Olivier Salvado

Olivier Salvado

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Olivier Salvado

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Non-linear realignment improves hippocampus subfield segmentation reliability.

Neuroimage 2019 Dec 17;203:116206. Epub 2019 Sep 17.

Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia; School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.neuroimage.2019.116206DOI Listing
December 2019

Sensitivity of a Preclinical Alzheimer's Cognitive Composite (PACC) to amyloid β load in preclinical Alzheimer's disease.

J Clin Exp Neuropsychol 2019 Aug 29;41(6):591-600. Epub 2019 Mar 29.

a The Florey Institute of Neuroscience and Mental Health , The University of Melbourne , Melbourne , VIC , Australia.

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http://dx.doi.org/10.1080/13803395.2019.1593949DOI Listing
August 2019

Klotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer's disease.

Neurobiol Aging 2019 04 6;76:162-165. Epub 2019 Jan 6.

Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Cooperative Research Centre for Mental Health, Carlton South, Victoria, Australia; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.12.014DOI Listing
April 2019

Implementing the centiloid transformation for C-PiB and β-amyloid F-PET tracers using CapAIBL.

Neuroimage 2018 12 18;183:387-393. Epub 2018 Aug 18.

Department of Molecular Imaging, Austin Health, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S10538119183074
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http://dx.doi.org/10.1016/j.neuroimage.2018.08.044DOI Listing
December 2018

MRI white matter lesion segmentation using an ensemble of neural networks and overcomplete patch-based voting.

Comput Med Imaging Graph 2018 11 3;69:43-51. Epub 2018 May 3.

Australian e-Health Research Centre, CSIRO, Brisbane, QLD, 4029, Australia.

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http://dx.doi.org/10.1016/j.compmedimag.2018.05.001DOI Listing
November 2018

Estimates of age-related memory decline are inflated by unrecognized Alzheimer's disease.

Neurobiol Aging 2018 10 11;70:170-179. Epub 2018 Jun 11.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia; CogState Ltd., Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.06.005DOI Listing
October 2018

Local contrast-enhanced MR images via high dynamic range processing.

Magn Reson Med 2018 09 4;80(3):1206-1218. Epub 2018 Feb 4.

School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Australia.

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http://doi.wiley.com/10.1002/mrm.27109
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http://dx.doi.org/10.1002/mrm.27109DOI Listing
September 2018

Amyloid burden and incident depressive symptoms in preclinical Alzheimer's disease.

J Affect Disord 2018 03 3;229:269-274. Epub 2018 Jan 3.

Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia; CogState Ltd., Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.jad.2017.12.101DOI Listing
March 2018

Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden.

Transl Psychiatry 2018 02 26;8(1):47. Epub 2018 Feb 26.

Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, WA, Australia.

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http://dx.doi.org/10.1038/s41398-018-0094-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865132PMC
February 2018

Partial volume model for brain MRI scan using MP2RAGE.

Hum Brain Mapp 2017 10 5;38(10):5115-5127. Epub 2017 Jul 5.

CSIRO Health and Biosecurity, the Australian eHealth Research Center, Herston, Queensland, Australia.

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http://dx.doi.org/10.1002/hbm.23719DOI Listing
October 2017

Using Robust Normative Data to Investigate the Neuropsychology of Cognitive Aging.

Arch Clin Neuropsychol 2017 Mar;32(2):142-154

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1093/arclin/acw106DOI Listing
March 2017

Federated optimisation of kinetic analysis problems.

Med Image Anal 2017 01 16;35:116-132. Epub 2016 Jun 16.

CSIRO, The Australian eHealth Research Centre, Level 5 UQ Health Sciences Building, Royal Brisbane and Women's Hospital, Herston, Queensland, 4029, Australia; School of Medicine, University of Queensland, St Lucia, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.media.2016.06.019DOI Listing
January 2017

Aβ-amyloid and Tau Imaging in Dementia.

Semin Nucl Med 2017 Jan 13;47(1):75-88. Epub 2016 Oct 13.

Department of Molecular Imaging & Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia; Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1053/j.semnuclmed.2016.09.006DOI Listing
January 2017

β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men.

Am J Geriatr Psychiatry 2016 12 17;24(12):1191-1195. Epub 2016 Aug 17.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT; U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT.

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http://dx.doi.org/10.1016/j.jagp.2016.08.007DOI Listing
December 2016

Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia.

J Mol Neurosci 2016 Nov 1;60(3):362-370. Epub 2016 Sep 1.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 155 Oak Street, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1007/s12031-016-0822-8DOI Listing
November 2016

Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study.

Lancet Neurol 2016 09 20;15(10):1044-53. Epub 2016 Jul 20.

Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(16)30125-9DOI Listing
September 2016

Automated visibility map of the internal colon surface from colonoscopy video.

Int J Comput Assist Radiol Surg 2016 Sep 4;11(9):1599-610. Epub 2016 Aug 4.

CSIRO Biomedical Informatics, The Australian e-Health Research Centre, Level 5, UQ Health Sciences, Brisbane, QLD, 4029, Australia.

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http://dx.doi.org/10.1007/s11548-016-1462-8DOI Listing
September 2016

Heritability and genetic correlation between the cerebral cortex and associated white matter connections.

Hum Brain Mapp 2016 06 23;37(6):2331-47. Epub 2016 Mar 23.

CSIRO Health and Biosecurity, The Australian eHealth Research Centre, Herston, Queensland, Australia.

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http://dx.doi.org/10.1002/hbm.23177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883001PMC
June 2016

Statistical machine learning to identify traumatic brain injury (TBI) from structural disconnections of white matter networks.

Neuroimage 2016 Apr 28;129:247-259. Epub 2016 Jan 28.

CSIRO Health and Biosecurity, The Australian e-Health & Research Centre, Herston, QLD, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2016.01.056DOI Listing
April 2016

Aβ-related memory decline in APOE ε4 noncarriers: Implications for Alzheimer disease.

Neurology 2016 04 30;86(17):1635-42. Epub 2016 Mar 30.

From The Florey Institute of Neuroscience and Mental Health (Y.Y.L., V.L.V., C.F., C.L.M., P.M.), The University of Melbourne, Parkville; Centre of Excellence for Alzheimer's Disease Research and Care (S.M.L., T.P., S.R.-S., R.N.M.), Edith Cowan University, Joondalup, Australia; Department of Psychiatry (R.H.P.), Yale University School of Medicine, New Haven, CT; Academic Unit for Psychiatry of Old Age (D.A.), St. Vincent's Health, The University of Melbourne, Kew; National Ageing Research Institute (D.A.), Parkville, Australia; Department of Neurology (P.J.S.), Warren Alpert Medical School of Brown University, Providence, RI; Commonwealth Scientific Industrial Research Organization (CSIRO) Preventative Health National Research Flagship (O.S., P.B.), Australian e-Health Research Centre-BiaMedIA, Brisbane; Departments of Nuclear Medicine and Centre for PET (V.L.V., C.C.R.) and Medicine (V.L.V., C.C.R.), Austin Health, Heidelberg; Sir James McCusker Alzheimer's Disease Research Unit (S.M.L., T.P.), Hollywood Private Hospital, Perth; Co-operative Research Centre for Mental Health (S.M.L., T.P.), Carlton South; and CogState Ltd. (P.M.), Melbourne, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000002604DOI Listing
April 2016

Cerebral Glucose Metabolism is Associated with Verbal but not Visual Memory Performance in Community-Dwelling Older Adults.

J Alzheimers Dis 2016 03;52(2):661-72

Centre of Excellence for Alzheimer's disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

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http://dx.doi.org/10.3233/JAD-151084DOI Listing
March 2016

Computer-aided detection of cerebral microbleeds in susceptibility-weighted imaging.

Comput Med Imaging Graph 2015 Dec 24;46 Pt 3:269-76. Epub 2015 Oct 24.

CSIRO Digital Productivity Flagship, The Australian e-Health Research Centre, Herston, QLD, Australia.

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http://dx.doi.org/10.1016/j.compmedimag.2015.10.001DOI Listing
December 2015

Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease.

Neuroimage Clin 2015 27;7:105-13. Epub 2014 Nov 27.

Queensland Brain Institute, Clem Jones Centre for Ageing Dementia Research, The University of Queensland, Brisbane, Qld 4072, Australia.

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http://dx.doi.org/10.1016/j.nicl.2014.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299972PMC
September 2015

Reproducibility of multiphase pseudo-continuous arterial spin labeling and the effect of post-processing analysis methods.

Neuroimage 2015 Aug 27;117:191-201. Epub 2015 May 27.

Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia; Department of Medicine, Austin Health and Northern Health, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.neuroimage.2015.05.048DOI Listing
August 2015

Grey scale texture analysis of endobronchial ultrasound mini probe images for prediction of benign or malignant aetiology.

Respirology 2015 Aug 25;20(6):960-6. Epub 2015 Jun 25.

Department of Thoracic Medicine, The Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1111/resp.12577DOI Listing
August 2015

Relationships between performance on the Cogstate Brief Battery, neurodegeneration, and Aβ accumulation in cognitively normal older adults and adults with MCI.

Arch Clin Neuropsychol 2015 Feb 2;30(1):49-58. Epub 2014 Dec 2.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia Cogstate Ltd., Melbourne, VIC, Australia.

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http://dx.doi.org/10.1093/arclin/acu068DOI Listing
February 2015

Comparison of MR-less PiB SUVR quantification methods.

Neurobiol Aging 2015 Jan 27;36 Suppl 1:S159-66. Epub 2014 Aug 27.

Preventative Health Flagship, CSIRO Digital Productivity and Services Flagship, Herston, Queensland, Australia.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.04.033DOI Listing
January 2015

MR-less surface-based amyloid assessment based on 11C PiB PET.

PLoS One 2014 10;9(1):e84777. Epub 2014 Jan 10.

CSIRO Preventative Health Flagship, CSIRO Computational Informatics, The Australian e-Health Research Centre, Herston, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084777PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888418PMC
October 2014

Lesion segmentation from multimodal MRI using random forest following ischemic stroke.

Neuroimage 2014 Sep 2;98:324-35. Epub 2014 May 2.

The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia; Department of Occupational Therapy, La Trobe University, Bundoora, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2014.04.056DOI Listing
September 2014

(18)F-florbetaben Aβ imaging in mild cognitive impairment.

Alzheimers Res Ther 2013 16;5(1). Epub 2013 Jan 16.

Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia ; Department of Medicine, University of Melbourne, Parkville, VIC 3010, Australia.

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http://dx.doi.org/10.1186/alzrt158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580329PMC
May 2014

Incidence of cerebral microbleeds in preclinical Alzheimer disease.

Neurology 2014 Apr 12;82(14):1266-73. Epub 2014 Mar 12.

From the Department of Nuclear Medicine and Centre for PET (P.A.Y., V.L.V., C.C.R.), Austin Health, Heidelberg; The University of Melbourne (P.A.Y., P.M.D., C.S., C.C.R.), Parkville; Department of Radiology (P.M.D., P.M.P., C.S.), Royal Melbourne Hospital, Parkville; National Ageing Research Institute (D.A.), Parkville; CSIRO Preventative Health Flagship (O.S.), Parkville; Florey Institute of Neuroscience and Mental Health (K.A.E., C.L.M., V.L.V.), The University of Melbourne, Parkville; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, Kew, Victoria; Centre of Excellence for Alzheimer's Disease Research and Care (R.N.M.), School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000000285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001205PMC
April 2014

Distance informed Track-Weighted Imaging (diTWI): a framework for sensitising streamline information to neuropathology.

Neuroimage 2014 Feb 3;86:60-6. Epub 2013 Aug 3.

The Australian e-Health Research Centre, CSIRO, Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2013.07.077DOI Listing
February 2014

Early prediction of treatment response in advanced gliomas with (18)F-dopa positron-emission tomography.

Curr Oncol 2014 Feb;21(1):e172-8

The Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, The University of Queensland, Brisbane, Australia.

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http://www.current-oncology.com/index.php/oncology/article/v
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http://dx.doi.org/10.3747/co.21.1772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921044PMC
February 2014

Bi-exponential magnetic resonance signal model for partial volume computation.

Med Image Comput Comput Assist Interv 2012 ;15(Pt 1):231-8

Université de Rennes 1, LTSI-Rennes, F-35000, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962685PMC
http://dx.doi.org/10.1007/978-3-642-33415-3_29DOI Listing
January 2013

MR-less surface-based amyloid estimation by subject-specific atlas selection and Bayesian fusion.

Med Image Comput Comput Assist Interv 2012 ;15(Pt 2):220-7

Australian e-Health Research Centre, CSIRO, Australia.

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http://dx.doi.org/10.1007/978-3-642-33418-4_28DOI Listing
January 2013

Patient specific prostate segmentation in 3-d magnetic resonance images.

IEEE Trans Med Imaging 2012 Oct 2;31(10):1955-64. Epub 2012 Aug 2.

Australian e-Health Research Centre, CSIRO, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1109/TMI.2012.2211377DOI Listing
October 2012

An atlas-based electron density mapping method for magnetic resonance imaging (MRI)-alone treatment planning and adaptive MRI-based prostate radiation therapy.

Int J Radiat Oncol Biol Phys 2012 May 11;83(1):e5-11. Epub 2012 Feb 11.

Australian e-Health Research Center, CSIRO ICT Commonwealth Scientific and Industrial Research Organisation Information and Communication Technologies Centre, Queensland, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S036030161103614
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http://dx.doi.org/10.1016/j.ijrobp.2011.11.056DOI Listing
May 2012

Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease.

J Alzheimers Dis 2011 ;24(1):47-59

Department of Pathology, The University of Melbourne, Parkville, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.3233/JAD-2010-101722DOI Listing
March 2012

Optical differentiation between malignant and benign lymphadenopathy by grey scale texture analysis of endobronchial ultrasound convex probe images.

Chest 2012 Mar 1;141(3):709-715. Epub 2011 Sep 1.

Department of Thoracic Medicine, The Royal Brisbane and Women's Hospital, Herston, Australia; School of Medicine, Faculty of Health Sciences, University of Queensland, St. Lucia, QLD, Australia.

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http://dx.doi.org/10.1378/chest.11-1016DOI Listing
March 2012

Constrained reverse diffusion for thick slice interpolation of 3D volumetric MRI images.

Comput Med Imaging Graph 2012 Mar 14;36(2):130-8. Epub 2011 Sep 14.

CSIRO ICT Centre, The Australian e-Health Research Centre, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.compmedimag.2011.08.004DOI Listing
March 2012

Reorientation of fiber orientation distributions using apodized point spread functions.

Magn Reson Med 2012 Mar 19;67(3):844-55. Epub 2011 Dec 19.

CSIRO Preventative Health National Research Flagship ICTC, The Australian e-Health Research Centre, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.

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http://dx.doi.org/10.1002/mrm.23058DOI Listing
March 2012

Apparent Fibre Density: a novel measure for the analysis of diffusion-weighted magnetic resonance images.

Neuroimage 2012 Feb 20;59(4):3976-94. Epub 2011 Oct 20.

CSIRO Preventative Health National Research Flagship ICTC, The Australian e-Health Research Centre, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1016/j.neuroimage.2011.10.045DOI Listing
February 2012

Detecting global and local hippocampal shape changes in Alzheimer's disease using statistical shape models.

Neuroimage 2012 Feb 14;59(3):2155-66. Epub 2011 Oct 14.

Australian e-Health Research Centre, CSIRO ICT Centre, Herston, Queensland, Australia.

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http://dx.doi.org/10.1016/j.neuroimage.2011.10.014DOI Listing
February 2012

Symmetric diffeomorphic registration of fibre orientation distributions.

Neuroimage 2011 Jun 18;56(3):1171-80. Epub 2011 Feb 18.

CSIRO Preventative Health National Research Flagship ICTC, The Australian e-Health Research Centre, Royal Brisbane and Women's Hospital, Herston, QLD, Australia.

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http://dx.doi.org/10.1016/j.neuroimage.2011.02.014DOI Listing
June 2011

Segmentation of the quadratus lumborum muscle using statistical shape modeling.

J Magn Reson Imaging 2011 Jun;33(6):1422-9

School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1002/jmri.22188DOI Listing
June 2011

Hashed nonlocal means for rapid image filtering.

IEEE Trans Pattern Anal Mach Intell 2011 Mar;33(3):485-99

Australian e-Health Research Centre, Royal Brisbane and Women’s Hospital, Herston, QLD, Australia.

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http://dx.doi.org/10.1109/TPAMI.2010.114DOI Listing
March 2011

Advances in structural and molecular neuroimaging in Alzheimer's disease.

Med J Aust 2011 Feb;194(4):S20-3

Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.

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February 2011

A magnetic resonance imaging-based workflow for planning radiation therapy for prostate cancer.

Med J Aust 2011 Feb;194(4):S24-7

Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia.

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February 2011

Progress in virtual reality simulators for surgical training and certification.

Med J Aust 2011 Feb;194(4):S38-40

Australian e-Health Research Centre, CSIRO ICT Centre, Brisbane, QLD, Australia.

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February 2011

Interactive image manipulation for surgical planning.

Med J Aust 2011 Feb;194(4):S41

Australian e-Health Research Centre, CSIRO ICT Centre, Brisbane, QLD, Australia.

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February 2011

Larger temporal volume in elderly with high versus low beta-amyloid deposition.

Brain 2010 Nov 25;133(11):3349-58. Epub 2010 Aug 25.

Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia.

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http://dx.doi.org/10.1093/brain/awq187DOI Listing
November 2010

Topology-corrected segmentation and local intensity estimates for improved partial volume classification of brain cortex in MRI.

J Neurosci Methods 2010 May 1;188(2):305-15. Epub 2010 Mar 1.

CSIRO Preventative Health National Research Flagship, ICTC, The Australian e-Health Research Centre-BioMedIA, Herston, Australia.

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http://dx.doi.org/10.1016/j.jneumeth.2010.02.020DOI Listing
May 2010

Combining autofluorescence and narrow band imaging with image analysis in the evaluation of preneoplastic lesions in the bronchus and larynx.

J Bronchology Interv Pulmonol 2010 Apr;17(2):109-16

*The Department of Thoracic Medicine §The University of Queensland, UQ Centre for Clinical Research, The Royal Brisbane and Women's Hospital ‡The Department of Respiratory Medicine, The Royal Children's Hospital, Herston †The Australian e-Health Research Centre, Australian Commonwealth Scientific and Industrial Research Organisation (CSIRO), Brisbane, QLD, Australia.

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http://dx.doi.org/10.1097/LBR.0b013e3181da2ca8DOI Listing
April 2010

Relationship between atrophy and beta-amyloid deposition in Alzheimer disease.

Ann Neurol 2010 Mar;67(3):317-24

Department of Nuclear Medicine and Center for PET, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1002/ana.21955DOI Listing
March 2010