Omar Abdel-Wahab

Omar Abdel-Wahab

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Omar Abdel-Wahab

Omar Abdel-Wahab

Publications by authors named "Omar Abdel-Wahab"

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100Publications

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Altered RNA Processing in Cancer Pathogenesis and Therapy.

Cancer Discov 2019 Oct 14. Epub 2019 Oct 14.

Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0399DOI Listing
October 2019

Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors.

Sci Transl Med 2019 Sep;11(511)

Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, New York, NY 11724, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaw3781DOI Listing
September 2019

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

Cancer Cell 2019 Aug;36(2):194-209.e9

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore; Department of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacological Sciences and Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.07.003DOI Listing
August 2019

Molecular Profiling of Tumor Tissue and Plasma Cell-Free DNA from Patients with Non-Langerhans Cell Histiocytosis.

Mol Cancer Ther 2019 Jun 23;18(6):1149-1157. Epub 2019 Apr 23.

Center for Personalized Cancer Therapy, Division of Blood and Marrow Transplantation, Division of Hematology/Oncology, Department of Medicine, University of California San Diego, Moores Cancer Center, La Jolla, California.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-1244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548628PMC
June 2019

BRAF in the cross-hairs.

Expert Rev Hematol 2019 Mar 26;12(3):183-193. Epub 2019 Feb 26.

a Leukemia Service , Memorial Sloan Kettering Cancer Center , New York , NY , USA.

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http://dx.doi.org/10.1080/17474086.2019.1583553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614740PMC
March 2019

Activating p53 and Inhibiting Superenhancers to Cure Leukemia.

Trends Pharmacol Sci 2018 12;39(12):1002-1004

Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01656147183019
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http://dx.doi.org/10.1016/j.tips.2018.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614867PMC
December 2018

ProteomeGenerator: A Framework for Comprehensive Proteomics Based on de Novo Transcriptome Assembly and High-Accuracy Peptide Mass Spectral Matching.

J Proteome Res 2018 11 19;17(11):3681-3692. Epub 2018 Oct 19.

Molecular Pharmacology Program , Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center , New York City , New York 10065 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00295
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http://dx.doi.org/10.1021/acs.jproteome.8b00295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727203PMC
November 2018

Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia.

Nature 2018 09 27;561(7721):127-131. Epub 2018 Aug 27.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41586-018-0465-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527314PMC
September 2018

KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function.

Oncogene 2018 08 14;37(34):4692-4710. Epub 2018 May 14.

Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, USA.

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http://dx.doi.org/10.1038/s41388-018-0273-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107480PMC
August 2018

Cancer-Specific Splicing Changes and the Potential for Splicing-Derived Neoantigens.

Cancer Cell 2018 08;34(2):181-183

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, 408 E. 69th Street, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614861PMC
August 2018

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.

Cancer Cell 2018 08;34(2):225-241.e8

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, Zuckerman 701, 408 East 69(th) Street, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373472PMC
August 2018

Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs.

Stem Cell Reports 2018 05 19;10(5):1610-1624. Epub 2018 Apr 19.

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1044A, New York, NY 10029, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711183014
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http://dx.doi.org/10.1016/j.stemcr.2018.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995368PMC
May 2018

Single-agent dabrafenib for -mutated histiocytosis.

Haematologica 2018 04 22;103(4):e177-e180. Epub 2018 Feb 22.

Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

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http://dx.doi.org/10.3324/haematol.2017.185298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865413PMC
April 2018

SETD2 - linking stem cell survival and transformation.

Cell Res 2018 04;28(4):393-394

Human Oncology and Pathogenesis Program and Acute Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

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http://dx.doi.org/10.1038/s41422-018-0025-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939039PMC
April 2018

Targeting mRNA Decapping in AML.

Cancer Cell 2018 03;33(3):339-341

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614869PMC
March 2018

The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.

Mol Cell 2018 02 27;69(3):412-425.e6. Epub 2018 Jan 27.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA; Institute of Genomic Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957072PMC
February 2018

Editorial overview: Cancer genomics: RNA metabolism and translation in cancer pathogenesis and therapy.

Curr Opin Genet Dev 2018 02;48:iv-vi

Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain; Universitat Pompeu Fabra, Barcelona 08003, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2018.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657511PMC
February 2018

Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.

PLoS One 2017 18;12(5):e0175523. Epub 2017 May 18.

Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175523PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436638PMC
September 2017

Identification and Targeting of Kinase Alterations in Histiocytic Neoplasms.

Hematol Oncol Clin North Am 2017 08 17;31(4):705-719. Epub 2017 May 17.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2017.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536849PMC
August 2017

High prevalence of myeloid neoplasms in adults with non-Langerhans cell histiocytosis.

Blood 2017 08 5;130(8):1007-1013. Epub 2017 Jul 5.

Service de Médecine Interne 2, Institut E3M, Centre de Références des Maladies Auto-Immunes et Systémiques Rares, Centre de Référence des Histiocytoses, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Pierre et Marie Curie, Paris, France.

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http://dx.doi.org/10.1182/blood-2017-01-761718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570678PMC
August 2017

Diagnosis and classification of hematologic malignancies on the basis of genetics.

Blood 2017 07 9;130(4):410-423. Epub 2017 Jun 9.

Human Oncology and Pathogenesis Program, Department of Medicine.

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http://dx.doi.org/10.1182/blood-2017-02-734541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533199PMC
July 2017

Therapeutic targeting of RNA splicing in myelodysplasia.

Semin Hematol 2017 07 12;54(3):167-173. Epub 2017 Jul 12.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY; Leukemia Service, Department\. of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2017.06.007DOI Listing
July 2017

Splicing factor mutations in MDS RARS and MDS/MPN-RS-T.

Int J Hematol 2017 Jun 2;105(6):720-731. Epub 2017 May 2.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, Zuckerman 601, 408 East 69th Street, New York, NY, 10065, USA.

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http://link.springer.com/10.1007/s12185-017-2242-0
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http://dx.doi.org/10.1007/s12185-017-2242-0DOI Listing
June 2017

How do messenger RNA splicing alterations drive myelodysplasia?

Blood 2017 05 27;129(18):2465-2470. Epub 2017 Mar 27.

Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1182/blood-2017-02-692715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418633PMC
May 2017

Modeling activating mutations in vivo.

Blood 2017 04;129(15):2046-2048

MEMORIAL SLOAN KETTERING CANCER CENTER.

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http://dx.doi.org/10.1182/blood-2017-03-770222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391629PMC
April 2017

Partial loss of genes might open therapeutic window.

Elife 2017 03 17;6. Epub 2017 Mar 17.

Human Oncology and Pathogenesis Program and the Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States.

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http://dx.doi.org/10.7554/eLife.25996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357136PMC
March 2017

Histiocytoses: emerging neoplasia behind inflammation.

Lancet Oncol 2017 02;18(2):e113-e125

Service de Médecine Interne 2, Centre National de Référence Maladies Auto Immunes Systémiques Rares, Institut E3M, Hôpital Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1016/S1470-2045(17)30031-1DOI Listing
February 2017

The clinical spectrum of Erdheim-Chester disease: an observational cohort study.

Blood Adv 2017 Feb;1(6):357-366

Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health. 10 Center Dr, Bldg 10, Room 3-2551, Bethesda, Maryland, USA, 20892. Telephone: 301-594-2952.

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http://dx.doi.org/10.1182/bloodadvances.2016001784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446206PMC
February 2017

Molecular Pathways: Understanding and Targeting Mutant Spliceosomal Proteins.

Clin Cancer Res 2017 Jan 10;23(2):336-341. Epub 2016 Nov 10.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-16-0131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241248PMC
January 2017

Treatment outcomes and secondary cancer incidence in young patients with hairy cell leukaemia.

Br J Haematol 2016 Nov 28;175(3):402-409. Epub 2016 Jun 28.

Leukemia Service, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1111/bjh.14207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539949PMC
November 2016

The Role of Additional Sex Combs-Like Proteins in Cancer.

Cold Spring Harb Perspect Med 2016 Oct 3;6(10). Epub 2016 Oct 3.

Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065.

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http://dx.doi.org/10.1101/cshperspect.a026526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046687PMC
October 2016

Anakinra as efficacious therapy for 2 cases of intracranial Erdheim-Chester disease.

Blood 2016 10 17;128(14):1896-1898. Epub 2016 Aug 17.

Department of Pediatrics, Hematology-Oncology, University of Utah, Primary Children's Hospital, Salt Lake City, UT.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2016-06-72
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http://dx.doi.org/10.1182/blood-2016-06-725143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054701PMC
October 2016

Genetic drivers of vulnerability and resistance in relapsed acute lymphoblastic leukemia.

Proc Natl Acad Sci U S A 2016 10 23;113(40):11071-11073. Epub 2016 Sep 23.

Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065

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http://dx.doi.org/10.1073/pnas.1613836113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056046PMC
October 2016

Emerging concepts of epigenetic dysregulation in hematological malignancies.

Nat Immunol 2016 09 1;17(9):1016-24. Epub 2016 Aug 1.

Department of Pathology and Perlmutter Cancer Center, New York University School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1038/ni.3517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134743PMC
September 2016

Therapeutic targeting of splicing in cancer.

Nat Med 2016 09;22(9):976-86

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, New York, USA.

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http://dx.doi.org/10.1038/nm.4165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644489PMC
September 2016

Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.

Cancer Cell 2016 09;30(3):371-373

Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569387PMC
September 2016

Diffuse reduction of cerebral grey matter volumes in Erdheim-Chester disease.

Orphanet J Rare Dis 2016 08 2;11(1):109. Epub 2016 Aug 2.

Department of Radiology, Well Cornell Medical College, New York, USA.

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http://dx.doi.org/10.1186/s13023-016-0490-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971748PMC
August 2016

Defining risk in MDS over time.

Blood 2016 08;128(7):885-6

MEMORIAL SLOAN KETTERING CANCER CENTER.

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http://dx.doi.org/10.1182/blood-2016-07-724930DOI Listing
August 2016

Histiocytic neoplasms in the era of personalized genomic medicine.

Curr Opin Hematol 2016 07;23(4):416-25

aDepartment of Pathology bDepartment of Neurology cHuman Oncology and Pathogenesis Program dLeukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112586PMC
July 2016

RNA splicing factors as oncoproteins and tumour suppressors.

Nat Rev Cancer 2016 07 10;16(7):413-30. Epub 2016 Jun 10.

Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1038/nrc.2016.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094465PMC
July 2016

Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.

Cancer Cell 2016 07 23;30(1):92-107. Epub 2016 Jun 23.

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945461PMC
July 2016

Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice.

Stem Cell Reports 2016 06 26;6(6):914-925. Epub 2016 May 26.

Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911496PMC
June 2016

ASXL1 plays an important role in erythropoiesis.

Sci Rep 2016 06 29;6:28789. Epub 2016 Jun 29.

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1038/srep28789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926121PMC
June 2016

Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis.

Genes Dev 2016 05;30(9):989-1001

Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1101/gad.278424.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863743PMC
May 2016

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells.

Nat Commun 2016 Feb 22;7:10739. Epub 2016 Feb 22.

Molecular Pharmacology and Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncomms10739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764878PMC
February 2016

Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia.

N Engl J Med 2015 Oct 9;373(18):1733-47. Epub 2015 Sep 9.

From the Institute of Hematology, Department of Medicine, and Centro di Ricerca Emato-Oncologico (CREO), University of Perugia, and Ospedale Santa Maria della Misericordia, Perugia (E.T., L.D.C., F.F., S.A., M.C., M.P.M., B.F.), the Department of Experimental, Diagnostic, and Specialty Medicine, Units of Hematology and Hematopathology, Bologna University School of Medicine, Bologna (A.B., S.A.P., P.L.Z.), Hematology Unit, Centro Trapianti e Terapie Cellulari Carlo Melzi, Dipartimento di Science Mediche Sperimentali e Cliniche, Azienda Ospedaliero Universitaria, Udine (F.Z.), the Department of Cellular Biotechnologies and Hematology, Division of Hematology, Sapienza University, Rome (A.P., R.F.), the Hematology and Bone Marrow Transplant Unit, Azienda Ospedaliera Regionale San Carlo, Potenza (M.C.), the Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara (D.R.), Hematology Unit, Ospedale Ferrarotto, Catania (G.M.), the Department of Onco-Hematology, Fondazione IRCCS, Policlinico San Matteo, Pavia (M.V.), Hematology Unit, Spedali Civili, Brescia (A. Anastasia), the Department of Medicine, Section of Hematology, University of Verona, Verona (A. Ambrosetti), Onco-Hematology Unit, Fondazione di Ricerca e Cura S.S. Giovanni Paolo II, Campobasso (V.F.), Institute of Hematology 1, IRCCS, Azienda Ospedaliero Universitaria San Martino-Istituto Nazionale per la Ricerca sul Cancro, Genoa (A.M.C.), the Department of Hematology, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona (P.L.), and the Hematology and Bone Marrow Transplant Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo (A.R.) - all in Italy; Leukemia Service (J.H.P., S.S.C., R.L.L., O.A-W., M.S.T.,) and Dermatology Service (M.E.L.), the Department of Medicine, Human Oncology and Pathogenesis Program (S.S., Y.R.C., E.K., R.L.L., C.Y.P., M.F.B., O.A-W.), the Departments of Epidemiology and Biostatistics (S.D.), Pathology (C.Y.P.), and Pharmaco

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http://dx.doi.org/10.1056/NEJMoa1506583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811324PMC
October 2015

BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition.

Cancer Cell 2015 Sep 3;28(3):370-83. Epub 2015 Sep 3.

Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Mechanism Based Therapeutics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894664PMC
September 2015