listing
February 2019

Quantitative Clonal Analysis and Single-Cell Transcriptomics Reveal Division Kinetics, Hierarchy, and Fate of Oral Epithelial Progenitor Cells.

Cell Stem Cell 2019 01 21;24(1):183-192.e8. Epub 2018 Nov 21.

Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320295PMC
January 2019

Tissue Mechanical Forces and Evolutionary Developmental Changes Act Through Space and Time to Shape Tooth Morphology and Function.

Bioessays 2018 12 2;40(12):e1800140. Epub 2018 Nov 2.

Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1002/bies.201800140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516060PMC
December 2018

Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage.

Development 2018 11 5;145(21). Epub 2018 Nov 5.

Program in Craniofacial Biology, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA

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http://dx.doi.org/10.1242/dev.166363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240316PMC
November 2018

Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development.

Front Genet 2018 16;9:542. Epub 2018 Nov 16.

Program in Craniofacial Biology, Departments of Orofacial Sciences and Pediatrics, Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, United States.

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http://dx.doi.org/10.3389/fgene.2018.00542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250787PMC
November 2018

Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.

Nature 2018 10;562(7727):E22

Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41586-018-0370-1DOI Listing
October 2018

The intestinal epithelial response to damage.

Sci China Life Sci 2018 Oct 4;61(10):1205-1211. Epub 2018 Sep 4.

Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA, 94143, USA.

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http://dx.doi.org/10.1007/s11427-018-9331-yDOI Listing
October 2018

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.

Nat Commun 2018 10 10;9(1):4055. Epub 2018 Oct 10.

Department of Cellular and Molecular Pharmacology, University of California San Francisco, Mission Bay Campus, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1038/s41467-018-06137-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180039PMC
October 2018

SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis.

Development 2018 07 17;145(14). Epub 2018 Jul 17.

Department of Cell and Developmental Biology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA

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http://dx.doi.org/10.1242/dev.164889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078335PMC
July 2018

Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.

Nature 2018 07 27;559(7712):109-113. Epub 2018 Jun 27.

Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41586-018-0257-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042247PMC
July 2018

Publisher Correction: FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells.

Nat Commun 2018 07 17;9(1):2854. Epub 2018 Jul 17.

Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41467-018-05361-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050296PMC
July 2018

Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia.

Elife 2018 06 13;7. Epub 2018 Jun 13.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.

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http://dx.doi.org/10.7554/eLife.36739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023609PMC
June 2018

FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells.

Nat Commun 2018 06 13;9(1):2333. Epub 2018 Jun 13.

Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41467-018-04399-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998134PMC
June 2018

Bmi1+ Progenitor Cell Dynamics in Murine Cornea During Homeostasis and Wound Healing.

Stem Cells 2018 04 17;36(4):562-573. Epub 2018 Jan 17.

Helsinki Institute of Life Science, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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http://doi.wiley.com/10.1002/stem.2767
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http://dx.doi.org/10.1002/stem.2767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929111PMC
April 2018

Plasticity within the niche ensures the maintenance of a stem cell population in the mouse incisor.

Development 2018 01 8;145(1). Epub 2018 Jan 8.

Helsinki Institute of Life Sciences, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland

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http://dx.doi.org/10.1242/dev.155929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825875PMC
January 2018

Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme.

Dev Cell 2018 01 28;44(2):165-178.e6. Epub 2017 Dec 28.

Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA; Center for Cellular Construction, University of California, San Francisco, CA 94143, USA; Graduate Program in Bioengineering, University of California, Berkeley, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826757PMC
January 2018

Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation.

Cell Rep 2018 01 28;22(4):1003-1015. Epub 2018 Jan 28.

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798462PMC
January 2018

Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor.

J Bone Miner Res 2017 Nov 31;32(11):2219-2231. Epub 2017 Jul 31.

Program in Craniofacial Biology and Department of Orofacial Sciences, UCSF School of Dentistry, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1002/jbmr.3202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685895PMC
November 2017

Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers.

J Biol Chem 2017 09 21;292(36):15062-15069. Epub 2017 Jul 21.

the Departments of Orofacial Sciences and Program in Craniofacial Biology and

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http://dx.doi.org/10.1074/jbc.M117.785923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592681PMC
September 2017

An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice.

Cell Stem Cell 2017 07 27;21(1):91-106.e6. Epub 2017 Apr 27.

Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501749PMC
July 2017

From snapshots to movies: Understanding early tooth development in four dimensions.

Dev Dyn 2017 06 11;246(6):442-450. Epub 2017 Apr 11.

Program in Craniofacial Biology and Department of Orofacial Sciences, University of California San Francisco, San Francisco, California.

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http://doi.wiley.com/10.1002/dvdy.24501
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http://dx.doi.org/10.1002/dvdy.24501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426979PMC
June 2017

FGF signaling refines Wnt gradients to regulate the patterning of taste papillae.

Development 2017 06 15;144(12):2212-2221. Epub 2017 May 15.

Department of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA 94143, USA

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http://dx.doi.org/10.1242/dev.148080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482992PMC
June 2017

Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis.

Elife 2017 05 5;6. Epub 2017 May 5.

Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, United States.

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http://dx.doi.org/10.7554/eLife.24712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419740PMC
May 2017

patterning of pluripotent stem cell-derived intestine recapitulates human development.

Development 2017 03 7;144(6):1045-1055. Epub 2016 Dec 7.

Department of Internal Medicine, Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA

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http://dx.doi.org/10.1242/dev.138453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358103PMC
March 2017

EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells.

Stem Cell Reports 2017 03 23;8(3):529-537. Epub 2017 Feb 23.

Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355632PMC
March 2017

Human Facial Shape and Size Heritability and Genetic Correlations.

Genetics 2017 02 14;205(2):967-978. Epub 2016 Dec 14.

Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, Colorado 80045

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http://dx.doi.org/10.1534/genetics.116.193185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289863PMC
February 2017

Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif.

Proc Natl Acad Sci U S A 2017 02 14;114(9):E1641-E1650. Epub 2017 Feb 14.

Institute of Microbiology of the Czech Academy of Sciences, v.v.i., 142 20 Prague 4, Czech Republic;

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http://dx.doi.org/10.1073/pnas.1615334114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338493PMC
February 2017

Identification of novel Fgf enhancers and their role in dental evolution.

Evol Dev 2016 Jan-Feb;18(1):31-40. Epub 2015 Jun 18.

Department of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1111/ede.12132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826035PMC
October 2016

Modeling craniofacial and skeletal congenital birth defects to advance therapies.

Hum Mol Genet 2016 Oct 26;25(R2):R86-R93. Epub 2016 Jun 26.

Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA, USA Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA

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http://dx.doi.org/10.1093/hmg/ddw171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036869PMC
October 2016

From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models.

Curr Top Dev Biol 2015 6;115:459-92. Epub 2015 Oct 6.

Program in Craniofacial Biology, University of California San Francisco, San Francisco, California, USA; Department of Orofacial Sciences, University of California San Francisco, San Francisco, California, USA; Department of Pediatrics, University of California San Francisco, San Francisco, California, USA; Institute for Human Genetics, University of California San Francisco, San Francisco, California, USA. Electronic address:

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http://dx.doi.org/10.1016/bs.ctdb.2015.07.003DOI Listing
September 2016

Watching a deep dive: Live imaging provides lessons about tooth invagination.

J Cell Biol 2016 09;214(6):645-7

Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA 94143 Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA 94143 Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143

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http://dx.doi.org/10.1083/jcb.201608088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021101PMC
September 2016

SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.

Proc Natl Acad Sci U S A 2016 09 12;113(39):E5731-40. Epub 2016 Sep 12.

School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047180PMC
http://dx.doi.org/10.1073/pnas.1611532113DOI Listing
September 2016

Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling.

Bone 2016 07 26;88:170-179. Epub 2016 Apr 26.

Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, United States; Program in Craniofacial Biology, University of California, San Francisco, San Francisco, CA, United States; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2016.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899137PMC
July 2016

αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development.

Nat Commun 2016 07 13;7:12133. Epub 2016 Jul 13.

Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/ncomms12133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947177PMC
July 2016

Expression of FGFs during early mouse tongue development.

Gene Expr Patterns 2016 03 31;20(2):81-7. Epub 2015 Dec 31.

Department of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA 94143, USA; Department of Pediatrics and Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gep.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842327PMC
March 2016

Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice.

PLoS One 2015 29;10(4):e0124861. Epub 2015 Apr 29.

Laboratory of Neurophysiology, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124861PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414615PMC
February 2016

Inhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects.

J Bone Miner Res 2016 Jan 6;31(1):152-62. Epub 2015 Aug 6.

Department of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1002/jbmr.2591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840178PMC
January 2016

Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis.

Dev Cell 2015 Dec;35(6):713-24

Department of Orofacial Sciences and Program in Craniofacial Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA; Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.11.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710359PMC
December 2015

Developing and regenerating a sense of taste.

Curr Top Dev Biol 2015 20;111:401-19. Epub 2015 Jan 20.

Departments of Orofacial Sciences and Pediatrics, University of California San Francisco, San Francisco, California, USA; Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, California, USA; Institute for Human Genetics, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1016/bs.ctdb.2014.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435577PMC
October 2015

Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo.

Stem Cell Reports 2015 Jun 3. Epub 2015 Jun 3.

Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Center for Organogenesis, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471827PMC
June 2015

Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model.

Sci Rep 2015 Jun 30;5:11658. Epub 2015 Jun 30.

Evo-Devo of Vertebrate Dentition, Institute of Functional Genomics of Lyon, ENS de Lyon, CNRS UMR 5242, Université Lyon 1 - Université de Lyon, 46 allée d'Italie, 69364 Lyon cedex 07, France.

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http://dx.doi.org/10.1038/srep11658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485067PMC
June 2015

Continuously growing rodent molars result from a predictable quantitative evolutionary change over 50 million years.

Cell Rep 2015 May 23;11(5):673-80. Epub 2015 Apr 23.

Department of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA 94143, USA; Department of Pediatrics and Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426059PMC
May 2015

Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis.

Cell Rep 2015 Apr 26;11(1):33-42. Epub 2015 Mar 26.

Departments of Orofacial Sciences and Pediatrics, Institute of Human Genetics and Program in Craniofacial Biology, UCSF, 513 Parnassus Avenue, San Francisco, CA 94143-0442, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394041PMC
April 2015

Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia.

Mol Genet Genomic Med 2014 Sep 20;2(5):422-9. Epub 2014 May 20.

Program in Craniofacial and Mesenchymal Biology, University of California San Francisco San Francisco, CA ; Center for Craniofacial Anomalies, Department of Orofacial Sciences, University of California San Francisco San Francisco, CA ; Institute for Human Genetics and Department of Pediatrics, University of California San Francisco San Francisco, CA.

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http://dx.doi.org/10.1002/mgg3.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190877PMC
September 2014

Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium.

Development 2014 Aug 3;141(15):2993-3002. Epub 2014 Jul 3.

Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Aurora, CO 80045, USA Graduate Program in Cell Biology, Stem Cells and Development, University of Colorado School of Medicine, Aurora, CO 80045, USA

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http://dev.biologists.org/content/develop/141/15/2993.full.p
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http://dev.biologists.org/cgi/doi/10.1242/dev.107631
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http://dx.doi.org/10.1242/dev.107631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197660PMC
August 2014

Replaying evolutionary transitions from the dental fossil record.

Nature 2014 Aug 30;512(7512):44-8. Epub 2014 Jul 30.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O. Box 56, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1038/nature13613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252015PMC
August 2014

Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages.

Exp Cell Res 2014 Jul 14;325(2):96-103. Epub 2014 Feb 14.

Program in Craniofacial and Mesenchymal Biology and Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2014.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072742PMC
July 2014

Current trends in stem cell therapy for improvement of bone quality.

Histol Histopathol 2014 Jun 11;29(6):691-7. Epub 2013 Dec 11.

Department of Oral and Maxillofacial Surgery, Hamamatsu Kita Hospital, Higashi-ku, Hamamatsu, Japan.

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http://dx.doi.org/10.14670/HH-29.691DOI Listing
June 2014

Craniofacial and dental development in Costello syndrome.

Am J Med Genet A 2014 Jun 25;164A(6):1425-30. Epub 2014 Mar 25.

Program in Craniofacial and Mesenchymal Biology, and Division of Craniofacial Anomalies, Department of Orofacial Sciences, University of California San Francisco, San Francisco, California.

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http://dx.doi.org/10.1002/ajmg.a.36475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115793PMC
June 2014

Isolation and culture of dental epithelial stem cells from the adult mouse incisor.

J Vis Exp 2014 May 1(87). Epub 2014 May 1.

Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco; Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco;

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http://dx.doi.org/10.3791/51266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141628PMC
May 2014

Dental findings in 14q terminal deletion syndrome.

Clin Dysmorphol 2014 Apr;23(2):60-2

Departments of aPediatrics bLaboratory Medicine cOrofacial Sciences dProgram in Craniofacial and Mesenchymal Biology eInstitute for Human Genetics, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1097/MCD.0000000000000026DOI Listing
April 2014

From molecules to mastication: the development and evolution of teeth.

Wiley Interdiscip Rev Dev Biol 2013 Mar-Apr;2(2):165-82. Epub 2012 May 3.

Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1002/wdev.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632217PMC
March 2014

Sprouty genes regulate proliferation and survival of human embryonic stem cells.

Sci Rep 2013 ;3:2277

Program in Craniofacial and Mesenchymal Biology and Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/srep02277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721083PMC
February 2014

On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells.

Genesis 2014 Feb 14;52(2):79-92. Epub 2013 Dec 14.

Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, California.

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http://dx.doi.org/10.1002/dvg.22732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252016PMC
February 2014

Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia.

Dev Biol 2014 Feb 18;386(1):1-11. Epub 2013 Dec 18.

Department of Orofacial Sciences, University of California, San Francisco, United States; Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, United States; Institute for Human Genetics, University of California, San Francisco, United States; Department of Pediatrics, University of California, San Francisco, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2013.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921686PMC
February 2014

Fibroblast growth factor signaling in mammalian tooth development.

Odontology 2014 Jan 17;102(1):1-13. Epub 2013 Dec 17.

Zhongshan Hospital of Dalian University, Dalian, 116001, China.

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http://dx.doi.org/10.1007/s10266-013-0142-1DOI Listing
January 2014

Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey.

Int J Oral Sci 2013 Sep 26;5(3):121-9. Epub 2013 Jul 26.

Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, San Francisco, USA.

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http://dx.doi.org/10.1038/ijos.2013.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967329PMC
September 2013

Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an effort to formulate a departmental policy.

J Pediatr 2013 Sep;163(3):616-7.e1

Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.jpeds.2013.05.047DOI Listing
September 2013

The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation.

Development 2013 Aug 17;140(16):3348-59. Epub 2013 Jul 17.

Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1242/dev.089193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737717PMC
August 2013

The dynamics of supernumerary tooth development are differentially regulated by Sprouty genes.

J Exp Zool B Mol Dev Evol 2013 Jul 19;320(5):307-20. Epub 2013 Apr 19.

Department of Teratology, Institute of Experimental Medicine AS CR, Prague, Czech Republic.

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http://dx.doi.org/10.1002/jez.b.22502DOI Listing
July 2013

BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor.

Nat Cell Biol 2013 Jul 2;15(7):846-52. Epub 2013 Jun 2.

Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/ncb2766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735916PMC
July 2013

If a stem cell dies in the crypt, and no one is around to see it….

Cell Stem Cell 2013 Apr;12(4):389-90

Biomedical Sciences Graduate Program, Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.stem.2013.03.009DOI Listing
April 2013

Injectable bone tissue engineering using expanded mesenchymal stem cells.

Stem Cells 2013 Mar;31(3):572-80

Center for Genetic and Regenerative Medicine, Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan.

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http://dx.doi.org/10.1002/stem.1300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043220PMC
March 2013

Characterization of dental epithelial stem cells from the mouse incisor with two-dimensional and three-dimensional platforms.

Tissue Eng Part C Methods 2013 Jan 16;19(1):15-24. Epub 2012 Aug 16.

Program in Craniofacial and Mesenchymal Biology and Department of Orofacial Sciences, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1089/ten.TEC.2012.0232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522131PMC
January 2013

Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis.

Cell Rep 2013 Jan 24;3(1):70-8. Epub 2013 Jan 24.

Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143-0452, USA.

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http://dx.doi.org/10.1016/j.celrep.2012.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563842PMC
January 2013

Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors.

Dev Cell 2012 Aug 19;23(2):317-28. Epub 2012 Jul 19.

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.devcel.2012.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690347PMC
August 2012

Stem cell and biomaterials research in dental tissue engineering and regeneration.

Dent Clin North Am 2012 Jul;56(3):495-520

Division of Endodontics, Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, CA 94143-0758, USA.

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http://dx.doi.org/10.1016/j.cden.2012.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494412PMC
July 2012

Expression of microRNAs in the stem cell niche of the adult mouse incisor.

PLoS One 2011 8;6(9):e24536. Epub 2011 Sep 8.

Program in Craniofacial and Mesenchymal Biology, Department of Orofacial Sciences, University of California San Francisco, San Francisco, United States of America.

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http://dx.plos.org/10.1371/journal.pone.0024536
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169592PMC
June 2012

E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor.

Dev Biol 2012 Jun 18;366(2):357-66. Epub 2012 Apr 18.

Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, UCSF, USA.

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http://dx.doi.org/10.1016/j.ydbio.2012.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690274PMC
June 2012

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable.

Nature 2011 Sep 18;478(7368):255-9. Epub 2011 Sep 18.

Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nature10408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251967PMC
September 2011

FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size.

PLoS Genet 2011 Jun 2;7(6):e1002098. Epub 2011 Jun 2.

Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1371/journal.pgen.1002098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107195PMC
June 2011

PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.

J Cell Sci 2011 Mar 1;124(Pt 5):745-54. Epub 2011 Feb 1.

Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1242/jcs.078071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039019PMC
March 2011