Oliver Sieber

Oliver Sieber

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Oliver Sieber

Oliver Sieber

Publications by authors named "Oliver Sieber"

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Evaluation of the transferability of survival calculators for stage II/III colon cancer across healthcare systems.

Int J Cancer 2019 07 20;145(1):132-142. Epub 2019 Jan 20.

Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

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http://doi.wiley.com/10.1002/ijc.32100
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http://dx.doi.org/10.1002/ijc.32100DOI Listing
July 2019

Immunoscore-has it scored for colon cancer precision medicine?

Ann Transl Med 2018 Nov;6(Suppl 1):S23

Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://atm.amegroups.com/article/view/21384/21815
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http://dx.doi.org/10.21037/atm.2018.09.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291583PMC
November 2018

Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series.

Lancet Gastroenterol Hepatol 2018 09 2;3(9):635-643. Epub 2018 Jul 2.

Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, Oxford, UK; Genomic Medicine Theme, National Institute for Health Research Oxford Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Oxford, UK; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.1016/S2468-1253(18)30117-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088509PMC
September 2018

deletions cause impaired PARP1 activity and chromosome instability in colorectal cancer.

Oncotarget 2018 Sep 4;9(69):33056-33058. Epub 2018 Sep 4.

Oliver M. Sieber: Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia; Department of Surgery, The University of Melbourne, Parkville, Victoria, Australia; Department of Biochemistry & Molecular Biology, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.18632/oncotarget.25887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145690PMC
September 2018

Interleukin 33 Signaling Restrains Sporadic Colon Cancer in an Interferon-γ-Dependent Manner.

Cancer Immunol Res 2018 04 20;6(4):409-421. Epub 2018 Feb 20.

Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and La Trobe University School of Cancer Medicine, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0218DOI Listing
April 2018

Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity.

Gastroenterology 2017 10 16;153(4):1082-1095. Epub 2017 Jun 16.

Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medial Research, Parkville, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia; Department of Surgery, The University of Melbourne, Parkville, VIC, Australia; School of Biomedical Sciences, Monash University, Clayton, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623120PMC
October 2017

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.

Cancer Cell 2017 04;31(4):563-575.e5

Olivia Newton-John Cancer Research Institute, La Trobe University School of Cancer Medicine, Heidelberg, VIC 3084, Australia; The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479329PMC
April 2017

Analysis of Mammalian Cell Proliferation and Macromolecule Synthesis Using Deuterated Water and Gas Chromatography-Mass Spectrometry.

Metabolites 2016 Oct 13;6(4). Epub 2016 Oct 13.

Institute for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Geelong 3216, Victoria, Australia.

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http://dx.doi.org/10.3390/metabo6040034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192440PMC
October 2016

Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer.

Oncoimmunology 2016 Jul 29;5(7):e1149667. Epub 2016 Jun 29.

Peter MacCallum Cancer Center and The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne ,Victoria, Australia; The Department of Pathology, University of Melbourne, Melbourne Victoria, Australia.

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http://dx.doi.org/10.1080/2162402X.2016.1149667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006930PMC
July 2016

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.

Mol Cancer Ther 2016 06 16;15(6):1217-26. Epub 2016 Mar 16.

Olivia Newton-John Cancer Research Institute and La Trobe University School of Cancer Medicine, Melbourne, Victoria, Australia. Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0724DOI Listing
June 2016

Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells.

Genom Data 2016 Mar 3;7:293-6. Epub 2016 Feb 3.

Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia; Tumour Biology Branch, Ludwig Institute for Cancer Research, Parkville, Victoria, Australia; Department Surgery, RMH, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1016/j.gdata.2016.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778681PMC
March 2016

Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis.

Mol Cancer Res 2015 Aug 1;13(8):1185-96. Epub 2015 May 1.

Sir Peter MacCallum Oncology Department, Differentiation and Transcription Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. University of Melbourne, Melbourne, Victoria, Australia. Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0014DOI Listing
August 2015

Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas.

Genes Chromosomes Cancer 2015 May 27;54(5):303-14. Epub 2015 Feb 27.

Adult Cancer Program, Prince of Wales Clinical School, Lowy Cancer Research Centre, UNSW, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1002/gcc.22243DOI Listing
May 2015

Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells.

PLoS One 2014 21;9(3):e88950. Epub 2014 Mar 21.

Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, Australia; Department of Pathology, University of Melbourne, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088950PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962334PMC
January 2015

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Sci Signal 2014 Sep 30;7(345):ra92. Epub 2014 Sep 30.

Ludwig Institute for Cancer Research, Melbourne, Victoria 3052, Australia. Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3052, Australia.

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http://dx.doi.org/10.1126/scisignal.2005411DOI Listing
September 2014

Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.

Epigenetics 2014 Aug 16;9(8):1092-100. Epub 2014 May 16.

Adult Cancer Program; Lowy Cancer Research Centre and Prince of Wales Clinical School; Sydney, NSW Australia.

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http://dx.doi.org/10.4161/epi.29222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164494PMC
August 2014

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.

Cancer Res 2014 Jun 22;74(12):3238-47. Epub 2014 Apr 22.

Authors' Affiliations: Ludwig Institute for Cancer Research; Systems Biology and Personalised Medicine Division; Structural Biology Division; Walter and Eliza Hall Institute of Medical Research; Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Parkville; VLSCI Life Sciences Computation Centre, a collaboration between Melbourne, Monash and LaTrobe Universities, c/o The University of Melbourne, Carlton; Oncogenic Transcription Laboratory, Ludwig Institute for Cancer Research, Austin, VIC, Australia; Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, QLD, Australia; Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, 08035 Barcelona; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN); Spain; Ludwig Collaborative Laboratory for Cancer Biology and Therapy, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; Ludwig Institute for Cancer Research Ltd., New York, New York; Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, University of Oxford; and Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Oxford, United KingdomAuthors' Affiliations: Ludwig Institute for Cancer Research; Systems Biology and Personalised Medicine Division; Structural Biology Division; Walter and Eliza Hall Institute of Medical Research; Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Parkville; VLSCI Life Sciences Computation Centre, a collaboration between Melbourne, Monash and LaTrobe Universities, c/o The University of Melbourne, Carlton; Oncogenic Transcription Laboratory, Ludwig Institute for Cancer Research, Austin, VIC, Australia; Cancer and Population Studies

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0013DOI Listing
June 2014

Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer.

J Clin Oncol 2013 Dec 23;31(34):4297-305. Epub 2013 Sep 23.

Enric Domingo, David N. Church, Rajarajan Ramamoorthy, and Ian P.M. Tomlinson, The Wellcome Trust Centre for Human Genetics, University of Oxford; David N. Church, David J. Kerr, and Rachel Midgley, Oxford Cancer Centre, Churchill Hospital; Yoko Yanagisawa, Elaine Johnstone, David J. Kerr, and Rachel Midgley, University of Oxford, Oxford; Rajarajan Ramamoorthy and Brian Davidson, University College London, Royal Free Hospital, London, United Kingdom; and Oliver Sieber, Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia.

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http://jco.ascopubs.org/content/early/2013/09/18/JCO.2013.50
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2013.50.0322
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http://dx.doi.org/10.1200/JCO.2013.50.0322DOI Listing
December 2013

Germline variants and advanced colorectal adenomas: adenoma prevention with celecoxib trial genome-wide association study.

Clin Cancer Res 2013 Dec 1;19(23):6430-7. Epub 2013 Oct 1.

Authors' Affiliations: Department of Surgery, Division of Surgical Oncology, Center for Genomic Medicine, Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, California; Department of Epidemiology and Statistics, Memorial Sloan-Kettering Cancer Center, New York; RIKEN Center for Genomic Medicine, Tokyo, Japan; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Edinburgh; Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom; Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville; Genetic and Molecular Epidemiology Laboratories, and Familial Cancer laboratory, Queensland Institute of Medical Research, Brisbane; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; and Department of Medicine, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037290PMC
December 2013

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations.

Am J Gastroenterol 2013 Nov 17;108(11):1785-93. Epub 2013 Sep 17.

1] Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Parkville, Victoria, Australia [2] Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1038/ajg.2013.292DOI Listing
November 2013

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion.

Mol Cancer 2013 Jan 3;12. Epub 2013 Jan 3.

Centre for Digestive Diseases, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark St, Whitechapel, London, E1 2AT, UK.

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http://dx.doi.org/10.1186/1476-4598-12-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544714PMC
January 2013

Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer.

Mutagenesis 2012 Mar;27(2):219-23

Molecular and Population Genetics Laboratory and Oxford NIHR Comprehensive Biomedical Research Centre, Nuffield Department of Clinical Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1093/mutage/ger070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610049PMC
March 2012

VECSEL gain characterization.

Opt Express 2012 Feb;20(4):4136-48

Department of Physics, Institute for Quantum Electronics, ETH Zurich, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1364/OE.20.004136DOI Listing
February 2012

Femtosecond VECSEL with tunable multi-gigahertz repetition rate.

Opt Express 2011 Nov;19(23):23538-43

Department of Physics, Institute for Quantum Electronics, Wolfgang-Pauli-Strasse 16, 8093 Zürich, Switzerland.

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http://dx.doi.org/10.1364/OE.19.023538DOI Listing
November 2011

New reagents for improved in vitro and in vivo examination of TGF-β signalling.

Growth Factors 2011 Oct;29(5):211-8

Department of Surgery, University of Melbourne, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.3109/08977194.2011.615311DOI Listing
October 2011

Experimental verification of soliton-like pulse-shaping mechanisms in passively mode-locked VECSELs.

Opt Express 2010 May;18(10):10143-53

Department of Physics, Institute of Quantum Electronics, ETH Zurich, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1364/OE.18.010143DOI Listing
May 2010

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer.

Clin Cancer Res 2009 Dec;15(24):7642-7651

Authors' Affiliations: Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research; Anatomic Pathology Department, Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Clinical Pharmacology, University of Oxford, Oxford, United Kingdom; Department of Medical Genetics, Biomedicum, University of Helsinki, Helsinki, Finland; Group of Molecular Oncology, Nanomedicine Research Program, Molecular Biology and Biochemistry Research Center (Centro de Investigación Bioquímica y Biología Molecular), Vall d'Hebron Hospital Research Institute, Barcelona, Spain; Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark; and GI Surgical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920750PMC
December 2009

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.

Exp Mol Pathol 2008 Dec 11;85(3):201-6. Epub 2008 Oct 11.

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK.

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http://dx.doi.org/10.1016/j.yexmp.2008.09.006DOI Listing
December 2008

Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma.

Int J Cancer 2007 Dec;121(12):2668-73

Colorectal Cancer Genetics, Institute for Cell and Molecular Sciences, Blizard Building, Barts and The London, Queen Mary's School of Medicine and Dentistry, 4 Newark St., Whitechapel E1 2AT, United Kingdom.

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http://dx.doi.org/10.1002/ijc.23028DOI Listing
December 2007

Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair.

Carcinogenesis 2005 Nov 29;26(11):2010-8. Epub 2005 Jun 29.

Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1093/carcin/bgi166DOI Listing
November 2005

Refining molecular analysis in the pathways of colorectal carcinogenesis.

Clin Gastroenterol Hepatol 2005 Nov;3(11):1115-23

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

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November 2005

Tissue, cell and stage specificity of (epi)mutations in cancers.

Nat Rev Cancer 2005 08;5(8):649-55

Molecular and Population Genetics Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

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http://dx.doi.org/10.1038/nrc1674DOI Listing
August 2005

Genomic stability and tumorigenesis.

Semin Cancer Biol 2005 Feb;15(1):61-6

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3PX, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S1044579X0400082
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http://dx.doi.org/10.1016/j.semcancer.2004.09.005DOI Listing
February 2005

Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice.

Proc Natl Acad Sci U S A 2005 Feb 14;102(8):2868-73. Epub 2005 Feb 14.

National Radiological Protection Board, Chilton, Didcot, Oxon OX11 ORQ, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0500039102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549446PMC
February 2005

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.

Cancer Res 2004 Dec;64(24):8876-81

Molecular and Population Genetics Laboratory, Histopathology Unit, and Experimental Pathology Laboratory, London Research Institute, Cancer Research United Kingdom, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2958DOI Listing
December 2004

An update on the genetics of colorectal cancer.

Hum Mol Genet 2004 Oct;13 Spec No 2:R177-85

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, UK.

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http://dx.doi.org/10.1093/hmg/ddh247DOI Listing
October 2004

Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway.

Cancer Res 2003 Nov;63(22):7595-9

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research United Kingdom, London WC2A 3PX, United Kingdom.

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November 2003

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma.

Cancer Lett 2003 Oct;200(2):149-52

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

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http://dx.doi.org/10.1016/s0304-3835(03)00391-4DOI Listing
October 2003

Genomic instability--the engine of tumorigenesis?

Nat Rev Cancer 2003 09;3(9):701-8

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

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http://dx.doi.org/10.1038/nrc1170DOI Listing
September 2003

Colorectal tumourigenesis in carriers of the APC I1307K variant: lone gunman or conspiracy?

J Pathol 2003 Feb;199(2):137-9

Molecular and Population Genetics Laboratory, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

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http://doi.wiley.com/10.1002/path.1272
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http://dx.doi.org/10.1002/path.1272DOI Listing
February 2003

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.

N Engl J Med 2003 Feb;348(9):791-9

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa025283DOI Listing
February 2003