Oliver T Keppler

Oliver T Keppler

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Oliver T Keppler

Publications by authors named "Oliver T Keppler"

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Post-translational Modification-Based Regulation of HIV Replication.

Front Microbiol 2018 11;9:2131. Epub 2018 Sep 11.

Max von Pettenkofer-Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02131
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http://dx.doi.org/10.3389/fmicb.2018.02131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141784PMC
September 2018

[The HIV reservoir in resting CD4 T-cells: Barrier on the road to an HIV cure].

MMW Fortschr Med 2018 Jun;160(Suppl 2):32-35

Virologie, Nationales Referenzzentrum für Retroviren Max von Pettenkofer-Institut, Ludwig-Maximilians-Universität München (LMU), Pettenkoferstr. 9a, D-80336, München, Deutschland.

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http://dx.doi.org/10.1007/s15006-018-0653-3DOI Listing
June 2018

Retrospective analysis of clinical and virological parameters of influenza cases at four university hospitals in Germany, 2015.

Infection 2017 Jun 18;45(3):349-354. Epub 2017 Mar 18.

Institute for Virology, Medical Center - University of Freiburg, Hermann-Herder-Str. 11, 79014, Freiburg, Germany.

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http://dx.doi.org/10.1007/s15010-017-1008-1DOI Listing
June 2017

Elevated prevalence of multidrug-resistant gram-negative organisms in HIV positive men.

BMC Infect Dis 2017 03 13;17(1):206. Epub 2017 Mar 13.

Institute for Medical Microbiology and Infection Control, University Hospital Frankfurt, Paul-Ehrlich-Str. 40, 60596, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1186/s12879-017-2286-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347171PMC
March 2017

HCV RNA Testing of Plasma Samples from Cornea Donors: Suitability of Plasma Samples Stored at 4 °C for up to 8 Days.

Transfus Med Hemother 2017 Jan 4;44(1):39-44. Epub 2016 Nov 4.

Institute of Medical Virology, Hospital of the Goethe University of Frankfurt, Frankfurt/M., Germany.

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https://www.karger.com/Article/FullText/449207
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http://dx.doi.org/10.1159/000449207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318926PMC
January 2017

Prevalence of K65R in patients treated with tenofovir disoproxil fumarate: recommendations based on the Frankfurt HIV Cohort Study Resistance Database (FHCS-RD).

Med Microbiol Immunol 2016 Aug 8;205(4):315-20. Epub 2016 Jan 8.

Department for Internal Medicine II/Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s00430-015-0448-4DOI Listing
August 2016

HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites.

J Virol 2016 08 11;90(15):6709-6723. Epub 2016 Jul 11.

Department of Infectious Diseases, Integrative Virology, Heidelberg University Hospital, Heidelberg, Germany

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http://dx.doi.org/10.1128/JVI.00504-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944280PMC
August 2016

Evolutionary study of leporid CD4 reveals a hotspot of genetic variability within the D2 domain.

Immunogenetics 2016 Jul 15;68(6-7):477-482. Epub 2016 Mar 15.

InBIO-Research Network in Biodiversity and Evolutionary Biology, CIBIO, Campus de Vairão, Universidade do Porto, Campus Agrário de Vairão, Rua Padre Armando Quintas, nr.7, 4485-661, Vairão, Portugal.

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http://dx.doi.org/10.1007/s00251-016-0909-yDOI Listing
July 2016

No SEVI-mediated enhancement of rectal HIV-1 transmission of HIV-1 in two humanized mouse cohorts.

Virology 2016 Jan 21;488:88-95. Epub 2015 Nov 21.

Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744509PMC
January 2016

Management of Microbiological Samples in a Confirmed Case of Ebola Virus Disease: Constraints and Limitations.

J Clin Microbiol 2015 Nov 24;53(11):3396-400. Epub 2015 Jun 24.

Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Frankfurt am Main, Germany

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http://dx.doi.org/10.1128/JCM.01142-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609678PMC
November 2015

Mouse Siglec-1 Mediates trans-Infection of Surface-bound Murine Leukemia Virus in a Sialic Acid N-Acyl Side Chain-dependent Manner.

J Biol Chem 2015 Nov 14;290(45):27345-59. Epub 2015 Sep 14.

From the Institute of Medical Virology, National Reference Center for Retroviruses, University of Frankfurt, 60596 Frankfurt am Main, Germany, the Department of Infectious Diseases, Virology, University of Heidelberg, 69120 Heidelberg, Germany,

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http://dx.doi.org/10.1074/jbc.M115.681338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646371PMC
November 2015

Vpx mediated degradation of SAMHD1 has only a very limited effect on lentiviral transduction rate in ex vivo cultured HSPCs.

Stem Cell Res 2015 Sep 3;15(2):271-80. Epub 2015 Jul 3.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, 8091, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766840PMC
September 2015

SAMHD1's protein expression profile in humans.

J Leukoc Biol 2015 Jul 2;98(1):5-14. Epub 2015 Feb 2.

*Institute of Medical Virology, National Reference Center for Retroviruses, University of Frankfurt, Germany; Department of Infectious Diseases, Integrative Virology, Institute of Pathology, and Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, Germany; German Centre for Infection Research, Heidelberg, Germany; and Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium

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http://dx.doi.org/10.1189/jlb.4HI0714-338RRDOI Listing
July 2015

Quantitation of endogenous nucleoside triphosphates and nucleosides in human cells by liquid chromatography tandem mass spectrometry.

Anal Bioanal Chem 2015 May 8;407(13):3693-704. Epub 2015 Mar 8.

pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s00216-015-8588-3DOI Listing
May 2015

Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care.

Lancet 2015 Apr 19;385(9976):1428-35. Epub 2014 Dec 19.

Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt/Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(14)62384-9DOI Listing
April 2015

HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.

J Virol 2014 Dec 1;88(24):14241-57. Epub 2014 Oct 1.

Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, Heidelberg, Germany

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http://dx.doi.org/10.1128/JVI.02333-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249113PMC
December 2014

Impact of raltegravir on HIV-1 RNA and DNA forms following initiation of antiretroviral therapy in treatment-naive patients.

J Antimicrob Chemother 2014 Oct 23;69(10):2809-18. Epub 2014 Jun 23.

Institute of Medical Virology, National Reference Center for Retroviruses, University Hospital Frankfurt, Frankfurt, Germany Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany

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http://dx.doi.org/10.1093/jac/dku213DOI Listing
October 2014

Differential loss of humoral immunity against measles, mumps, rubella and varicella-zoster virus in children treated for cancer.

Vaccine 2014 Jun 29;32(27):3357-61. Epub 2014 Apr 29.

Pediatric Hematology and Oncology, Children's Hospital of the University of Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2014.04.042DOI Listing
June 2014

p21 regulates the HIV-1 restriction factor SAMHD1.

Proc Natl Acad Sci U S A 2014 Apr 7;111(14):E1322-4. Epub 2014 Mar 7.

AIDS Research Institute-IrsiCaixa and AIDS Unit, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, Spain.

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http://dx.doi.org/10.1073/pnas.1322059111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986173PMC
April 2014

MxB/Mx2: the latest piece in HIV's interferon puzzle.

EMBO Rep 2013 Dec 1;14(12):1028-9. Epub 2013 Nov 1.

Department of Infectious Diseases, University Hospital Heidelberg, Germany.

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http://dx.doi.org/10.1038/embor.2013.172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981093PMC
December 2013

Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients.

Hepatology 2013 Oct 7;58(4):1270-6. Epub 2013 Aug 7.

Medizinische Klinik 1, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt, Germany.

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http://dx.doi.org/10.1002/hep.26488DOI Listing
October 2013

Restrictions to HIV-1 replication in resting CD4+ T lymphocytes.

Cell Res 2013 Jul 4;23(7):876-85. Epub 2013 Jun 4.

Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/cr.2013.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698640PMC
July 2013

Conformation-specific display of 4E10 and 2F5 epitopes on self-assembling protein nanoparticles as a potential HIV vaccine.

Chem Biol Drug Des 2012 Sep 3;80(3):349-57. Epub 2012 Jul 3.

Molecular and Cell Biology Department, University of Connecticut, Storrs, 06250, USA.

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http://dx.doi.org/10.1111/j.1747-0285.2012.01423.xDOI Listing
September 2012

HIV-1 Vpu's lipid raft association is dispensable for counteraction of the particle release restriction imposed by CD317/Tetherin.

Virology 2012 Mar 4;424(1):33-44. Epub 2012 Jan 4.

Department of Infectious Diseases, Virology, University of Heidelberg, INF 324, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.virol.2011.12.008DOI Listing
March 2012

β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release.

Retrovirology 2011 Feb 10;8. Epub 2011 Feb 10.

Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1186/1742-4690-8-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049139PMC
February 2011

High natural permissivity of primary rabbit cells for HIV-1, with a virion infectivity defect in macrophages as the final replication barrier.

J Virol 2010 Dec 22;84(23):12300-14. Epub 2010 Sep 22.

Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01607-10
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http://dx.doi.org/10.1128/JVI.01607-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976396PMC
December 2010

Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses.

J Virol 2010 Nov 11;84(21):11374-84. Epub 2010 Aug 11.

Department of Infectious Diseases, Virology, University of Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1128/JVI.01067-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953199PMC
November 2010

HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.

J Biol Chem 2009 Oct 7;284(43):29692-703. Epub 2009 Aug 7.

Department of Virology, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M109.027144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785601PMC
October 2009

HIV pseudovirion vaccine exposing Env "fusion intermediates"-response to immunisation in human CD4/CCR5-transgenic rats.

Vaccine 2009 Apr 13;27(16):2202-12. Epub 2009 Feb 13.

Forschungsschwerpunkt Infektion und Krebs, F020, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.vaccine.2009.02.014DOI Listing
April 2009

High-level transfection of primary rabbit T lymphocytes.

J Immunol Methods 2008 Jul 7;336(1):85-9. Epub 2008 Apr 7.

Department of Virology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jim.2008.03.006DOI Listing
July 2008

Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration.

Retrovirology 2008 Jul 8;5:58. Epub 2008 Jul 8.

Department of Virology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1186/1742-4690-5-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557013PMC
July 2008

Analysis of the exposure of induced HIV glycoprotein epitopes in a potential HIV pseudovirion vaccine.

Vaccine 2007 Mar 27;25(12):2161-7. Epub 2006 Dec 27.

Deutsches Krebsforschungszentrum, F020, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.vaccine.2006.12.014DOI Listing
March 2007

HIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcription.

Proc Natl Acad Sci U S A 2007 Jan 5;104(3):1015-20. Epub 2007 Jan 5.

Department of Virology, University of Heidelberg, 69120 Heidelberg, Germany.

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http://www.pnas.org/lookup/doi/10.1073/pnas.0607414104
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http://dx.doi.org/10.1073/pnas.0607414104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783356PMC
January 2007

The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity.

J Biol Chem 2006 Jul 10;281(28):19618-30. Epub 2006 May 10.

Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany.

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http://www.jbc.org/content/281/28/19618.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M513802200
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http://dx.doi.org/10.1074/jbc.M513802200DOI Listing
July 2006

Role of macrophages in HIV infection and persistence.

Expert Rev Clin Immunol 2006 Jul;2(4):613-26

Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1586/1744666X.2.4.613DOI Listing
July 2006

Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1.

J Leukoc Biol 2006 Mar 19;79(3):616-27. Epub 2005 Dec 19.

Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1189/jlb.0805461DOI Listing
March 2006

Efficient nonviral gene delivery into primary lymphocytes from rats and mice.

FASEB J 2006 Mar 9;20(3):500-2. Epub 2006 Jan 9.

Department of Virology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1096/fj.05-4651fjeDOI Listing
March 2006

Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef.

J Virol 2005 Feb;79(3):1655-65

Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1128/JVI.79.3.1655-1665.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544094PMC
February 2005

In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells.

J Virol 2003 May;77(10):5846-54

Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, California 94141-9100, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154038PMC
http://dx.doi.org/10.1128/jvi.77.10.5846-5854.2003DOI Listing
May 2003

Versatile biosynthetic engineering of sialic acid in living cells using synthetic sialic acid analogues.

J Biol Chem 2002 Feb 20;277(8):6688-95. Epub 2001 Dec 20.

Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109973200
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http://dx.doi.org/10.1074/jbc.M109973200DOI Listing
February 2002