Olle Korsgren

Olle Korsgren

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Olle Korsgren

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Imagining a better future for all people with type 1 diabetes mellitus.

Authors:
Olle Korsgren Jay S Skyler Oskar Skog Frida Sundberg Gun Forsander Johnny Ludvigsson

Nat Rev Endocrinol 2019 Nov;15(11):623-624

Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1038/s41574-019-0257-8DOI Listing
November 2019

Teplizumab in Relatives at Risk for Type 1 Diabetes.

Authors:
Olle Korsgren Oskar Skog Johnny Ludvigsson

N Engl J Med 2019 11;381(19):1879-1880

Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1056/NEJMc1912500DOI Listing
November 2019

Characterisation of the endocrine pancreas in type 1 diabetes: islet size is maintained but islet number is markedly reduced.

Authors:
Peter Seiron Anna Wiberg Enida Kuric Lars Krogvold Frode L Jahnsen Knut Dahl-Jørgensen Oskar Skog Olle Korsgren

J Pathol Clin Res 2019 Oct 7;5(4):248-255. Epub 2019 Sep 7.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1002/cjp2.140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817830PMC
October 2019

Comparing the Effects of the mTOR Inhibitors Azithromycin and Rapamycin on In Vitro Expanded Regulatory T Cells.

Authors:
Marcus Bergström Malin Müller Marie Karlsson Hanne Scholz Nils Tore Vethe Olle Korsgren

Cell Transplant 2019 Sep 12:963689719872488. Epub 2019 Sep 12.

Department of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1177/0963689719872488DOI Listing
September 2019

On the dynamics of the human endocrine pancreas and potential consequences for the development of type 1 diabetes.

Authors:
Oskar Skog Olle Korsgren

Acta Diabetol 2019 Sep 13. Epub 2019 Sep 13.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s00592-019-01420-8DOI Listing
September 2019

Proton MR spectroscopy of human pancreas allografts.

Authors:
Jan Weis Håkan Ahlström Olle Korsgren

MAGMA 2019 Aug 1;32(4):511-517. Epub 2019 Apr 1.

Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s10334-019-00740-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647368PMC
August 2019

Islets for Research: Nothing Is Perfect, but We Can Do Better.

Authors:
Rita Nano Julie A Kerr-Conte Domenico Bosco Marie Karlsson Vanessa Lavallard Raffaella Melzi Valery Gmyr Alessia Mercalli Thierry Berney François Pattou Olle Korsgren Lorenzo Piemonti

Diabetes 2019 Aug;68(8):1541-1543

Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy

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http://dx.doi.org/10.2337/db19-0367DOI Listing
August 2019

Heterogeneity of human pancreatic islet isolation around Europe: results of a survey study.

Authors:
Rita Nano Julie A Kerr-Conte Hanne Scholz Marten Engelse Marie Karlsson Frantisek Saudek Domenico Bosco Barbara Antonioli Federico Bertuzzi Paul R V Johnson Barbara Ludwing Zhidong Ling Diedert L De Paep Bart Keymeulen François Pattou Thierry Berney Olle Korsgren Eelco de Koning Lorenzo Piemonti

Transplantation 2019 Jul 17. Epub 2019 Jul 17.

Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1097/TP.0000000000002777DOI Listing
July 2019

Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence.

Authors:
Oskar Skog Karin Klingel Merja Roivainen Olle Korsgren

Diabetologia 2019 06 27;62(6):1097-1099. Epub 2019 Feb 27.

Department of Immunology, Genetics and Pathology, The Rudbeck Laboratory C11, Clinical Immunology, Uppsala University, Dag Hammarskjölds väg 20, 751 85, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s00125-019-4841-1DOI Listing
June 2019

Characterization of host defense molecules in the human pancreas.

Authors:
Anton Stenwall Sofie Ingvast Oskar Skog Olle Korsgren

Islets 2019 26;11(4):89-101. Epub 2019 Jun 26.

a Department of Immunology, Genetics and Pathology, Uppsala University , Uppsala , Sweden.

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http://dx.doi.org/10.1080/19382014.2019.1585165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682263PMC
June 2019

Synthesis and preclinical evaluation of the CRTH2 antagonist [C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass.

Authors:
Jonas Eriksson Tamal Roy Supaporn Sawadjoon Kim Bachmann Christian Sköld Mats Larhed Jan Weis Ram Kumar Selvaraju Olle Korsgren Olof Eriksson Luke R Odell

Nucl Med Biol 2019 04 13;71:1-10. Epub 2019 Apr 13.

Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.nucmedbio.2019.04.002DOI Listing
April 2019

Open Randomized Multicenter Study to Evaluate Safety and Efficacy of Low Molecular Weight Sulfated Dextran in Islet Transplantation.

Authors:
Bengt von Zur-Mühlen Torbjörn Lundgren Levent Bayman Christian Berne Nancy Bridges Thomas Eggerman Aksel Foss Julia Goldstein Trond Jenssen Carl Jorns Yvonne Morrison Mikael Rydén Traci Schwieger Gunnar Tufveson Bo Nilsson Olle Korsgren

Transplantation 2019 03;103(3):630-637

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1097/TP.0000000000002425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389380PMC
March 2019

Protein Kinase R Is Constitutively Expressed in the Human Pancreas.

Authors:
Alexander Jonsson Erik Yngve Marie Karlsson Sofie Ingvast Oskar Skog Olle Korsgren

J Histochem Cytochem 2019 02 28;67(2):99-105. Epub 2018 Sep 28.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1369/0022155418802838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354319PMC
February 2019

Comparison of Clostripain and Neutral Protease as Supplementary Enzymes for Human Islet Isolation.

Authors:
Heide Brandhorst Paul R Johnson Johanna Mönch Manfred Kurfürst Olle Korsgren Daniel Brandhorst

Cell Transplant 2019 02 13;28(2):176-184. Epub 2018 Nov 13.

1 Nuffield Department of Surgical Sciences, University of Oxford, UK.

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http://dx.doi.org/10.1177/0963689718811614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362525PMC
February 2019

Detection and quantification of beta cells by PET imaging: why clinical implementation has never been closer.

Authors:
Martin Gotthardt Decio L Eizirik Henk-Jan Aanstoot Olle Korsgren Dick Mul Frank Martin Marti Boss Tom J P Jansen Sanne A M van Lith Mijke Buitinga Olof Eriksson Miriam Cnop Maarten Brom

Diabetologia 2018 12 3;61(12):2516-2519. Epub 2018 Oct 3.

Department of Radiology and Nuclear Medicine, Radboud university medical centre, PO Box 9101, 6500 HB, Nijmegen, the Netherlands.

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http://link.springer.com/10.1007/s00125-018-4745-5
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http://dx.doi.org/10.1007/s00125-018-4745-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223852PMC
December 2018

The development of a GPR44 targeting radioligand [C]AZ12204657 for in vivo assessment of beta cell mass.

Authors:
Mahabuba Jahan Peter Johnström Ram K Selvaraju Marie Svedberg Maria Sörhede Winzell Jenny Bernström Lee Kingston Magnus Schou Zhisheng Jia Stanko Skrtic Lars Johansson Olle Korsgren Lars Farde Christer Halldin Olof Eriksson

EJNMMI Res 2018 Dec 27;8(1):113. Epub 2018 Dec 27.

Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.

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https://ejnmmires.springeropen.com/articles/10.1186/s13550-0
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http://dx.doi.org/10.1186/s13550-018-0465-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306373PMC
December 2018

No Evidence for Presence of Mucosal-Associated Invariant T Cells in the Insulitic Lesions in Patients Recently Diagnosed with Type 1 Diabetes.

Authors:
Enida Kuric Lars Krogvold Kristian F Hanssen Knut Dahl-Jørgensen Oskar Skog Olle Korsgren

Am J Pathol 2018 08 25;188(8):1744-1748. Epub 2018 May 25.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Department of Biomedicine, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.ajpath.2018.04.009DOI Listing
August 2018

Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus.

Authors:
Per-Ola Carlsson Daniel Espes Amir Sedigh Avi Rotem Baruch Zimerman Helena Grinberg Tali Goldman Uriel Barkai Yuval Avni Gunilla T Westermark Lina Carlbom Håkan Ahlström Olof Eriksson Johan Olerud Olle Korsgren

Am J Transplant 2018 07 2;18(7):1735-1744. Epub 2018 Feb 2.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1111/ajt.14642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055594PMC
July 2018

Calcium: A Crucial Potentiator for Efficient Enzyme Digestion of the Human Pancreas.

Authors:
Torsten Eich Magnus Ståhle Bengt Gustafsson Rune Horneland Marko Lempinen Torbjörn Lundgren Ehab Rafael Gunnar Tufveson Bengt von Zur-Mühlen Johan Olerud Hanne Scholz Olle Korsgren

Cell Transplant 2018 07 26;27(7):1031-1038. Epub 2018 Jun 26.

1 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1177/0963689718779350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158545PMC
July 2018

Aetiology of type 1 diabetes: Physiological growth in children affects disease progression.

Authors:
Oskar Skog Olle Korsgren

Diabetes Obes Metab 2018 04 28;20(4):775-785. Epub 2017 Nov 28.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1111/dom.13144DOI Listing
April 2018

Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT.

Authors:
Shadab Abadpour Bente Halvorsen Afaf Sahraoui Olle Korsgren Pål Aukrust Hanne Scholz

J Mol Endocrinol 2018 04 12;60(3):171-183. Epub 2018 Jan 12.

Section for Transplant SurgeryOslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1530/JME-17-0182DOI Listing
April 2018

Expression profiles of stress-related genes in islets from donors with progressively impaired glucose metabolism.

Authors:
Marcus Lundberg Anton Stenwall Angie Tegehall Olle Korsgren Oskar Skog

Islets 2018 03 15;10(2):69-79. Epub 2018 Feb 15.

a Department of Immunology, Genetics and Pathology , Uppsala University , Uppsala , Sweden.

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http://dx.doi.org/10.1080/19382014.2018.1433980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895176PMC
March 2018

In Vivo Visualization of β-Cells by Targeting of GPR44.

Authors:
Olof Eriksson Peter Johnström Zsolt Cselenyi Mahabuba Jahan Ram K Selvaraju Marianne Jensen-Waern Akihiro Takano Maria Sörhede Winzell Christer Halldin Stanko Skrtic Olle Korsgren

Diabetes 2018 02 5;67(2):182-192. Epub 2017 Dec 5.

Division of Immunology, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.2337/db17-0764DOI Listing
February 2018

Pancreatic imaging using an antibody fragment targeting the zinc transporter type 8: a direct comparison with radio-iodinated Exendin-4.

Authors:
Olof Eriksson Olle Korsgren Ram Kumar Selvaraju Marjorie Mollaret Yann de Boysson Fabrice Chimienti Mohamed Altai

Acta Diabetol 2018 Jan 24;55(1):49-57. Epub 2017 Oct 24.

Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75185, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s00592-017-1059-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794837PMC
January 2018

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.

Authors:
Anke Fuchs Mateusz Gliwiński Nathali Grageda Rachel Spiering Abul K Abbas Silke Appel Rosa Bacchetta Manuela Battaglia David Berglund Bruce Blazar Jeffrey A Bluestone Martin Bornhäuser Anja Ten Brinke Todd M Brusko Nathalie Cools Maria Cristina Cuturi Edward Geissler Nick Giannoukakis Karolina Gołab David A Hafler S Marieke van Ham Joanna Hester Keli Hippen Mauro Di Ianni Natasa Ilic John Isaacs Fadi Issa Dorota Iwaszkiewicz-Grześ Elmar Jaeckel Irma Joosten David Klatzmann Hans Koenen Cees van Kooten Olle Korsgren Karsten Kretschmer Megan Levings Natalia Maria Marek-Trzonkowska Marc Martinez-Llordella Djordje Miljkovic Kingston H G Mills Joana P Miranda Ciriaco A Piccirillo Amy L Putnam Thomas Ritter Maria Grazia Roncarolo Shimon Sakaguchi Silvia Sánchez-Ramón Birgit Sawitzki Ljiljana Sofronic-Milosavljevic Megan Sykes Qizhi Tang Marta Vives-Pi Herman Waldmann Piotr Witkowski Kathryn J Wood Silvia Gregori Catharien M U Hilkens Giovanna Lombardi Phillip Lord Eva M Martinez-Caceres Piotr Trzonkowski

Front Immunol 2017 15;8:1844. Epub 2018 Jan 15.

Department of Clinical Immunology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland.

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http://dx.doi.org/10.3389/fimmu.2017.01844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775516PMC
January 2018

Erratum. Direct Substrate Delivery Into Mitochondrial Fission-Deficient Pancreatic Islets Rescues Insulin Secretion. Diabetes 2017;66:1247-1257.

Authors:
Uma D Kabra Katrin Pfuhlmann Adriana Migliorini Susanne Keipert Daniel Lamp Olle Korsgren Moritz Gegg Stephen C Woods Paul T Pfluger Heiko Lickert Charles Affourtit Matthias H Tschöp Martin Jastroch

Diabetes 2017 12 12;66(12):3144. Epub 2017 Oct 12.

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http://dx.doi.org/10.2337/db17-er12dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697945PMC
December 2017

Quantifying the Effects of Different Neutral Proteases on Human Islet Integrity.

Authors:
Heide Brandhorst Paul R V Johnson Olle Korsgren Daniel Brandhorst

Cell Transplant 2017 11;26(11):1733-1741

1 Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1177/0963689717727544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784524PMC
November 2017

Multicenter Assessment of Animal-free Collagenase AF-1 for Human Islet Isolation.

Authors:
Daniel Brandhorst Géraldine Parnaud Andrew Friberg Vanessa Lavallard Sandrine Demuylder-Mischler Stephen Hughes Julia Saphörster Manfred Kurfürst Olle Korsgren Thierry Berney Paul R V Johnson

Cell Transplant 2017 10;26(10):1688-1693

1 Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1177/0963689717731574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753983PMC
October 2017

Erratum. National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65:3418-3428.

Authors:
Camillo Ricordi Julia S Goldstein A N Balamurugan Gregory L Szot Tatsuya Kin Chengyang Liu Christine W Czarniecki Barbara Barbaro Nancy D Bridges Jose Cano William R Clarke Thomas L Eggerman Lawrence G Hunsicker Dixon B Kaufman Aisha Khan David-Erick Lafontant Elina Linetsky Xunrong Luo James F Markmann Ali Naji Olle Korsgren Jose Oberholzer Nicole A Turgeon Daniel Brandhorst Andrew S Friberg Ji Lei Ling-Jia Wang Joshua J Wilhelm Jamie Willits Xiaomin Zhang Bernhard J Hering Andrew M Posselt Peter G Stock A M James Shapiro

Diabetes 2017 09 29;66(9):2531. Epub 2017 Jun 29.

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http://dx.doi.org/10.2337/db17-er09aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566298PMC
September 2017

Comment on Rodriguez-Calvo et al. Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset. Diabetes 2017;66:1334-1345.

Authors:
Oskar Skog Olle Korsgren

Diabetes 2017 09;66(9):e8-e9

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

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http://dx.doi.org/10.2337/db17-0589DOI Listing
September 2017

Islet Encapsulation: Physiological Possibilities and Limitations.

Authors:
Olle Korsgren

Diabetes 2017 07;66(7):1748-1754

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

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http://dx.doi.org/10.2337/db17-0065DOI Listing
July 2017

Pre-transplantation P-magnetic resonance spectroscopy for quality assessment of human pancreatic grafts - A feasibility study.

Authors:
Lina Carlbom Jan Weis Lars Johansson Olle Korsgren Håkan Ahlström

Magn Reson Imaging 2017 06 8;39:98-102. Epub 2017 Feb 8.

Department of Surgical Sciences, Uppsala University, Sweden.

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http://dx.doi.org/10.1016/j.mri.2017.02.004DOI Listing
June 2017

Direct Substrate Delivery Into Mitochondrial Fission-Deficient Pancreatic Islets Rescues Insulin Secretion.

Authors:
Uma D Kabra Katrin Pfuhlmann Adriana Migliorini Susanne Keipert Daniel Lamp Olle Korsgren Moritz Gegg Stephen C Woods Paul T Pfluger Heiko Lickert Charles Affourtit Matthias H Tschöp Martin Jastroch

Diabetes 2017 05 7;66(5):1247-1257. Epub 2017 Feb 7.

Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany

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http://dx.doi.org/10.2337/db16-1088DOI Listing
May 2017

[C]5-hydroxy-tryptophan PET for Assessment of Islet Mass During Progression of Type 2 Diabetes.

Authors:
Lina Carlbom Daniel Espes Mark Lubberink Mats Martinell Lars Johansson Håkan Ahlström Per-Ola Carlsson Olle Korsgren Olof Eriksson

Diabetes 2017 05 28;66(5):1286-1292. Epub 2017 Feb 28.

Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden

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http://dx.doi.org/10.2337/db16-1449DOI Listing
May 2017

Glial cell-line derived neurotrophic factor protects human islets from nutrient deprivation and endoplasmic reticulum stress induced apoptosis.

Authors:
Shadab Abadpour Sven O Göpel Simen W Schive Olle Korsgren Aksel Foss Hanne Scholz

Sci Rep 2017 05 8;7(1):1575. Epub 2017 May 8.

Section for Transplant Surgery, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1038/s41598-017-01805-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431546PMC
May 2017

Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary? Reply to Campbell-Thompson ML, Atkinson MA, Butler AE et al [letter].

Authors:
Marcus Lundberg Peter Seiron Sofie Ingvast Olle Korsgren Oskar Skog

Diabetologia 2017 04 22;60(4):756-757. Epub 2017 Jan 22.

Department of Immunology, Genetics and Pathology, The Rudbeck Laboratory C11, Clinical Immunology, Uppsala University, Dag Hammarskjölds väg 20, 751 85, Uppsala, Sweden.

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http://link.springer.com/10.1007/s00125-017-4212-8
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http://dx.doi.org/10.1007/s00125-017-4212-8DOI Listing
April 2017

Human Adipose-Derived Mesenchymal Stem Cells Respond to Short-Term Hypoxia by Secreting Factors Beneficial for Human Islets In Vitro and Potentiate Antidiabetic Effect In Vivo.

Authors:
Simen W Schive Mohammad Reza Mirlashari Grete Hasvold Mengyu Wang Dag Josefsen Hans Petter Gullestad Olle Korsgren Aksel Foss Gunnar Kvalheim Hanne Scholz

Cell Med 2017 14;9(3):103-116. Epub 2017 Apr 14.

Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.3727/215517917X693401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509020PMC
April 2017

Demonstration of Tissue Resident Memory CD8 T Cells in Insulitic Lesions in Adult Patients with Recent-Onset Type 1 Diabetes.

Authors:
Enida Kuric Peter Seiron Lars Krogvold Bjørn Edwin Trond Buanes Kristian F Hanssen Oskar Skog Knut Dahl-Jørgensen Olle Korsgren

Am J Pathol 2017 Mar;187(3):581-588

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.ajpath.2016.11.002DOI Listing
March 2017

Insulitis in human diabetes: a histological evaluation of donor pancreases.

Authors:
Marcus Lundberg Peter Seiron Sofie Ingvast Olle Korsgren Oskar Skog

Diabetologia 2017 02 28;60(2):346-353. Epub 2016 Oct 28.

Department of Immunology, Genetics and Pathology, The Rudbeck Laboratory C11, Clinical Immunology, Uppsala University, Dag Hammarskjölds väg 20, 751 85, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s00125-016-4140-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518093PMC
February 2017

Cost and clinical outcome of islet transplantation in Norway 2010-2015.

Authors:
Simen W Schive Aksel Foss Afaf Sahraoui Kristine Kloster-Jensen Geir Hafsahl Gunnar Kvalheim Torbjørn Lundgren Bengt von Zur-Mühlen Marie Felldin Ehab Rafael Marko Lempinen Olle Korsgren Trond G Jenssen Vinod Mishra Hanne Scholz

Clin Transplant 2017 01 9;31(1). Epub 2016 Dec 9.

Department of Transplant Medicine, Cancer Institute, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1111/ctr.12871DOI Listing
January 2017

Characterization of Innate Immunity in an Extended Whole Blood Model of Human Islet Allotransplantation.

Authors:
Maria Hårdstedt Susanne Lindblom Alex Karlsson-Parra Bo Nilsson Olle Korsgren

Cell Transplant 2016 16;25(3):503-15. Epub 2015 Jun 16.

Department of Immunology, Genetics and Pathology, Clinical Immunology, The Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.3727/096368915X688461DOI Listing
December 2016

Treatment with Tacrolimus and Sirolimus Reveals No Additional Adverse Effects on Human Islets In Vitro Compared to Each Drug Alone but They Are Reduced by Adding Glucocorticoids.

Authors:
Kristine Kloster-Jensen Afaf Sahraoui Nils Tore Vethe Olle Korsgren Stein Bergan Aksel Foss Hanne Scholz

J Diabetes Res 2016 18;2016:4196460. Epub 2016 Jan 18.

Department of Transplant Medicine, Oslo University Hospital, P.O. Box 4950, 0424 Oslo, Norway; Institute for Surgical Research, Oslo University Hospital, P.O. Box 4950, 0424 Oslo, Norway; Institute of Clinical Medicine, University of Oslo, P.O. Box 1171, Blindern, 0318 Oslo, Norway.

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http://downloads.hindawi.com/journals/jdr/2016/4196460.pdf
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http://www.hindawi.com/journals/jdr/2016/4196460/
Publisher Site
http://dx.doi.org/10.1155/2016/4196460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739465PMC
December 2016

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial.

Authors:
David K C Cooper Rita Bottino Pierre Gianello Melanie Graham Wayne J Hawthorne Allan D Kirk Olle Korsgren Chung-Gyu Park Collin Weber

Xenotransplantation 2016 Jan-Feb;23(1):46-52. Epub 2016 Feb 25.

Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1111/xen.12226DOI Listing
December 2016

Evaluation of Perfluorohexyloctane/Polydimethylsiloxane for Pancreas Preservation for Clinical Islet Isolation and Transplantation.

Authors:
Magnus Sthle Aksel Foss Bengt Gustafsson Marko Lempinen Torbjrn Lundgren Ehab Rafael Gunnar Tufveson Bastian Theisinger Daniel Brandhorst Olle Korsgren Andrew Friberg

Cell Transplant 2016 12 27;25(12):2269-2276. Epub 2016 May 27.

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http://dx.doi.org/10.3727/096368916X691709DOI Listing
December 2016

An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets.

Authors:
Erna Domsgen Katharina Lind Lingjia Kong Michael H Hühn Omid Rasool Frank van Kuppeveld Olle Korsgren Riitta Lahesmaa Malin Flodström-Tullberg

Sci Rep 2016 12 21;6:39378. Epub 2016 Dec 21.

The Center for Infectious Medicine, Department of Medicine HS, Karolinska Institutet, Karolinska University Hospital, Stockholm, 141 86, Sweden.

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http://dx.doi.org/10.1038/srep39378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175199PMC
December 2016

Type 1 Diabetes Mellitus Donor Mesenchymal Stromal Cells Exhibit Comparable Potency to Healthy Controls In Vitro.

Authors:
Lindsay C Davies Jessica J Alm Nina Heldring Guido Moll Caroline Gavin Ioannis Batsis Hong Qian Mikael Sigvardsson Bo Nilsson Lauri E Kyllonen Kaija T Salmela Per-Ola Carlsson Olle Korsgren Katarina Le Blanc

Stem Cells Transl Med 2016 Nov 13;5(11):1485-1495. Epub 2016 Jul 13.

Center for Hematology and Regenerative Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden

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http://dx.doi.org/10.5966/sctm.2015-0272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070499PMC
November 2016

National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities.

Authors:
Camillo Ricordi Julia S Goldstein A N Balamurugan Gregory L Szot Tatsuya Kin Chengyang Liu Christine W Czarniecki Barbara Barbaro Nancy D Bridges Jose Cano William R Clarke Thomas L Eggerman Lawrence G Hunsicker Dixon B Kaufman Aisha Khan David-Erick Lafontant Elina Linetsky Xunrong Luo James F Markmann Ali Naji Olle Korsgren Jose Oberholzer Nicole A Turgeon Daniel Brandhorst Xiaojuan Chen Andrew S Friberg Ji Lei Ling-Jia Wang Joshua J Wilhelm Jamie Willits Xiaomin Zhang Bernhard J Hering Andrew M Posselt Peter G Stock A M James Shapiro Xiaojuan Chen

Diabetes 2016 11 27;65(11):3418-3428. Epub 2016 Jul 27.

Clinical Islet Transplant Program and Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.2337/db16-0234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079635PMC
November 2016

Corrigendum to "Cardiovascular side-effects and insulin secretion after intravenous administration of radiolabeled Exendin-4 in pigs" [Nucl Med Biol 43 (2016) 397-402].

Authors:
Anneli Rydén Görel Nyman Lovisa Nalin Susanne Andreasson Irina Velikyan Olle Korsgren Olof Eriksson Marianne Jensen-Waern

Nucl Med Biol 2016 11 7;43(11):742. Epub 2016 Sep 7.

Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.nucmedbio.2016.08.013DOI Listing
November 2016

Pancreatic perfusion and subsequent response to glucose in healthy individuals and patients with type 1 diabetes.

Authors:
Lina Carlbom Daniel Espes Mark Lubberink Olof Eriksson Lars Johansson Leif Jansson Olle Korsgren Håkan Ahlström Per-Ola Carlsson

Diabetologia 2016 09 16;59(9):1968-72. Epub 2016 Jun 16.

Department of Medical Cell Biology, Uppsala University, Husargatan 3, SE-751 23, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s00125-016-4016-2DOI Listing
September 2016

Positron Emission Tomography to Assess the Outcome of Intraportal Islet Transplantation.

Authors:
Olof Eriksson Ramkumar Selvaraju Torsten Eich Mariam Willny Torkel B Brismar Lina Carlbom Håkan Ahlström Gunnar Tufvesson Torbjörn Lundgren Olle Korsgren

Diabetes 2016 09 20;65(9):2482-9. Epub 2016 Jun 20.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.2337/db16-0222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001185PMC
September 2016

Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement.

Authors:
James F Markmann Stephen T Bartlett Paul Johnson Olle Korsgren Bernhard J Hering David Scharp Thomas W H Kay Jonathan Bromberg Jon S Odorico Gordon C Weir Nancy Bridges Raja Kandaswamy Peter Stock Peter Friend Mitsukazu Gotoh David K C Cooper Chung-Gyu Park Philip J OʼConnell Cherie Stabler Shinichi Matsumoto Barbara Ludwig Pratik Choudhary Boris Khovatchev Michael R Rickels Megan Sykes Kathryn Wood Kristy Kraemer Albert Hwa Edward Stanley Camillo Ricordi Mark Zimmerman Julia Greenstein Eduard Montanya Timo Otonkoski

Transplantation 2016 Jul;100(7):e25-31

1 Division of Transplantation, Massachusetts General Hospital, Boston, MA. 2 Department of Surgery, University of Maryland School of Medicine, Baltimore, MD. 3 Nuffield Department of Surgical Sciences and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom. 4 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. 5 Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN. 6 Prodo Laboratories, LLC, Irvine, CA. 7 The Scharp-Lacy Research Institute, Irvine, CA. 8 St. Vincent's Institute of Medical Research, Victoria, Australia. 9 Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Victoria, Australia. 10 Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI. 11 Joslin Diabetes Center and Harvard Medical School, Boston MA. 12 National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. 13 Division of Transplantation, University of San Francisco Medical Center, San Francisco, CA. 14 Department of Surgery, Fukushima Medical University, Fukushima, Japan. 15 Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA. 16 Xenotransplantation Research Center, Department of Microbiology and Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea. 17 The Center for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia. 18 Department of Biomedical Engineering, University of Florida, Gainesville, FL. 19 Otsuka Pharmaceutical Factory inc, Naruto Japan. 20 National Center for Global Health and Medicine, Tokyo, Japan. 21 Department of Medicine III, Technische Universität Dresden, Dresden, Germany. 22 Paul Langerhans Institute Dresden of Helmholtz Centre Munich at University Clinic

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July 2016

Cardiovascular side-effects and insulin secretion after intravenous administration of radiolabeled Exendin-4 in pigs.

Authors:
Anneli Rydén Görel Nyman Lovisa Nalin Susanne Andreasson Irina Velikyan Olle Korsgren Olof Eriksson Marianne Jensen-Waern

Nucl Med Biol 2016 07 16;43(7):397-402. Epub 2016 Apr 16.

Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.nucmedbio.2016.04.002DOI Listing
July 2016

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia.

Authors:
Bernhard J Hering William R Clarke Nancy D Bridges Thomas L Eggerman Rodolfo Alejandro Melena D Bellin Kathryn Chaloner Christine W Czarniecki Julia S Goldstein Lawrence G Hunsicker Dixon B Kaufman Olle Korsgren Christian P Larsen Xunrong Luo James F Markmann Ali Naji Jose Oberholzer Andrew M Posselt Michael R Rickels Camillo Ricordi Mark A Robien Peter A Senior A M James Shapiro Peter G Stock Nicole A Turgeon

Diabetes Care 2016 Jul 18;39(7):1230-40. Epub 2016 Apr 18.

Emory Transplant Center, Emory University, Atlanta, GA.

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http://dx.doi.org/10.2337/dc15-1988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317236PMC
July 2016

Identification of proliferative and mature β-cells in the islets of Langerhans.

Authors:
Erik Bader Adriana Migliorini Moritz Gegg Noah Moruzzi Jantje Gerdes Sara S Roscioni Mostafa Bakhti Elisabeth Brandl Martin Irmler Johannes Beckers Michaela Aichler Annette Feuchtinger Christin Leitzinger Hans Zischka Rui Wang-Sattler Martin Jastroch Matthias Tschöp Fausto Machicao Harald Staiger Hans-Ulrich Häring Helena Chmelova Julie A Chouinard Nikolay Oskolkov Olle Korsgren Stephan Speier Heiko Lickert

Nature 2016 07 11;535(7612):430-4. Epub 2016 Jul 11.

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http://dx.doi.org/10.1038/nature18624DOI Listing
July 2016

GPR44 is a pancreatic protein restricted to the human beta cell.

Authors:
Ewa Hellström-Lindahl Angelika Danielsson Fredrik Ponten Paul Czernichow Olle Korsgren Lars Johansson Olof Eriksson

Acta Diabetol 2016 Jun 14;53(3):413-21. Epub 2015 Oct 14.

Department of Medicinal Chemistry, Preclinical PET Platform, Uppsala University, 751 83, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s00592-015-0811-3DOI Listing
June 2016

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome.

Authors:
Oscar E Simonson Dimitrios Mougiakakos Nina Heldring Giulio Bassi Henrik J Johansson Magnus Dalén Regina Jitschin Sergey Rodin Matthias Corbascio Samir El Andaloussi Oscar P B Wiklander Joel Z Nordin Johan Skog Charlotte Romain Tina Koestler Laila Hellgren-Johansson Petter Schiller Per-Olof Joachimsson Hans Hägglund Mattias Mattsson Janne Lehtiö Omid R Faridani Rickard Sandberg Olle Korsgren Mauro Krampera Daniel J Weiss Karl-Henrik Grinnemo Katarina Le Blanc

Stem Cells Transl Med 2016 Jun;5(6):845

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http://dx.doi.org/10.5966/sctm.2015-0021erratumDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878323PMC
June 2016

An Apparent Deficiency of Lymphatic Capillaries in the Islets of Langerhans in the Human Pancreas.

Authors:
Erik Korsgren Olle Korsgren

Diabetes 2016 04 28;65(4):1004-8. Epub 2016 Jan 28.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

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http://dx.doi.org/10.2337/db15-1285DOI Listing
April 2016

Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes.

Authors:
Lars Krogvold Anna Wiberg Bjørn Edwin Trond Buanes Frode Lars Jahnsen Kristian F Hanssen Erik Larsson Olle Korsgren Oskar Skog Knut Dahl-Jørgensen

Diabetologia 2016 Mar 24;59(3):492-501. Epub 2015 Nov 24.

Paediatric Department, Oslo University Hospital HF, PO Box 4950, Nydalen, N-0424, Oslo, Norway.

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http://dx.doi.org/10.1007/s00125-015-3820-4DOI Listing
March 2016

The effects of exendin-4 treatment on graft failure: an animal study using a novel re-vascularized minimal human islet transplant model.

Authors:
Afaf Sahraoui Maria Sörhede Winzell Tracy Gorman Dave M Smith Stanko Skrtic Merete Hoeyem Shadab Abadpour Lars Johansson Olle Korsgren Aksel Foss Hanne Scholz

PLoS One 2015 20;10(3):e0121204. Epub 2015 Mar 20.

Institute for Surgical Research and Section for Transplantation Surgery, Oslo University Hospital, Oslo, Norway.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368803PMC
February 2016

Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement.

Authors:
Stephen T Bartlett James F Markmann Paul Johnson Olle Korsgren Bernhard J Hering David Scharp Thomas W H Kay Jonathan Bromberg Jon S Odorico Gordon C Weir Nancy Bridges Raja Kandaswamy Peter Stock Peter Friend Mitsukazu Gotoh David K C Cooper Chung-Gyu Park Phillip OʼConnell Cherie Stabler Shinichi Matsumoto Barbara Ludwig Pratik Choudhary Boris Kovatchev Michael R Rickels Megan Sykes Kathryn Wood Kristy Kraemer Albert Hwa Edward Stanley Camillo Ricordi Mark Zimmerman Julia Greenstein Eduard Montanya Timo Otonkoski

Transplantation 2016 Feb;100 Suppl 2:S1-44

1 Department of Surgery, University of Maryland School of Medicine, Baltimore MD. 2 Division of Transplantation, Massachusetts General Hospital, Boston MA. 3 Nuffield Department of Surgical Sciences and Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom. 4 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. 5 Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN. 6 Prodo Laboratories, LLC, Irvine, CA. 7 The Scharp-Lacy Research Institute, Irvine, CA. 8 Department of Medicine, St. Vincent's Hospital, St. Vincent's Institute of Medical Research and The University of Melbourne Victoria, Australia. 9 Division of Transplantation, Department of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI. 10 Joslin Diabetes Center and Harvard Medical School, Boston, MA. 11 National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. 12 Division of Transplantation, University of San Francisco Medical Center, San Francisco, CA. 13 Department of Surgery, Fukushima Medical University, Fukushima, Japan. 14 Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA. 15 Xenotransplantation Research Center, Department of Microbiology and Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea. 16 The Center for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia. 17 Diabetes Research Institute, School of Medicine, University of Miami, Coral Gables, FL. 18 National Center for Global Health and Medicine, Tokyo, Japan. 19 Otsuka Pharmaceutical Factory inc, Naruto Japan. 20 Department of Medicine III, Technische Universität Dresden, Dresden, Germany. 21 Paul Langerhans Institute Dresden of Helmholtz Centre Munich at University Clinic Carl Gustav

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http://dx.doi.org/10.1097/TP.0000000000001055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741413PMC
February 2016

Glucose Effectiveness: The Mouse Trap in the Development of Novel ß-Cell Replacement Therapies.

Authors:
Erik Korsgren Olle Korsgren

Transplantation 2016 Jan;100(1):111-5

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1097/TP.0000000000000900DOI Listing
January 2016

Comparison of Neutral Proteases and Collagenase Class I as Essential Enzymes for Human Islet Isolation.

Authors:
Heide Brandhorst Manfred Kurfürst Paul R Johnson Olle Korsgren Daniel Brandhorst

Transplant Direct 2016 Jan 15;2(1):e47. Epub 2015 Dec 15.

Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, United Kingdom.; Department of Immunology, Genetics and Pathology, University of Uppsala, Uppsala, Sweden.

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http://dx.doi.org/10.1097/TXD.0000000000000552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946504PMC
January 2016

Immunological shielding by induced recruitment of regulatory T-lymphocytes delays rejection of islets transplanted in muscle.

Authors:
Evelina Vågesjö Gustaf Christoffersson Tomas B Waldén Per-Ola Carlsson Magnus Essand Olle Korsgren Mia Phillipson

Cell Transplant 2015 29;24(2):263-76. Epub 2014 Jan 29.

Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.3727/096368914X678535DOI Listing
November 2015

Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer's disease.

Authors:
Gabriel Westman David Berglund Johan Widén Martin Ingelsson Olle Korsgren Lars Lannfelt Dag Sehlin Anna-Karin Lidehall Britt-Marie Eriksson

PLoS One 2014 7;9(5):e96779. Epub 2014 May 7.

Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096779PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013077PMC
October 2015

Graft function 1 year after pregnancy in an islet-transplanted patient.

Authors:
Simen W Schive Hanne Scholz Afaf Sahraoui Kristine Kloster-Jensen Geir Hafsahl Olle Korsgren Aksel Foss Trond G Jenssen

Transpl Int 2015 Oct 11;28(10):1235-9. Epub 2015 May 11.

Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1111/tri.12596DOI Listing
October 2015

Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets in vitro.

Authors:
Kristine Kloster-Jensen Nils Tore Vethe Sara Bremer Shadab Abadpour Olle Korsgren Aksel Foss Stein Bergan Hanne Scholz

Transpl Int 2015 Oct 23;28(10):1152-61. Epub 2015 Jun 23.

Department of Transplantation Medicine, Oslo University Hospital, Norway.

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http://dx.doi.org/10.1111/tri.12617DOI Listing
October 2015

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome.

Authors:
Oscar E Simonson Dimitrios Mougiakakos Nina Heldring Giulio Bassi Henrik J Johansson Magnus Dalén Regina Jitschin Sergey Rodin Matthias Corbascio Samir El Andaloussi Oscar P B Wiklander Joel Z Nordin Johan Skog Charlotte Romain Tina Koestler Laila Hellgren-Johansson Petter Schiller Per-Olof Joachimsson Hans Hägglund Mattias Mattsson Janne Lehtiö Omid R Faridani Rickard Sandberg Olle Korsgren Mauro Krampera Daniel J Weiss Karl-Henrik Grinnemo Katarina Le Blanc

Stem Cells Transl Med 2015 Oct 18;4(10):1199-213. Epub 2015 Aug 18.

Departments of Molecular Medicine and Surgery, Cardiothoracic Surgery and Anesthesia, and Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Department of Internal Medicine, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany; Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy; Cancer Proteomics Mass Spectrometry, Science for Life Laboratory, Department of Oncology-Pathology, Department of Medical Biochemistry and Biophysics, and Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden; Center for Diseases of Aging, Vaccine and Gene Therapy Institute Florida, Port St. Lucie, Florida, USA; Exosome Diagnostics Inc., New York, New York, USA; Departments of Cardiothoracic Surgery, Hematology, and Immunology, Genetics and Pathology, Uppsala University Hospital, Uppsala, Sweden; Ludwig Institute for Cancer Research, Stockholm, Sweden; Health Sciences Research Facility, Department of Medicine, University of Vermont, Burlington, Vermont, USA

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http://dx.doi.org/10.5966/sctm.2015-0021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572899PMC
October 2015

Mesenchymal stromal cells support endothelial cell interactions in an intramuscular islet transplantation model.

Authors:
Moa Fransson Johan Brännström Ida Duprez Magnus Essand Katarina Le Blanc Olle Korsgren Peetra U Magnusson

Regen Med Res 2015 30;3. Epub 2015 Sep 30.

Department of Immunology, Genetics and Pathology, Division of Clinical Immunology, Uppsala, Sweden ; Department of Immunology, Genetics and Pathology, The Rudbeck Laboratory, Dag Hammarskjölds Väg 20, SE-751 85 Uppsala, Sweden.

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http://dx.doi.org/10.1186/s40340-015-0010-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589952PMC
October 2015

The human pancreas proteome defined by transcriptomics and antibody-based profiling.

Authors:
Angelika Danielsson Fredrik Pontén Linn Fagerberg Björn M Hallström Jochen M Schwenk Mathias Uhlén Olle Korsgren Cecilia Lindskog

PLoS One 2014 29;9(12):e115421. Epub 2014 Dec 29.

Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278897PMC
September 2015

Tribute to Carl-Gustav Groth (1933-2014), first president of the International Xenotransplantation Association.

Authors:
David K C Cooper Leo Buhler Michael Breimer Olle Korsgren Annika Tibell Lars Wennberg Emanuele Cozzi Anthony J F d'Apice Bernhard Hering Ian F C McKenzie Richard N Pierson Megan Sykes Takaaki Kobayashi

Xenotransplantation 2014 Mar-Apr;21(2):97-8

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http://dx.doi.org/10.1111/xen.12098DOI Listing
July 2015

Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro: Results From the DiViD Study.

Authors:
Lars Krogvold Oskar Skog Görel Sundström Bjørn Edwin Trond Buanes Kristian F Hanssen Johnny Ludvigsson Manfred Grabherr Olle Korsgren Knut Dahl-Jørgensen

Diabetes 2015 Jul 12;64(7):2506-12. Epub 2015 Feb 12.

Paediatric Department, Oslo University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.2337/db14-1911DOI Listing
July 2015

Mesenchymal stromal cells to halt the progression of type 1 diabetes?

Authors:
Per-Ola Carlsson Olle Korsgren Katarina Le Blanc

Curr Diab Rep 2015 Jul;15(7):46

Department of Medical Cell Biology, Uppsala University, Husargatan 3, Box 571, 75123, Uppsala, Sweden,

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July 2015

Anakinra and tocilizumab enhance survival and function of human islets during culture: implications for clinical islet transplantation.

Authors:
Afaf Sahraoui Kristine Kloster-Jensen Thor Ueland Olle Korsgren Aksel Foss Hanne Scholz

Cell Transplant 2014 29;23(10):1199-211. Epub 2013 Apr 29.

Institute for Surgical Research, Oslo University Hospital Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.3727/096368913X667529DOI Listing
June 2015

Clostripain, the Missing Link in the Enzyme Blend for Efficient Human Islet Isolation.

Authors:
Magnus Ståhle Aksel Foss Bengt Gustafsson Marko Lempinen Torbjörn Lundgren Ehab Rafael Gunnar Tufveson Olle Korsgren Andrew Friberg

Transplant Direct 2015 Jun 24;1(5):e19. Epub 2015 Jun 24.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1097/TXD.0000000000000528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946465PMC
June 2015

Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes.

Authors:
Lars Krogvold Bjørn Edwin Trond Buanes Gun Frisk Oskar Skog Mahesh Anagandula Olle Korsgren Dag Undlien Morten C Eike Sarah J Richardson Pia Leete Noel G Morgan Sami Oikarinen Maarit Oikarinen Jutta E Laiho Heikki Hyöty Johnny Ludvigsson Kristian F Hanssen Knut Dahl-Jørgensen

Diabetes 2015 May 24;64(5):1682-7. Epub 2014 Nov 24.

Paediatric Department, Oslo University Hospital, Oslo, Norway Faculty of Medicine, University of Oslo, Oslo, Norway

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http://dx.doi.org/10.2337/db14-1370DOI Listing
May 2015

Human islet distribution programme for basic research: activity over the last 5 years.

Authors:
Rita Nano Domenico Bosco Julie A Kerr-Conte Marie Karlsson Solange Charvier Raffaella Melzi Rimed Ezzouaoui Alessia Mercalli Albert Hwa François Pattou Olle Korsgren Thierry Berney Lorenzo Piemonti

Diabetologia 2015 May 21;58(5):1138-40. Epub 2015 Feb 21.

Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.

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http://dx.doi.org/10.1007/s00125-015-3536-5DOI Listing
May 2015

A novel model for studies of blood-mediated long-term responses to cellular transplants.

Authors:
Maria Hårdstedt Susanne Lindblom Jaan Hong Bo Nilsson Olle Korsgren Gunnar Ronquist

Ups J Med Sci 2015 Mar 17;120(1):28-39. Epub 2014 Oct 17.

Department of Immunology, Genetics and Pathology, Clinical Immunology, The Rudbeck Laboratory, Uppsala University , Uppsala , Sweden.

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http://dx.doi.org/10.3109/03009734.2014.965290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389005PMC
March 2015

Preserved β-cell function in type 1 diabetes by mesenchymal stromal cells.

Authors:
Per-Ola Carlsson Erik Schwarcz Olle Korsgren Katarina Le Blanc

Diabetes 2015 Feb 9;64(2):587-92. Epub 2014 Sep 9.

Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2337/db14-0656DOI Listing
February 2015

Expression of human leukocyte antigen class I in endocrine and exocrine pancreatic tissue at onset of type 1 diabetes.

Authors:
Oskar Skog Stella Korsgren Anna Wiberg Angelika Danielsson Bjørn Edwin Trond Buanes Lars Krogvold Olle Korsgren Knut Dahl-Jørgensen

Am J Pathol 2015 Jan;185(1):129-38

Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.ajpath.2014.09.004DOI Listing
January 2015

Positron emission tomography ligand [11C]5-hydroxy-tryptophan can be used as a surrogate marker for the human endocrine pancreas.

Authors:
Olof Eriksson Daniel Espes Ram K Selvaraju Emma Jansson Gunnar Antoni Jens Sörensen Mark Lubberink Ali-Reza Biglarnia Jan W Eriksson Anders Sundin Håkan Ahlström Barbro Eriksson Lars Johansson Per-Ola Carlsson Olle Korsgren

Diabetes 2014 Oct 21;63(10):3428-37. Epub 2014 May 21.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db13-18
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http://dx.doi.org/10.2337/db13-1877DOI Listing
October 2014

Purification of regulatory T cells with the use of a fully enclosed high-speed microfluidic system.

Authors:
Ruud Hulspas Lydia Villa-Komaroff Erin Koksal Kenol Etienne Patricia Rogers Matt Tuttle Olle Korsgren John C Sharpe David Berglund

Cytotherapy 2014 Oct 22;16(10):1384-9. Epub 2014 Jul 22.

Department of Immunology, Genetics and Pathology, Section of Transplantation Surgery, Uppsala University, Uppsala, Sweden; Department of Surgical Sciences, Section of Transplantation Surgery, Uppsala University, Uppsala, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2014.05.016DOI Listing
October 2014

Evaluation of RT-PCR and immunohistochemistry as tools for detection of enterovirus in the human pancreas and islets of Langerhans.

Authors:
Oskar Skog Sofie Ingvast Olle Korsgren

J Clin Virol 2014 Oct 30;61(2):242-7. Epub 2014 Jul 30.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.jcv.2014.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165708PMC
October 2014

Positron emission tomography imaging of the glucagon-like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs.

Authors:
Lovisa Nalin Ram K Selvaraju Irina Velikyan Marie Berglund Susanne Andréasson Anna Wikstrand Anneli Rydén Mark Lubberink Fouad Kandeel Görel Nyman Olle Korsgren Olof Eriksson Marianne Jensen-Waern

Eur J Nucl Med Mol Imaging 2014 Sep 19;41(9):1800-10. Epub 2014 Mar 19.

Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s00259-014-2745-3DOI Listing
September 2014

Infection of human islets of Langerhans with two strains of Coxsackie B virus serotype 1: assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway.

Authors:
Mahesh Anagandula Sarah J Richardson M Steven Oberste Amir-Babak Sioofy-Khojine Heikki Hyöty Noel G Morgan Olle Korsgren Gun Frisk

J Med Virol 2014 Aug 19;86(8):1402-11. Epub 2013 Nov 19.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1002/jmv.23835DOI Listing
August 2014

Utilization of small pediatric donors including infants for pancreas and kidney transplantation: exemplification of the surgical technique and the surveillance.

Authors:
Ali-Reza Biglarnia William Bennet Thomas Nilsson Erik Larsson Anders Magnusson Shinji Yamamoto Tomas Lorant Amir Sedigh Bengt von Zur-Mühlen Lars Bäckman Olle Korsgren Gunnar Tufveson

Ann Surg 2014 Aug;260(2):e5-7

Department of Transplantation, Surgical Sciences, Uppsala University Hospital Uppsala University Uppsala, Sweden Transplant Institute Sahlgrenska University Hospital Gothenburg, Sweden Department of Nephrology, Medical Sciences Uppsala University Hospital Uppsala University Uppsala, Sweden Department of Immunology, Genetics and Pathology Uppsala University Hospital Uppsala University Uppsala, Sweden Department of Radiology, Oncology and Radiation Science Uppsala University Hospital Uppsala University Uppsala, Sweden Department of Transplantation, Surgical Sciences Uppsala University Hospital Uppsala University Uppsala, Sweden Rudbeck Laboratory Department of Immunology, Genetics and Pathology Uppsala University Hospital Uppsala University Uppsala, Sweden Department of Transplantation, Surgical Sciences Uppsala University Hospital Uppsala University Uppsala, Sweden.

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http://dx.doi.org/10.1097/SLA.0000000000000751DOI Listing
August 2014

[Swedish medical research does not need more control].

Authors:
Peter Andersén Torbjörn Bäckström Gisela Dahlquist Jan-Erik Damber Anna Engström-Laurent Yngve Gustafson Paul Hjemdahl Olle Korsgren Håkan Olsson Mikael Wiberg Anders Widmark

Lakartidningen 2014 May 27-Jun 10;111(22-23):980-1

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August 2014

Pre-clinical evaluation of [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 for imaging of insulinoma.

Authors:
Ram Kumar Selvaraju Irina Velikyan Veronika Asplund Lars Johansson Zhanhong Wu Ivan Todorov Jack Shively Fouad Kandeel Barbro Eriksson Olle Korsgren Olof Eriksson

Nucl Med Biol 2014 Jul 29;41(6):471-6. Epub 2014 Mar 29.

Preclinical PET Platform (PPP), Department of Medicinal Chemistry, Uppsala University, SE-751 83 Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.nucmedbio.2014.03.017DOI Listing
July 2014

Decreased proportion of cytomegalovirus specific CD8 T-cells but no signs of general immunosenescence in Alzheimer's disease.

Authors:
Gabriel Westman Anna-Karin Lidehall Peetra Magnusson Martin Ingelsson Lena Kilander Lars Lannfelt Olle Korsgren Britt-Marie Eriksson

PLoS One 2013 14;8(10):e77921. Epub 2013 Oct 14.

Department of Medical Sciences, Uppsala University, Uppsala, Sweden ; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796487PMC
June 2014

Detection of metastatic insulinoma by positron emission tomography with [(68)ga]exendin-4-a case report.

Authors:
Olof Eriksson Irina Velikyan Ram K Selvaraju Fouad Kandeel Lars Johansson Gunnar Antoni Barbro Eriksson Jens Sörensen Olle Korsgren

J Clin Endocrinol Metab 2014 May 10;99(5):1519-24. Epub 2014 Feb 10.

Preclinical PET Platform (O.E., I.V., R.K.S.), Department of Medicinal Chemistry, Uppsala University, SE-751 83 Uppsala, Sweden; Department of Radiology, Oncology, and Radiation Sciences (I.V., L.J., G.A., J.S.), Uppsala University, SE-751 83 Uppsala, Sweden; PET Centre (I.V., G.A., J.S.), Centre for Medical Imaging, Uppsala University Hospital, Uppsala, SE-751 83 Sweden; Beckman Research Institute of the City of Hope (F.K.), Duarte, California 91010; AstraZeneca R&D (L.J.), SE-431 50 Mölndal, Sweden; Department of Medical Sciences (B.E.), Uppsala University, SE-751 83 Uppsala, Sweden; and Department of Immunology, Genetics, and Pathology (O.K.), Uppsala University SE-751 83, Uppsala, Sweden.

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http://dx.doi.org/10.1210/jc.2013-3541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010711PMC
May 2014

Gene expression analysis of human islets in a subject at onset of type 1 diabetes.

Authors:
Johan Hopfgarten Per-Anton Stenwall Anna Wiberg Mahesh Anagandula Sofie Ingvast Therese Rosenling Olle Korsgren Oskar Skog

Acta Diabetol 2014 Apr 27;51(2):199-204. Epub 2013 Apr 27.

IGP, Rudbeck Laboratory C11, Department of Immunology, Genetics and Pathology, Uppsala University, 751 85, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s00592-013-0479-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770827PMC
April 2014

Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study.

Authors:
Lars Krogvold Bjørn Edwin Trond Buanes Johnny Ludvigsson Olle Korsgren Heikki Hyöty Gun Frisk Kristian F Hanssen Knut Dahl-Jørgensen

Diabetologia 2014 Apr 16;57(4):841-3. Epub 2014 Jan 16.

Paediatric Department, Oslo University Hospital HF, P. O. Box, 4950, Nydalen, 0424, Oslo, Norway,

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http://dx.doi.org/10.1007/s00125-013-3155-yDOI Listing
April 2014

Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry?

Authors:
Sara F Hansson Stella Korsgren Fredrik Pontén Olle Korsgren

Diabetologia 2014 Mar 19;57(3):645-6. Epub 2013 Dec 19.

Proteomics Core Facility, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1007/s00125-013-3138-zDOI Listing
March 2014

Quantitative imaging of serotonergic biosynthesis and degradation in the endocrine pancreas.

Authors:
Olof Eriksson Ram K Selvaraju Lars Johansson Jan W Eriksson Anders Sundin Gunnar Antoni Jens Sörensen Barbro Eriksson Olle Korsgren

J Nucl Med 2014 Mar 13;55(3):460-5. Epub 2014 Feb 13.

Department of Medicinal Chemistry, Preclinical PET Platform, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.2967/jnumed.113.125187DOI Listing
March 2014

Treatment efficacy and immune stimulation by AdCD40L gene therapy of spontaneous canine malignant melanoma.

Authors:
Sara Westberg Arian Sadeghi Emma Svensson Thomas Segall Maria Dimopoulou Olle Korsgren Akseli Hemminki Angelica S I Loskog Thomas H Tötterman Henrik von Euler

J Immunother 2013 Jul-Aug;36(6):350-8

University Animal Hospital, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden.

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January 2014

Imaging the in vivo fate of human T cells following transplantation in immunoincompetent mice - implications for clinical cell therapy trials.

Authors:
David Berglund Marie Karlsson Senthilkumar Palanisamy Björn Carlsson Olle Korsgren Olof Eriksson

Transpl Immunol 2013 Dec 29;29(1-4):105-8. Epub 2013 Sep 29.

Department of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala University, Sweden; Department of Surgical Sciences, Section of Transplantation Surgery, Uppsala University, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.trim.2013.09.009DOI Listing
December 2013

Human islet isolation processing times shortened by one hour: minimized incubation time between tissue harvest and islet purification.

Authors:
Magnus Ståhle Minna Honkanen-Scott Sofie Ingvast Olle Korsgren Andrew S Friberg

Transplantation 2013 Dec;96(12):e91-3

Department of Immunology Genetics and Pathology Division of Clinical Immunology University Hospital Uppsala, Sweden.

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http://dx.doi.org/10.1097/01.TP.0000437562.31212.d5DOI Listing
December 2013

In vivo imaging of the glucagonlike peptide 1 receptor in the pancreas with 68Ga-labeled DO3A-exendin-4.

Authors:
Ram K Selvaraju Irina Velikyan Lars Johansson Zhanhong Wu Ivan Todorov Jack Shively Fouad Kandeel Olle Korsgren Olof Eriksson

J Nucl Med 2013 Aug 12;54(8):1458-63. Epub 2013 Jun 12.

Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.2967/jnumed.112.114066DOI Listing
August 2013

Induction of an antiviral state and attenuated coxsackievirus replication in type III interferon-treated primary human pancreatic islets.

Authors:
Katharina Lind Sarah J Richardson Pia Leete Noel G Morgan Olle Korsgren Malin Flodström-Tullberg

J Virol 2013 Jul 1;87(13):7646-54. Epub 2013 May 1.

Department of Medicine HS, The Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1128/JVI.03431-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700265PMC
July 2013

Revisiting the notion of type 1 diabetes being a T-cell-mediated autoimmune disease.

Authors:
Oskar Skog Stella Korsgren Asa Melhus Olle Korsgren

Curr Opin Endocrinol Diabetes Obes 2013 Apr;20(2):118-23

Department of Immunology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1097/MED.0b013e32835edb89DOI Listing
April 2013

A vast amount of enzyme activity fails to be absorbed within the human pancreas: implications for cost-effective islet isolation procedures.

Authors:
Andrew S Friberg Olle Korsgren Mikko Hellgren

Transplantation 2013 Mar;95(6):e36-8

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http://dx.doi.org/10.1097/TP.0b013e318283a859DOI Listing
March 2013