Publications by authors named "Omnia Magdy Hendawy"

3 Publications

  • Page 1 of 1

Potential Anticancer Lipoxygenase Inhibitors from the Red Sea-Derived Brown Algae : An In-Silico-Supported In-Vitro Study.

Antibiotics (Basel) 2021 Apr 10;10(4). Epub 2021 Apr 10.

Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

LC-MS-assisted metabolomic profiling of the Red Sea-derived brown algae "Sargassaceae" dereplicated eleven compounds -. Further phytochemical investigation afforded two new aryl cresol -, along with eight known compounds -. Both new metabolites, along with showed moderate in vitro antiproliferative activity against HepG2, MCF-7, and Caco-2. Pharmacophore-based virtual screening suggested both 5-LOX and 15-LOX as the most probable target linked to their observed antiproliferative activity. The in vitro enzyme assays revealed and were able to inhibit 5-LOX more preferentially than 15-LOX, while showed a convergent inhibitory activity toward both enzymes. Further in-depth in silico investigation revealed the molecular interactions inside both enzymes' active sites and explained the varying inhibitory activity for and toward 5-LOX and 15-LOX.
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http://dx.doi.org/10.3390/antibiotics10040416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069941PMC
April 2021

Holospiniferoside: A New Antitumor Cerebroside from The Red Sea Cucumber In Vitro and In Silico Studies.

Molecules 2021 Mar 12;26(6). Epub 2021 Mar 12.

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

Chemical investigation of the methanolic extract of the Red Sea cucumber led to the isolation of a new cerebroside, holospiniferoside (), together with thymidine (), methyl--d-glucopyranoside (), a new triacylglycerol (), and cholesterol (). Their chemical structures were established by NMR and mass spectrometric analysis, including gas chromatography-mass spectrometry (GC-MS) and high-resolution mass spectrometry (HRMS). All the isolated compounds are reported in this species for the first time. Moreover, compound exhibited promising in vitro antiproliferative effect on the human breast cancer cell line (MCF-7) with IC of 20.6 µM compared to the IC of 15.3 µM for the drug cisplatin. To predict the possible mechanism underlying the cytotoxicity of compound , a docking study was performed to elucidate its binding interactions with the active site of the protein Mdm2-p53. Compound displayed an apoptotic activity via strong interaction with the active site of the target protein. This study highlights the importance of marine natural products in the design of new anticancer agents.
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http://dx.doi.org/10.3390/molecules26061555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001240PMC
March 2021

Nano-Delivery Systems for Improving Therapeutic Efficiency of Dietary Polyphenols.

Altern Ther Health Med 2021 Jun;27(S1):162-177

Dietary polyphenols, primarily categorized into flavonoids (flavanols, flavones, flavan-3-ols, anthocyanidins, flavanones, and isoflavones) and nonflavonoids (stilbenes and phenolic acids) are reported to have health-promoting effects, such as antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, and cardioprotective properties. However, their applications in functional food and medications are limited due to their low bioavailability and insufficient systemic delivery. Nano-delivery system conveyances frameworks astoundingly influence the take-up properties of the stacked atoms because the molecule small shape, size, and surface properties of the nanoparticles apply a vital role in the improvement of the systemic delivery of polyphenols This includes nano-emulsion, nano-encapsulation, polymer nanoparticles (NPs), nano-liposomes, solid liquid nanoparticles, cyclodextrins, and polyphenol-loaded hydrogels. Nano-technology is a rapidly developing area that guarantees the improvement of materials with novel measurements, new properties, and more extensive scope for utilization. This review reports the different therapeutic applications of dietary polyphenols, their biological activities, and different nano-delivery systems successfully developed for overcoming the delivery challenges. These applications also seek to improve their bioavailability, reduce toxicity, and enhance dietary polyphenol uptake across the gastrointestinal tract.
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June 2021
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