Publications by authors named "Olivier Provot"

32Publications

Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation.

Eur J Med Chem 2020 Oct 4;209:112873. Epub 2020 Oct 4.

Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2020.112873DOI Listing
October 2020

Synthesis and Anticancer Properties of Oxazepines Related to Azaisoerianin and IsoCoQuines.

ChemMedChem 2020 Jun 2. Epub 2020 Jun 2.

Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France.

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http://dx.doi.org/10.1002/cmdc.202000197DOI Listing
June 2020

Developments of isoCombretastatin A-4 derivatives as highly cytotoxic agents.

Eur J Med Chem 2020 Mar 30;190:112110. Epub 2020 Jan 30.

Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2020.112110DOI Listing
March 2020

Synthesis of 2,3-Substituted β--Glycosyl Indoles through C-H Activation/Annulation Process under Rh(III)-Catalysis.

Org Lett 2020 Jan 20;22(1):57-61. Epub 2019 Dec 20.

BioCIS, Univ. Paris-Sud, CNRS , University Paris-Saclay , Châtenay-Malabry , 92296 , France.

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http://dx.doi.org/10.1021/acs.orglett.9b03893DOI Listing
January 2020

N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents.

Eur J Med Chem 2019 Apr 16;168:176-188. Epub 2019 Feb 16.

BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 92290, Châtenay-Malabry, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.02.038DOI Listing
April 2019

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.

J Med Chem 2019 02 21;62(4):1902-1916. Epub 2018 Dec 21.

BioCIS, Université Paris-Sud, CNRS, Équipe Labellisée Ligue Contre le Cancer , Université Paris-Saclay , F-92290 Châtenay-Malabry , France.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01386DOI Listing
February 2019

One-Pot Synthesis of 2-Styrylindoles from Ortho-Substituted Chloroenynes.

J Org Chem 2018 12 11;83(24):15323-15332. Epub 2018 Dec 11.

Univ. Paris-Sud, BioCIS, CNRS, University Paris-Saclay, Equipe Labellisée Ligue Contre Le Cancer, F-92296 Châtenay-Malabry , France.

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http://dx.doi.org/10.1021/acs.joc.8b02563DOI Listing
December 2018

Unexpected Oxidative Ring Opening of Electron-Rich 3-Aminobenzofurans into α-Ketoimines Derivatives.

J Org Chem 2019 02 29;84(4):1725-1733. Epub 2018 Oct 29.

Univ. Paris-Sud, BioCIS, CNRS, University Paris-Saclay, Equipe Labellisée Ligue Contre Le Cancer , F-92296 Châtenay-Malabry , France.

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http://dx.doi.org/10.1021/acs.joc.8b01685DOI Listing
February 2019

Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors.

Eur J Med Chem 2017 Feb 9;127:1025-1034. Epub 2016 Nov 9.

BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 92290, Châtenay-Malabry, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.11.012DOI Listing
February 2017

Selective Metal-Free Deoxygenation of Unsymmetrical 1,2-Dicarbonyl Compounds by Chlorotrimethylsilane and Sodium Iodide.

Org Lett 2016 07 23;18(13):3238-41. Epub 2016 Jun 23.

BioCIS, Université Paris-Sud, CNRS, équipe labellisée Ligue Contre le Cancer, Université Paris-Saclay , 92290 Châtenay-Malabry, France.

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https://www.researchgate.net/profile/Ling-Zhi_Yuan2/publicat
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http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b01491
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http://dx.doi.org/10.1021/acs.orglett.6b01491DOI Listing
July 2016

IsoCombretaQuinazolines: Potent Cytotoxic Agents with Antitubulin Activity.

ChemMedChem 2015 Aug 15;10(8):1392-402. Epub 2015 Jun 15.

Univ. Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Equipe Labellisée Ligue Contre le Cancer, LabEx LERMIT, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, 92296 (France).

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http://dx.doi.org/10.1002/cmdc.201500069DOI Listing
August 2015

Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents.

Eur J Med Chem 2015 Jan 15;90:834-44. Epub 2014 Dec 15.

University Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Equipe Labellisée Ligue Contre Le Cancer, LabEx LERMIT, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry F-92296, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.12.024DOI Listing
January 2015

Discovery of azaisoerianin derivatives as potential antitumors agents.

Eur J Med Chem 2014 May 13;78:178-89. Epub 2014 Mar 13.

Univ Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, LabEx LERMIT, Equipe Labellisée Ligue Contre le Cancer, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry F-92296, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.03.032DOI Listing
May 2014

Therapeutic modalities of squalenoyl nanocomposites in colon cancer: an ongoing search for improved efficacy.

ACS Nano 2014 Mar 26;8(3):2018-32. Epub 2014 Feb 26.

Faculté de Pharmacie, Université Paris-Sud , Institut Galien Paris Sud, UMR CNRS 8612, 5 rue J.-B. Clément, Châtenay-Malabry, Paris, F-92296, France.

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http://dx.doi.org/10.1021/nn500517aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060170PMC
March 2014

Discovery and hit to lead optimization of novel combretastatin A-4 analogues: dependence of C-linker length and hybridization.

Anticancer Agents Med Chem 2013 Dec;13(10):1614-35

Univ. Paris-Sud 11, CNRS, BioCIS-UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.2174/187152061310131206162302DOI Listing
December 2013

Csp2-N bond formation via ligand-free Pd-catalyzed oxidative coupling reaction of N-tosylhydrazones and indole derivatives.

J Org Chem 2013 Sep 14;78(17):8485-95. Epub 2013 Aug 14.

Université Paris-Sud, CNRS, BioCIS-UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, rue J.-B. Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1021/jo401217xDOI Listing
September 2013

Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs.

Eur J Med Chem 2013 Apr 4;62:28-39. Epub 2013 Jan 4.

Univ. Paris-Sud, CNRS, BioCIS-UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry F-92296, France.

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http://dx.doi.org/10.1016/j.ejmech.2012.12.042DOI Listing
April 2013

Synthesis of ortho/ortho'-substituted 1,1-diarylethylenes through cross-coupling reactions of sterically encumbered hydrazones and aryl halides.

J Org Chem 2013 Jan 3;78(2):445-54. Epub 2013 Jan 3.

Université Paris-Sud, CNRS, BioCIS-UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, rue J.-B. Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1021/jo3023268DOI Listing
January 2013

Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.

Eur J Med Chem 2012 Jun 9;52:22-32. Epub 2012 Mar 9.

Univ. Paris-Sud, CNRS, BioCIS-UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry F-92296, France.

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http://dx.doi.org/10.1016/j.ejmech.2012.03.001DOI Listing
June 2012

B-ring-modified isocombretastatin A-4 analogues endowed with interesting anticancer activities.

ChemMedChem 2011 Dec 11;6(12):2179-91. Epub 2011 Oct 11.

Université Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, 92296, France.

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http://dx.doi.org/10.1002/cmdc.201100325DOI Listing
December 2011

The metabolic fate of isocombretastatin A-4 in human liver microsomes: identification, synthesis and biological evaluation of metabolites.

ChemMedChem 2011 Oct 11;6(10):1781-8. Epub 2011 Jul 11.

Univ Paris-Sud, Faculté de Pharmacie, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, 5 Rue J.-B. Clément, Châtenay-Malabry 92296, France.

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http://dx.doi.org/10.1002/cmdc.201100193DOI Listing
October 2011

Discovery of isoerianin analogues as promising anticancer agents.

ChemMedChem 2011 Mar 14;6(3):488-97. Epub 2011 Jan 14.

Université Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 Rue J.-B. Clément, Châtenay-Malabry, 92296, France.

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http://dx.doi.org/10.1002/cmdc.201000456DOI Listing
March 2011

Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4.

Eur J Med Chem 2010 Sep 12;45(9):3617-26. Epub 2010 May 12.

University Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1016/j.ejmech.2010.05.007DOI Listing
September 2010

Palladium-catalyzed Markovnikov terminal arylalkynes hydrostannation: application to the synthesis of 1,1-diarylethylenes.

J Org Chem 2009 Feb;74(3):1337-40

Laboratoire de Chimie Therapeutique, Faculte de Pharmacie, Universite Paris-Sud, CNRS, BioCIS, UMR 8076, rue J. B. Clement, Chatenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1021/jo802460zDOI Listing
February 2009

Synthesis and antitumor activity of benzils related to combretastatin A-4.

Bioorg Med Chem Lett 2008 Jun 25;18(11):3266-71. Epub 2008 Apr 25.

Univ Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, rue J.B. Clément, F-92296 Châtenay-Malabry, France.

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http://dx.doi.org/10.1016/j.bmcl.2008.04.053DOI Listing
June 2008

Regiocontrol of the palladium-catalyzed tin hydride addition to Z-enynols: remarkable Z-directing effects.

J Org Chem 2007 May 14;72(10):3868-74. Epub 2007 Apr 14.

Univ Paris-Sud, and CNRS, BioCIS UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1021/jo0701435DOI Listing
May 2007

Platinum oxide catalyzed silylation of aryl halides with triethylsilane: an efficient synthetic route to functionalized aryltriethylsilanes.

Org Lett 2006 Mar;8(5):931-4

Laboratoire de Chimie Thérapeutique, BioCIS - CNRS (UMR 8076), Université Paris-Sud XI, Faculté de Pharmacie, rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France.

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http://dx.doi.org/10.1021/ol052996uDOI Listing
March 2006

Platinum oxide catalyzed hydrosilylation of unsymmetrical internal aryl alkynes under ortho-substituent regiocontrol.

Org Lett 2005 Dec;7(25):5625-8

Laboratoire de Chimie Thérapeutique, BioCIS - CNRS (UMR 8076), Université Paris-Sud XI, Faculté de Pharmacie, rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France.

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http://dx.doi.org/10.1021/ol052245sDOI Listing
December 2005

Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane.

Org Biomol Chem 2003 Aug;1(16):2859-64

UMR 8076 BioCIS, Faculté de Pharmacie, rue J.-B. Clément, F-92296 Châtenay-Malabry, France.

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http://dx.doi.org/10.1039/b302835fDOI Listing
August 2003

Synthesis and antimalarial activity of 2-methoxyprop-2-yl peroxides derivatives.

Bioorg Med Chem Lett 2003 Jan;13(1):75-7

UPRES A 8076 BioCIS, Laboratoire de synthèse et conception des molécules d'intérêt thérapeutique, Faculté de Pharmacie, rue J.-B. Clément, F-92296 Châtenay Malabry Cedex, France.

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http://dx.doi.org/10.1016/s0960-894x(02)00837-5DOI Listing
January 2003