Oliver Howes

Oliver Howes

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Oliver Howes

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Determinants of treatment response in first-episode psychosis: an F-DOPA PET study.

Mol Psychiatry 2019 Oct 20;24(10):1502-1512. Epub 2018 Apr 20.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.

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http://dx.doi.org/10.1038/s41380-018-0042-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331038PMC
October 2019

Neuroinflammation in schizophrenia: meta-analysis of microglial imaging studies.

Psychol Med 2019 Oct 25;49(13):2186-2196. Epub 2018 Oct 25.

Psychiatric Imaging Group, MRC Clinical Sciences Centre, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1017/S0033291718003057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366560PMC
October 2019

The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: A PET imaging study.

Psychiatry Res Neuroimaging 2019 Sep 19;291:34-41. Epub 2019 Jul 19.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK; Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital, London W12 0NN, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, W12 0NN, UK; South London and Maudsley NHS Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pscychresns.2019.07.005DOI Listing
September 2019

Pre-frontal parvalbumin interneurons in schizophrenia: a meta-analysis of post-mortem studies.

J Neural Transm (Vienna) 2019 Sep 16. Epub 2019 Sep 16.

Psychosis Studies [PO63], Inst. of Psychiatry, Psychology and Neuroscience, King's College London, 5th Floor, Main Building, Denmark Hill, London, UK.

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http://dx.doi.org/10.1007/s00702-019-02080-2DOI Listing
September 2019

The association of psychosocial risk factors for mental health with a brain marker altered by inflammation: A translocator protein (TSPO) PET imaging study.

Brain Behav Immun 2019 Aug 18;80:742-750. Epub 2019 May 18.

Psychiatric Imaging Group MRC London Institute of Medical Sciences, Hammersmith Hospital, London W12 0NN, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 0NN, UK; Institute of Psychiatry, Neurology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2019.05.023DOI Listing
August 2019

The effects of voice content on stress reactivity: A simulation paradigm of auditory verbal hallucinations.

Schizophr Res 2019 Aug 1. Epub 2019 Aug 1.

Institute of Psychiatry, Psychology & Neuroscience, King's College London, Department of Psychology, London, UK; Department of Psychology, University of Bath, Bath, UK.

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http://dx.doi.org/10.1016/j.schres.2019.07.019DOI Listing
August 2019

The efficacy and heterogeneity of antipsychotic response in schizophrenia: A meta-analysis.

Mol Psychiatry 2019 Aug 30. Epub 2019 Aug 30.

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.

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http://dx.doi.org/10.1038/s41380-019-0502-5DOI Listing
August 2019

Altered glutamatergic response and functional connectivity in treatment resistant schizophrenia: the effect of riluzole and therapeutic implications.

Psychopharmacology (Berl) 2019 Jul 28;236(7):1985-1997. Epub 2019 Feb 28.

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.

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http://dx.doi.org/10.1007/s00213-019-5188-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642056PMC
July 2019

Disrupted-in-schizophrenia 1 functional polymorphisms and D /D receptor availability: A [ C]-(+)-PHNO imaging study.

Genes Brain Behav 2019 Jul 2:e12596. Epub 2019 Jul 2.

Psychiatric Imaging Group, Robert Steiner MRI Unit, MRC London Institute of Medical Sciences, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1111/gbb.12596DOI Listing
July 2019

Glutamate levels in the anterior cingulate cortex in un-medicated first episode psychosis: a proton magnetic resonance spectroscopy study.

Sci Rep 2019 Jul 2;9(1):8685. Epub 2019 Jul 2.

Psychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.

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http://dx.doi.org/10.1038/s41598-019-45018-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606579PMC
July 2019

Task-induced functional brain connectivity mediates the relationship between striatal D2/3 receptors and working memory.

Elife 2019 Jul 10;8. Epub 2019 Jul 10.

Institute of Psychiatry, Psychology and Neuroscience (IOPPN), King's College London, London, United Kingdom.

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http://dx.doi.org/10.7554/eLife.45045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620042PMC
July 2019

Antipsychotics: Mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology.

Neuropharmacology 2019 Jul 9:107704. Epub 2019 Jul 9.

Department of Psychosis Studies, 5th Floor, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, PO63 De Crespigny Park, London, SE5 8AF, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.107704DOI Listing
July 2019

The effects of cannabinoid 1 receptor compounds on memory: a meta-analysis and systematic review across species.

Psychopharmacology (Berl) 2019 Jun 5. Epub 2019 Jun 5.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park Road, London, SE5 8AF, UK.

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http://dx.doi.org/10.1007/s00213-019-05283-3DOI Listing
June 2019

Prevalence of treatment-resistant psychoses in the community: A naturalistic study.

J Psychopharmacol 2019 Jun 26:269881119855995. Epub 2019 Jun 26.

1 Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.

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http://dx.doi.org/10.1177/0269881119855995DOI Listing
June 2019

Understanding and Predicting Variability in Response to Treatment in Psychotic Disorders: In Vivo Findings.

Clin Pharmacol Ther 2019 May 18;105(5):1079-1081. Epub 2019 Mar 18.

Psychiatric Imaging Group MRC London Institute of Medical Sciences, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1002/cpt.1357DOI Listing
May 2019

Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures.

Mol Psychiatry 2019 04 6;24(4):549-561. Epub 2018 Mar 6.

Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/s41380-018-0041-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004314PMC
April 2019

Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies.

Psychopharmacology (Berl) 2019 Apr 18;236(4):1119-1129. Epub 2019 Mar 18.

Psychiatric Imaging Group, MRC London Institute of Medical Sciences Centre (LMS), Du Cane Road, London, W12 0NN, UK.

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http://link.springer.com/10.1007/s00213-019-05196-1
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http://dx.doi.org/10.1007/s00213-019-05196-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591186PMC
April 2019

Mesolimbic Dopamine Function Is Related to Salience Network Connectivity: An Integrative Positron Emission Tomography and Magnetic Resonance Study.

Biol Psychiatry 2019 03 29;85(5):368-378. Epub 2018 Sep 29.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, De Crespigny Park, London, United Kingdom; Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital, London, United Kingdom; Faculty of Medicine, Institute of Clinical Sciences, Imperial College London, London, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00063223183185
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http://dx.doi.org/10.1016/j.biopsych.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360933PMC
March 2019

Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms.

Trends Neurosci 2019 03 6;42(3):205-220. Epub 2019 Jan 6.

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK; MRC London Institute of Medical Sciences, Hammersmith Hospital, London, W12 0NN, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK; South London and Maudsley NHS Foundation Trust, London, SE5 8AF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401206PMC
March 2019

Clinical Guidance on the Identification and Management of Treatment-Resistant Schizophrenia.

J Clin Psychiatry 2019 Mar 5;80(2). Epub 2019 Mar 5.

Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.

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https://www.psychiatrist.com/JCP/article/Pages/2019/v80/18co
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http://dx.doi.org/10.4088/JCP.18com12123DOI Listing
March 2019

Enhanced Dopamine in Prodromal Schizophrenia (EDiPS): a new animal model of relevance to schizophrenia.

NPJ Schizophr 2019 Mar 29;5(1). Epub 2019 Mar 29.

Queensland Brain Institute, University of Queensland, Brisbane, QLD, 4072, Australia.

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http://dx.doi.org/10.1038/s41537-019-0074-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441087PMC
March 2019

Vitamin D and clinical symptoms in First Episode Psychosis (FEP): A prospective cohort study.

Schizophr Res 2019 Feb 25;204:381-388. Epub 2018 Aug 25.

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; National Psychosis Service, South London and Maudsley NHS Foundation Trust, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09209964183050
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http://dx.doi.org/10.1016/j.schres.2018.08.011DOI Listing
February 2019

The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study.

Biol Psychiatry 2019 01 11;85(1):79-87. Epub 2018 Jul 11.

Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Imperial College, Hammersmith Hospital, London, United Kingdom; Institute of Clinical Sciences, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269123PMC
January 2019

Sex difference in brain CB1 receptor availability in man.

Neuroimage 2019 01 5;184:834-842. Epub 2018 Oct 5.

Turku PET Centre, Turku University Hospital, Finland; Department of Psychiatry, University of Turku and Turku University Hospital, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10538119183197
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http://dx.doi.org/10.1016/j.neuroimage.2018.10.013DOI Listing
January 2019

Neural Responsivity to Food Cues in Patients With Unmedicated First-Episode Psychosis.

JAMA Netw Open 2019 Jan 4;2(1):e186893. Epub 2019 Jan 4.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2018.6893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420094PMC
January 2019

Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis.

Neuropsychopharmacology 2018 12 30;43(13):2652-2659. Epub 2018 Jan 30.

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1038/s41386-017-0004-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955214PMC
December 2018

Trends in mortality in schizophrenia and their implications.

Acta Psychiatr Scand 2018 12;138(6):489-491

Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital, London, UK.

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http://doi.wiley.com/10.1111/acps.12977
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http://dx.doi.org/10.1111/acps.12977DOI Listing
December 2018

Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity.

Schizophr Res 2018 Dec 17. Epub 2018 Dec 17.

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London SE5 8AF, UK; Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital, London W12 0NN, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2018.12.011DOI Listing
December 2018

The effects of haloperidol on microglial morphology and translocator protein levels: An in vivo study in rats using an automated cell evaluation pipeline.

J Psychopharmacol 2018 11 21;32(11):1264-1272. Epub 2018 Aug 21.

1 MRC London Institute of Medical Sciences, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1177/0269881118788830DOI Listing
November 2018

Frontostriatal functional connectivity and striatal dopamine synthesis capacity in schizophrenia in terms of antipsychotic responsiveness: an [18F]DOPA PET and fMRI study.

Psychol Med 2018 Nov 21:1-10. Epub 2018 Nov 21.

Department of Brain & Cognitive Sciences,College of Natural Sciences, Seoul National University,Seoul,Republic of Korea.

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http://dx.doi.org/10.1017/S0033291718003471DOI Listing
November 2018

Defining the Locus of Dopaminergic Dysfunction in Schizophrenia: A Meta-analysis and Test of the Mesolimbic Hypothesis.

Schizophr Bull 2018 10;44(6):1301-1311

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1093/schbul/sbx180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933516PMC
October 2018

The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.

Hum Mol Genet 2018 10;27(20):3498-3506

Psychiatric Imaging Group, Robert Steiner MRI Unit, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1093/hmg/ddy242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168972PMC
October 2018

The relationship between cortical glutamate and striatal dopamine in first-episode psychosis: a cross-sectional multimodal PET and magnetic resonance spectroscopy imaging study.

Lancet Psychiatry 2018 10 17;5(10):816-823. Epub 2018 Sep 17.

Department of Psychosis Studies, King's College, London, UK; Psychiatric Imaging Group MRC London Institute of Medical Sciences, Hammersmith Hospital, London, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2215-0366(18)30268-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162342PMC
October 2018

Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia.

Proc Natl Acad Sci U S A 2018 10 8;115(43):E10167-E10176. Epub 2018 Oct 8.

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1809298115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205436PMC
October 2018

Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study.

Psychol Med 2018 09 12;48(12):1985-1992. Epub 2018 Jan 12.

Department of Psychosis Studies,Institute of Psychiatry,Psychology & Neuroscience,Kings College London,De Crespigny Park,London SE5 8AF,UK.

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http://dx.doi.org/10.1017/S0033291717003506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933521PMC
September 2018

Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data.

Biol Psychiatry 2018 09 6;84(6):433-442. Epub 2018 Mar 6.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.biopsych.2018.02.1171DOI Listing
September 2018

Antipsychotic drugs: challenges and future directions.

World Psychiatry 2018 Jun;17(2):170-171

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1002/wps.20522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980606PMC
June 2018

Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: An [C]PBR28 study.

Schizophr Res 2018 05 12;195:206-214. Epub 2017 Oct 12.

Psychiatric Imaging Group, MRC Clinical Sciences Centre, Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital, London, W12 0NN, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.schres.2017.08.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027955PMC
May 2018

The Relationship Between Dopamine Synthesis Capacity and Release: Implications for Psychosis.

Neuropsychopharmacology 2018 05;43(6):1195-1196

Psychiatric Imaging, Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1038/npp.2017.293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916363PMC
May 2018

Platform for systems medicine research and diagnostic applications in psychotic disorders-The METSY project.

Eur Psychiatry 2018 04 1;50:40-46. Epub 2018 Feb 1.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland; School of Medical Sciences, Örebro University, 702 81 Örebro, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.eurpsy.2017.12.001DOI Listing
April 2018

The relationship between dopamine receptor blockade and cognitive performance in schizophrenia: a [C]-raclopride PET study with aripiprazole.

Transl Psychiatry 2018 04 24;8(1):87. Epub 2018 Apr 24.

Department of Brain and Cognitive Sciences, College of Natural Science, Seoul National University, Seoul, 08826, Republic of Korea.

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http://www.nature.com/articles/s41398-018-0134-6
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http://dx.doi.org/10.1038/s41398-018-0134-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913226PMC
April 2018

Translation and cross-cultural adaptation of the Sexual Function Questionnaire (SFQ) into Brazilian Portuguese.

Trends Psychiatry Psychother 2017 Apr-Jun;39(2):110-115

Núcleo de Formação Específica em Psiquiatria, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.

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http://dx.doi.org/10.1590/2237-6089-2016-0089DOI Listing
February 2018

Effect of Citalopram on Emotion Processing in Humans: A Combined 5-HT [C]CUMI-101 PET and Functional MRI Study.

Neuropsychopharmacology 2018 02 4;43(3):655-664. Epub 2017 Aug 4.

Medical Research Council London Institute of Medical Sciences, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1038/npp.2017.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693328PMC
February 2018

Higher serotonin transporter availability in early-onset obsessive-compulsive disorder patients undergoing escitalopram treatment: A [ C]DASB PET study.

Hum Psychopharmacol 2018 01 6;33(1). Epub 2017 Dec 6.

Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.1002/hup.2642DOI Listing
January 2018

Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology.

J Psychopharmacol 2018 01 14;32(1):3-29. Epub 2017 Dec 14.

6 The Sackler Centre and Forensic and Neurodevelopmental Science Behavioural and Developmental Psychiatry, Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1177/0269881117741766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805024PMC
January 2018

Single cocaine exposure does not alter striatal pre-synaptic dopamine function in mice: an [ F]-FDOPA PET study.

J Neurochem 2017 12 26;143(5):551-560. Epub 2017 Oct 26.

Psychiatric Imaging, Medical Research Council, London Institute of Medical Sciences, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/jnc.14223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798585PMC
December 2017

Cholesterol and triglyceride levels in first-episode psychosis: systematic review and meta-analysis.

Br J Psychiatry 2017 Dec 5;211(6):339-349. Epub 2017 Oct 5.

Toby Pillinger, MRCP, Katherine Beck, MRCPsych, Brendon Stubbs, PhD, Institute of Psychiatry, Psychology and Neuroscience, King's College London, and South London and Maudsley National Health Service (NHS) Foundation Trust, London; Oliver D. Howes, PhD MRCPsych, Institute of Psychiatry, Psychology and Neuroscience, King's College London, South London and Maudsley NHS Foundation Trust, Medical Research Council London Institute of Medical Sciences, Hammersmith Hospital, and Institute of Clinical Sciences, Faculty of Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1192/bjp.bp.117.200907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709673PMC
December 2017

Hyperprolactinaemia in first episode psychosis - A longitudinal assessment.

Schizophr Res 2017 11 27;189:117-125. Epub 2017 Jul 27.

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; National Psychosis Service, South London and Maudsley NHS Foundation Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2017.07.037DOI Listing
November 2017

Heterogeneity and Homogeneity of Regional Brain Structure in Schizophrenia: A Meta-analysis.

JAMA Psychiatry 2017 11;74(11):1104-1111

Medical Research Council London Institute of Medical Sciences, London, England.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.2663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669456PMC
November 2017

Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors.

Sci Rep 2017 11 3;7(1):15025. Epub 2017 Nov 3.

Department of Psychosis Studies, King's College London, Institute of Psychiatry, Psychology & Neuroscience, De Crespigny Park, London, SE5 8AF, UK.

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http://dx.doi.org/10.1038/s41598-017-14203-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670208PMC
November 2017

The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life.

Elife 2017 11 28;6. Epub 2017 Nov 28.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom.

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http://dx.doi.org/10.7554/eLife.29088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705207PMC
November 2017

30 Years on: How the Neurodevelopmental Hypothesis of Schizophrenia Morphed Into the Developmental Risk Factor Model of Psychosis.

Schizophr Bull 2017 10;43(6):1190-1196

Psychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.

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http://dx.doi.org/10.1093/schbul/sbx121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737804PMC
October 2017

First-Episode Schizophrenia and Diabetes Risk-Reply.

JAMA Psychiatry 2017 07;74(7):763

Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, England2South London and Maudsley NHS Foundation Trust, London, England3MRC London Institute of Medical Sciences, Hammersmith Hospital, London, England4Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, England.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.0765DOI Listing
July 2017

Association of Stimulant Use With Dopaminergic Alterations in Users of Cocaine, Amphetamine, or Methamphetamine: A Systematic Review and Meta-analysis.

JAMA Psychiatry 2017 05;74(5):511-519

Psychiatric Imaging Group, Medical Research Council London Institute of Medical Sciences Centre, London, England2Psychiatric Imaging Group, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, England3Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, England.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.0135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419581PMC
May 2017

The Role of Antipsychotic Plasma Levels in the Treatment of Schizophrenia.

Am J Psychiatry 2017 05;174(5):421-426

From RAND Corporation, Boston; and King's College and MRC Clinical Sciences Centre, Imperial College, London.

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http://dx.doi.org/10.1176/appi.ajp.2016.16040402DOI Listing
May 2017

Regional Differences in Serotonin Transporter Occupancy by Escitalopram: An [C]DASB PK-PD Study.

Clin Pharmacokinet 2017 04;56(4):371-381

Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul, 03080, Korea.

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http://link.springer.com/10.1007/s40262-016-0444-x
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http://dx.doi.org/10.1007/s40262-016-0444-xDOI Listing
April 2017

Presynaptic Dopamine Capacity in Patients with Treatment-Resistant Schizophrenia Taking Clozapine: An [F]DOPA PET Study.

Neuropsychopharmacology 2017 Mar 18;42(4):941-950. Epub 2016 Nov 18.

Department of Brain & Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea.

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http://dx.doi.org/10.1038/npp.2016.258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312074PMC
March 2017

Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology.

Am J Psychiatry 2017 Mar 6;174(3):216-229. Epub 2016 Dec 6.

From King's College London, Institute of Psychiatry, Psychology, and Neuroscience; MRC Clinical Sciences Centre; Institute of Clinical Sciences, Imperial College, and Hammersmith Hospital London; the Department of Psychiatry, University of Toronto, and the Centre for Addiction and Mental Health, Toronto; the Section of Psychiatry and Treatment Resistant Psychosis and the Laboratory of Translational Psychiatry, School of Medicine of Naples Federico II, Naples; the Departments of Psychiatry and Neuroscience, Erasmus Medical Center, and Antes Mental Health Care, Rotterdam, the Netherlands; the Feinstein Institute for Medical Research, Psychiatry Research, Zucker Hillside Hospital, Hofstra Northwell School of Medicine; the Division of Psychiatry, University College London; Laboratorio Interdisciplinar de Neurociencia Clinica, Universidade Federal de São Paulo, São Paulo; the Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore; the University of Melbourne and St. Vincent's Hospital, Sydney; the Department of Psychiatry and Behavioral Sciences, New York Medical College, New York; the Department of Psychiatry, Tel Aviv University, Tel Aviv; the Division of Health Sciences, School of Psychology and Mental Health, Faculty of Biology, Medicine, and Health, University of Manchester, and the Manchester Academic Health Science Centre, Manchester Mental Health and Social Care NHS Trust, Manchester; the Department of Psychiatry, University of Alberta, Edmonton; the Center for Neuropsychiatric Schizophrenia Research and the Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, University of Copenhagen, Copenhagen; the Department of Psychiatry, University of São Paulo Medical School, São Paulo; the Department of Psychiatry, University of Munich, Munich; the Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical University Innsbruck, Innsbruck, Austria; Programa de Esquizofrenia and Laboratorio Interdisciplinar de Neurociencia Clinica, Universidade Federal de São Paulo, São Paulo; the National Psychosis Service, South London and Maudsley NHS Foundation Trust; the Neuroscience and Behavior Department, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo; the Department of Psychiatry, University of British Columbia; Lundbeck LLC, Deerfield, Ill.; University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh; the Department of General Psychiatry, Institute of Mental Health, Singapore; the Deparment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg; the Brain and Mind Centre, University of Sydney, Sydney; the School of Pharmacy, University of Auckland, Auckland, New Zealand; the Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago; the Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich; the Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo; the Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne, and Melbourne Health, Victoria; the Schizophrenia Division, Centre for Addiction and Mental Health, Toronto; the Centre for Mental Health, Swinburne University, the Monash Alfred Psychiatry Research Centre, and the Department of Psychiatry, St. Vincent's Hospital Melbourne, Sydney; the School of Pharmacy, University of Otago, Otago, New Zealand; COS and Associates Ltd., Hong Kong; the Department of Neuropsychiatry, Keio University School of Medicine, Keio, Japan; the Department of Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands; Swinburne University and Monash Alfred Psychiatry Research Centre, Brain and Psychological Sciences Research Centre, Melbourne; the Istanbul Faculty of Medicine, Istanbul University, Istanbul; Clinical Research and Early Development, F. Hoffmann -La Roche Ltd., Basel, Switzerland; the Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, and the MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff; Psychiatry Research, Zucker Hillside Hospital, Long Island Jewish Medical Center, Hofstra Northwell School of Medicine, and the Feinstein Institute for Medical Research, New York.

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http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2016.16
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http://dx.doi.org/10.1176/appi.ajp.2016.16050503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231547PMC
March 2017

Impaired Glucose Homeostasis in First-Episode Schizophrenia: A Systematic Review and Meta-analysis.

JAMA Psychiatry 2017 Mar;74(3):261-269

Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, England2MRC London Institute of Medical Sciences, Hammersmith Hospital, London, England3Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, England.

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http://dx.doi.org/10.1001/jamapsychiatry.2016.3803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352957PMC
March 2017

Auditory verbal hallucinations and continuum models of psychosis: A systematic review of the healthy voice-hearer literature.

Clin Psychol Rev 2017 02 1;51:125-141. Epub 2016 Nov 1.

Institute of Psychiatry, Psychology & Neuroscience, King's College London, Department of Psychology, London, UK; NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1016/j.cpr.2016.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240854PMC
February 2017

The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.

Biol Psychiatry 2017 01 6;81(1):9-20. Epub 2016 Aug 6.

Psychosis Studies, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2016.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675052PMC
January 2017

Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics?

Br J Psychiatry 2016 11;209(5):361-365

Robin M. Murray, FRS, FRCPsych, Diego Quattrone, MD, Sridhar Natesan, PhD, King's College London, Institute of Psychiatry, Psychology and Neuroscience, and NIHR Maudsley Biomedical Research Centre, London. UK; Jim van Os, PhD, MRCPsych, King's College London, Institute of Psychiatry, Psychology and Neuroscience, NIHR Maudsley Biomedical Research Centre, London, UK, and Department of Psychiatry and Psychology, Maastricht University Medical Center, The Netherlands; Merete Nordentoft, PhD, Mental Health Center, University of Copenhagen, Denmark; Oliver Howes, PhD, MRCPsych, King's College London, Institute of Psychiatry, Psychology and Neuroscience, NIHR Maudsley Biomedical Research Centre, and MRC Clinical Sciences Centre, Imperial College London, London, UK; Marta Di Forti, PhD, MRCPsych, King's College London, Institute of Psychiatry, Psychology and Neuroscience, and NIHR Maudsley Biomedical Research Centre, London, UK; David Taylor, PhD, King's College London, Institute of Psychiatry, Psychology and Neuroscience, and NIHR Maudsley Biomedical Research Centre, London, UK.

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http://dx.doi.org/10.1192/bjp.bp.116.182683DOI Listing
November 2016

The effects of Δ-tetrahydrocannabinol on the dopamine system.

Nature 2016 11;539(7629):369-377

Psychiatric Imaging Group, Robert Steiner MR Unit, MRC Clinical Sciences Centre, Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.

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http://dx.doi.org/10.1038/nature20153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123717PMC
November 2016

Adversity in childhood linked to elevated striatal dopamine function in adulthood.

Schizophr Res 2016 10 23;176(2-3):171-176. Epub 2016 Jun 23.

King's College London, King's Health Partners, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.schres.2016.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147458PMC
October 2016

Phosphodiesterase 10A in Schizophrenia: A PET Study Using [(11)C]IMA107.

Am J Psychiatry 2016 07 19;173(7):714-21. Epub 2016 Feb 19.

From the Department of Psychosis Studies, the Neurodegeneration Imaging Group, the Department of Basic and Clinical Neuroscience, and the Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London; the Division of Brain Sciences, Department of Medicine, and the Psychiatric Imaging Group, Medical Research Council Clinical Sciences Centre, Institute of Clinical Science, Imperial College London, London; and Imanova Ltd., Centre for Imaging Sciences, Hammersmith Hospital, London.

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http://dx.doi.org/10.1176/appi.ajp.2015.15040518DOI Listing
July 2016

Consistent biological findings in major depression: Results from serotonin transporter meta-analyses.

J Affect Disord 2016 07 22;199:171. Epub 2016 Apr 22.

King's College London, London, UK; MRC Clinical Science Centre, London, UK; Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.jad.2016.04.043DOI Listing
July 2016

Targeting glutamate to treat schizophrenia: lessons from recent clinical studies.

Psychopharmacology (Berl) 2016 07 23;233(13):2425-8. Epub 2016 May 23.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1007/s00213-016-4318-6DOI Listing
July 2016

Schizophrenia: inorganic no more.

Lancet Psychiatry 2016 Jul;3(7):600-2

Psychiatric Imaging Group, MRC Clinical Sciences Centre, Institute of Clinical Sciences, Hammersmith Hospital, Imperial College London, London W12 0NN, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2215-0366(16)30096-7DOI Listing
July 2016

Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness.

Psychopharmacology (Berl) 2016 May 5;233(9):1637-50. Epub 2016 Feb 5.

Department of Psychosis Studies, Institute of Psychiatry, Neurology and Neuroscience (IoPPN), King's College London, Denmark Hill, London, SE5 8AZ, UK.

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http://link.springer.com/content/pdf/10.1007%2Fs00213-016-42
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http://link.springer.com/10.1007/s00213-016-4218-9
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http://dx.doi.org/10.1007/s00213-016-4218-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828495PMC
May 2016

Brain-imaging studies of treatment-resistant schizophrenia: a systematic review.

Lancet Psychiatry 2016 May 4;3(5):451-63. Epub 2016 Mar 4.

Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK; Psychiatric Imaging Group, Medical Research Council Clinical Sciences Centre, Institute of Clinical Science, Imperial College London, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S22150366150054
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http://dx.doi.org/10.1016/S2215-0366(15)00540-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796640PMC
May 2016

Immune influences on the brain: new findings and implications for treatment.

Psychopharmacology (Berl) 2016 May;233(9):1539-41

IoPPN, King's College London, London, SE5 8AF, UK.

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http://dx.doi.org/10.1007/s00213-016-4287-9DOI Listing
May 2016

Response to Narendran and Frankle: The Interpretation of PET Microglial Imaging in Schizophrenia.

Am J Psychiatry 2016 05;173(5):537-8

From the Department of Psychiatric Imaging and the Institute of Clinical Science, Imperial College London; and the Centre for Neuroimaging Sciences, King's College London.

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http://dx.doi.org/10.1176/appi.ajp.2016.15111417rDOI Listing
May 2016

Editorial: Reporting guidelines for psychopharmacology.

Psychopharmacology (Berl) 2016 Apr;233(7):1131-4

Department of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.

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http://dx.doi.org/10.1007/s00213-016-4252-7DOI Listing
April 2016

Prevalence and implications of Truman symptoms in subjects at ultra high risk for psychosis.

Psychiatry Res 2016 Apr 2;238:270-276. Epub 2016 Feb 2.

Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK; "OASIS" Prodromal Clinic, SLaM NHS Foundation Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2016.02.001DOI Listing
April 2016

Dopamine and the aberrant salience hypothesis of schizophrenia.

World Psychiatry 2016 Feb;15(1):3-4

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1002/wps.20276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780291PMC
February 2016