Publications by authors named "Olivier Lequin"

66Publications

Hyperglucosylated adhesin-derived peptides as antigenic probes in multiple sclerosis: Structure optimization and immunological evaluation.

J Pept Sci 2020 Nov 12;26(11):e3281. Epub 2020 Aug 12.

Laboratory of Peptide and Protein Chemistry and Biology, Department of Neurosciences, Psychology, Drug Research and Child Health-Section of Pharmaceutical Sciences and Nutraceutics, University of Florence, Sesto Fiorentino, Italy.

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http://dx.doi.org/10.1002/psc.3281DOI Listing
November 2020

Introducing sequential aza-amino acids units induces repeated β-turns and helical conformations in peptides.

Org Biomol Chem 2020 May 24;18(18):3452-3458. Epub 2020 Feb 24.

Université Paris-Saclay, CNRS, BioCIS, 92290 Châtenay-Malabry, France.

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http://dx.doi.org/10.1039/c9ob02654aDOI Listing
May 2020

A Plant-Specific N-terminal Extension Reveals Evolutionary Functional Divergence within Translocator Proteins.

iScience 2020 Mar 7;23(3):100889. Epub 2020 Feb 7.

Louvain Institute of Biomolecular Science and Technology (LIBST), University of Louvain (UCLouvain), Croix du Sud 4-5, L7.07.14, 1348 Louvain-la-Neuve, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.100889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033594PMC
March 2020

Author Correction: Reprogramming Escherichia coli for the production of prenylated indole diketopiperazine alkaloids.

Sci Rep 2019 Oct 15;9(1):15009. Epub 2019 Oct 15.

Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91198, Gif-sur-Yvette, cedex, France.

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http://dx.doi.org/10.1038/s41598-019-51404-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791860PMC
October 2019

Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging.

J Med Chem 2019 11 25;62(21):9743-9752. Epub 2019 Oct 25.

CEA, Institut des Sciences du Vivant Frédéric Joliot, Service d'Ingénierie Moléculaire des Protéines (SIMOPRO), Université Paris-Saclay , Gif-sur-Yvette 91190 , France.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054845PMC
November 2019

Reprogramming Escherichia coli for the production of prenylated indole diketopiperazine alkaloids.

Sci Rep 2019 06 25;9(1):9208. Epub 2019 Jun 25.

Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91198, Gif-sur-Yvette, cedex, France.

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http://dx.doi.org/10.1038/s41598-019-45519-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592928PMC
June 2019

Characterization of the High-Affinity Drug Ligand Binding Site of Mouse Recombinant TSPO.

Int J Mol Sci 2019 Mar 21;20(6). Epub 2019 Mar 21.

Sorbonne Université, Ecole Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules (LBM), 4 place Jussieu, F-75005 Paris, France.

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http://dx.doi.org/10.3390/ijms20061444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470738PMC
March 2019

Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins.

Chem Sci 2018 May 13;9(19):4483-4487. Epub 2018 Apr 13.

Laboratoire des Biomolécules, LBM , Département de Chimie , École Normale Supérieure , PSL University , Sorbonne Université , CNRS , 75005 Paris , France . Email:

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http://dx.doi.org/10.1039/c8sc00886hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958345PMC
May 2018

Time dependence of NMR observables reveals salient differences in the accumulation of early aggregated species between human islet amyloid polypeptide and amyloid-β.

Phys Chem Chem Phys 2018 Apr;20(14):9561-9573

Sorbonne Université, Ecole Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules (LBM), 4 place Jussieu, F-75005 Paris, France.

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http://xlink.rsc.org/?DOI=C7CP07516B
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http://dx.doi.org/10.1039/c7cp07516bDOI Listing
April 2018

The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands.

Beilstein J Org Chem 2017 21;13:2842-2853. Epub 2017 Dec 21.

Molécules Fluorées et Chimie Médicinale, BioCIS, Univ. Paris-Sud, CNRS, Université Paris Saclay, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry Cedex, France.

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http://dx.doi.org/10.3762/bjoc.13.276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753055PMC
December 2017

A single mutation on the human amyloid polypeptide modulates fibril growth and affects the mechanism of amyloid-induced membrane damage.

Biochim Biophys Acta Biomembr 2018 Feb 27. Epub 2018 Feb 27.

Sorbonne Université, Ecole Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules, 4 place Jussieu, F-75005 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2018.02.018DOI Listing
February 2018

Incorporation of Non-canonical Amino Acids into 2,5-Diketopiperazines by Cyclodipeptide Synthases.

Angew Chem Int Ed Engl 2018 03 21;57(12):3118-3122. Epub 2018 Feb 21.

Institute for Integrated Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 91198, Gif-sur-Yvette cedex, France.

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http://dx.doi.org/10.1002/anie.201712536DOI Listing
March 2018

Insight into the mechanism of action of temporin-SHa, a new broad-spectrum antiparasitic and antibacterial agent.

PLoS One 2017 20;12(3):e0174024. Epub 2017 Mar 20.

Sorbonne Universités, UPMC Univ Paris 06, CNRS, Institut de Biologie Paris-Seine (IBPS), Biogenèse des Signaux Peptidiques (BIOSIPE), Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174024PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358776PMC
August 2017

Designed Glycopeptidomimetics Disrupt Protein-Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability.

J Med Chem 2016 Mar 4;59(5):2025-40. Epub 2016 Feb 4.

Molécules Fluorées et Chimie Médicinale, BioCIS, Univ. Paris-Sud, CNRS, Université Paris Saclay , 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry Cedex, France.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01629DOI Listing
March 2016

Distribution of Pico- and Nanosecond Motions in Disordered Proteins from Nuclear Spin Relaxation.

Biophys J 2015 Sep;109(5):988-99

Département de Chimie, École Normale Supérieure-PSL Research University, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, LBM, Paris, France; Centre National de la Recherche Scientifique, UMR 7203 LBM, Paris, France. Electronic address:

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http://www.cell.com/biophysj/pdf/S0006-3495(15)00731-6.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000634951500731
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http://dx.doi.org/10.1016/j.bpj.2015.06.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564687PMC
September 2015

(R)-α-trifluoromethylalanine containing short peptide in the inhibition of amyloid peptide fibrillation.

Biopolymers 2015 Sep;104(5):601-10

Sorbonne Universités, UPMC Univ Paris 06, Laboratoire des Biomolécules, 4 Place Jussieu, F-75005, Paris, France.

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http://doi.wiley.com/10.1002/bip.22670
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http://dx.doi.org/10.1002/bip.22670DOI Listing
September 2015

Cholesterol modulates the interaction of the islet amyloid polypeptide with membranes.

Mol Membr Biol 2014 Nov-Dec;31(7-8):239-49. Epub 2014 Dec 15.

Sorbonne Universités , UPMC Univ Paris 06, Laboratoire des Biomolécules , Paris, France .

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http://dx.doi.org/10.3109/09687688.2014.987182DOI Listing
August 2015

Glaser oxidative coupling on peptides: stabilization of β-turn structure via a 1,3-butadiyne constraint.

Bioorg Med Chem 2014 Dec 22;22(24):6924-32. Epub 2014 Oct 22.

École Normale Supérieure-PSL Research University, Département de Chimie, 24, rue Lhomond, 75005 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, LBM, 4 place Jussieu, F-75005 Paris, France; CNRS, UMR 7203 LBM, F-75005 Paris, France.

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http://dx.doi.org/10.1016/j.bmc.2014.10.026DOI Listing
December 2014

Investigating the role of GXXXG motifs in helical folding and self-association of plasticins, Gly/Leu-rich antimicrobial peptides.

Biophys Chem 2015 Jan 28;196:40-52. Epub 2014 Sep 28.

Sorbonne Universités, UPMC Univ Paris 06, Ecole Normale Supérieure-PSL Research University, Département de chimie, CNRS UMR 7203 Laboratoire des Biomolécules, 4 place Jussieu, F-75005 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.bpc.2014.09.004DOI Listing
January 2015

Structure-activity relationships of sugar-based peptidomimetics as modulators of amyloid β-peptide early oligomerization and fibrillization.

Eur J Med Chem 2014 Oct 10;86:752-8. Epub 2014 Sep 10.

Molécules Fluorées et Chimie Médicinale, BioCIS UMR-CNRS 8076, LabEx LERMIT, Université Paris-Sud, Faculté de Pharmacie, 5 Rue Jean-Baptiste Clément, 92296 Châtenay-Malabry Cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.09.031DOI Listing
October 2014

Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1.

J Med Chem 2014 Jan 9;57(2):421-34. Epub 2014 Jan 9.

Laboratoire des BioMolécules, UMR 7203, Université Pierre et Marie Curie-Paris 6, ENS, CNRS, 4, Place Jussieu, 75252 Paris Cedex 05, France.

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http://dx.doi.org/10.1021/jm401419pDOI Listing
January 2014

Evaluation of membrane models and their composition for islet amyloid polypeptide-membrane aggregation.

Biochim Biophys Acta 2013 Sep 23;1828(9):2091-8. Epub 2013 May 23.

UPMC Univ Paris 06, UMR 7203 CNRS-UPMC-ENS, Laboratoire des Biomolécules, 4 place Jussieu, 75005 Paris, France.

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http://dx.doi.org/10.1016/j.bbamem.2013.05.014DOI Listing
September 2013

Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121: insights from biochemical studies and crystal structures.

J Biol Chem 2013 Jun 25;288(24):17347-59. Epub 2013 Apr 25.

Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), iBiTec-S, Service d'Ingénierie Moléculaire des Protéines, 91191 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1074/jbc.M112.443853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682536PMC
June 2013

3-Substituted prolines: from synthesis to structural applications, from peptides to foldamers.

Molecules 2013 Feb 19;18(2):2307-27. Epub 2013 Feb 19.

Laboratoire des BioMolécules, Université Pierre et Marie Curie-Sorbonne Universités, UMR 7203 and FR 2769, Paris 75005, France.

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http://dx.doi.org/10.3390/molecules18022307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270394PMC
February 2013

Tryptophan within basic peptide sequences triggers glycosaminoglycan-dependent endocytosis.

FASEB J 2013 Feb 15;27(2):738-49. Epub 2012 Oct 15.

Université Pierre et Marie Curie, Université Paris 6, Unité Mixte de Recherche 7203, Paris, France.

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http://dx.doi.org/10.1096/fj.12-216176DOI Listing
February 2013

A microplate fluorescence assay for DAPA aminotransferase by detection of the vicinal diamine 7,8-diaminopelargonic acid.

Anal Biochem 2013 Jan 12;432(2):90-6. Epub 2012 Oct 12.

Laboratoire Charles Friedel, Chimie ParisTech ENSCP, 75231 Paris Cedex 05, France.

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http://dx.doi.org/10.1016/j.ab.2012.09.038DOI Listing
January 2013

The C-terminal domain of the Uup protein is a DNA-binding coiled coil motif.

J Struct Biol 2012 Dec 17;180(3):577-84. Epub 2012 Sep 17.

UPMC Université Paris 06, Laboratoire des BioMolécules UMR 7203, 4 place Jussieu, 75005 Paris, France.

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http://dx.doi.org/10.1016/j.jsb.2012.09.005DOI Listing
December 2012

Membrane interactions of two arginine-rich peptides with different cell internalization capacities.

Biochim Biophys Acta 2012 Jul;1818(7):1755-63

UPMC-Paris 06, UMR 7203 CNRS, ENS, Laboratoire des BioMolecules, 4, place jussieu, Paris F-75005, France.

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http://dx.doi.org/10.1016/j.bbamem.2012.02.024DOI Listing
July 2012

Secondary structure and NMR resonance assignments of the C-terminal DNA-binding domain of Uup protein.

Biomol NMR Assign 2012 Oct;6(2):197-200

Laboratoire des BioMolécules UMR 7203, UPMC Université Paris 06, 4 place Jussieu, 75005 Paris, France.

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http://dx.doi.org/10.1007/s12104-012-9356-3DOI Listing
October 2012

Sugar-based peptidomimetics inhibit amyloid β-peptide aggregation.

Eur J Med Chem 2011 Dec 12;46(12):5959-69. Epub 2011 Oct 12.

Molécules Fluorées et Chimie Médicinale, BioCIS UMR-CNRS 8076, IPSIT, LabEx LERMIT, Université Paris-Sud 11, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry Cedex, France.

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http://dx.doi.org/10.1016/j.ejmech.2011.10.008DOI Listing
December 2011

β-Amino acids containing peptides and click-cyclized peptide as β-turn mimics: a comparative study with 'conventional' lactam- and disulfide-bridged hexapeptides.

J Pept Sci 2011 Sep 6;17(9):632-43. Epub 2011 Jun 6.

UPMC Univ Paris, Laboratoire des BioMolécules, Place Jussieu, Boîte courrier, Paris, France.

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http://dx.doi.org/10.1002/psc.1382DOI Listing
September 2011

Methods to determine slow diffusion coefficients of biomolecules: applications to Engrailed 2, a partially disordered protein.

J Biomol NMR 2011 Jul 21;50(3):209-18. Epub 2011 May 21.

Département de chimie, Ecole Normale Supérieure, France.

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http://dx.doi.org/10.1007/s10858-011-9510-8DOI Listing
July 2011

1H, 13C and 15N resonance assignment of a 114-residue fragment of Engrailed 2 homeoprotein, a partially disordered protein.

Biomol NMR Assign 2011 Oct 23;5(2):229-31. Epub 2011 Apr 23.

UPMC Univ Paris 06, 4 Place Jussieu, 75252, Paris, Cedex 05, France.

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http://dx.doi.org/10.1007/s12104-011-9306-5DOI Listing
October 2011

The combination of prolinoamino acids and cyclopropylamino acids leads to fully functionalized, stable β-turns in water.

Chembiochem 2011 May 29;12(7):1039-42. Epub 2011 Mar 29.

UPMC Université Paris, Laboratoire des BioMolécules, UMR and FR, France.

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http://dx.doi.org/10.1002/cbic.201000707DOI Listing
May 2011

Sequence-dependent enrichment of a model phosphopeptide: a combined MALDI-TOF and NMR study.

Anal Chem 2011 Apr 23;83(8):3003-10. Epub 2011 Mar 23.

Université P. et M. Curie Paris 6, UMR 7203 CNRS-UPMC-ENS, 4, Place Jussieu, 75005 Paris, Ecole Normale Supérieure, Département de Chimie, 24, rue Lhomond, 75005 Paris, France.

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http://dx.doi.org/10.1021/ac103134eDOI Listing
April 2011

Temporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide.

J Biol Chem 2010 May 22;285(22):16880-92. Epub 2010 Mar 22.

ER3 Biogenèse des Signaux Peptidiques, Université Pierre et Marie Curie, University of Paris 06, F-75005 Paris, France.

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http://www.jbc.org/content/285/22/16880.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M109.097204
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http://dx.doi.org/10.1074/jbc.M109.097204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878016PMC
May 2010

Prolinoamino acids as tools to build bifunctionalized, stable beta-turns in water.

Chembiochem 2010 Jan;11(1):55-8

UPMC Université de Paris 06, UMR 7203 CNRS-UPMC-ENS, Laboratoire des Biomolécules, UPMC, 4 Place Jussieu, Paris Cedex 05, France.

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http://dx.doi.org/10.1002/cbic.200900572DOI Listing
January 2010

Evidence that biosynthesis of the neurotoxic alkaloids anatoxin-a and homoanatoxin-a in the cyanobacterium Oscillatoria PCC 6506 occurs on a modular polyketide synthase initiated by L-proline.

J Am Chem Soc 2009 Jun;131(22):7512-3

Laboratoire de Biochimie des Microorganismes: Enzymologie, Métabolisme et Antibiotiques (UMR CNRS 7223), ENSCP, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05, France.

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http://dx.doi.org/10.1021/ja9024353DOI Listing
June 2009

Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.

Proc Natl Acad Sci U S A 2009 May 22;106(18):7426-31. Epub 2009 Apr 22.

Service d'Ingénierie Moléculaire des Protéines, Biologie Structurale et Mécanismes, Commissariat à l'Energie Atomique, Institut de Biologie et Technologies de Saclay, F-91191 Gif-sur-Yvette, France.

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http://dx.doi.org/10.1073/pnas.0812191106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678619PMC
May 2009

Mechanism of antibacterial action of dermaseptin B2: interplay between helix-hinge-helix structure and membrane curvature strain.

Biochemistry 2009 Jan;48(2):313-27

Peptidome de la Peau des Amphibiens, UPMC Universite Paris 06, CNRS FRE 2852, F-75005 Paris, France.

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http://dx.doi.org/10.1021/bi802025aDOI Listing
January 2009

High affinity Grb2-SH3 domain ligand incorporating Cbeta-substituted prolines in a Sos-derived decapeptide.

Bioorg Med Chem 2007 Feb 6;15(3):1439-47. Epub 2006 Nov 6.

Université Pierre et Marie Curie-Paris 6, UMR 7613, Paris, France; CNRS, UMR 7613, Synthèse, Structure et Fonction de Molécules Bioactives, Paris, France.

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http://dx.doi.org/10.1016/j.bmc.2006.11.002DOI Listing
February 2007

Comparison of penetratin and other homeodomain-derived cell-penetrating peptides: interaction in a membrane-mimicking environment and cellular uptake efficiency.

Biochemistry 2006 Feb;45(5):1408-20

Synthèse, Structure et Fonction de Molécules Bioactives, UMR 7613 CNRS, Université Pierre et Marie Curie, boîte 45, 4 place Jussieu, 75252 Paris Cedex 05, France.

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http://dx.doi.org/10.1021/bi0518390DOI Listing
February 2006

Dermaseptin S9, an alpha-helical antimicrobial peptide with a hydrophobic core and cationic termini.

Biochemistry 2006 Jan;45(2):468-80

Synthèse, structure et fonction de molécules bioactives, UMR 7613 CNRS, Université Pierre et Marie Curie, Case Courrier 45, 4 Place Jussieu, 75252 Paris Cedex 05, France.

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http://dx.doi.org/10.1021/bi051711iDOI Listing
January 2006

Conformational analysis of the C-terminal Gly-Leu-Met-NH2 tripeptide of substance P bound to the NK-1 receptor.

Chem Biol 2005 May;12(5):555-65

Synthèse, Structure et Fonction de Molécules Bioactives, Unite Mixte de Recherche 7613, Centre National de la Recherche Scientifique-Université Paris 6, Paris, France.

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http://dx.doi.org/10.1016/j.chembiol.2005.03.005DOI Listing
May 2005

N- and Calpha-methylation in biologically active peptides: synthesis, structural and functional aspects.

Curr Med Chem 2004 Nov;11(21):2799-822

UMR 7613 CNRS-Université Pierre & Marie Curie, Structure and Function of Bioactive Molecules, Case courrier 182, 4 place Jussieu, 75005 Paris, France.

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http://dx.doi.org/10.2174/0929867043364108DOI Listing
November 2004

Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates.

Proc Natl Acad Sci U S A 2003 Dec 1;100(25):14784-9. Epub 2003 Dec 1.

Beckman Institute and Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1073/pnas.2334390100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC299803PMC
December 2003

Helical structure of dermaseptin B2 in a membrane-mimetic environment.

Biochemistry 2003 Sep;42(34):10311-23

UMR 7613 CNRS, Université Paris 6, Structure et fonction de molécules bioactives, Université Pierre et Marie Curie, Case Courrier 45, 4 Place Jussieu, 75252 Paris Cedex 05, France.

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http://dx.doi.org/10.1021/bi034401dDOI Listing
September 2003

Structural and biological effects of a beta2- or beta3-amino acid insertion in a peptide.

Eur J Biochem 2003 Mar;270(5):939-49

UMR 7613 CNRS-Paris 6, Université Pierre et Marie Curie, Paris, France.

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http://dx.doi.org/10.1046/j.1432-1033.2003.03456.xDOI Listing
March 2003

Mapping the heparin-binding site on the 13-14F3 fragment of fibronectin.

J Biol Chem 2002 Dec 10;277(52):50629-35. Epub 2002 Oct 10.

Department of Biochemistry and Oxford Centre for Molecular Sciences, University of Oxford, South Parks Rd., Oxford OX1 3QU, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M208956200DOI Listing
December 2002

Involvement of the second extracellular loop (E2) of the neurokinin-1 receptor in the binding of substance P. Photoaffinity labeling and modeling studies.

J Biol Chem 2002 Jun 11;277(25):22386-94. Epub 2002 Apr 11.

Unité Mixte de Recherches 7613 CNRS, Université Paul et Marie Curie, 4 place Jussieu, 75252 Paris cedex 05, France.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110614200
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http://dx.doi.org/10.1074/jbc.M110614200DOI Listing
June 2002