Olli Simell

Olli Simell

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Olli Simell

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Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies.

J Clin Endocrinol Metab 2018 08;103(8):2870-2878

Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1210/jc.2017-02040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097602PMC
August 2018

Cesarean Section on the Risk of Celiac Disease in the Offspring: The Teddy Study.

J Pediatr Gastroenterol Nutr 2018 03;66(3):417-424

*Dr. v. Hauner Children's Hospital, University Munich Medical Center, Munich, Germany †Health Informatics Institute, Department of Paediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL, USA ‡Institute of Diabetes Research, Helmholtz Zentrum München, Klinikum rechts der Isar, Technische Universität München, and Forschergruppe Diabetes e.V., Neuherberg, Germany §Department of Clinical Sciences, Lund University, Skane University Hosptial, Malmo, Sweden ||Digestive Health Institute, University of Colorado, Children's Hospital Colorado, Aurora, CO, USA ¶Medicity Laboratory, University of Turku, Turku, Finland #Tampere Centre for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland **Pacific Northwest Diabetes Research Institute, Seattle WA, USA ††Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora CO, USA ‡‡Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta GA, USA §§Department of Paediatrics, Turku University Hospital, Turku, Finland ||||Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland ¶¶Departments of Physiology, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1097/MPG.0000000000001682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787038PMC
March 2018

Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study.

Diabetes Care 2016 Sep 16;39(9):1535-42. Epub 2016 Jun 16.

Health Informatics Institute, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL.

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http://dx.doi.org/10.2337/dc16-0181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001144PMC
September 2016

Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI).

Metabolism 2016 09 27;65(9):1361-75. Epub 2016 May 27.

Department of Pediatrics, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, PL 52, 20521 Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2016.05.012DOI Listing
September 2016

Role of humoral beta-cell autoimmunity in type 1 diabetes.

Pediatr Diabetes 2016 07;17 Suppl 22:17-24

Department of Pediatrics, PEDEGO Research Group, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.

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http://doi.wiley.com/10.1111/pedi.12386
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http://dx.doi.org/10.1111/pedi.12386DOI Listing
July 2016

Reduced β-cell function in early preclinical type 1 diabetes.

Eur J Endocrinol 2016 Mar 30;174(3):251-9. Epub 2015 Nov 30.

Department of PaediatricsUniversity of Turku and Turku University Hospital, Turku, FinlandMediCity LaboratoriesDepartment of Clinical Medicine, University of Turku, Lemminkäisenkatu 3, 20520 Turku, FinlandPEDEGO Research UnitDepartment of Paediatrics, Medical Research Centre Oulu, University of Oulu, Oulu, FinlandDepartment of Children and AdolescentsOulu University Hospital, Oulu, FinlandClinical Research CentreTurku University Hospital, Turku, FinlandDepartment of PaediatricsTampere University Hospital, Tampere, FinlandNovo Nordisk Farma OyCMR Department, Espoo, FinlandDiabetes Outpatient ClinicTampere, FinlandDepartment of PaediatricsTurku University Hospital, Turku, FinlandResearch Centre of Applied and Preventive Cardiovascular MedicineUniversity of Turku, Turku, FinlandImmunogenetics LaboratoryUniversity of Turku, Turku, FinlandDepartment of Clinical MicrobiologyUniversity of Eastern Finland, Kuopio, FinlandChildren's HospitalUniversity of Helsinki and Helsinki University Hospital, Helsinki, FinlandResearch Programs UnitDiabetes and Obesity, University of Helsinki, Helsinki, FinlandFolkhälsan Research CentreUniversity of Helsinki, Helsinki, FinlandDepartment of PhysiologyInstitute of Biomedicine, University of Turku, Turku, Finland Department of PaediatricsUniversity of Turku and Turku University Hospital, Turku, FinlandMediCity LaboratoriesDepartment of Clinical Medicine, University of Turku, Lemminkäisenkatu 3, 20520 Turku, FinlandPEDEGO Research UnitDepartment of Paediatrics, Medical Research Centre Oulu, University of Oulu, Oulu, FinlandDepartment of Children and AdolescentsOulu University Hospital, Oulu, FinlandClinical Research CentreTurku University Hospital, Turku, FinlandDepartment of PaediatricsTampere University Hospital, Tampere, FinlandNovo Nordisk Farma OyCMR Department, Espoo, FinlandDiabetes Outpatient ClinicTampere, FinlandDepartment of PaediatricsTurku University Hospital, Turku, FinlandResearch Centre of Applied and Preventive Cardiovascu

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http://dx.doi.org/10.1530/EJE-15-0674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712442PMC
March 2016

Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes.

J Clin Endocrinol Metab 2016 Feb 22;101(2):723-9. Epub 2015 Dec 22.

Medicity (M.M., M.Ko., V.S.), Department of Pediatrics (M.M., J.M., M.Ko., J.T.), Immunogenetics Laboratory (J.I.), University of Turku and Turku University Hospital, and Research Center of Applied and Preventive Cardiovascular Medicine (O.S.), and Department of Physiology (J.T.), Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland; Department of Pediatrics (R.V.), Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology, Medical Research Center Oulu, University of Oulu, FI 90014 Oulu, Finland; Department of Children and Adolescents (R.V.), Oulu University Hospital, FI 90029 Oulu, Finland; Department of Virology (H.H.), School of Medicine, University of Tampere, and Department of Pediatrics (M.Kn.), Tampere University Hospital, FI-33520 Tampere, Finland; Fimlab Laboratories (H.H.), Pirkanmaa Hospital District, FI-33014 Tampere, Finland; Children's Hospital (M.Kn.), University of Helsinki and Helsinki University Hospital, Research Programs Unit (M.Kn.), Diabetes and Obesity, University of Helsinki, and Folkhälsan Research Center (M.Kn.), FI-00290 Helsinki, Finland.

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http://dx.doi.org/10.1210/jc.2015-3504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880127PMC
February 2016

Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study.

JAMA Pediatr 2016 Jan;170(1):20-8

National Institute for Health and Welfare, Nutrition Unit, Helsinki, Finland12School of Health Sciences and Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland 13The Science Center of Pirkanmaa Hospita.

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http://www.melk.no/sitefiles/6/EarlyExposureofProbioticsandI
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http://archpedi.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamapediatrics.2015.2757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803028PMC
January 2016

Food consumption and risk of childhood asthma.

Pediatr Allergy Immunol 2015 Dec 12;26(8):789-96. Epub 2015 May 12.

Nutrition Unit, Department of Lifestyle and Participation, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1111/pai.12352DOI Listing
December 2015

Dysfunction in macrophage toll-like receptor signaling caused by an inborn error of cationic amino acid transport.

Mol Immunol 2015 Oct 22;67(2 Pt B):416-25. Epub 2015 Jul 22.

Department of Pediatrics, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, PL 52, 20521 Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2015.07.006DOI Listing
October 2015

Association of Adiponectin with Adolescent Cardiovascular Health in a Dietary Intervention Study.

J Pediatr 2015 Aug 15;167(2):353-60.e1. Epub 2015 May 15.

Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.

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https://linkinghub.elsevier.com/retrieve/pii/S00223476150042
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http://dx.doi.org/10.1016/j.jpeds.2015.04.044DOI Listing
August 2015

OGTT and random plasma glucose in the prediction of type 1 diabetes and time to diagnosis.

Diabetologia 2015 Aug 19;58(8):1787-96. Epub 2015 May 19.

Department of Pediatrics, PEDEGO Research Group, Medical Research Center, Oulu University Hospital and University of Oulu, PO Box 5000, FIN-90014, Oulu, Finland,

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http://link.springer.com/10.1007/s00125-015-3621-9
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http://dx.doi.org/10.1007/s00125-015-3621-9DOI Listing
August 2015

Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease.

J Autoimmun 2015 Jul 12;61:45-53. Epub 2015 Jun 12.

Immunogenetics Laboratory, University of Turku, Turku, Finland; Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1016/j.jaut.2015.05.005DOI Listing
July 2015

HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study.

Am J Gastroenterol 2015 Jun 26;110(6):915-20. Epub 2015 May 26.

1] Pediatric Epidemiology Center, University of South Florida, Tampa, Florida, USA [2] Department of Clinical Sciences, Lund University, Malmo, Sweden.

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http://dx.doi.org/10.1038/ajg.2015.150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487515PMC
June 2015

Antibodies to deamidated gliadin peptide in diagnosis of celiac disease in children.

J Pediatr Gastroenterol Nutr 2015 May;60(5):626-31

*Department of Clinical Microbiology †Department of Pediatrics, University of Eastern Finland ‡Department of Pediatrics and Adolescent Medicine, University of Turku, Turku §A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio ||Department of Pediatrics, University of Oulu and Oulu University Hospital, Oulu ¶Children's Hospital, University of Helsinki, Helsinki #Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland.

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http://www.naspghan.org/files/documents/pdfs/cme/jpgn/Antibo
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http://dx.doi.org/10.1097/MPG.0000000000000666DOI Listing
May 2015

HbA1c Predicts Time to Diagnosis of Type 1 Diabetes in Children at Risk.

Diabetes 2015 May 18;64(5):1719-27. Epub 2014 Dec 18.

Department of Pediatrics, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland

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http://dx.doi.org/10.2337/db14-0497DOI Listing
May 2015

CD4⁺ T-cell proliferation responses to wheat polypeptide stimulation in children at different stages of type 1 diabetes autoimmunity.

Pediatr Diabetes 2015 May 30;16(3):177-88. Epub 2015 Jan 30.

Department of Pediatrics, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Department of Medical Microbiology and Immunology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1111/pedi.12256DOI Listing
May 2015

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study.

Diabetologia 2015 May 10;58(5):980-7. Epub 2015 Feb 10.

Department of Pediatrics, Morsani College of Medicine, University of South Florida, 3650 Spectrum Boulevard, Suite 100, Tampa, FL, 33612, USA,

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http://dx.doi.org/10.1007/s00125-015-3514-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393776PMC
May 2015

Gut virome sequencing in children with early islet autoimmunity.

Diabetes Care 2015 May 12;38(5):930-3. Epub 2015 Feb 12.

Department of Pediatrics, University Hospital Motol, and 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

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http://dx.doi.org/10.2337/dc14-2490DOI Listing
May 2015

The association of dietary alpha-linolenic acid with blood pressure and subclinical atherosclerosis in people born small for gestational age: the Special Turku Coronary Risk Factor Intervention Project study.

J Pediatr 2015 May 18;166(5):1252-1257.e2. Epub 2015 Feb 18.

Research Centre of Applied and Preventive Cardiovascular Medicine; Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland.

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https://linkinghub.elsevier.com/retrieve/pii/S00223476150002
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http://dx.doi.org/10.1016/j.jpeds.2015.01.020DOI Listing
May 2015

Decrease in circulating concentrations of soluble receptors for advanced glycation end products at the time of seroconversion to autoantibody positivity in children with prediabetes.

Diabetes Care 2015 Apr 8;38(4):665-70. Epub 2015 Jan 8.

Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland Department of Pediatrics, Tampere University Hospital, Tampere, Finland

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http://dx.doi.org/10.2337/dc14-1186DOI Listing
April 2015

High lipoprotein(a) concentrations are associated with impaired endothelial function in children.

J Pediatr 2015 Apr 4;166(4):947-52.e1-2. Epub 2015 Feb 4.

Department of Medicine, University of Turku, Turku, Finland; Division of Medicine, Turku University Hospital, Turku, Finland.

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https://linkinghub.elsevier.com/retrieve/pii/S00223476140122
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http://dx.doi.org/10.1016/j.jpeds.2014.12.051DOI Listing
April 2015

Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes.

Clin Epigenetics 2015 26;7:34. Epub 2015 Mar 26.

Department of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska Institutet, Stockholm, Sweden ; Folkhälsan Institute of Genetics, Helsinki, and Research Programs Unit, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1186/s13148-015-0064-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396570PMC
April 2015

Metabolic syndrome from adolescence to early adulthood: effect of infancy-onset dietary counseling of low saturated fat: the Special Turku Coronary Risk Factor Intervention Project (STRIP).

Circulation 2015 Feb 20;131(7):605-13. Epub 2015 Jan 20.

From the Research Centre of Applied and Preventive Cardiovascular Medicine, Turku, Finland (M.N., K.P., M.J., C.G.M., M.S., O.S., O.T.R.); Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Health and Physical Activity, Turku, Finland (K.P.); Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland (M.J., T.R., J.S.A.V.); Murdoch Children's Research Institute, Melbourne, Australia (M.J.); Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia (C.G.M.); Departments of Pediatrics and Adolescent Medicine (H.N., O.S.) and Clinical Physiology and Nuclear Medicine (O.T.R.), University of Turku and Turku University Hospital, Turku, Finland; Turku Institute for Child and Youth Research, Turku, Finland (A.J.); and Institute for Health and Welfare, Turku, Finland (A.J.).

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http://circ.ahajournals.org/content/early/2015/01/20/CIRCULA
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http://circ.ahajournals.org/cgi/doi/10.1161/CIRCULATIONAHA.1
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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.010532DOI Listing
February 2015

Antibodies to Lactobacilli and Bifidobacteria in young children with different propensity to develop islet autoimmunity.

J Immunol Res 2014 4;2014:325938. Epub 2014 Mar 4.

Immunology Group, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 19, 50411 Tartu, Estonia ; Centre for Translational Medicine, University of Tartu, Ravila 19, 50411 Tartu, Estonia.

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http://dx.doi.org/10.1155/2014/325938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987879PMC
January 2015

Distensibility of the aorta and carotid artery and left ventricular mass from childhood to early adulthood.

Hypertension 2015 Jan 27;65(1):146-52. Epub 2014 Oct 27.

From the Research Centre of Applied and Preventive Cardiovascular Medicine (H.M., K.P., P.S., O.S., M.J., O.T.R.), Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Health and Physical Activity (K.P.), Department of Medicine (T.R., J.S.A.V.), and Department of Clinical Physiology and Nuclear Medicine (OT.R.), University of Turku, Turku, Finland; Division of Medicine (T.R., J.S.A.V., M.J.), Department of Clinical Physiology and Nuclear Medicine (OT.R.), and Department of Paediatrics and Adolescent Medicine (H.N., O.S.), Turku University Hospital, Turku, Finland; and Department of Paediatrics, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland (E.J.).

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.114.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03316DOI Listing
January 2015

Th1/Th17 plasticity is a marker of advanced β cell autoimmunity and impaired glucose tolerance in humans.

J Immunol 2015 Jan 5;194(1):68-75. Epub 2014 Dec 5.

Children's Hospital, University of Helsinki and Helsinki University Central Hospital, 00281 Helsinki, Finland; Respiratory, Inflammatory and Autoimmune Diseases, Innovative Medicine, AstraZeneca, 43183 Mölndal, Sweden

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1401653
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http://dx.doi.org/10.4049/jimmunol.1401653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273995PMC
January 2015

Interactions between genetic variants and dietary lipid composition: effects on circulating LDL cholesterol in children.

Am J Clin Nutr 2014 Dec 8;100(6):1569-77. Epub 2014 Oct 8.

From the Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland (AVA-O, NP, MKO, VM, KP, and TR); the Department of Food and Environmental Sciences (VM) and the Institute for Molecular Medicine Finland (FIMM) (JK), University of Helsinki, Helsinki, Finland; the Department of Clinical Chemistry, Fimlab Laboratories, Pirkanmaa Hospital District, School of Medicine, University of Tampere, Tampere, Finland (TL); the Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland (MK); Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland (KP); the Department of Pediatrics, Turku University Hospital, Turku, Finland (HN and OS); Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland (AJK, PS, and MA-K); NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland (PS and MA-K); Oulu University Hospital, Oulu, Finland (MA-K); Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom (MA-K); the Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland (JSV and TR); and the Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland (OTR).

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http://dx.doi.org/10.3945/ajcn.114.085027DOI Listing
December 2014

An increase in serum 25-hydroxyvitamin D concentrations preceded a plateau in type 1 diabetes incidence in Finnish children.

J Clin Endocrinol Metab 2014 Nov 25;99(11):E2353-6. Epub 2014 Jul 25.

Department of Pediatrics (M.M., V.S., J.M., O.S., J.T., R.H.), University of Turku, 20520 Turku, Finland and Turku University Hospital, 20520 Turku, Finland; Immunogenetics Laboratory (J.I.), University of Turku, 20520 Turku, Finland; Department of Clinical Microbiology (J.I.), University of Eastern Finland, 70211 Kuopio, Finland; Department of Pediatrics (R.V.), University of Oulu, 90014 Oulu, Finland and Oulu University Hospital, 90029 Oulu, Finland; Department of Virology (H.H.), University of Tampere, 33520 Tampere, Finland; Fimlab Laboratories (H.H.), Pirkanmaa Hospital District, 33520 Tampere, Finland; Children's Hospital (M.K.), University of Helsinki and Helsinki University Central Hospital 00029 Helsinki, Finland; Diabetes and Obesity Research Program (M.K.), University of Helsinki, 00014 Helsinki, Finland; Folkhälsan Research Center (M.K.), 00290 Helsinki, Finland; Department of Pediatrics (M.K.), Tampere University Hospital, 33521 Tampere, Finland; and Department of Physiology (J.T.), University of Turku, 20520 Turku, Finland.

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http://dx.doi.org/10.1210/jc.2014-1455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596932PMC
November 2014

Cow's milk allergy and the association between fatty acids and childhood asthma risk.

J Allergy Clin Immunol 2014 Aug 27;134(2):488-90. Epub 2014 May 27.

Nutrition Unit, Department of Lifestyle and Participation, National Institute for Health and Welfare, Helsinki, Finland; School of Health Sciences, University of Tampere, Tampere, Finland; Research Center for Child Health and Science Centre of Pirkanmaa Hospital District, Tampere University Hospital and University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1016/j.jaci.2014.04.012DOI Listing
August 2014

Microbial exposure in infancy and subsequent appearance of type 1 diabetes mellitus-associated autoantibodies: a cohort study.

JAMA Pediatr 2014 Aug;168(8):755-63

Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland7Children's Hospital, University of Helsinki, and University Central Hospital, Helsinki, Finland8University of Helsinki, Diabetes and Obesity Research.

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http://dx.doi.org/10.1001/jamapediatrics.2014.296DOI Listing
August 2014

Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility.

Diabetes 2014 Jul 18;63(7):2402-14. Epub 2014 Feb 18.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, FinlandThe Finnish Centre of Excellence in Molecular Systems Immunology and Physiology Research, Helsinki, Finland

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http://dx.doi.org/10.2337/db13-1775DOI Listing
July 2014

Food diversity in infancy and the risk of childhood asthma and allergies.

J Allergy Clin Immunol 2014 Apr 25;133(4):1084-91. Epub 2014 Jan 25.

School of Health Sciences, University of Tampere, Tampere, Finland; Nutrition Unit, Department of Lifestyle and Participation, National Institute for Health and Welfare, Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland; Science Center of Pirkanmaa Hospital District, Tampere, Finland.

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http://dx.doi.org/10.1016/j.jaci.2013.12.1069DOI Listing
April 2014

Maternal dietary fatty acid intake during pregnancy and the risk of preclinical and clinical type 1 diabetes in the offspring.

Br J Nutr 2014 Mar;111(5):895-903

Nutrition Unit, Department of Lifestyle and Participation, National Institute for Health and Welfare, PO Box 30, FI-00271 Helsinki, Finland.

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http://dx.doi.org/10.1017/S0007114513003073DOI Listing
March 2014

Human bocavirus 1 may suppress rhinovirus-associated immune response in wheezing children.

J Allergy Clin Immunol 2014 Jan;133(1):256-8.e1-4

Department of Pediatrics, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1016/j.jaci.2013.10.014DOI Listing
January 2014

Interactions of y+LAT1 and 4F2hc in the y+l amino acid transporter complex: consequences of lysinuric protein intolerance-causing mutations.

Gen Physiol Biophys 2013 Dec 12;32(4):479-88. Epub 2013 Aug 12.

Department of Medical Biochemistry and Genetics, Institute of Biomedicine, University of Turku, Turku, Finland.

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http://www.elis.sk/index.php?page=shop.product_details&f
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http://dx.doi.org/10.4149/gpb_2013050DOI Listing
December 2013

Cohort profile: Steps to the healthy development and well-being of children (the STEPS Study).

Int J Epidemiol 2013 Oct 9;42(5):1273-84. Epub 2012 Nov 9.

Turku Institute for Child and Youth Research, University of Turku, Turku, Finland, Department of Public Health, University of Turku, Turku, Finland, Research Office and Turku Clinical Research Centre, Turku University Hospital, Turku, Finland, Department of Psychology, University of Turku, Turku, Finland, Department of Education, University of Turku, Turku, Finland, Department of Logopedics, University of Turku, Turku, Finland, Department of Pediatrics, Turku University Hospital, Turku, Finland, Department of Psychology and Logopedics, Abo Akademi University, Turku, Finland, School of Business and Economics, Abo Akademi University, Turku, Finland and Department of Pediatrics, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1093/ije/dys150DOI Listing
October 2013

Insulin secretion and sensitivity in the prediction of type 1 diabetes in children with advanced β-cell autoimmunity.

Eur J Endocrinol 2013 Oct 14;169(4):479-85. Epub 2013 Sep 14.

Children's Hospital, University of Helsinki and Helsinki University Central Hospital, PO Box 22, FI-00014 Helsinki, Finland.

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https://eje.bioscientifica.com/view/journals/eje/169/4/479.x
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http://dx.doi.org/10.1530/EJE-13-0206DOI Listing
October 2013

Human parechovirus seroprevalence in Finland and the Netherlands.

J Clin Virol 2013 Sep 23;58(1):211-5. Epub 2013 Jul 23.

Department of Medical Microbiology, Laboratory of Clinical Virology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jcv.2013.06.036DOI Listing
September 2013

Human rhinoviruses in INDIS-study material-evidence for recovery of viable rhinovirus from fecal specimens.

J Med Virol 2013 Aug;85(8):1466-72

Department of Infectious Disease Surveillance and Control, Virology Unit, National Institute for Health and Welfare (THL), Helsinki, Finland.

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http://doi.wiley.com/10.1002/jmv.23593
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http://dx.doi.org/10.1002/jmv.23593DOI Listing
August 2013

Association of fitness with vascular intima-media thickness and elasticity in adolescence.

Pediatrics 2013 Jul 10;132(1):e77-84. Epub 2013 Jun 10.

Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland.

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http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2
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http://dx.doi.org/10.1542/peds.2013-0041DOI Listing
July 2013

Hyperglycemia and lower diet quality in pregnant overweight women and increased infant size at birth and at 13 months of age--STEPS study.

Early Hum Dev 2013 Jun 1;89(6):439-44. Epub 2013 Feb 1.

Turku Institute for Child and Youth Research, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1016/j.earlhumdev.2013.01.007DOI Listing
June 2013

Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.

JAMA 2013 Jun;309(23):2473-9

Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstaedter Landstrase 1, Neuherberg, Germany 85764.

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http://dx.doi.org/10.1001/jama.2013.6285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878912PMC
June 2013

Genome-wide comparison of two RNA-stabilizing reagents for transcriptional profiling of peripheral blood.

Transl Res 2013 Mar 5;161(3):181-8. Epub 2012 Nov 5.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.

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http://linkinghub.elsevier.com/retrieve/pii/S193152441200364
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http://dx.doi.org/10.1016/j.trsl.2012.10.003DOI Listing
March 2013

Human rhinoviruses including group C are common in stool samples of young Finnish children.

J Clin Virol 2013 Mar 27;56(3):250-4. Epub 2012 Dec 27.

University of Tampere, School of Medicine, Tampere, Finland.

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http://dx.doi.org/10.1016/j.jcv.2012.11.020DOI Listing
March 2013

Body mass index, fitness and physical activity from childhood through adolescence.

Br J Sports Med 2013 Jan 18;47(2):71-7. Epub 2012 Jul 18.

Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1136/bjsports-2011-090704DOI Listing
January 2013

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Authors:
Momoko Horikoshi Hanieh Yaghootkar Dennis O Mook-Kanamori Ulla Sovio H Rob Taal Branwen J Hennig Jonathan P Bradfield Beate St Pourcain David M Evans Pimphen Charoen Marika Kaakinen Diana L Cousminer Terho Lehtimäki Eskil Kreiner-Møller Nicole M Warrington Mariona Bustamante Bjarke Feenstra Diane J Berry Elisabeth Thiering Thiemo Pfab Sheila J Barton Beverley M Shields Marjan Kerkhof Elisabeth M van Leeuwen Anthony J Fulford Zoltán Kutalik Jing Hua Zhao Marcel den Hoed Anubha Mahajan Virpi Lindi Liang-Kee Goh Jouke-Jan Hottenga Ying Wu Olli T Raitakari Marie N Harder Aline Meirhaeghe Ioanna Ntalla Rany M Salem Karen A Jameson Kaixin Zhou Dorota M Monies Vasiliki Lagou Mirna Kirin Jani Heikkinen Linda S Adair Fowzan S Alkuraya Ali Al-Odaib Philippe Amouyel Ehm Astrid Andersson Amanda J Bennett Alexandra I F Blakemore Jessica L Buxton Jean Dallongeville Shikta Das Eco J C de Geus Xavier Estivill Claudia Flexeder Philippe Froguel Frank Geller Keith M Godfrey Frédéric Gottrand Christopher J Groves Torben Hansen Joel N Hirschhorn Albert Hofman Mads V Hollegaard David M Hougaard Elina Hyppönen Hazel M Inskip Aaron Isaacs Torben Jørgensen Christina Kanaka-Gantenbein John P Kemp Wieland Kiess Tuomas O Kilpeläinen Norman Klopp Bridget A Knight Christopher W Kuzawa George McMahon John P Newnham Harri Niinikoski Ben A Oostra Louise Pedersen Dirkje S Postma Susan M Ring Fernando Rivadeneira Neil R Robertson Sylvain Sebert Olli Simell Torsten Slowinski Carla M T Tiesler Anke Tönjes Allan Vaag Jorma S Viikari Jacqueline M Vink Nadja Hawwa Vissing Nicholas J Wareham Gonneke Willemsen Daniel R Witte Haitao Zhang Jianhua Zhao James F Wilson Michael Stumvoll Andrew M Prentice Brian F Meyer Ewan R Pearson Colin A G Boreham Cyrus Cooper Matthew W Gillman George V Dedoussis Luis A Moreno Oluf Pedersen Maiju Saarinen Karen L Mohlke Dorret I Boomsma Seang-Mei Saw Timo A Lakka Antje Körner Ruth J F Loos Ken K Ong Peter Vollenweider Cornelia M van Duijn Gerard H Koppelman Andrew T Hattersley John W Holloway Berthold Hocher Joachim Heinrich Chris Power Mads Melbye Mònica Guxens Craig E Pennell Klaus Bønnelykke Hans Bisgaard Johan G Eriksson Elisabeth Widén Hakon Hakonarson André G Uitterlinden Anneli Pouta Debbie A Lawlor George Davey Smith Timothy M Frayling Mark I McCarthy Struan F A Grant Vincent W V Jaddoe Marjo-Riitta Jarvelin Nicholas J Timpson Inga Prokopenko Rachel M Freathy

Nat Genet 2013 Jan 2;45(1):76-82. Epub 2012 Dec 2.

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.2477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605762PMC
January 2013

Left ventricular mass and geometry in adolescence: early childhood determinants.

Hypertension 2012 Nov 17;60(5):1266-72. Epub 2012 Sep 17.

University of Turku, Research Centre of Applied and Preventive Cardiovascular Medicine, Kiinamyllynkatu 10, FI-20520 Turku, Finland.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.194290DOI Listing
November 2012