SimpleXMLElement Object ( [PubmedArticle] => Array ( [0] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => In-Process [Owner] => NLM ) [PMID] => 32047908 [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 10 [Day] => 02 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1523-5866 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 22 [Issue] => 7 [PubDate] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 07 [Day] => 07 ) ) [Title] => Neuro-oncology [ISOAbbreviation] => Neuro Oncol ) [ArticleTitle] => TSPO imaging-guided characterization of the immunosuppressive myeloid tumor microenvironment in patients with malignant glioma. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 1030-1043 ) [ELocationID] => 10.1093/neuonc/noaa023 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Tumor-associated microglia and macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) are potent immunosuppressors in the glioma tumor microenvironment (TME). Their infiltration is associated with tumor grade, progression, and therapy resistance. Specific tools for image-guided analysis of spatiotemporal changes in the immunosuppressive myeloid tumor compartments are missing. We aimed (i) to evaluate the role of fluorodeoxyglucose (18F)DPA-714* (translocator protein [TSPO]) PET-MRI in the assessment of the immunosuppressive TME in glioma patients, and (ii) to cross-correlate imaging findings with in-depth immunophenotyping. [1] => To characterize the glioma TME, a mixed collective of 9 glioma patients underwent [18F]DPA-714-PET-MRI in addition to [18F]fluoro-ethyl-tyrosine (FET)-PET-MRI. Image-guided biopsy samples were immunophenotyped by multiparametric flow cytometry and immunohistochemistry. In vitro autoradiography was performed for image validation and assessment of tracer binding specificity. [2] => We found a strong relationship (r = 0.84, P = 0.009) between the [18F]DPA-714 uptake and the number and activation level of glioma-associated myeloid cells (GAMs). TSPO expression was mainly restricted to human leukocyte antigen D related-positive (HLA-DR+) activated GAMs, particularly to tumor-infiltrating HLA-DR+ MDSCs and TAMs. [18F]DPA-714-positive tissue volumes exceeded [18F]FET-positive volumes and showed a differential spatial distribution. [3] => [18F]DPA-714-PET may be used to non-invasively image the glioma-associated immunosuppressive TME in vivo. This imaging paradigm may also help to characterize the heterogeneity of the glioma TME with respect to the degree of myeloid cell infiltration at various disease stages. [18F]DPA-714 may also facilitate the development of new image-guided therapies targeting the myeloid-derived TME. ) [CopyrightInformation] => © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. 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[ELocationID] => Array ( [0] => E5985 [1] => 10.3390/ijms20235985 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => A major concern caused by the discontinuation of disease modifying treatment for multiple sclerosis (MS) is a rebound of disease activity. Hypotheses about the underlying mechanism of fingolimod (FTY) induced exaggerated inflammatory responses are diverse. So far, vaccinations as a trigger for rebound activity following FTY suspension have not been described. However, several reports have highlighted the occurrence of neurological and autoimmune side effects after single or combined multi-vaccination procedures. Here, we describe the case of a highly active female MS patient demonstrating recurrent, severe MS relapses accompanied by extensive MRI activity, subsequent to yellow fever vaccination two months following FTY withdrawal. Blood and cerebrospinal fluid immunophenotyping indicated a B cell/plasma cell autoreactivity. Following a therapy with natalizumab the clinical, laboratory, MRI, and disease course improved significantly. This case hints towards a combined immunological mechanism characterized by molecular mimicry, bystander activation, and lymphocyte re-egress, resulting in extensive neurological impairment and shows that natalizumab represents a therapeutic option to counteract B cell mediated autoreactivity. 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 1910-1927 ) [ELocationID] => 10.1158/2326-6066.CIR-18-0865 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Glioblastoma (GBM) is a non-T-cell-inflamed cancer characterized by an immunosuppressive microenvironment that impedes dendritic cell maturation and T-cell cytotoxicity. Proangiogenic cytokines such as VEGF and angiopoietin-2 (Ang-2) have high expression in glioblastoma in a cell-specific manner and not only drive tumor angiogenesis and vascular permeability but also negatively regulate T-lymphocyte and innate immune cell responses. Consequently, the alleviation of immunosuppression might be a prerequisite for successful immune checkpoint therapy in GBM. We here combined antiangiogenic and immune checkpoint therapy and demonstrated improved therapeutic efficacy in syngeneic, orthotopic GBM models. We observed that blockade of VEGF, Ang-2, and programmed cell death protein-1 (PD-1) significantly extended survival compared with vascular targeting alone. In the GBM microenvironment, triple therapy increased the numbers of CTLs, which inversely correlated with myeloid-derived suppressor cells and regulatory T cells. Transcriptome analysis of GBM microvessels indicated a global vascular normalization that was highest after triple therapy. Our results propose a rationale to overcome tumor immunosuppression and the current limitations of VEGF monotherapy by integrating the synergistic effects of VEGF/Ang-2 and PD-1 blockade to reinforce antitumor immunity through a normalized vasculature. 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SimpleXMLElement Object ( [Year] => 2020 [Month] => 05 [Day] => 26 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 05 [Day] => 26 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1460-2156 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 142 [Issue] => 11 [PubDate] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 11 [Day] => 01 ) ) [Title] => Brain : a journal of neurology [ISOAbbreviation] => Brain ) [ArticleTitle] => Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 3411-3427 ) [ELocationID] => 10.1093/brain/awz301 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Although the CNS is immune privileged, continuous search for pathogens and tumours by immune cells within the CNS is indispensable. Thus, distinct immune-cell populations also cross the blood-brain barrier independently of inflammation/under homeostatic conditions. It was previously shown that effector memory T cells populate healthy CNS parenchyma in humans and, independently, that CCR5-expressing lymphocytes as well as CCR5 ligands are enriched in the CNS of patients with multiple sclerosis. Apart from the recently described CD8+ CNS tissue-resident memory T cells, we identified a population of CD4+CCR5high effector memory cells as brain parenchyma-surveilling cells. These cells used their high levels of VLA-4 to arrest on scattered VCAM1, their open-conformation LFA-1 to crawl preferentially against the flow in search for sites permissive for extravasation, and their stored granzyme K (GZMK) to induce local ICAM1 aggregation and perform trans-, rather than paracellular diapedesis through unstimulated primary brain microvascular endothelial cells. This study included peripheral blood mononuclear cell samples from 175 healthy donors, 29 patients infected with HIV, with neurological symptoms in terms of cognitive impairment, 73 patients with relapsing-remitting multiple sclerosis in remission, either 1-4 weeks before (n = 29), or 18-60 months after the initiation of natalizumab therapy (n = 44), as well as white matter brain tissue of three patients suffering from epilepsy. We here provide ex vivo evidence that CCR5highGZMK+CD4+ effector memory T cells are involved in CNS immune surveillance during homeostasis, but could also play a role in CNS pathology. Among CD4+ T cells, this subset was found to dominate the CNS of patients without neurological inflammation ex vivo. The reduction in peripheral blood of HIV-positive patients with neurological symptoms correlated to their CD4 count as a measure of disease progression. Their peripheral enrichment in multiple sclerosis patients and specific peripheral entrapment through the CNS infiltration inhibiting drug natalizumab additionally suggests a contribution to CNS autoimmune pathology. Our transcriptome analysis revealed a migratory phenotype sharing many features with tissue-resident memory and Th17.1 cells, most notably the transcription factor eomesodermin. Knowledge on this cell subset should enable future studies to find ways to strengthen the host defence against CNS-resident pathogens and brain tumours or to prevent CNS autoimmunity. [CopyrightInformation] => © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Herich [ForeName] => Sebastian [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Schneider-Hohendorf [ForeName] => Tilman [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rohlmann [ForeName] => Astrid [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Institute of Anatomy and Molecular Neurobiology University of Münster, Münster, Germany. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Khaleghi Ghadiri [ForeName] => Maryam [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurosurgery, University Hospital Münster, Münster, Germany. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Schulte-Mecklenbeck [ForeName] => Andreas [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Zondler [ForeName] => Lisa [Initials] => L [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Anesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Janoschka [ForeName] => Claudia [Initials] => C [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ostkamp [ForeName] => Patrick [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany. ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Richter [ForeName] => Jannis [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany. ) ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Breuer [ForeName] => Johanna [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany. ) ) [10] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Dimitrov [ForeName] => Stoyan [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany. ) ) [11] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rammensee [ForeName] => Hans-Georg [Initials] => HG [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Immunology, Institute for Cell Biology, University of Tübingen, Tübingen, Germany. ) ) [12] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Grauer [ForeName] => Oliver M [Initials] => OM [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany. ) ) [13] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Klotz [ForeName] => Luisa [Initials] => L [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany. ) ) [14] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gross [ForeName] => Catharina C [Initials] => CC [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology with 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 1-7 ) [ELocationID] => 10.1080/02688697.2019.1639615 [Abstract] => SimpleXMLElement Object ( [AbstractText] => SimpleXMLElement Object ( [b] => Array ( [0] => Objective [1] => Methods [2] => Results [3] => Conclusions ) [sup] => Array ( [0] => 18 [1] => 18 [2] => 18 [3] => 18 [4] => 18 [5] => 18 [6] => 18 [7] => 18 ) ) ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kristin Schmitz [ForeName] => Ann [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => a Department of Neurosurgery, Faculty of Medicine, Heinrich-Heine-University Düsseldorf , Düsseldorf , Germany. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Sorg [ForeName] => Rüdiger V [Initials] => RV [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => b Institute for Transplantation Diagnostics and Cell Therapeutics, Faculty of Medicine, Heinrich-Heine-University Düsseldorf , Düsseldorf , Germany. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Stoffels [ForeName] => Gabriele [Initials] => G [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => c Institute of Neuroscience and Medicine, Research Center Jülich , Jülich , Germany. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Grauer [ForeName] => Oliver M [Initials] => OM [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => d Department of Neurology, Faculty of Medicine, Westfälische Wilhelms-University Münster , Münster , Germany. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Galldiks [ForeName] => Norbert [Initials] => N [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => c Institute 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Electronic ) [Year] => 2019 [Month] => 08 [Day] => 13 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => Br J Neurosurg [NlmUniqueID] => 8800054 [ISSNLinking] => 0268-8697 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => 18F-FET PET [1] => Glioblastoma multiforme [2] => dendritic cell vaccination [3] => pseudoprogression ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2019 [Month] => 8 [Day] => 14 [Hour] => 6 [Minute] => 0 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2019 [Month] => 8 [Day] => 14 [Hour] => 6 [Minute] => 0 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2019 [Month] => 8 [Day] => 14 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 31407920 [1] => 10.1080/02688697.2019.1639615 ) ) ) ) [6] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => PubMed-not-MEDLINE [Owner] => NLM ) [PMID] => 29887830 [DateRevised] => SimpleXMLElement Object ( [Year] => 2020 [Month] => 09 [Day] => 30 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Electronic-eCollection ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1664-2295 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Print ) [Volume] => 9 [PubDate] => SimpleXMLElement Object ( [Year] => 2018 ) ) [Title] => Frontiers in neurology [ISOAbbreviation] => Front Neurol ) [ArticleTitle] => A Novel PKD1 Mutation Associated With Autosomal Dominant Kidney Disease and Cerebral Cavernous Malformation. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 383 ) [ELocationID] => 10.3389/fneur.2018.00383 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the presence of renal cysts and specific extrarenal abnormalities. ADPKD is caused by mutations in either or genes that encode for integral membrane proteins Polycystin-1 (PC1) and Polycystin-2 (PC2), respectively. Extrarenal involvement includes noncystic manifestations such as dilatation of the aortic root, artery dissection and intracranial aneurysms. Cerebral cavernous malformation (CCM) is a rare vascular malformation disorder characterized by closely clustered and irregularly dilated capillaries that can be asymptomatic or cause variable neurological manifestations, such as seizures, non-specific headaches, progressive or transient focal neurologic deficits, and cerebral hemorrhages. Familial CCM is typically associated with mutations in (), , and (). The co-occurrence of ADPKD and CCM has been previously described in a single patient, although genetic analysis was not performed in this study. We report here a family with ADPKD associated with CCM in two sisters. Direct sequencing of the index patient revealed a single novel heterozygous frameshift mutation in , and lack of mutations in genes usually related to CCM. 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) ) [7] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 29801515 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 03 [Day] => 14 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 03 [Day] => 14 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1745-6215 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 19 [Issue] => 1 [PubDate] => SimpleXMLElement Object ( [Year] => 2018 [Month] => May [Day] => 25 ) ) [Title] => Trials [ISOAbbreviation] => Trials ) [ArticleTitle] => A randomized controlled phase II trial of vaccination with lysate-loaded, mature dendritic cells integrated into standard radiochemotherapy of newly diagnosed glioblastoma (GlioVax): study protocol for a randomized controlled trial. 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[1] => One hundred and thirty-six newly diagnosed, isocitrate dehydrogenase wildtype GBM patients will be randomly allocated (1:1 ratio, stratified by O6-methylguanine-DNA-methyltransferase promotor methylation status) after near-complete resection in a multicenter, prospective phase II trial into two groups: (1) patients receiving the current therapeutic "gold standard" of radio/temozolomide chemotherapy and (2) patients receiving DC vaccination as an add-on to the standard therapy. A recruitment period of 30 months is anticipated; follow-up will be 2 years. The primary objective of the study is to compare overall survival (OS) between the two groups. Secondary objectives are comparing progression-free survival (PFS) and 6-, 12- and 24-month OS and PFS rates, the safety profile, overall and neurological performance and quality of life. [2] => Until now, close to 500 GBM patients have been treated with DC vaccination in clinical trials or on a compassionate-use basis. Results have been encouraging, but cannot provide robust evidence of clinical efficacy because studies have been non-controlled or patient numbers have been low. Therefore, a prospective, randomized phase II trial with a sufficiently large number of patients is now mandatory for clear evidence regarding the impact of DC vaccination on PFS and OS in GBM. [3] => Protocol code: GlioVax, date of registration: 17. February 2017. Trial identifier: EudraCT-Number 2017-000304-14. German Registry for Clinical Studies, ID: DRKS00013248 (approved primary register in the WHO network) and at ClinicalTrials.gov , ID: NCT03395587 . 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TR has received travel expenses and financial research support from Genzyme and has received honoraria for lecturing from Genzyme, Biogen and Teva. OG has received honoraria for lecturing and travel expenses for attending meetings from Roche and Bristol-Myers-Squibb. HW has received honoraria for lecturing, travel expenses for attending meetings from Bayer Health Care, Biogen Idec/Elan Corporation, Lilly, Lundbeck Merck Serono, Novartis, Sanofi Aventis, and TEVA Neuroscience; has served/serves as a consultant for Biogen Idec, Merck Serono, Novartis Pharma Sanofi-Aventis; and receives research support from Bayer Schering Pharma, Biogen Idec/Elan Corporation, Merck Serono, Novartis, Novo Nordisk and Sanofi-Aventis. SGM has received honoraria for lecturing and travel expenses for attending meetings and has received financial research support from Bayer, Bayer Schering, Biogen Idec, Genzyme, Merck Serono, MSD, Novartis, Novo Nordisk, Sanofi-Aventis and Teva. ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2017 [Month] => 4 [Day] => 29 [Hour] => 6 [Minute] => 0 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2017 [Month] => 4 [Day] => 30 [Hour] => 6 [Minute] => 0 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2017 [Month] => 4 [Day] => 30 [Hour] => 6 [Minute] => 1 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 28450895 [1] => 10.1177/1756285616666741 [2] => 10.1177_1756285616666741 [3] => 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To the best of our knowledge, this is the first study to report such findings. Since the last course of rituximab was applied over 3 years ago, it is conceivable that the strong B cell inhibition by ibrutinib led to PML. 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At the tumor side, we found an increase in CD14(high)CD15(pos) monocytic MDSCs and high frequencies of CD14(low)CD15(pos) granulocytic MDSCs that displayed an activated phenotype with downregulation of CD16 and upregulation of HLA-DR molecules, which did not inhibit T-cell proliferative responses in vitro. However, a strong association between granulocytic MDSCs and CD4(+) effector memory T-cells (TEM) within the tumors was detected. Tumor-derived CD4(+) TEM expressed high levels of PD-1 when compared with their blood-derived counterparts and were functionally exhausted. The respective ligand, PD-L1, was significantly upregulated on tumor-derived MDSCs, and T-cell co-culture experiments confirmed that glioma-infiltrating MDSCs can induce PD-1 expression on CD4(+) TEM. [3] => Our findings provide a detailed characterization of different MDSC subsets in GBM patients and indicate that both granulocytic MDSCs in peripheral blood and at the tumor site play a major role in GBM-induced T-cell suppression. ) [CopyrightInformation] => © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. 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Specific effects of diclofenac and ibuprofen on STAT-3 were investigated by comparing their effects with those of the specific STAT-3 inhibitor STATTIC. [2] => Ibuprofen treatment led to a stronger inhibition of cell growth and migration than treatment with diclofenac. Proliferation was affected by cell cycle arrest at different checkpoints by both agents. In addition, diclofenac, but not ibuprofen, decreased lactate levels in all concentrations used. Both decreased STAT-3 phosphorylation; however, diclofenac led to decreased c-myc expression and subsequent reduction in LDH-A activity, whereas treatment with ibuprofen in higher doses induced c-myc expression and less LDH-A alteration. [3] => This study indicates that both ibuprofen and diclofenac strongly inhibit glioma cells, but the subsequent metabolic responses of both agents are distinct. 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[2] => In a cohort of 86 HIV patients we found that the grade of neurocognitive impairment and the severity of MRI signal abnormalities correlated with decreasing CD4/CD8-ratios and increased frequencies of HLA-DR expressing CD4+ and CD8+ T cells reaching the highest values in the CSF samples. Importantly, HLA-DR upregulation was still detectable in virologically suppressed HIV patients. Further, T-cell subpopulation analysis of 40 HIV patients showed a significant shift from naïve to effector memory (EM) T cells that was negatively correlated with the grade of neurocognitive impairment in the PB samples. Moreover, PD-1 was significantly increased on CD4+ memory T cells with highest levels on EM T cells in HIV patients with mild or severe neurocognitive alterations. [3] => The CD4/CD8 ratio, the proportion of EM to naïve T cells and the immune activation profile of CD4+ and CD8+ T cells in PB and CSF might be useful parameters to monitor the efficacy of cART and to identify HIV patients at risk of further neurocognitive deterioration. ) ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Grauer [ForeName] => Oliver M [Initials] => OM [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology, University Hospital of Muenster Albert-Schweitzer-Campus 1, D-48149, Muenster, Germany. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Reichelt [ForeName] => Doris [Initials] => D [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Internal Medicine D, University Hospital of Muenster Albert-Schweitzer-Campus 1, 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Europaische chirurgische Forschung. Recherches chirurgicales europeennes [ISOAbbreviation] => Eur Surg Res ) [ArticleTitle] => Glioma tissue obtained by modern ultrasonic aspiration with a simple sterile suction trap for primary cell culture and pathological evaluation. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 37-42 ) [ELocationID] => 10.1159/000364943 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Ultrasonic aspiration is widely used in the resection of brain tumors. Nevertheless, tumor tissue fragments obtained by ultrasonic aspiration are usually discarded. In this study, we demonstrate that these fragments are possible sources of material for histopathological study and tissue culture and compare their microscopic features and viability in tissue culture of cavitron ultrasonic surgical aspirator tissue fragments. [1] => Brain tumor tissue collected by ultrasonic aspiration (CUSA EXcel®; Integra Radionics Inc.) in a simple sterile suction trap during resection was processed for primary cell culture. Cell viability and immunohistological markers were measured by the WST-1 test, microscopy and immunofluorescent evaluation. [2] => Six gliomas are presented to demonstrate that these tissue fragments show good preservation of histological detail and tissue viability in culture. [3] => Utilization of this material may facilitate pathological interpretation by providing a more representative sample of tumor histology as well as an adequate and sterile biosource of material for tissue culture studies. ) ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Schroeteler [ForeName] => Juliane [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurosurgery, University Hospital Münster, Münster, Germany. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Reeker [ForeName] => Ralf [Initials] => R ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Suero Molina [ForeName] => Eric [Initials] => E ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Brokinkel [ForeName] => Benjamin [Initials] => B ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Holling [ForeName] => Markus [Initials] => M ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Grauer [ForeName] => Oliver M [Initials] => OM ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Senner [ForeName] => Volker [Initials] => V ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Stummer [ForeName] => Walter [Initials] => W ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ewelt [ForeName] => Christian [Initials] => C ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Journal Article [1] => Research Support, Non-U.S. Gov't ) ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2014 [Month] => 07 [Day] => 18 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Switzerland [MedlineTA] => Eur Surg Res [NlmUniqueID] => 0174752 [ISSNLinking] => 0014-312X ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Brain [QualifierName] => pathology ) [1] => SimpleXMLElement Object ( [DescriptorName] => Brain Neoplasms [QualifierName] => pathology ) [2] => SimpleXMLElement Object ( [DescriptorName] => Cell Culture Techniques ) [3] => SimpleXMLElement Object ( [DescriptorName] => Cell Line, Tumor ) [4] => SimpleXMLElement Object ( [DescriptorName] => Endoscopic Ultrasound-Guided Fine Needle Aspiration ) [5] => SimpleXMLElement Object ( [DescriptorName] => Glioblastoma [QualifierName] => pathology ) [6] => SimpleXMLElement Object ( [DescriptorName] => Humans ) ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2014 [Month] => 01 [Day] => 13 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2014 [Month] => 05 [Day] => 28 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2014 [Month] => 7 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2014 [Month] => 7 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2015 [Month] => 6 [Day] => 30 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 25059972 [1] => 000364943 [2] => 10.1159/000364943 ) ) ) ) [15] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 22752934 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2013 [Month] => 02 [Day] => 20 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2019 [Month] => 12 [Day] => 10 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1097-0215 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 132 [Issue] => 4 [PubDate] => SimpleXMLElement Object ( [Year] => 2013 [Month] => Feb [Day] => 15 ) ) [Title] => International journal of cancer [ISOAbbreviation] => Int J Cancer ) [ArticleTitle] => Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 843-53 ) [ELocationID] => 10.1002/ijc.27712 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Lactate formation in highly proliferative tumors such as malignant gliomas is associated with poor survival and contributes to the suppression of local immunity. Here, we report that diclofenac used at nontoxic concentrations significantly decreased lactate production in murine glioma cells and inhibited the expression of lactate dehydrogenase-A in vitro. Lactate reduction was accompanied by a dose-dependent inhibition of cell growth and a cell cycle arrest at the G2/M checkpoint. In the presence of diclofenac, murine bone marrow-derived dendritic cells (DCs) showed enhanced IL-12, but decreased IL-10 secretion on Toll-like receptor stimulation with R848 that correlated with reduced lactate levels in the glioma cell coculture and a blockade of signal transducers and activators of transcription 3 phosphorylation. In vivo, diclofenac treatment diminished intratumoral lactate levels and resulted in a significant delay of glioma growth. Ex vivo analyses revealed that tumor-infiltrating DCs regained their capacity to produce IL-12 on R848 stimulation. Moreover, diclofenac reduced the number of tumor-infiltrating regulatory T cells and impaired the upregulation of the Treg activation marker CD25. Nevertheless, a single intratumoral injection of R848 combined with diclofenac failed to induce an additional survival advantage in glioma-bearing mice. Further analyses illustrated that the presence of diclofenac during T-cell activation compromised INF-γ production and T-cell proliferation, indicating that immunotherapeutic approaches have to be carefully timed when combined with diclofenac. In summary, diclofenac appears as an attractive agent for targeting lactate production and counteracting local immune suppression in malignant gliomas. 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 674-93 ) [ELocationID] => 10.1111/j.1750-3639.2009.00315.x [Abstract] => SimpleXMLElement Object ( [AbstractText] => Despite aggressive multimodal treatment approaches, the prognosis for patients with diffuse gliomas remains disappointing. Glioma cells often extensively infiltrate in the surrounding brain parenchyma, a phenomenon that helps them to escape surgical removal, radiation exposure and chemotherapy. Moreover, conventional therapy is often associated with considerable local and systemic side effects. Therefore, the development of novel therapeutic approaches is essential to improve the outcome of these patients. Immunotherapy offers the opportunity to specifically target residual radio-and chemoresistant tumor cells without damaging healthy neighboring brain tissue. Significant progress has been made in recent years both in understanding the mechanisms of immune regulation in the central nervous system (CNS) as well as tumor-induced and host-mediated immunosuppression elicited by gliomas. In this review, after discussing the special requirements needed for the initiation and control of immune responses in the CNS, we focus on immunological phenomena observed in glioma patients, discuss different immunological approaches to attack glioma-associated target structures and touch on further strategies to improve the efficacy of immunotherapy of gliomas. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Grauer [ForeName] => Oliver M [Initials] => OM [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Wesseling [ForeName] => Pieter [Initials] => P ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Adema [ForeName] => Gosse J [Initials] => GJ ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Journal Article [1] => Research Support, Non-U.S. Gov't [2] => Review ) ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Switzerland [MedlineTA] => Brain Pathol [NlmUniqueID] => 9216781 [ISSNLinking] => 1015-6305 ) [ChemicalList] => SimpleXMLElement Object ( [Chemical] => Array ( [0] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Antigens, Neoplasm ) [1] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Cancer Vaccines ) ) ) [CitationSubset] => IM [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Antigens, Neoplasm [QualifierName] => immunology ) [1] => SimpleXMLElement Object ( [DescriptorName] => Antineoplastic Protocols ) [2] => SimpleXMLElement Object ( [DescriptorName] => Brain Neoplasms [QualifierName] => Array ( [0] => immunology [1] => therapy ) ) [3] => SimpleXMLElement Object ( [DescriptorName] => Cancer Vaccines [QualifierName] => Array ( [0] => immunology [1] => therapeutic use ) ) [4] => SimpleXMLElement Object ( [DescriptorName] => Central Nervous System [QualifierName] => immunology ) [5] => SimpleXMLElement Object ( [DescriptorName] => Combined Modality Therapy ) [6] => SimpleXMLElement Object ( [DescriptorName] => Dendritic Cells [QualifierName] => immunology ) [7] => SimpleXMLElement Object ( [DescriptorName] => Glioma [QualifierName] => Array ( [0] => immunology [1] => therapy ) ) [8] => SimpleXMLElement Object ( [DescriptorName] => Humans ) [9] => SimpleXMLElement Object ( [DescriptorName] => Immunotherapy ) ) ) [NumberOfReferences] => 302 ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2009 [Month] => 9 [Day] => 12 [Hour] => 6 [Minute] => 0 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2009 [Month] => 9 [Day] => 12 [Hour] => 6 [Minute] => 0 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2009 [Month] => 11 [Day] => 5 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 19744040 [1] => BPA315 [2] => 10.1111/j.1750-3639.2009.00315.x ) ) ) ) [17] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => MEDLINE [Owner] => NLM ) [PMID] => 19028999 [DateCompleted] => SimpleXMLElement Object ( [Year] => 2009 [Month] => 09 [Day] => 10 ) [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 01 [Day] => 03 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1522-8517 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Print ) [Volume] => 11 [Issue] => 4 [PubDate] => SimpleXMLElement Object ( [Year] => 2009 [Month] => Aug ) ) [Title] => Neuro-oncology [ISOAbbreviation] => Neuro Oncol ) [ArticleTitle] => Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 394-402 ) [ELocationID] => 10.1215/15228517-2008-104 [Abstract] => SimpleXMLElement Object ( [AbstractText] => The brain is a specialized immune site representing a unique tumor microenvironment. The availability of fresh brain tumor material for ex vivo analysis is often limited because large parts of many brain tumors are resected using ultrasonic aspiration. We analyzed ultrasonic tumor aspirates as a biosource to study immune suppressive mechanisms in 83 human brain tumors. Lymphocyte infiltrates in brain tumor tissues and ultrasonic aspirates were comparable with respect to lymphocyte content and viability. Applying ultrasonic aspirates, we detected massive infiltration of CD4+FoxP3+CD25(high) CD127(low) regulatory T cells (Tregs) in glioblastomas (n = 29) and metastatic brain tumors (n = 20). No Treg accumulation was observed in benign tumors such as meningiomas (n = 10) and pituitary adenomas (n = 5). A significant Treg increase in blood was seen only in patients with metastatic brain tumors. Tregs in high-grade tumors exhibited an activated phenotype as indicated by decreased proliferation and elevated CTLA-4 and FoxP3 expression relative to blood Tregs. Functional analysis showed that the tumor-derived Tregs efficiently suppressed cytokine secretion and proliferation of autologous intratumoral lymphocytes. Most tumor-infiltrating Tregs were localized in close proximity to effector T cells, as visualized by immunohistochemistry. Furthermore, 61% of the malignant brain tumors expressed programmed death ligand-1 (PD-L1), while the inhibitory PD-1 receptor was expressed on CD4+ effector cells present in 26% of tumors. In conclusion, using ultrasonic tumor aspirates as a biosource we identified Tregs and the PD-L1/PD-1 pathway as immune suppressive mechanisms in malignant but not benign human brain tumors. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Jacobs [ForeName] => Joannes F M [Initials] => JF [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences /278 TIL, Post Box 9101, 6500 HB Nijmegen, The Netherlands. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Idema [ForeName] => Albert J [Initials] => AJ ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Bol [ForeName] => Kalijn F [Initials] => KF ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 6720-9 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Local TLR stimulation is an attractive approach to induce antitumor immunity. In this study, we compared various TLR ligands for their ability to affect murine GL261 cells in vitro and to eradicate established intracerebral murine gliomas in vivo. Our data show that GL261 cells express TLR2, TLR3, and TLR4 and respond to the corresponding TLR ligands with increasing MHC class I expression and inducing IL-6 secretion in vitro, while TLR5, TLR7, and TLR9 are essentially absent. Remarkably, CpG-oligonucleotides (CpG-ODN, TLR9) appeared to inhibit GL261 cell proliferation in a cell-type specific, but CpG-motif and TLR9-independent manner. A single intratumoral injection of CpG-ODN most effectively inhibited glioma growth in vivo and cured 80% of glioma-bearing C57BL/6 mice. Intratumoral injection of Pam3Cys-SK4 (TLR1/2) or R848 (TLR7) also produced a significant survival benefit, whereas poly(I:C) (TLR3) or purified LPS (TLR4) stimulation alone was not effective. Additional studies using TLR9(+/+) wild-type and TLR9(-/-) knockout mice revealed that the efficacy of local CpG-ODN treatment in vivo required TLR9 expression on nontumor cells. Additional experiments demonstrated increased frequencies of tumor-infiltrating IFN-gamma producing CD4(+) and CD8(+) effector T cells and a marked increase in the ratio of CD4(+) effector T cells to CD4(+)FoxP3(+) regulatory T cells upon CpG-ODN treatment. Surviving CpG-ODN treated mice were also protected from a subsequent tumor challenge without further addition of CpG-ODN. 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[Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 5390-6 ) [ELocationID] => 10.1158/0008-5472.CAN-07-6023 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Immunostimulatory cytidyl guanosyl (CpG) motifs are of great interest as cancer vaccine adjuvants. They act as potent inducers of Th1 responses, including the activation of cytotoxic CD8(+) T lymphocytes (CTL). Whereas animal models have provided clear evidence that CpG enhances antitumor immunity, clinical trials in humans have thus far been less successful. Applying cryosurgery as an instant in situ tumor destruction technique, we now show that timing of CpG administration crucially affects colocalization of antigen and CpG within EEA-1(+) and LAMP-1(+) compartments within dendritic cells in vivo. Moreover, antigen/CpG colocalization is directly correlated with antigen cross-presentation, the presence of CTL, and protective antitumor immunity. 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These data might aid in the design of future immunotherapeutic strategies for cancer patients. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Nierkens [ForeName] => Stefan [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => den Brok [ForeName] => Martijn H [Initials] => MH ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Sutmuller [ForeName] => Roger P M [Initials] => RP ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Grauer [ForeName] => Oliver M [Initials] => OM ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Bennink [ForeName] => Erik [Initials] => E ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Morgan [ForeName] => Mary E [Initials] => ME ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Figdor [ForeName] => Carl G [Initials] => CG ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ruers [ForeName] => Theo J M [Initials] => TJ ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Adema [ForeName] => Gosse J [Initials] => GJ ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Array ( [0] => Evaluation Study [1] => Journal Article [2] => Research Support, Non-U.S. Gov't ) ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => Cancer Res [NlmUniqueID] => 2984705R [ISSNLinking] => 0008-5472 ) [ChemicalList] => SimpleXMLElement Object ( [Chemical] => Array ( [0] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Adjuvants, Immunologic ) [1] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Antigens, Neoplasm ) [2] => SimpleXMLElement Object ( [RegistryNumber] => 0 [NameOfSubstance] => Dinucleoside Phosphates ) [3] => SimpleXMLElement Object ( [RegistryNumber] => 2382-65-2 [NameOfSubstance] => cytidylyl-3'-5'-guanosine ) ) ) [CitationSubset] => IM [CommentsCorrectionsList] => SimpleXMLElement Object ( [CommentsCorrections] => SimpleXMLElement Object ( [@attributes] => Array ( [RefType] => ErratumIn ) [RefSource] => Cancer Res. 2008 Aug 15;68(16):6859 ) ) [MeshHeadingList] => SimpleXMLElement Object ( [MeshHeading] => Array ( [0] => SimpleXMLElement Object ( [DescriptorName] => Adjuvants, Immunologic [QualifierName] => pharmacokinetics ) [1] => SimpleXMLElement Object ( [DescriptorName] => Animals ) [2] => SimpleXMLElement Object ( [DescriptorName] => Antigens, Neoplasm [QualifierName] => metabolism ) [3] => SimpleXMLElement Object ( [DescriptorName] => Dendritic Cells [QualifierName] => Array ( [0] => immunology [1] => metabolism ) ) [4] => SimpleXMLElement Object ( [DescriptorName] => Dinucleoside Phosphates [QualifierName] => Array ( [0] => administration & dosage [1] => pharmacokinetics ) ) [5] => SimpleXMLElement Object ( [DescriptorName] => Drug Administration Schedule ) [6] => SimpleXMLElement Object ( [DescriptorName] => Immunotherapy ) [7] => SimpleXMLElement Object ( [DescriptorName] => Melanoma, Experimental [QualifierName] => Array ( [0] => immunology [1] => metabolism [2] => therapy ) ) [8] => SimpleXMLElement Object ( [DescriptorName] => Mice ) [9] => SimpleXMLElement Object ( [DescriptorName] => Mice, Inbred C57BL ) [10] => SimpleXMLElement Object ( [DescriptorName] => Neoplasm Transplantation ) [11] => SimpleXMLElement Object ( [DescriptorName] => Time Factors ) [12] => SimpleXMLElement Object ( [DescriptorName] => Tissue Distribution ) [13] => SimpleXMLElement Object ( [DescriptorName] => Treatment Outcome ) [14] => SimpleXMLElement Object ( [DescriptorName] => Tumor Cells, Cultured ) ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2008 [Month] => 7 [Day] => 3 [Hour] => 9 [Minute] => 0 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2008 [Month] => 8 [Day] => 6 [Hour] => 9 [Minute] => 0 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2008 [Month] => 7 [Day] => 3 [Hour] => 9 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 18593941 [1] => 68/13/5390 [2] => 10.1158/0008-5472.CAN-07-6023 ) ) ) ) ) ) Oliver M Grauer | PubFacts

Publications by authors named "Oliver M Grauer"

23Publications

Fulminant MS Reactivation Following Combined Fingolimod Cessation and Yellow Fever Vaccination.

Int J Mol Sci 2019 Nov 28;20(23). Epub 2019 Nov 28.

Department of Neurology with Institute of Translational Neurology, University Hospital Muenster, D-48149 Muenster, Germany.

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November 2019

Ineffective treatment of PML with pembrolizumab: Exhausted memory T-cell subsets as a clue?

Neurol Neuroimmunol Neuroinflamm 2019 11 9;6(6):e627. Epub 2019 Oct 9.

From the Department of Neurology with Institute of Translational Neurology, University of Muenster, Germany.

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November 2019

Targeting B cells in relapsing-remitting multiple sclerosis: from pathophysiology to optimal clinical management.

Ther Adv Neurol Disord 2017 Jan 2;10(1):51-66. Epub 2016 Sep 2.

Department of Neurology, University of Münster, Münster, Germany.

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January 2017

CD4+ T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients.

Neuro Oncol 2016 06 17;18(6):807-18. Epub 2015 Nov 17.

Department of Neurology, University Hospital of Regensburg, Regensburg, Germany (D.D., U.B.); Department of Neurosurgery, University Hospital of Muenster, Muenster, Germany (J.W., W.S.); Institute of Neuropathology, University Hospital of Muenster, Muenster, Germany (M.H.); Department of Neurology, University Hospital of Muenster, Muenster, Germany (T.S.-H., H.W., O.M.G.).

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June 2016

Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms.

PLoS One 2015 20;10(10):e0140613. Epub 2015 Oct 20.

Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany.

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June 2016

Neurocognitive decline in HIV patients is associated with ongoing T-cell activation in the cerebrospinal fluid.

Ann Clin Transl Neurol 2015 Sep 18;2(9):906-19. Epub 2015 Aug 18.

Department of Neurology, University Hospital of Muenster Albert-Schweitzer-Campus 1, D-48149, Muenster, Germany.

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September 2015

The role of ion channels in malignant brain tumors.

J Neurooncol 2015 Nov 3;125(2):225-35. Epub 2015 Sep 3.

Department of Neurology, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.

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November 2015

Immunotherapy of diffuse gliomas: biological background, current status and future developments.

Brain Pathol 2009 Oct;19(4):674-93

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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October 2009

Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors.

Neuro Oncol 2009 Aug 21;11(4):394-402. Epub 2008 Nov 21.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences /278 TIL, Post Box 9101, 6500 HB Nijmegen, The Netherlands.

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August 2009

In vivo colocalization of antigen and CpG [corrected] within dendritic cells is associated with the efficacy of cancer immunotherapy.

Cancer Res 2008 Jul;68(13):5390-6

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands.

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July 2008