Publications by authors named "Olivier De Wever"

100Publications

Recombinant extracellular vesicles as biological reference material for method development, data normalization and assessment of (pre-)analytical variables.

Nat Protoc 2021 Jan 15. Epub 2021 Jan 15.

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
January 2021

A Systematic Review on Extracellular Vesicles-Enriched Fat Grafting: A Shifting Paradigm.

Aesthet Surg J 2020 Dec 15. Epub 2020 Dec 15.

Faculty of Medicine and Health Sciences; and Department of Plastic and Reconstructive Surgery, Ghent University Hospital, Ghent, Belgium.

View Article and Find Full Text PDF
December 2020

Targeting USP13 mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in Non-Small Cell Lung Cancer.

Int J Cancer 2020 Nov 19. Epub 2020 Nov 19.

Laboratory of Medical and Molecular Oncology, Oncology Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium.

View Article and Find Full Text PDF
November 2020

Preparation of Multi-omics Grade Extracellular Vesicles by Density-Based Fractionation of Urine.

STAR Protoc 2020 Sep 27;1(2):100073. Epub 2020 Jul 27.

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
September 2020

Splenic Hematopoietic and Stromal Cells in Cancer Progression.

Cancer Res 2020 Sep 30. Epub 2020 Sep 30.

Cancer Research Institute Ghent (CRIG), Ghent, Belgium.

View Article and Find Full Text PDF
September 2020

Splenic F-FDG uptake on baseline PET/CT is associated with oncological outcomes and tumor immune state in uterine cervical cancer.

Gynecol Oncol 2020 Nov 25;159(2):335-343. Epub 2020 Aug 25.

Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Gynecological Pelvic Oncology Network (GYPON), Ghent, Belgium; Radiation Oncology, Department of Human Structure and Repair, Ghent University Hospital, Belgium.

View Article and Find Full Text PDF
November 2020

Feasibility of Mechanical Extrusion to Coat Nanoparticles with Extracellular Vesicle Membranes.

Cells 2020 07 29;9(8). Epub 2020 Jul 29.

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, 9000 Ghent, Belgium.

View Article and Find Full Text PDF
July 2020

Chitosan/γ-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer.

Biomaterials 2020 Oct 7;257:120218. Epub 2020 Jul 7.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal. Electronic address:

View Article and Find Full Text PDF
October 2020

Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine.

J Extracell Vesicles 2020 11;9(1):1736935. Epub 2020 Mar 11.

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
March 2020

Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases.

Trends Cancer 2020 03 16;6(3):236-246. Epub 2020 Jan 16.

Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium; Laboratory for Experimental Cancer Research, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
March 2020

Comparative Profiling of Metastatic 4T1- vs. Non-metastatic Py230-Based Mammary Tumors in an Intraductal Model for Triple-Negative Breast Cancer.

Front Immunol 2019 17;10:2928. Epub 2019 Dec 17.

Laboratory of Biochemistry, Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

View Article and Find Full Text PDF
November 2020

Analyzing bacterial extracellular vesicles in human body fluids by orthogonal biophysical separation and biochemical characterization.

Nat Protoc 2020 01 27;15(1):40-67. Epub 2019 Nov 27.

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
January 2020

Fibroblasts Fuel Immune Escape in the Tumor Microenvironment.

Trends Cancer 2019 11 29;5(11):704-723. Epub 2019 Oct 29.

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium; Gynecologic Pelvic Oncology Network Ghent (GYPON), Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium. Electronic address:

View Article and Find Full Text PDF
November 2019

Anti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma.

Melanoma Res 2020 02;30(1):39-51

Laboratory of Proteinchemistry, Proteomics & Epigenetic Signaling (PPES), Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

View Article and Find Full Text PDF
February 2020

Cellular and sub-cellular Cu isotope fractionation in the human neuroblastoma SH-SY5Y cell line: proliferating versus neuron-like cells.

Anal Bioanal Chem 2019 Jul 16;411(19):4963-4971. Epub 2019 May 16.

Department of Chemistry, Atomic & Mass Spectrometry - A&MS Research Unit, Ghent University, Campus Sterre, Krijgslaan 281-S12, 9000, Ghent, Belgium.

View Article and Find Full Text PDF
July 2019

A supporting ecosystem to mature extracellular vesicles into clinical application.

EMBO J 2019 05 11;38(9). Epub 2019 Apr 11.

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
May 2019

A 3D CFD model of the interstitial fluid pressure and drug distribution in heterogeneous tumor nodules during intraperitoneal chemotherapy.

Drug Deliv 2019 Dec;26(1):404-415

a Biofluid, Tissue and Solid Mechanics for Medical Applications (bioMMeda), Department of Electronics and Information Systems , Ghent University , Ghent , Belgium.

View Article and Find Full Text PDF
December 2019

Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models.

Int J Cancer 2019 08 20;145(3):735-747. Epub 2019 Feb 20.

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
August 2019

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

View Article and Find Full Text PDF
November 2018

Impact of the Microenvironment on Tumour Budding in Colorectal Cancer.

Adv Exp Med Biol 2018;1110:101-111

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
July 2019

Transparent reporting of experimental parameters in assays measuring phenotypic steps in metastasis.

Clin Exp Metastasis 2018 12 28;35(8):715-725. Epub 2018 Oct 28.

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
December 2018

Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer.

J Exp Clin Cancer Res 2018 Aug 15;37(1):191. Epub 2018 Aug 15.

Laboratory of Biochemistry, Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

View Article and Find Full Text PDF
August 2018

Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition.

Medchemcomm 2018 Jun 18;9(6):1011-1016. Epub 2018 May 18.

SynBioC Research Group , Department of Green Chemistry and Technology , Faculty of Bioscience Engineering , Ghent University , Coupure Links 653 , B-9000 Ghent , Belgium . Email:

View Article and Find Full Text PDF
June 2018

Targeting Polo-like kinase 1 and TRAIL enhances apoptosis in non-small cell lung cancer.

Oncotarget 2018 Jun 19;9(47):28731-28744. Epub 2018 Jun 19.

Laboratory of Molecular Oncology and Department of Medical Oncology, Oncologisch Centrum, Universitair Ziekenhuis Brussel, Brussels, Belgium.

View Article and Find Full Text PDF
June 2018

Synthesis of C-ring-modified blebbistatin derivatives and evaluation of their myosin II ATPase inhibitory potency.

Bioorg Med Chem Lett 2018 07 22;28(13):2261-2264. Epub 2018 May 22.

Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653 bl. B, 9000 Gent, Belgium. Electronic address:

View Article and Find Full Text PDF
July 2018

Urinary extracellular vesicle biomarkers in urological cancers: From discovery towards clinical implementation.

Int J Biochem Cell Biol 2018 06 11;99:236-256. Epub 2018 Apr 11.

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent, Ghent, Belgium. Electronic address:

View Article and Find Full Text PDF
June 2018

Hypoxia imaging with F-FAZA PET/CT predicts radiotherapy response in esophageal adenocarcinoma xenografts.

Radiat Oncol 2018 Mar 7;13(1):39. Epub 2018 Mar 7.

Laboratory of Experimental Surgery, Department of Gastro- Intestinal Surgery, Ghent University Hospital, De Pintelaan 185, B-9000, Ghent, Belgium.

View Article and Find Full Text PDF
March 2018

Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo.

Biomaterials 2018 03 23;158:95-105. Epub 2017 Dec 23.

Laboratory Experimental Cancer Research (LECR), Ghent University, De Pintelaan 185, 9000 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent University, De Pintelaan 185, 9000 Ghent, Belgium. Electronic address:

View Article and Find Full Text PDF
March 2018

Glucocorticoids indirectly decrease colon cancer cell proliferation and invasion via effects on cancer-associated fibroblasts.

Exp Cell Res 2018 01 28;362(2):332-342. Epub 2017 Nov 28.

Laboratory of Experimental Cancer Research, Department of Radiation Oncology & Experimental Cancer Research, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Department Health Sciences, Odisee University College, Ghent, Belgium. Electronic address:

View Article and Find Full Text PDF
January 2018

Polyelectrolyte-Enrobed Cancer Cells in View of Personalized Immune-Therapy.

Adv Sci (Weinh) 2017 06 2;4(6):1700050. Epub 2017 May 2.

Department of Pharmaceutics Ghent University 9000 Ghent Belgium.

View Article and Find Full Text PDF
June 2017

Confounding factors of ultrafiltration and protein analysis in extracellular vesicle research.

Sci Rep 2017 06 2;7(1):2704. Epub 2017 Jun 2.

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
June 2017

Tumour tissue transport after intraperitoneal anticancer drug delivery.

Int J Hyperthermia 2017 08;33(5):534-542

a Laboratory for Experimental Surgery, Department of Surgery , Ghent University , Ghent , Belgium.

View Article and Find Full Text PDF
August 2017

Improved xenograft efficiency of esophageal adenocarcinoma cell lines through in vivo selection.

Oncol Rep 2017 Jul 15;38(1):71-81. Epub 2017 May 15.

Laboratory of Experimental Surgery, Department of Surgery, Ghent University Hospital, Ghent, Belgium.

View Article and Find Full Text PDF
July 2017

Methodological Guidelines to Study Extracellular Vesicles.

Circ Res 2017 May;120(10):1632-1648

From the Biomedical Engineering and Physics (F.A.W.C., T.G.v.L., E.v.d.P.), Vesicle Observation Centre (F.A.W.C., A.G., T.G.v.L., E.v.d.P., G.S., R.N.), and Laboratory of Experimental Clinical Chemistry (A.G., G.S., R.N.), Academic Medical Center, University of Amsterdam, The Netherlands; Extracellular Vesicles and Membrane Repair, UMR-5248-CBMN CNRS, University of Bordeaux, IPB, Pessac, France (A.R.B.); Department of Genetics, Cell- and Immunobology, Semmelweis University, Budapest, Hungary (E.I.B.); VRCM, UMRS-1076, INSERM, Aix-Marseille University, UFR de Pharmacie, Marseille, France (F.D.-G., R.L.); Haematology and vascular biology department, CHU La Conception, APHM, Marseille, France (F.D.-G., R.L.); Exosomes Research Group, Department of Pathology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands (E.E.E.D., D.M.P.); Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden (S.E.-A., Y.L.); Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom (S.E.-A., I.M.); Bristol Heart Institute, University of Bristol, United Kingdom (C.E.); National Heart & Lung Institute, Imperial College London, United Kingdom (C.E.); 1st Chair and Department of Cardiology, Medical University of Warsaw, Poland (A.G.); Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Belgium (A.H., O.d.W.); Cancer Research Institute Ghent, Belgium (A.H., O.d.W.); Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia (A.F.H.); Department of Medicine, University of North Carolina at Chapel Hill (N.M.); Institute of Technology, University of Tartu, Estonia (I.M.); Scintillon Institute, San Diego, CA (J.P.N.); Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY (S.S.); and EV Core Facility, University of Helsinki and EV-Group, Division of Biochemistry and Biotechnology, Department of Biosciences, University of Helsinki, Finland (P.R.M.S.).

View Article and Find Full Text PDF
May 2017

ADAM-17/FHL2 colocalisation suggests interaction and role of these proteins in colorectal cancer.

Tumour Biol 2017 Mar;39(3):1010428317695024

1 Department of Pathology, Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium.

View Article and Find Full Text PDF
March 2017

Developments and future clinical outlook of taxane nanomedicines.

J Control Release 2017 05 20;253:137-152. Epub 2017 Mar 20.

Department of Pharmaceutics, Ghent University, Ghent, Belgium. Electronic address:

View Article and Find Full Text PDF
May 2017

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research.

Authors:
Jan Van Deun Pieter Mestdagh Patrizia Agostinis Özden Akay Sushma Anand Jasper Anckaert Zoraida Andreu Martinez Tine Baetens Els Beghein Laurence Bertier Geert Berx Janneke Boere Stephanie Boukouris Michel Bremer Dominik Buschmann James B Byrd Clara Casert Lesley Cheng Anna Cmoch Delphine Daveloose Eva De Smedt Seyma Demirsoy Victoria Depoorter Bert Dhondt Tom A P Driedonks Aleksandra Dudek Abdou Elsharawy Ilaria Floris Andrew D Foers Kathrin Gärtner Abhishek D Garg Edward Geeurickx Jan Gettemans Farzaneh Ghazavi Bernd Giebel Tom Groot Kormelink Grace Hancock Hetty Helsmoortel Andrew F Hill Vincent Hyenne Hina Kalra David Kim Joanna Kowal Sandra Kraemer Petra Leidinger Carina Leonelli Yaxuan Liang Lien Lippens Shu Liu Alessandra Lo Cicero Shaun Martin Suresh Mathivanan Prabhu Mathiyalagan Támas Matusek Gloria Milani Marta Monguió-Tortajada Liselot M Mus Dillon C Muth Andrea Németh Esther N M Nolte-'t Hoen Lorraine O'Driscoll Roberta Palmulli Michael W Pfaffl Bjarke Primdal-Bengtson Erminia Romano Quentin Rousseau Susmita Sahoo Natalia Sampaio Monisha Samuel Benjamin Scicluna Bieke Soen Anneleen Steels Johannes V Swinnen Maarit Takatalo Safia Thaminy Clotilde Théry Joeri Tulkens Isabel Van Audenhove Susanne van der Grein Alan Van Goethem Martijn J van Herwijnen Guillaume Van Niel Nadine Van Roy Alexander R Van Vliet Niels Vandamme Suzanne Vanhauwaert Glenn Vergauwen Frederik Verweij Annelynn Wallaert Marca Wauben Kenneth W Witwer Marijke I Zonneveld Olivier De Wever Jo Vandesompele An Hendrix

Nat Methods 2017 02;14(3):228-232

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
February 2017

Discovery of (S)-3'-hydroxyblebbistatin and (S)-3'-aminoblebbistatin: polar myosin II inhibitors with superior research tool properties.

Org Biomol Chem 2017 Mar;15(9):2104-2118

SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium.

View Article and Find Full Text PDF
March 2017

Mathematical modeling of intraperitoneal drug delivery: simulation of drug distribution in a single tumor nodule.

Drug Deliv 2017 Nov;24(1):491-501

a Biofluid, Tissue and Solid Mechanics for Medical Applications (bioMMeda), Department of Electronics and Information Systems, iMinds Medical IT Department, Ghent University , Ghent , Belgium.

View Article and Find Full Text PDF
November 2017

When Neighbors Talk: Colon Cancer Cell Invasion and Tumor Microenvironment Myofibroblasts.

Curr Drug Targets 2017 ;18(8):964-982

Laboratory of Experimental Cancer Research, Department of Radiation Oncology & Experimental Cancer Research, Ghent University Hospital, De Pintelaan 185, Building 2RTP, Belgium.

View Article and Find Full Text PDF
April 2018

Comparison of the Adipose and Luminal Mammary Gland Compartment as Orthotopic Inoculation Sites in a 4T1-Based Immunocompetent Preclinical Model for Triple-Negative Breast Cancer.

J Mammary Gland Biol Neoplasia 2016 12 6;21(3-4):113-122. Epub 2016 Oct 6.

Laboratory of Biochemistry, Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

View Article and Find Full Text PDF
December 2016

Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts.

Oncotarget 2016 11;7(46):75603-75615

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
November 2016

Nanoscopic tumor tissue distribution of platinum after intraperitoneal administration in a xenograft model of ovarian cancer.

J Pharm Biomed Anal 2016 Nov 3;131:256-262. Epub 2016 Sep 3.

Department of Surgery, Laboratory of Experimental Surgery, Ghent University Hospital, B-9000 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent University Hospital, B-9000 Ghent, Belgium. Electronic address:

View Article and Find Full Text PDF
November 2016

Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity.

BMC Cancer 2016 08 22;16:667. Epub 2016 Aug 22.

Laboratory of Stem Cells, Development & Cancer, Department of Cell Biology & Histology, Faculty of Medicine & Nursing, University of the Basque Country (UPV/EHU), Leioa, Biscay, Spain.

View Article and Find Full Text PDF
August 2016

Function of extracellular vesicle-associated miRNAs in metastasis.

Cell Tissue Res 2016 09 11;365(3):621-41. Epub 2016 Jun 11.

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
September 2016

SMARCAD1 knockdown uncovers its role in breast cancer cell migration, invasion, and metastasis.

Expert Opin Ther Targets 2016 09 13;20(9):1035-43. Epub 2016 Jun 13.

a Department of Pharmacology & Therapeutics, College of Medicine & Health Sciences , United Arab Emirates University , Al-Ain , UAE.

View Article and Find Full Text PDF
September 2016

APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma.

Clin Cancer Res 2016 Sep 25;22(18):4746-55. Epub 2016 Mar 25.

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota. Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota.

View Article and Find Full Text PDF
September 2016

Quantitative and Functional Requirements for Bioluminescent Cancer Models.

In Vivo 2016 Jan-Feb;30(1):1-11

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium

View Article and Find Full Text PDF
September 2016

Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer.

Oncotarget 2016 Jan;7(3):3068-83

Laboratory of Molecular Oncology and Department of Medical Oncology, Oncologisch Centrum, UZ Brussel, Vrije Universiteit Brussels, Bruxelles, Belgium.

View Article and Find Full Text PDF
January 2016

FHL2: a scaffold protein of carcinogenesis, tumour-stroma interactions and treatment response.

Histol Histopathol 2016 May 17;31(5):469-78. Epub 2015 Dec 17.

Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.

View Article and Find Full Text PDF
May 2016

Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling.

Oncotarget 2015 Sep;6(29):26615-32

Department of Radiation Oncology and Experimental Cancer Research, Laboratory of Experimental Cancer Research, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
September 2015

Combined inhibition of rho-associated protein kinase and EGFR suppresses the invasive phenotype in EGFR-dependent lung cancer cells.

Lung Cancer 2015 Nov 20;90(2):167-74. Epub 2015 Aug 20.

Laboratory of Molecular Oncology and Department of Medical Oncology, Oncologisch Centrum, Universitair Ziekenhuis Brussel, Belgium. Electronic address:

View Article and Find Full Text PDF
November 2015

Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics.

Virchows Arch 2015 Oct 11;467(4):367-82. Epub 2015 Aug 11.

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.

View Article and Find Full Text PDF
October 2015

The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia.

Biochim Biophys Acta 2015 Oct 23;1853(10 Pt A):2515-25. Epub 2015 Jul 23.

Institute of Molecular Medicine and Cell Research, University of Freiburg, D-79104 Freiburg, Germany; BIOSS Centre for Biological Signaling Studies, University of Freiburg, D-79104 Freiburg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

View Article and Find Full Text PDF
October 2015

Impact of neoadjuvant therapy on cancer-associated fibroblasts in rectal cancer.

Radiother Oncol 2015 Sep 25;116(3):449-54. Epub 2015 May 25.

Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium. Electronic address:

View Article and Find Full Text PDF
September 2015

Combined targeting of EGFR/HER promotes anti-tumor efficacy in subsets of KRAS mutant lung cancer resistant to single EGFR blockade.

Oncotarget 2015 Aug;6(24):20132-44

Laboratory of Molecular Oncology and Department of Medical Oncology, Oncologisch Centrum, Universitair Ziekenhuis Brussel, Brussels, Belgium.

View Article and Find Full Text PDF
August 2015

Cancer-associated fibroblasts connect metastasis-promoting communication in colorectal cancer.

Front Oncol 2015 23;5:63. Epub 2015 Mar 23.

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University , Ghent , Belgium.

View Article and Find Full Text PDF
April 2015

Fibroblast-induced matrix remodeling paves the path for invasion.

Cell Cycle 2015 ;14(6):793-4

a Department of Pathology ; Ghent University and Ghent University Hospital ; Ghent , Belgium.

View Article and Find Full Text PDF
May 2015

Expression profiling of migrated and invaded breast cancer cells predicts early metastatic relapse and reveals Krüppel-like factor 9 as a potential suppressor of invasive growth in breast cancer.

Oncoscience 2014 18;1(1):69-81. Epub 2013 Jan 18.

Center for Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium ; Laboratory of Pathology, Antwerp University Hospital, Wilrijkstraat 10, B-2650 Edegem (Antwerp), Belgium.

View Article and Find Full Text PDF
January 2015

Crosstalk between the microbiome and cancer cells by quorum sensing peptides.

Peptides 2015 Feb 3;64:40-8. Epub 2015 Jan 3.

Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, Ghent B-9000, Belgium. Electronic address:

View Article and Find Full Text PDF
February 2015

The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling.

J Extracell Vesicles 2014 18;3. Epub 2014 Sep 18.

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium.

View Article and Find Full Text PDF
October 2014

Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells.

Blood 2014 Jul 13;124(4):555-66. Epub 2014 Jun 13.

Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel, Brussels, Belgium;

View Article and Find Full Text PDF
July 2014