Oliver G Ottmann

Oliver G Ottmann

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Oliver G Ottmann

Oliver G Ottmann

Publications by authors named "Oliver G Ottmann"

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The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis.

Leukemia 2019 09 8;33(9):2319-2323. Epub 2019 Apr 8.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1038/s41375-019-0468-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756289PMC
September 2019

CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells.

Blood 2018 01 9;131(3):311-322. Epub 2017 Nov 9.

Division of Infection and Immunity, School of Medicine.

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http://dx.doi.org/10.1182/blood-2017-05-787598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774207PMC
January 2018

Continuously expanding CAR NK-92 cells display selective cytotoxicity against B-cell leukemia and lymphoma.

Cytotherapy 2017 02 22;19(2):235-249. Epub 2016 Nov 22.

Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2016.10.009DOI Listing
February 2017

CD19-CAR engineered NK-92 cells are sufficient to overcome NK cell resistance in B-cell malignancies.

J Cell Mol Med 2016 07 23;20(7):1287-94. Epub 2016 Mar 23.

Institute for Transfusion Medicine and Immunohematology, J.W. Goethe University Frankfurt/Main, Red Cross Blood Donor Service Baden-Württemberg-Hessen, Dresden, Germany.

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http://dx.doi.org/10.1111/jcmm.12810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929308PMC
July 2016

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia.

N Engl J Med 2015 Sep;373(10):920-8

From the Department of Hematology, University Hospital of Bern and University of Bern, Bern, Switzerland (G.M.B., E.O.L., M.D.); the Department of Hematology, School of Medicine, Cardiff University, Cardiff, United Kingdom (O.G.O.); Upstate Oncology Associates, Greenville, SC (G.S.); the Section of Hematology and Oncology, University of Chicago, Chicago (O.O.); the Divisions of Hematologic Malignancies and Hematology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore (M.A.M.); the Department of Hematology, University Hospital Essen, Essen, Germany (A.R.); and Geron, Menlo Park (B.B., M.S.), and the Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Gehr Family Center for Leukemia Research, Duarte (D.S.S.) - both in California.

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http://dx.doi.org/10.1056/NEJMoa1503479DOI Listing
September 2015

Treatment of patients with advanced cancer with the natural killer cell line NK-92.

Cytotherapy 2013 Dec 1;15(12):1563-70. Epub 2013 Oct 1.

Institute for Transfusion Medicine and Immunohematology, Goethe University Hospital, Frankfurt am Main, Germany; German Red Cross Blood Donation Service, Baden-Württemberg-Hessen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2013.06.017DOI Listing
December 2013

Endoplasmic reticulum protein GliPR1 regulates G protein signaling and the cell cycle and is overexpressed in AML.

Oncol Rep 2013 Nov 4;30(5):2254-62. Epub 2013 Sep 4.

Department of Hematology/Oncology and Infectious Diseases, J.W. Goethe University Hospital, D‑60590 Frankfurt/Main, Germany.

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http://dx.doi.org/10.3892/or.2013.2716DOI Listing
November 2013

Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFκB pathway and overexpressed in AML.

Int J Oncol 2013 Jul 29;43(1):246-54. Epub 2013 Apr 29.

Department of Hematology/Oncology and Infectious Diseases, J.W. Goethe-University Hospital, 60595 Frankfurt/Main, Germany.

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http://dx.doi.org/10.3892/ijo.2013.1924DOI Listing
July 2013

Nilotinib population pharmacokinetics and exposure-response analysis in patients with imatinib-resistant or -intolerant chronic myeloid leukemia.

Eur J Clin Pharmacol 2013 Apr 5;69(4):813-23. Epub 2012 Oct 5.

HRB Clinical Research Facility, Galway, and Trinity College, National University of Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1007/s00228-012-1385-4DOI Listing
April 2013

HIV-1 infection suppresses expression of host cell cycle-associated gene PDS5A.

Intervirology 2012 25;55(4):263-75. Epub 2011 Aug 25.

Department of Hematology/Oncology and Infectious Diseases, Johann Wolfgang Goethe University Hospital, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1159/000328323DOI Listing
September 2012

Polo-like kinases in AML.

Expert Opin Investig Drugs 2012 Aug 6;21(8):1069-74. Epub 2012 Jun 6.

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http://dx.doi.org/10.1517/13543784.2012.691163DOI Listing
August 2012

Knockdown of ERM family member moesin in host cells increases HIV type 1 replication.

AIDS Res Hum Retroviruses 2011 Dec 19;27(12):1317-22. Epub 2011 May 19.

Department of Hematology/Oncology and Infectious Diseases, J. W. Goethe-University Hospital, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1089/AID.2010.0147DOI Listing
December 2011

The DAC system and associations with acute leukemias and myelodysplastic syndromes.

Invest New Drugs 2010 Dec 14;28 Suppl 1:S36-49. Epub 2010 Dec 14.

Medizinische Klinik II, Abteilung für Hämatologie und Onkologie der, Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s10637-010-9595-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003828PMC
December 2010

Inhibition of X4-tropic HIV type 1 replication by knockdown of the cellular protein LEREPO4.

AIDS Res Hum Retroviruses 2010 Oct 6;26(10):1155-61. Epub 2010 Oct 6.

Department of Hematology/Oncology and Infectious Diseases, J.W. Goethe-University Hospital, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1089/aid.2010.0041DOI Listing
October 2010

Management of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).

Hematology Am Soc Hematol Educ Program 2009 :371-81

Medizinische Klinik II, Department of Hematology and Oncology, Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1182/asheducation-2009.1.371DOI Listing
March 2010

Inhibition of HIV-1 replication by small interfering RNAs directed against glioma pathogenesis related protein (GliPR) expression.

Retrovirology 2010 Mar 31;7:26. Epub 2010 Mar 31.

Department of Hematology/Oncology and Infectious Diseases, J. W. Goethe-University Hospital, Theodor Stern Kai 7, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1186/1742-4690-7-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859388PMC
March 2010

Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia.

Hematology Am Soc Hematol Educ Program 2005 :118-22

Universitatsklinik Frankfurt, Medizinische Klinik III, Theodor-Stern-Kai 7, Frankfurt D-60590, Germany.

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http://dx.doi.org/10.1182/asheducation-2005.1.118DOI Listing
November 2009

First-line treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia in adults.

Curr Opin Oncol 2009 Jun;21 Suppl 1:S43-6

Medizinische Klinik II, Department of Hematology and Oncology, Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1097/01.cco.0000357476.43164.6bDOI Listing
June 2009

The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines.

BMC Cancer 2009 Feb 13;9:53. Epub 2009 Feb 13.

Med, Klinik II/Abt, Hämatologie, Johann Wolfgang Goethe-Universität, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1186/1471-2407-9-53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654659PMC
February 2009

Impact of leukapheresis on early death rate in adult acute myeloid leukemia presenting with hyperleukocytosis.

Transfusion 2007 Oct;47(10):1843-50

Department of Internal Medicine II, University Hospital, Johann Wolfgang Goethe-University, Theodor Stern-Kai 7, D-60590 Frankfurt am Main, Germany.

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http://doi.wiley.com/10.1111/j.1537-2995.2007.01406.x
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http://dx.doi.org/10.1111/j.1537-2995.2007.01406.xDOI Listing
October 2007

Current status of growth factors in the treatment of acute myeloid and lymphoblastic leukemia.

Semin Hematol 2007 Jul;44(3):183-92

Department of Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S003719630700070
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http://dx.doi.org/10.1053/j.seminhematol.2007.04.007DOI Listing
July 2007

Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia.

Haematologica 2007 Apr;92(4):542-5

Medizinische Klinik II, Abt. Hämatologie/Onkologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, Frankfurt, Germany.

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http://dx.doi.org/10.3324/haematol.10758DOI Listing
April 2007

Targeting the oligomerization domain of ETO interferes with RUNX1/ETO oncogenic activity in t(8;21)-positive leukemic cells.

Cancer Res 2007 Mar;67(5):2280-9

Institute for Biomedical Research, Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt/M, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3360DOI Listing
March 2007

Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation.

Int J Oncol 2007 Feb;30(2):349-55

Department of Internal Medicine-Hematology and Oncology, University Hospital of Münster, Germany.

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February 2007

FLT3-ITD-, but not BCR/ABL-transformed cells require concurrent Akt/mTor blockage to undergo apoptosis after histone deacetylase inhibitor treatment.

Blood 2006 Mar 22;107(5):2094-7. Epub 2005 Nov 22.

Universitätsklinikum Marburg und Giessen, Standort Marburg, Klinik für Hämatologie, Onkologie, und Immunologie, Marburg, Germany.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-08-33
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http://dx.doi.org/10.1182/blood-2005-08-3317DOI Listing
March 2006

Transcriptional profiling of human hematopoiesis during in vitro lineage-specific differentiation.

Stem Cells 2005 Sep 13;23(8):1154-69. Epub 2005 Jun 13.

Department of Hematology, Oncology and Transfusion Medicine, University Hospital Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.

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http://dx.doi.org/10.1634/stemcells.2004-0171DOI Listing
September 2005

Mechanisms of resistance to natural killer cell-mediated cytotoxicity in acute lymphoblastic leukemia.

Exp Hematol 2005 Mar;33(3):344-52

Center for Internal Medicine, Department of Hematology/Oncology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1016/j.exphem.2004.11.006DOI Listing
March 2005

Development of hygromas or severe edema during treatment with the tyrosine kinase inhibitor STI571 is not associated with platelet-derived growth factor receptor (PDGFR) gene polymorphisms.

Leuk Res 2004 Nov;28(11):1153-7

Department of Hematology and Oncology, Medizinische Klinik III, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt a.M., Germany.

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http://dx.doi.org/10.1016/j.leukres.2004.03.007DOI Listing
November 2004

Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia.

Haematologica 2004 Apr;89(4):419-26

Med. Klinik III/Abtl. Hämatologie, Johann Wolfgang Goethe-Universität, 60590 Frankfurt, Germany.

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April 2004

Mechanisms of resistance to STI571 (Imatinib) in Philadelphia-chromosome positive acute lymphoblastic leukemia.

Leuk Lymphoma 2004 Apr;45(4):655-60

Department of Hematology and Oncology, University Hospital, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1080/10428190310001625755DOI Listing
April 2004

Regulation of human IL-18 gene expression: interaction of PU.1 with GC-box binding protein is involved in human IL-18 expression in myeloid cells.

Eur J Immunol 2004 Mar;34(3):817-826

Department of Hematology, Johann Wolfgang Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1002/eji.200324420DOI Listing
March 2004

p53-independent anti-tumor effects of the nitrogen-containing bisphosphonate zoledronic acid.

Cancer Sci 2004 Feb;95(2):186-92

Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Sakyo-ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2004.tb03202.xDOI Listing
February 2004

Antiproliferative efficacy of the third-generation bisphosphonate, zoledronic acid, combined with other anticancer drugs in leukemic cell lines.

Int J Hematol 2004 Jan;79(1):37-43

Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.

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http://dx.doi.org/10.1007/bf02983531DOI Listing
January 2004

Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis.

Oncogene 2003 Oct;22(44):6900-8

Med. Klinik III/Abtl. Hämatologie, Johann Wolfgang Goethe-Universität, D-60590 Frankfurt, Germany.

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http://dx.doi.org/10.1038/sj.onc.1206747DOI Listing
October 2003

The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate.

Blood 2003 Sep 22;102(6):2229-35. Epub 2003 May 22.

Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, 54 Kawahara-cho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1182/blood-2003-01-0305DOI Listing
September 2003

The ABL tyrosine kinase inhibitor STI571 (Glivec) in Philadelphia positive acute lymphoblastic leukemia - promises, pitfalls and possibilities.

Hematol J 2002 ;3(1):2-6

Medizinische Klinik III, Department of Hematology and Oncology, Johann Wolfgang Goethe-Universität, Frankfurt, Germany.

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http://dx.doi.org/10.1038/sj.thj.6200151DOI Listing
July 2003

Comparison of TaqMan real-time PCR and p24 Elisa for quantification of in vitro HIV-1 replication.

J Virol Methods 2003 Feb;107(2):169-75

Medizinische Klinik III der Johann Wolfgang Goethe Universität, Theodor-Stern Kai 7, D-60590, Frankfurt, Germany.

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http://dx.doi.org/10.1016/s0166-0934(02)00230-6DOI Listing
February 2003

Imatinib in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia: current status and evolving concepts.

Best Pract Res Clin Haematol 2002 Dec;15(4):757-69

Medizinische Klinik III, Abteilung für Hämatologie und Onkologie, Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, D-60590, Frankfurt, Germany.

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http://dx.doi.org/10.1053/beha.2002.0233DOI Listing
December 2002

Targeted therapies in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia.

Semin Hematol 2002 Oct;39(4 Suppl 3):32-7

Department of Hematology Oncology, University of Frankfurt, Frankfurt, Germany.

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http://dx.doi.org/10.1053/shem.2002.36927DOI Listing
October 2002

Expression of interleukin-18 receptor in fibroblast-like synoviocytes.

Arthritis Res 2002 14;4(2):139-44. Epub 2001 Nov 14.

Rheumazentrum Rhein-Main, Marienburgstrasse 2, D-60528 Frankfurt, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC83844PMC
http://dx.doi.org/10.1186/ar390DOI Listing
June 2002

Folinic acid antagonizes methotrexate-induced differentiation of monocyte progenitors.

Rheumatol Int 2002 Jun 20;22(2):60-7. Epub 2002 Apr 20.

Medizinische Klinik III, Klinikum der Johann Wolfgang, Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt/M., Germany.

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http://dx.doi.org/10.1007/s00296-002-0188-9DOI Listing
June 2002

Coordination of cell growth in cocultures by a genetic proliferation control system.

Biotechnol Bioeng 2002 May;78(3):346-52

Department of Gene Regulation and Differentiation, German Research Center for Biotechnology, D-38124 Braunschweig, Germany.

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http://dx.doi.org/10.1002/bit.10196DOI Listing
May 2002

Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation.

Blood 2002 Mar;99(5):1860-2

Division of Hematology/Oncology, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1182/blood.v99.5.1860DOI Listing
March 2002

[Therapy of Philadelphia chromosome positive acute lymphatic leukemia (Ph+ ALL) with an inhibitor of abl-tyrosine kinase (Glivec)].

Med Klin (Munich) 2002 Jan;97 Suppl 1:16-21

Abteilung Hämatologie/Onkologie, Medizinische Klinik III der Johann-Wolfgang-Goethe-Universität Frankfurt/Main.

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January 2002