Publications by authors named "Oliver Ottmann"

100Publications

TKI vs relapse after HSCT: is the jury still out?

Authors:
Oliver G Ottmann

Blood 2020 Oct;136(15):1705-1706

Cardiff University.

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http://dx.doi.org/10.1182/blood.2020007021DOI Listing
October 2020

Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure.

N Engl J Med 2019 12;381(24):2315-2326

From the South Australian Health and Medical Research Institute and the University of Adelaide, Adelaide, SA, Australia (T.P.H., D.Y., D.M.R.); Memorial Sloan Kettering Cancer Center, New York (M.J.M., M.S.T., J.H.P.); University of Texas M.D. Anderson Cancer Center, Houston (J.E.C.); Kobe University Graduate School of Medicine, Kobe (H.M.), and the National Cancer Center Hospital East, Chiba (Y.M.) - both in Japan; Hôpital Saint-Louis, Paris (D.R.), and the University of Bordeaux, Bordeaux (F.-X.M.) - both in France; Dana-Farber Cancer Institute, Boston (D.J.D.); Sapienza University, Rome (M.B.); Singapore General Hospital, Singapore (Y.-T.G.); University of Michigan Comprehensive Cancer Center, Ann Arbor (M.T.); Universitätsklinikum Jena, Jena (A.H.), Charité Hospital, Berlin (P.C.), and the Department for Hematology-Oncology, Goethe University Hospital, Frankfurt am Main (F.L.) - all in Germany; University of Cardiff, Cardiff, United Kingdom (O.O.); Veterans Affairs Portland Health Care System (M.C.H.) and Oregon Health and Science University Knight Cancer Institute (M.C.H., B.J.D.), Portland; Hospital de la Princesa and Instituto de Investigación Sanitaria Princesa, Madrid (J.L.S.); Huntsman Cancer Institute, University of Utah, Salt Lake City (M.W.N.D.); Amsterdam University Medical Centers, VU University Medical Center, Amsterdam (J.J.W.M.J.); Novartis Pharma, Basel, Switzerland (D.H., Y.D., C.M., F.H.-P., K.G.V.); and Seoul St. Mary's Hematology Hospital, Catholic University of Korea, Seoul, South Korea (D.-W.K.).

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http://dx.doi.org/10.1056/NEJMoa1902328DOI Listing
December 2019

Clinicians' Perspectives on Cure in Adult Patients with Acute Lymphoblastic Leukemia with Minimal Residual Disease: A Delphi Study.

Adv Ther 2019 11 4;36(11):3017-3029. Epub 2019 Oct 4.

Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1007/s12325-019-01099-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822800PMC
November 2019

The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis.

Leukemia 2019 09 8;33(9):2319-2323. Epub 2019 Apr 8.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1038/s41375-019-0468-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756289PMC
September 2019

Tyrosine kinase inhibitor therapy or transplant in children with Philadelphia chromosome-positive acute lymphoblastic leukaemia: striking the balance.

Authors:
Oliver Ottmann

Lancet Haematol 2018 Dec;5(12):e606-e607

Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(18)30181-9DOI Listing
December 2018

CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells.

Blood 2018 01 9;131(3):311-322. Epub 2017 Nov 9.

Division of Infection and Immunity, School of Medicine.

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http://dx.doi.org/10.1182/blood-2017-05-787598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774207PMC
January 2018

Complete Hematologic and Molecular Response in Adult Patients With Relapsed/Refractory Philadelphia Chromosome-Positive B-Precursor Acute Lymphoblastic Leukemia Following Treatment With Blinatumomab: Results From a Phase II, Single-Arm, Multicenter Study.

J Clin Oncol 2017 Jun 29;35(16):1795-1802. Epub 2017 Mar 29.

Giovanni Martinelli and Cristina Papayannidis, Institute of Hematology and Medical Oncology "L. and A. Seràgnoli", Bologna; Alessandro Rambaldi, University of Milan Hematology and Bone Marrow Transplant Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy; Nicolas Boissel, University Paris Diderot, Hôpital Saint-Louis, Paris; Patrice Chevallier, Centre Hospitalier Universitaire Nantes, Nantes, France; Oliver Ottmann, Cardiff University, Cardiff; Adele K. Fielding, University College London Cancer Institute, London, United Kingdom; Nicola Gökbuget, University Hospital, Goethe University, Frankfurt; Max S. Topp, Universitätsklinikum Würzburg, Würzburg, Germany; Ellen K. Ritchie, Weill Cornell Medical College and New York Presbyterian Hospital, New York, NY; Lulu Ren Sterling, Amgen, San Francisco; Jonathan Benjamin, Amgen, Thousand Oaks; and Anthony Stein, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA.

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http://dx.doi.org/10.1200/JCO.2016.69.3531DOI Listing
June 2017

Continuously expanding CAR NK-92 cells display selective cytotoxicity against B-cell leukemia and lymphoma.

Cytotherapy 2017 02 22;19(2):235-249. Epub 2016 Nov 22.

Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2016.10.009DOI Listing
February 2017

CD19-CAR engineered NK-92 cells are sufficient to overcome NK cell resistance in B-cell malignancies.

J Cell Mol Med 2016 07 23;20(7):1287-94. Epub 2016 Mar 23.

Institute for Transfusion Medicine and Immunohematology, J.W. Goethe University Frankfurt/Main, Red Cross Blood Donor Service Baden-Württemberg-Hessen, Dresden, Germany.

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http://dx.doi.org/10.1111/jcmm.12810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929308PMC
July 2016

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia.

N Engl J Med 2015 Sep;373(10):920-8

From the Department of Hematology, University Hospital of Bern and University of Bern, Bern, Switzerland (G.M.B., E.O.L., M.D.); the Department of Hematology, School of Medicine, Cardiff University, Cardiff, United Kingdom (O.G.O.); Upstate Oncology Associates, Greenville, SC (G.S.); the Section of Hematology and Oncology, University of Chicago, Chicago (O.O.); the Divisions of Hematologic Malignancies and Hematology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore (M.A.M.); the Department of Hematology, University Hospital Essen, Essen, Germany (A.R.); and Geron, Menlo Park (B.B., M.S.), and the Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Gehr Family Center for Leukemia Research, Duarte (D.S.S.) - both in California.

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http://dx.doi.org/10.1056/NEJMoa1503479DOI Listing
September 2015

Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1.

Mol Oncol 2015 Jan 11;9(1):140-54. Epub 2014 Aug 11.

Department of Gynecology, School of Medicine, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528686PMC
January 2015

Treatment of patients with advanced cancer with the natural killer cell line NK-92.

Cytotherapy 2013 Dec 1;15(12):1563-70. Epub 2013 Oct 1.

Institute for Transfusion Medicine and Immunohematology, Goethe University Hospital, Frankfurt am Main, Germany; German Red Cross Blood Donation Service, Baden-Württemberg-Hessen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2013.06.017DOI Listing
December 2013

Endoplasmic reticulum protein GliPR1 regulates G protein signaling and the cell cycle and is overexpressed in AML.

Oncol Rep 2013 Nov 4;30(5):2254-62. Epub 2013 Sep 4.

Department of Hematology/Oncology and Infectious Diseases, J.W. Goethe University Hospital, D‑60590 Frankfurt/Main, Germany.

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http://dx.doi.org/10.3892/or.2013.2716DOI Listing
November 2013

Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFκB pathway and overexpressed in AML.

Int J Oncol 2013 Jul 29;43(1):246-54. Epub 2013 Apr 29.

Department of Hematology/Oncology and Infectious Diseases, J.W. Goethe-University Hospital, 60595 Frankfurt/Main, Germany.

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http://dx.doi.org/10.3892/ijo.2013.1924DOI Listing
July 2013

Nilotinib population pharmacokinetics and exposure-response analysis in patients with imatinib-resistant or -intolerant chronic myeloid leukemia.

Eur J Clin Pharmacol 2013 Apr 5;69(4):813-23. Epub 2012 Oct 5.

HRB Clinical Research Facility, Galway, and Trinity College, National University of Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1007/s00228-012-1385-4DOI Listing
April 2013

Polo-like kinases in AML.

Expert Opin Investig Drugs 2012 Aug 6;21(8):1069-74. Epub 2012 Jun 6.

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http://dx.doi.org/10.1517/13543784.2012.691163DOI Listing
August 2012

HIV-1 infection suppresses expression of host cell cycle-associated gene PDS5A.

Intervirology 2012 25;55(4):263-75. Epub 2011 Aug 25.

Department of Hematology/Oncology and Infectious Diseases, Johann Wolfgang Goethe University Hospital, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1159/000328323DOI Listing
September 2012

Knockdown of ERM family member moesin in host cells increases HIV type 1 replication.

AIDS Res Hum Retroviruses 2011 Dec 19;27(12):1317-22. Epub 2011 May 19.

Department of Hematology/Oncology and Infectious Diseases, J. W. Goethe-University Hospital, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1089/AID.2010.0147DOI Listing
December 2011

The DAC system and associations with acute leukemias and myelodysplastic syndromes.

Invest New Drugs 2010 Dec 14;28 Suppl 1:S36-49. Epub 2010 Dec 14.

Medizinische Klinik II, Abteilung für Hämatologie und Onkologie der, Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s10637-010-9595-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003828PMC
December 2010

Inhibition of X4-tropic HIV type 1 replication by knockdown of the cellular protein LEREPO4.

AIDS Res Hum Retroviruses 2010 Oct 6;26(10):1155-61. Epub 2010 Oct 6.

Department of Hematology/Oncology and Infectious Diseases, J.W. Goethe-University Hospital, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1089/aid.2010.0041DOI Listing
October 2010

IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis.

Haematologica 2010 Oct 21;95(10):1668-74. Epub 2010 May 21.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Strasse 1, Hannover, Germany.

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http://dx.doi.org/10.3324/haematol.2010.025494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948091PMC
October 2010

Inhibition of HIV-1 replication by small interfering RNAs directed against glioma pathogenesis related protein (GliPR) expression.

Retrovirology 2010 Mar 31;7:26. Epub 2010 Mar 31.

Department of Hematology/Oncology and Infectious Diseases, J. W. Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1186/1742-4690-7-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859388PMC
March 2010

Management of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).

Hematology Am Soc Hematol Educ Program 2009 :371-81

Medizinische Klinik II, Department of Hematology and Oncology, Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1182/asheducation-2009.1.371DOI Listing
March 2010

First-line treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia in adults.

Curr Opin Oncol 2009 Jun;21 Suppl 1:S43-6

Medizinische Klinik II, Department of Hematology and Oncology, Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1097/01.cco.0000357476.43164.6bDOI Listing
June 2009

The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines.

BMC Cancer 2009 Feb 13;9:53. Epub 2009 Feb 13.

Med, Klinik II/Abt, Hämatologie, Johann Wolfgang Goethe-Universität, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1186/1471-2407-9-53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654659PMC
February 2009

Optimizing outcomes for patients with advanced disease in chronic myelogenous leukemia.

Semin Oncol 2008 Feb;35(1 Suppl 1):S1-17; quiz S18-20

Professor of Medicine, and Chief, Division of Hematology and Medical Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2007.12.002DOI Listing
February 2008

An immunological method for the detection of BCR-ABL fusion protein and monitoring its activation.

Leuk Res 2008 Jun 26;32(6):936-43. Epub 2007 Dec 26.

Department of Hematology, Quest Diagnostics Nichols Institute, 33608 Ortega Highway, San Juan Capistrano, CA 92690, USA.

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http://dx.doi.org/10.1016/j.leukres.2007.11.023DOI Listing
June 2008

Phosphorylation levels of BCR-ABL, CrkL, AKT and STAT5 in imatinib-resistant chronic myeloid leukemia cells implicate alternative pathway usage as a survival strategy.

Leuk Res 2008 Apr 27;32(4):643-9. Epub 2007 Sep 27.

Department of Hematopathology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA 92675, USA.

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http://dx.doi.org/10.1016/j.leukres.2007.08.009DOI Listing
April 2008

Impact of leukapheresis on early death rate in adult acute myeloid leukemia presenting with hyperleukocytosis.

Transfusion 2007 Oct;47(10):1843-50

Department of Internal Medicine II, University Hospital, Johann Wolfgang Goethe-University, Theodor Stern-Kai 7, D-60590 Frankfurt am Main, Germany.

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http://doi.wiley.com/10.1111/j.1537-2995.2007.01406.x
Publisher Site
http://dx.doi.org/10.1111/j.1537-2995.2007.01406.xDOI Listing
October 2007

Current status of growth factors in the treatment of acute myeloid and lymphoblastic leukemia.

Semin Hematol 2007 Jul;44(3):183-92

Department of Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S003719630700070
Publisher Site
http://dx.doi.org/10.1053/j.seminhematol.2007.04.007DOI Listing
July 2007

The tyrosine kinase inhibitor AMN107 (Nilotinib) exhibits off-target effects in lymphoblastic cell lines.

Leuk Lymphoma 2007 Jul;48(7):1379-88

Department of Medicine II, Hematology and Oncology, Johann Wolfgang Goethe-University Hospital. Frankfurt am Main, Germany.

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http://www.tandfonline.com/doi/full/10.1080/1042819070138518
Publisher Site
http://dx.doi.org/10.1080/10428190701385181DOI Listing
July 2007

Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia.

Haematologica 2007 Apr;92(4):542-5

Medizinische Klinik II, Abt. Hämatologie/Onkologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, Frankfurt, Germany.

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http://dx.doi.org/10.3324/haematol.10758DOI Listing
April 2007

Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment.

Proc Natl Acad Sci U S A 2007 Mar 5;104(11):4594-9. Epub 2007 Mar 5.

Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Ismaningerstrasse 22, D-81675 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.0604716104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810334PMC
March 2007

Targeting the oligomerization domain of ETO interferes with RUNX1/ETO oncogenic activity in t(8;21)-positive leukemic cells.

Cancer Res 2007 Mar;67(5):2280-9

Institute for Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt/M, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3360DOI Listing
March 2007

Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation.

Int J Oncol 2007 Feb;30(2):349-55

Department of Internal Medicine-Hematology and Oncology, University Hospital of Münster, Germany.

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February 2007