Olivier Lichtarge

Olivier Lichtarge

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Olivier Lichtarge

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CAGI5: Objective performance assessments of predictions based on the Evolutionary Action equation.

Hum Mutat 2019 Sep 7;40(9):1436-1454. Epub 2019 Aug 7.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/humu.23873DOI Listing
September 2019

Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling.

Am J Physiol Heart Circ Physiol 2018 07 30;315(1):H109-H121. Epub 2018 Mar 30.

Department of Pharmacological and Pharmaceutical Sciences, University of Houston, College of Pharmacy, Texas Medical Center , Houston, Texas.

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https://www.physiology.org/doi/10.1152/ajpheart.00034.2018
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http://dx.doi.org/10.1152/ajpheart.00034.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087776PMC
July 2018

Potential role of Plasmodium falciparum exported protein 1 in the chloroquine mode of action.

Int J Parasitol Drugs Drug Resist 2018 04 27;8(1):31-35. Epub 2017 Dec 27.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA; Computational and Integrative Biomedical Research Center, Baylor College of Medicine, Houston, TX, 77030, USA; Department of Pharmacology, Baylor College of Medicine, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1016/j.ijpddr.2017.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963095PMC
April 2018

A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures.

Cell 2018 02;172(5):924-936.e11

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832058PMC
February 2018

Objective assessment of the evolutionary action equation for the fitness effect of missense mutations across CAGI-blinded contests.

Hum Mutat 2017 09 21;38(9):1072-1084. Epub 2017 Jun 21.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/humu.23266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600169PMC
September 2017

Codon-level co-occurrences of germline variants and somatic mutations in cancer are rare but often lead to incorrect variant annotation and underestimated impact prediction.

PLoS One 2017 28;12(3):e0174766. Epub 2017 Mar 28.

Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174766PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370158PMC
August 2017

DISCOVERY OF FUNCTIONAL AND DISEASE PATHWAYS BY COMMUNITY DETECTION IN PROTEIN-PROTEIN INTERACTION NETWORKS.

Pac Symp Biocomput 2017 ;22:336-347

Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140035PMC
http://dx.doi.org/10.1142/9789813207813_0032DOI Listing
June 2017

HUMAN KINASES DISPLAY MUTATIONAL HOTSPOTS AT COGNATE POSITIONS WITHIN CANCER.

Pac Symp Biocomput 2017 ;22:414-425

Structural Computational Biology and Molecular Biophysics, Baylor College of Medicine, One Baylor Plaza Houston, TX, 77030, USA†The authors gratefully acknowledge support from the National Institutes of Health (GM066099 and GM079656), from the National Science Foundation (DBI-1356569), and from DARPA (N66001-15-C-4042),

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157159PMC
http://dx.doi.org/10.1142/9789813207813_0039DOI Listing
June 2017

β-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway.

J Biol Chem 2017 06 25;292(24):9967-9974. Epub 2017 Apr 25.

From the Verna and Marrs McLean Department of Biochemistry and Molecular Biology and

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http://dx.doi.org/10.1074/jbc.M117.787119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473248PMC
June 2017

Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling.

Hum Mutat 2017 05 28;38(5):569-580. Epub 2017 Feb 28.

Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/humu.23193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516182PMC
May 2017

Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome.

Blood 2016 12 31;128(26):3061-3072. Epub 2016 Oct 31.

Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX; and.

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http://dx.doi.org/10.1182/blood-2016-02-702373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201093PMC
December 2016

REPURPOSING GERMLINE EXOMES OF THE CANCER GENOME ATLAS DEMANDS A CAUTIOUS APPROACH AND SAMPLE-SPECIFIC VARIANT FILTERING.

Pac Symp Biocomput 2016 ;21:207-18

Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA†Co-first authors.,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720392PMC
October 2016

Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H).

J Pathol 2016 10;240(2):224-34

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1002/path.4770DOI Listing
October 2016

Cooperativity of Negative Autoregulation Confers Increased Mutational Robustness.

Phys Rev Lett 2016 Jun 22;116(25):258104. Epub 2016 Jun 22.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1103/PhysRevLett.116.258104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152588PMC
June 2016

Intramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation.

Proc Natl Acad Sci U S A 2016 Mar 15;113(13):3539-44. Epub 2016 Mar 15.

Verna and Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030

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http://dx.doi.org/10.1073/pnas.1516579113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822589PMC
March 2016

UET: a database of evolutionarily-predicted functional determinants of protein sequences that cluster as functional sites in protein structures.

Nucleic Acids Res 2016 Jan 20;44(D1):D308-12. Epub 2015 Nov 20.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA Department of Structural and Computational Biology and Molecular Biophysics, Houston, TX 77030, USA Computational and Integrative Biomedical Research Center, Baylor College of Medicine, Houston, TX 77030, USA Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA

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http://dx.doi.org/10.1093/nar/gkv1279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702906PMC
January 2016

Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival.

Neoplasia 2015 Oct;17(10):789-803

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2015.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656807PMC
October 2015

Prediction and redesign of protein-protein interactions.

Prog Biophys Mol Biol 2014 Nov-Dec;116(2-3):194-202. Epub 2014 May 27.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Computational and Integrative Biomedical Research Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pbiomolbio.2014.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246023PMC
September 2015

Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor.

Proc Natl Acad Sci U S A 2015 Jun 11;112(22):7097-102. Epub 2015 May 11.

Departments of Cell Biology, Medicine, and Neurobiology, Duke University School of Medicine, Durham, NC 27710;

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http://dx.doi.org/10.1073/pnas.1502742112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460444PMC
June 2015

Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors.

J Biol Chem 2015 Jan 17;290(5):2870-8. Epub 2014 Dec 17.

From the Graduate Program in Structural and Computational Biology and Molecular Biophysics, the Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030

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http://dx.doi.org/10.1074/jbc.M114.622233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317032PMC
January 2015

A formal perturbation equation between genotype and phenotype determines the Evolutionary Action of protein-coding variations on fitness.

Genome Res 2014 Dec 12;24(12):2050-8. Epub 2014 Sep 12.

Department of Molecular and Human Genetics, Department of Biochemistry & Molecular Biology, Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA; Computational and Integrative Biomedical Research Center, Baylor College of Medicine, Houston, Texas 77030, USA

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http://dx.doi.org/10.1101/gr.176214.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248321PMC
December 2014

Single nucleotide variations: biological impact and theoretical interpretation.

Protein Sci 2014 Dec 20;23(12):1650-66. Epub 2014 Oct 20.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/pro.2552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253807PMC
December 2014

Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels.

J Biol Chem 2014 Oct 5;289(43):29961-74. Epub 2014 Sep 5.

From the Graduate Program in Structural and Computational Biology and Molecular Biophysics, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, and

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http://dx.doi.org/10.1074/jbc.M114.574483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208005PMC
October 2014

Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate.

Cell 2014 Aug;158(4):916-928

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Computational and Integrative Biomedical Research Center, Baylor College of Medicine, Houston, TX 77030, USA; Verna and Marrs McLean Department of Biochemistry and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167585PMC
August 2014

Negative feedback in genetic circuits confers evolutionary resilience and capacitance.

Cell Rep 2014 Jun 5;7(6):1789-95. Epub 2014 Jun 5.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Computational and Integrative Biomedical Research Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103627PMC
June 2014

Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases.

Mol Cell Biol 2014 Feb 18;34(3):374-85. Epub 2013 Nov 18.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1128/MCB.01248-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911504PMC
February 2014

Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues.

PLoS Genet 2014 Jan 23;10(1):e1004121. Epub 2014 Jan 23.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America ; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900401PMC
January 2014

Accounting for epistatic interactions improves the functional analysis of protein structures.

Bioinformatics 2013 Nov 10;29(21):2714-21. Epub 2013 Sep 10.

Department of Molecular and Human Genetics, CIBR Center for Computational and Integrative Biomedical Research and Program in Structural and Computational Biology & Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030 and Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1093/bioinformatics/btt489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799481PMC
November 2013

Prediction and experimental validation of enzyme substrate specificity in protein structures.

Proc Natl Acad Sci U S A 2013 Nov 21;110(45):E4195-202. Epub 2013 Oct 21.

Department of Molecular and Human Genetics and Computational and Integrative Biomedical Research Center, Baylor College of Medicine, Houston, TX 77030.

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http://dx.doi.org/10.1073/pnas.1305162110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831482PMC
November 2013

The maternal-to-zygotic transition targets actin to promote robustness during morphogenesis.

PLoS Genet 2013 Nov 7;9(11):e1003901. Epub 2013 Nov 7.

Verna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820746PMC
November 2013

Function prediction from networks of local evolutionary similarity in protein structure.

BMC Bioinformatics 2013 28;14 Suppl 3:S6. Epub 2013 Feb 28.

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1186/1471-2105-14-S3-S6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584919PMC
July 2013

A large-scale evaluation of computational protein function prediction.

Authors:
Predrag Radivojac Wyatt T Clark Tal Ronnen Oron Alexandra M Schnoes Tobias Wittkop Artem Sokolov Kiley Graim Christopher Funk Karin Verspoor Asa Ben-Hur Gaurav Pandey Jeffrey M Yunes Ameet S Talwalkar Susanna Repo Michael L Souza Damiano Piovesan Rita Casadio Zheng Wang Jianlin Cheng Hai Fang Julian Gough Patrik Koskinen Petri Törönen Jussi Nokso-Koivisto Liisa Holm Domenico Cozzetto Daniel W A Buchan Kevin Bryson David T Jones Bhakti Limaye Harshal Inamdar Avik Datta Sunitha K Manjari Rajendra Joshi Meghana Chitale Daisuke Kihara Andreas M Lisewski Serkan Erdin Eric Venner Olivier Lichtarge Robert Rentzsch Haixuan Yang Alfonso E Romero Prajwal Bhat Alberto Paccanaro Tobias Hamp Rebecca Kaßner Stefan Seemayer Esmeralda Vicedo Christian Schaefer Dominik Achten Florian Auer Ariane Boehm Tatjana Braun Maximilian Hecht Mark Heron Peter Hönigschmid Thomas A Hopf Stefanie Kaufmann Michael Kiening Denis Krompass Cedric Landerer Yannick Mahlich Manfred Roos Jari Björne Tapio Salakoski Andrew Wong Hagit Shatkay Fanny Gatzmann Ingolf Sommer Mark N Wass Michael J E Sternberg Nives Škunca Fran Supek Matko Bošnjak Panče Panov Sašo Džeroski Tomislav Šmuc Yiannis A I Kourmpetis Aalt D J van Dijk Cajo J F ter Braak Yuanpeng Zhou Qingtian Gong Xinran Dong Weidong Tian Marco Falda Paolo Fontana Enrico Lavezzo Barbara Di Camillo Stefano Toppo Liang Lan Nemanja Djuric Yuhong Guo Slobodan Vucetic Amos Bairoch Michal Linial Patricia C Babbitt Steven E Brenner Christine Orengo Burkhard Rost Sean D Mooney Iddo Friedberg

Nat Methods 2013 Mar 27;10(3):221-7. Epub 2013 Jan 27.

School of Informatics and Computing, Indiana University, Bloomington, Indiana, USA.

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http://dx.doi.org/10.1038/nmeth.2340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584181PMC
March 2013

ETAscape: analyzing protein networks to predict enzymatic function and substrates in Cytoscape.

Bioinformatics 2012 Aug 11;28(16):2186-8. Epub 2012 Jun 11.

Departments of Molecular and Human Genetics, Program Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/bioinformatics/bts331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413384PMC
August 2012

The use of evolutionary patterns in protein annotation.

Curr Opin Struct Biol 2012 Jun 24;22(3):316-25. Epub 2012 May 24.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.sbi.2012.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439137PMC
June 2012

Evolutionary trace for prediction and redesign of protein functional sites.

Methods Mol Biol 2012 ;819:29-42

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1007/978-1-61779-465-0_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892863PMC
April 2012

Separation of recombination and SOS response in Escherichia coli RecA suggests LexA interaction sites.

PLoS Genet 2011 Sep 1;7(9):e1002244. Epub 2011 Sep 1.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164682PMC
September 2011

Protein function prediction: towards integration of similarity metrics.

Curr Opin Struct Biol 2011 Apr 24;21(2):180-8. Epub 2011 Feb 24.

Department of Molecular and Human Genetics, 1 Baylor Plaza, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.sbi.2011.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120633PMC
April 2011

PyETV: a PyMOL evolutionary trace viewer to analyze functional site predictions in protein complexes.

Bioinformatics 2010 Dec 6;26(23):2981-2. Epub 2010 Oct 6.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/bioinformatics/btq566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982157PMC
December 2010

An angiotensin II type 1 receptor activation switch patch revealed through evolutionary trace analysis.

Biochem Pharmacol 2010 Jul 21;80(1):86-94. Epub 2010 Mar 21.

Laboratory for Molecular Cardiology, The Danish National Research Foundation Centre for Cardiac Arrhythmia, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Juliane Mariesvej 20, section 9312, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.bcp.2010.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864232PMC
July 2010

Evolution: a guide to perturb protein function and networks.

Curr Opin Struct Biol 2010 Jun 3;20(3):351-9. Epub 2010 May 3.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.sbi.2010.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916956PMC
June 2010

Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors.

Proc Natl Acad Sci U S A 2010 Apr 12;107(17):7787-92. Epub 2010 Apr 12.

Verna and Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1073/pnas.0914877107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867884PMC
April 2010

Evolutionary trace annotation of protein function in the structural proteome.

J Mol Biol 2010 Mar 28;396(5):1451-73. Epub 2009 Dec 28.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.jmb.2009.12.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831211PMC
March 2010

Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation.

Mol Pharmacol 2010 Mar 28;77(3):405-15. Epub 2009 Dec 28.

Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Medical School, 6431 Fannin St, Houston, TX 77030, USA.

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http://dx.doi.org/10.1124/mol.109.058115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835418PMC
March 2010

Functional rescue of beta-adrenoceptor dimerization and trafficking by pharmacological chaperones.

Traffic 2009 Aug 9;10(8):1019-33. Epub 2009 Jun 9.

Département de Biochimie, Groupe de Recherche Universitaire sur le Médicament and Institut de recherche en Immunologie et en Cancérologie, Université de Montréal, Québec, Canada.

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http://dx.doi.org/10.1111/j.1600-0854.2009.00932.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755524PMC
August 2009

Evolutionary Trace Annotation Server: automated enzyme function prediction in protein structures using 3D templates.

Bioinformatics 2009 Jun 23;25(11):1426-7. Epub 2009 Mar 23.

Department of Molecular and Human Genetics, Program in Structural and Computational Biology and Molecular, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/bioinformatics/btp160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682511PMC
June 2009

Prediction of enzyme function based on 3D templates of evolutionarily important amino acids.

BMC Bioinformatics 2008 Jan 11;9:17. Epub 2008 Jan 11.

Department of Molecular and Human Genetics, Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1186/1471-2105-9-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219985PMC
January 2008

Composite motifs integrating multiple protein structures increase sensitivity for function prediction.

Comput Syst Bioinformatics Conf 2007 ;6:343-55

Department of Computer Science, Rice University, Houston, TX 77005, USA.

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December 2007

Graph sharpening plus graph integration: a synergy that improves protein functional classification.

Bioinformatics 2007 Dec 31;23(23):3217-24. Epub 2007 Oct 31.

Department of Industrial & Information Systems Engineering, Ajou University, San 5, Wonchun-dong, Yeoungtong-gu, 443-749, Suwon, Korea.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btm511DOI Listing
December 2007

Cavity-aware motifs reduce false positives in protein function prediction.

Comput Syst Bioinformatics Conf 2006 :311-23

Department of Computer Science, Rice University, Houston, TX 77005, USA.

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June 2007

Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions.

Nat Struct Mol Biol 2007 Apr 11;14(4):301-7. Epub 2007 Mar 11.

Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, One Baylor Plaza, BCM225, Houston, Texas 77030-3411, USA.

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http://www.nature.com/articles/nsmb1214
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http://dx.doi.org/10.1038/nsmb1214DOI Listing
April 2007

Cavity scaling: automated refinement of cavity-aware motifs in protein function prediction.

J Bioinform Comput Biol 2007 Apr;5(2a):353-82

Department of Computer Science, Rice University, Houston, TX 77005, USA.

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April 2007

Rapid detection of similarity in protein structure and function through contact metric distances.

Nucleic Acids Res 2006 27;34(22):e152. Epub 2006 Nov 27.

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/nar/gkl788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702494PMC
January 2007

Rank information: a structure-independent measure of evolutionary trace quality that improves identification of protein functional sites.

Proteins 2006 Oct;65(1):111-23

Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine,Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/prot.21101DOI Listing
October 2006

Evolutionary identification of a subtype specific functional site in the ligand binding domain of steroid receptors.

Proteins 2006 Sep;64(4):1046-57

W. M. Keck Center for Computational and Structural Biology, Baylor College of Medicine, Houston Texas 77030, USA.

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http://dx.doi.org/10.1002/prot.21074DOI Listing
September 2006

ET viewer: an application for predicting and visualizing functional sites in protein structures.

Bioinformatics 2006 Aug 29;22(16):2049-50. Epub 2006 Jun 29.

Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/bioinformatics/btl285DOI Listing
August 2006