Oliver Eickelberg

Oliver Eickelberg

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Oliver Eickelberg

Publications by authors named "Oliver Eickelberg"

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Altered relaxation times in MRI indicate bronchopulmonary dysplasia.

Thorax 2020 Feb 2;75(2):184-187. Epub 2019 May 2.

Department of Neonatology, Perinatal Center Grosshadern, Dr von Hauner Children's Hospital, Ludwig Maximilian University of Munich, Munich, Germany

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http://dx.doi.org/10.1136/thoraxjnl-2018-212384DOI Listing
February 2020

CX3CR1-fractalkine axis drives kinetic changes of monocytes in fibrotic interstitial lung diseases.

Eur Respir J 2020 Feb 20;55(2). Epub 2020 Feb 20.

Comprehensive Pneumology Center, Ludwig-Maximilians University (LMU), University Hospital Grosshadern, and Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany

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http://dx.doi.org/10.1183/13993003.00460-2019DOI Listing
February 2020

The Oncogene ECT2 Contributes to a Hyperplastic, Proliferative Lung Epithelial Cell Phenotype in Idiopathic Pulmonary Fibrosis.

Am J Respir Cell Mol Biol 2019 Dec;61(6):713-726

Lung Repair and Regeneration, Comprehensive Pneumology Center, Ludwig Maximilians University, University Hospital Großhadern, and Helmholtz Zentrum München, Member of the German Center for Lung Research, Munich, Germany.

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http://dx.doi.org/10.1165/rcmb.2019-0047OCDOI Listing
December 2019

Proteasome activator PA200 regulates myofibroblast differentiation.

Sci Rep 2019 Oct 23;9(1):15224. Epub 2019 Oct 23.

Comprehensive Pneumology Center (CPC), University Hospital of the Ludwig-Maximilians-University (LMU) and Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Max-Lebsche Platz 31, 81377, Munich, Germany.

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http://dx.doi.org/10.1038/s41598-019-51665-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811633PMC
October 2019

Three Is Better than One: An Improved Multiple-Hit Model of Primary Graft Dysfunction.

Am J Respir Cell Mol Biol 2019 Aug;61(2):141-142

1Division of Pulmonary Sciences and Critical Care MedicineUniversity of Colorado Anschutz Medical CampusAurora, Colorado.

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http://dx.doi.org/10.1165/rcmb.2019-0082EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670037PMC
August 2019

Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.

Authors:
Camille Moore Rachel Z Blumhagen Ivana V Yang Avram Walts Julie Powers Tarik Walker Makenna Bishop Pamela Russell Brian Vestal Jonathan Cardwell Cheryl R Markin Susan K Mathai Marvin I Schwarz Mark P Steele Joyce Lee Kevin K Brown James E Loyd James D Crapo Edwin K Silverman Michael H Cho Judith A James Joel M Guthridge Joy D Cogan Jonathan A Kropski Jeffrey J Swigris Carol Bair Dong Soon Kim Wonjun Ji Hocheol Kim Jin Woo Song Lisa A Maier Karin A Pacheco Nikhil Hirani Azin S Poon Feng Li R Gisli Jenkins Rebecca Braybrooke Gauri Saini Toby M Maher Philip L Molyneaux Peter Saunders Yingze Zhang Kevin F Gibson Daniel J Kass Mauricio Rojas John Sembrat Paul J Wolters Harold R Collard John S Sundy Thomas O'Riordan Mary E Strek Imre Noth Shwu-Fan Ma Mary K Porteous Maryl E Kreider Namrata B Patel Yoshikazu Inoue Masaki Hirose Toru Arai Shinobu Akagawa Oliver Eickelberg Isis Enlil Fernandez Jürgen Behr Nesrin Mogulkoc Tamera J Corte Ian Glaspole Sara Tomassetti Claudia Ravaglia Venerino Poletti Bruno Crestani Raphael Borie Caroline Kannengiesser Helen Parfrey Christine Fiddler Doris Rassl Maria Molina-Molina Carlos Machahua Ana Montes Worboys Gunnar Gudmundsson Helgi J Isaksson David J Lederer Anna J Podolanczuk Sydney B Montesi Elisabeth Bendstrup Vivi Danchel Moises Selman Annie Pardo Michael T Henry Michael P Keane Peter Doran Martina Vašáková Martina Sterclova Christopher J Ryerson Pearce G Wilcox Tsukasa Okamoto Haruhiko Furusawa Yasunari Miyazaki Geoffrey Laurent Svetlana Baltic Cecilia Prele Yuben Moodley Barry S Shea Ken Ohta Maho Suzukawa Osamu Narumoto Steven D Nathan Drew C Venuto Merte L Woldehanna Nurdan Kokturk Joao A de Andrade Tracy Luckhardt Tejaswini Kulkarni Francesco Bonella Seamus C Donnelly Aoife McElroy Michelle E Armstong Alvaro Aranda Roberto G Carbone Francesco Puppo Kenneth B Beckman Deborah A Nickerson Tasha E Fingerlin David A Schwartz

Am J Respir Crit Care Med 2019 07;200(2):199-208

1 National Jewish Health, Denver, Colorado.

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http://dx.doi.org/10.1164/rccm.201810-1891OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635791PMC
July 2019

Defining the Cell Types That Drive Idiopathic Pulmonary Fibrosis Using Single-Cell RNA Sequencing.

Am J Respir Crit Care Med 2019 Jun;199(12):1454-1456

1 Department of Medicine University of Colorado Anschutz Medical Campus Denver, Colorado.

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http://dx.doi.org/10.1164/rccm.201901-0197EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580670PMC
June 2019

The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease.

EBioMedicine 2019 May 4;43:562-575. Epub 2019 May 4.

Comprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.03.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562022PMC
May 2019

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung.

J Vis Exp 2019 05 20(147). Epub 2019 May 20.

Department of Medicine, University of Colorado Denver;

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http://dx.doi.org/10.3791/59450DOI Listing
May 2019

Ezrin in Asthma: A First Step to Early Biomarkers of Airway Epithelial Dysfunction.

Am J Respir Crit Care Med 2019 Feb;199(4):408-410

1 Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Anschutz Medical Campus Denver, Colorado.

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http://dx.doi.org/10.1164/rccm.201810-1964EDDOI Listing
February 2019

Dissecting the molecular effects of cigarette smoke on proteasome function.

J Proteomics 2019 02 14;193:1-9. Epub 2018 Dec 14.

Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians University, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2018.12.015DOI Listing
February 2019

Inhibition of B cell-dependent lymphoid follicle formation prevents lymphocytic bronchiolitis after lung transplantation.

JCI Insight 2019 02 7;4(3). Epub 2019 Feb 7.

Comprehensive Pneumology Center, Member of the German Center for Lung Research, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Ludwig-Maximilians University Munich, Munich Germany.

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http://dx.doi.org/10.1172/jci.insight.123971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413786PMC
February 2019

Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis.

Am J Physiol Lung Cell Mol Physiol 2018 11 28;315(5):L682-L696. Epub 2018 Jun 28.

Comprehensive Pneumology Center, University Hospital of the Ludwig-Maximilians University, Munich and Helmholtz Zentrum München, Member of the Comprehensive Pneumology Center-Munich BioArchive, Member of the German Center for Lung Research , Munich , Germany.

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http://dx.doi.org/10.1152/ajplung.00439.2017DOI Listing
November 2018

Pharmacometabolic response to pirfenidone in pulmonary fibrosis detected by MALDI-FTICR-MSI.

Eur Respir J 2018 09 15;52(3). Epub 2018 Sep 15.

Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.

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http://dx.doi.org/10.1183/13993003.02314-2017DOI Listing
September 2018

Preservation with α-antitrypsin improves primary graft function of murine lung transplants.

J Heart Lung Transplant 2018 08 30;37(8):1021-1028. Epub 2018 Mar 30.

Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München and University Hospital of the Ludwig-Maximilians University, Munich, Germany; German Center for Lung Research, Munich, Germany; Max Planck Institute of Neurobiology, Planegg-Martinsried, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183142
Publisher Site
http://dx.doi.org/10.1016/j.healun.2018.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078707PMC
August 2018

Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures.

Am J Physiol Lung Cell Mol Physiol 2018 05 18;314(5):L708-L723. Epub 2018 Jan 18.

Division of Respiratory Sciences and Critical Care Medicine, University of Colorado , Denver, Colorado.

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http://dx.doi.org/10.1152/ajplung.00408.2017DOI Listing
May 2018

Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.

Am J Physiol Lung Cell Mol Physiol 2018 05 4;314(5):L695-L707. Epub 2018 Jan 4.

Comprehensive Pneumology Center, University Hospital of the Ludwig-Maximilians-University Munich and Helmholtz Zentrum München, Member of the CPC-M BioArchive, Member of the German Center for Lung Research (DZL) , Munich , Germany.

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http://dx.doi.org/10.1152/ajplung.00205.2017DOI Listing
May 2018

Breaking the In Vitro Barrier in Respiratory Medicine. Engineered Microphysiological Systems for Chronic Obstructive Pulmonary Disease and Beyond.

Am J Respir Crit Care Med 2018 04;197(7):869-875

1 Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado; and.

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http://dx.doi.org/10.1164/rccm.201709-1795PPDOI Listing
April 2018

Epithelial Progenitor Cells Take Center Stage in Lung Transplantation.

Am J Respir Crit Care Med 2018 04;197(8):981-983

1 Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Anschutz Medical Campus, Aurora, Colorado and.

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http://dx.doi.org/10.1164/rccm.201712-2557EDDOI Listing
April 2018

FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis.

Respir Res 2018 04 19;19(1):67. Epub 2018 Apr 19.

Comprehensive Pneumology Center, Ludwig-Maximilians-Universität and Helmholtz Zentrum Munich, Max-Lebsche-Platz 31, 81377, Munich, Germany.

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http://dx.doi.org/10.1186/s12931-018-0768-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909279PMC
April 2018

Overproduction of growth differentiation factor 15 promotes human rhinovirus infection and virus-induced inflammation in the lung.

Am J Physiol Lung Cell Mol Physiol 2018 03 30;314(3):L514-L527. Epub 2017 Nov 30.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health , Denver, Colorado.

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http://dx.doi.org/10.1152/ajplung.00324.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048458PMC
March 2018

FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis.

EMBO Mol Med 2018 02;10(2):276-293

Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany

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http://dx.doi.org/10.15252/emmm.201606261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801513PMC
February 2018

microRNA cluster 106a~363 is involved in T helper 17 cell differentiation.

Immunology 2017 11 28;152(3):402-413. Epub 2017 Jul 28.

Comprehensive Pneumology Centre, Helmholtz Zentrum München, University Hospital of the Ludwig Maximilians University, Member of the German Centre for Lung Research, Munich, Germany.

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http://dx.doi.org/10.1111/imm.12775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629441PMC
November 2017

Pulmonary CCR2CD4 T cells are immune regulatory and attenuate lung fibrosis development.

Thorax 2017 11 5;72(11):1007-1020. Epub 2017 Aug 5.

Comprehensive Pneumology Center, Helmholtz Center Munich Germany, Member of the German Center for Lung Research (DZL), Munich, Germany.

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http://dx.doi.org/10.1136/thoraxjnl-2016-208423DOI Listing
November 2017

Recovery from Critical Illness: Physical Rehabilitation in the Intensive Care Unit, Timing of Persistent Critical Illness, and Caregiver Outcomes.

Am J Respir Crit Care Med 2017 10;196(8):1068-1070

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, Colorado.

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http://dx.doi.org/10.1164/rccm.201704-0828RRDOI Listing
October 2017

Systems medicine advances in interstitial lung disease.

Eur Respir Rev 2017 Sep 27;26(145). Epub 2017 Sep 27.

Comprehensive Pneumology Center, Ludwig-Maximilians-Universität, University Hospital Grosshadern and Helmholtz Zentrum München and Member of the German Center for Lung Research, Munich, Germany

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http://dx.doi.org/10.1183/16000617.0021-2017DOI Listing
September 2017

The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease.

Eur Respir J 2017 07 5;50(1). Epub 2017 Jul 5.

Division of Respiratory Sciences and Critical Care Medicine, University of Colorado, Denver, CO, USA.

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http://dx.doi.org/10.1183/13993003.01805-2016DOI Listing
July 2017

D-tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease.

J Allergy Clin Immunol 2017 May 23;139(5):1525-1535. Epub 2016 Sep 23.

Comprehensive Pneumology Center, Ludwig Maximilians University Hospital, Member of the German Center for Lung Research (DZL), and Helmholtz Zentrum München, Munich, Germany; Division of Experimental Asthma Research, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Member of the German Center for Lung Research (DZL), Borstel, Germany; Institute for Experimental Medicine, Christian-Albrechts-Universitaet zu Kiel, Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.09.003DOI Listing
May 2017

Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma.

Sci Rep 2017 04 6;7:46026. Epub 2017 Apr 6.

Early origins of chronic lung disease, Priority Area Asthma &Allergy, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Borstel, Germany.

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http://dx.doi.org/10.1038/srep46026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382551PMC
April 2017

X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice.

Sci Rep 2017 03 24;7(1):402. Epub 2017 Mar 24.

Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, 85748, Garching, Germany.

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http://dx.doi.org/10.1038/s41598-017-00489-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428469PMC
March 2017

Detecting Swelling States of Red Blood Cells by "Cell-Fluid Coupling Spectroscopy".

Adv Sci (Weinh) 2017 02 13;4(2):1600238. Epub 2016 Oct 13.

Photonics and Optoelectronics Group Department of Physics and Center for Nanoscience Ludwig-Maximilians-Universität Amalienstr. 5480799 Munich Germany; Photonics and Optoelectronics Group Nanosystems Initiative Munich (NIM) Schellingstraße 480799 Munich Germany.

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http://dx.doi.org/10.1002/advs.201600238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323883PMC
February 2017

Nasal high flow reduces dead space.

J Appl Physiol (1985) 2017 01 17;122(1):191-197. Epub 2016 Nov 17.

HELIOS Klinik Hagen-Ambrock, Witten-Herdecke University, Hagen, Germany.

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http://dx.doi.org/10.1152/japplphysiol.00584.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283847PMC
January 2017

Validating Metal-Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications.

Adv Healthc Mater 2017 Jan 15;6(2). Epub 2016 Nov 15.

Comprehensive Pneumology Center (CPC), University Hospital, University of Munich (LMU), Member of the German Center for Lung Research (DZL), 81377, Munich, Germany.

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http://dx.doi.org/10.1002/adhm.201600818DOI Listing
January 2017

Cigarette smoke alters the secretome of lung epithelial cells.

Proteomics 2017 01;17(1-2)

Comprehensive, Pneumology Center (CPC), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), University Hospital, Ludwig-Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1002/pmic.201600243DOI Listing
January 2017

Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.

J Exp Med 2017 01 15;214(1):143-163. Epub 2016 Dec 15.

Comprehensive Pneumology Center, Research Unit Lung Repair and Regeneration, Helmholtz Center Munich, Ludwig Maximilians University Munich, University Hospital Grosshadern, 81377 Munich, Germany

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http://dx.doi.org/10.1084/jem.20160675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206496PMC
January 2017

Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection.

Part Fibre Toxicol 2017 01 10;14(1). Epub 2017 Jan 10.

Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Ingolstädter Landstr. 1, D-85764, Neuherberg, Germany.

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http://dx.doi.org/10.1186/s12989-016-0181-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223553PMC
January 2017

A novel role of MMP-13 for murine DC function: its inhibition dampens T-cell activation.

Int Immunol 2016 10 26;28(10):473-487. Epub 2016 Feb 26.

Comprehensive Pneumology Center, University Hospital of the Ludwig-Maximilians-University Munich, Asklepios Kliniken Gauting and Helmholtz Zentrum München, Member of the German Center for Lung Research, 81377 Munich, Germany Department of Respiratory Diseases, Klinik Augustinum München, 81375 Munich, Germany

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http://dx.doi.org/10.1093/intimm/dxw008DOI Listing
October 2016

Peripheral blood myeloid-derived suppressor cells reflect disease status in idiopathic pulmonary fibrosis.

Eur Respir J 2016 10 1;48(4):1171-1183. Epub 2016 Sep 1.

Comprehensive Pneumology Center, Ludwig-Maximilians-University, University Hospital Grosshadern, and Helmholtz Zentrum München, Member of the German Center for Lung Research, Munich, Germany

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http://dx.doi.org/10.1183/13993003.01826-2015DOI Listing
October 2016

Facilitated Diagnosis of Pneumothoraces in Newborn Mice Using X-ray Dark-Field Radiography.

Invest Radiol 2016 10;51(10):597-601

From the *Institute of Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Munich; †Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, Garching; and ‡Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München and Ludwig-Maximilians-University Hospital Munich, Munich, Germany.

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http://dx.doi.org/10.1097/RLI.0000000000000285DOI Listing
October 2016

Immune Mechanisms in Pulmonary Fibrosis.

Am J Respir Cell Mol Biol 2016 09;55(3):309-22

1 Pediatric Infectiology, Immunology, and Cystic Fibrosis, Children's Hospital of the University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1165/rcmb.2016-0121TRDOI Listing
September 2016

Cigarette smoke causes acute airway disease and exacerbates chronic obstructive lung disease in neonatal mice.

Am J Physiol Lung Cell Mol Physiol 2016 09 22;311(3):L602-10. Epub 2016 Jul 22.

Comprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany;

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http://dx.doi.org/10.1152/ajplung.00124.2016DOI Listing
September 2016

Repositioning compounds from cancer drug discovery to IPF: PI3K inhibition.

Thorax 2016 08 15;71(8):675-6. Epub 2016 Jun 15.

Comprehensive Pneumology Center, University Hospital, Ludwig-Maximilians-University and Helmholtz Zentrum München, Munich, Germany.

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http://dx.doi.org/10.1136/thoraxjnl-2016-208680DOI Listing
August 2016

Exercise Reduces Lung Fibrosis Involving Serotonin/Akt Signaling.

Med Sci Sports Exerc 2016 07;48(7):1276-84

1Laboratory of Pulmonary and Exercise Immunology, Nove de Julho University, São Paulo, BRAZIL; 2Laboratory of Experimental Therapeutics, School of Medicine, University of São Paulo, São Paulo, BRAZIL; 3COPD and Asthma Research Group, Department of Pneumology, University Hospital Freiburg, Freiburg, GERMANY; 4Laboratory of Cellular Biology, School of Medicine, University of Sao Paulo, São Paulo, BRAZIL; 5Comprehensive Pneumology Centre, University Hospital of the Ludwig Maximilians University Munich, Munich, GERMANY; 6Laboratory of Immunopharmacology, Institute Oswaldo Cruz, Oswaldo Cruz Foundation, Rio de Janeiro, BRAZIL; and 7Laboratory of Experimental Air Pollution, Department of Pathology, School of Medicine, University of Sao Paulo, São Paulo, BRAZIL.

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http://dx.doi.org/10.1249/MSS.0000000000000907DOI Listing
July 2016

Inhibition of Proteasome Activity Induces Formation of Alternative Proteasome Complexes.

J Biol Chem 2016 Jun 18;291(25):13147-59. Epub 2016 Apr 18.

From the Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians University, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), 81377 Munich, Germany,

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http://dx.doi.org/10.1074/jbc.M116.717652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933230PMC
June 2016

Inflammaging increases susceptibility to cigarette smoke-induced COPD.

Oncotarget 2016 May;7(21):30068-83

Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), 85764 Neuherberg, Germany.

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http://dx.doi.org/10.18632/oncotarget.4027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058664PMC
May 2016

Validation of the 2nd Generation Proteasome Inhibitor Oprozomib for Local Therapy of Pulmonary Fibrosis.

PLoS One 2015 4;10(9):e0136188. Epub 2015 Sep 4.

Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians University, Helmholtz Zentrum München, Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136188PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560391PMC
May 2016

Surface proteome analysis identifies platelet derived growth factor receptor-alpha as a critical mediator of transforming growth factor-beta-induced collagen secretion.

Int J Biochem Cell Biol 2016 May 22;74:44-59. Epub 2016 Feb 22.

Comprehensive Pneumology Center, University Hospital of the Ludwig-Maximilians-University Munich and Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.02.013DOI Listing
May 2016

Systematic phenotyping and correlation of biomarkers with lung function and histology in lung fibrosis.

Am J Physiol Lung Cell Mol Physiol 2016 05 18;310(10):L919-27. Epub 2016 Mar 18.

Comprehensive Pneumology Center, University Hospital of the Ludwig Maximilians University and Helmholtz Zentrum München, Munich, Germany

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http://dx.doi.org/10.1152/ajplung.00183.2015DOI Listing
May 2016

Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction.

Mediators Inflamm 2015 31;2015:408935. Epub 2015 Mar 31.

Department of Pediatric Pulmonology, Hauner Children's Hospital, Ludwig Maximilians University, The German Center for Lung Research (DZL), 80377 Munich, Germany ; Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1155/2015/408935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397025PMC
February 2016

Metabolomics screening identifies reduced L-carnitine to be associated with progressive emphysema.

Clin Sci (Lond) 2016 Feb 12;130(4):273-87. Epub 2015 Nov 12.

Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany

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http://www.clinsci.org/content/ppclinsci/130/4/273.full.pdf
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http://clinsci.org/cgi/doi/10.1042/CS20150438
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February 2016

Pharmacokinetic and pharmacometabolomic study of pirfenidone in normal mouse tissues using high mass resolution MALDI-FTICR-mass spectrometry imaging.

Histochem Cell Biol 2016 Feb 8;145(2):201-11. Epub 2015 Dec 8.

Research Unit Analytical Pathology, German Research Center for Environmental Health (GmbH), Helmholtz Zentrum München, Neuherberg, Germany.

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http://link.springer.com/content/pdf/10.1007%2Fs00418-015-13
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http://link.springer.com/10.1007/s00418-015-1382-7
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http://dx.doi.org/10.1007/s00418-015-1382-7DOI Listing
February 2016

Coactivator-Associated Arginine Methyltransferase-1 Function in Alveolar Epithelial Senescence and Elastase-Induced Emphysema Susceptibility.

Am J Respir Cell Mol Biol 2015 Dec;53(6):769-81

1 Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research, Neuherberg, Germany.

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http://dx.doi.org/10.1165/rcmb.2014-0216OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455466PMC
December 2015

Computer-aided diagnosis of pulmonary diseases using x-ray darkfield radiography.

Phys Med Biol 2015 Dec 18;60(24):9253-68. Epub 2015 Nov 18.

Department of Applied Mathematics and Computer Science, Technical University of Denmark, Richard Petersens Plads, Building 324, 2800 Kgs. Lyngby, Denmark.

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http://dx.doi.org/10.1088/0031-9155/60/24/9253DOI Listing
December 2015

Improved In vivo Assessment of Pulmonary Fibrosis in Mice using X-Ray Dark-Field Radiography.

Sci Rep 2015 Dec 1;5:17492. Epub 2015 Dec 1.

Lehrstuhl für Biomedizinische Physik, Physik-Department &Institut für Medizintechnik, Technische Universität München, Garching, Germany.

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http://dx.doi.org/10.1038/srep17492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664921PMC
December 2015

Aging and Lung Disease. Clinical Impact and Cellular and Molecular Pathways.

Ann Am Thorac Soc 2015 Dec;12(12):S222-7

4 Comprehensive Pneumology Center, Ludwig-Maximilians-University and Helmholtz Zentrum München, Munich, Germany.

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http://dx.doi.org/10.1513/AnnalsATS.201508-484PLDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137674PMC
December 2015

Regulation of 26S Proteasome Activity in Pulmonary Fibrosis.

Am J Respir Crit Care Med 2015 Nov;192(9):1089-101

1 Comprehensive Pneumology Center (CPC), University Hospital of the Ludwig-Maximilians University (LMU), LMU, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

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http://dx.doi.org/10.1164/rccm.201412-2270OCDOI Listing
November 2015

Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures.

Eur Respir J 2015 Oct 30;46(4):1150-66. Epub 2015 Apr 30.

Comprehensive Pneumology Center, Helmholtz Center Munich, Ludwig Maximilians University Munich, University Hospital Grosshadern, Member of the German Center for Lung Research (DZL), Munich, Germany

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http://dx.doi.org/10.1183/09031936.00183214DOI Listing
October 2015

Proteasome function is not impaired in healthy aging of the lung.

Aging (Albany NY) 2015 Oct;7(10):776-92

Comprehensive Pneumology Center (CPC), University Hospital Ludwig-Maximilians University, Helmholtz Zentrum München, Munich, Member of the German Center for Lung Research (DZL), Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637206PMC
http://dx.doi.org/10.18632/aging.100820DOI Listing
October 2015

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Authors:
Martin Hrabě de Angelis George Nicholson Mohammed Selloum Jacqui White Hugh Morgan Ramiro Ramirez-Solis Tania Sorg Sara Wells Helmut Fuchs Martin Fray David J Adams Niels C Adams Thure Adler Antonio Aguilar-Pimentel Dalila Ali-Hadji Gregory Amann Philippe André Sarah Atkins Aurelie Auburtin Abdel Ayadi Julien Becker Lore Becker Elodie Bedu Raffi Bekeredjian Marie-Christine Birling Andrew Blake Joanna Bottomley Mike Bowl Véronique Brault Dirk H Busch James N Bussell Julia Calzada-Wack Heather Cater Marie-France Champy Philippe Charles Claire Chevalier Francesco Chiani Gemma F Codner Roy Combe Roger Cox Emilie Dalloneau André Dierich Armida Di Fenza Brendan Doe Arnaud Duchon Oliver Eickelberg Chris T Esapa Lahcen El Fertak Tanja Feigel Irina Emelyanova Jeanne Estabel Jack Favor Ann Flenniken Alessia Gambadoro Lilian Garrett Hilary Gates Anna-Karin Gerdin George Gkoutos Simon Greenaway Lisa Glasl Patrice Goetz Isabelle Goncalves Da Cruz Alexander Götz Jochen Graw Alain Guimond Wolfgang Hans Geoff Hicks Sabine M Hölter Heinz Höfler John M Hancock Robert Hoehndorf Tertius Hough Richard Houghton Anja Hurt Boris Ivandic Hughes Jacobs Sylvie Jacquot Nora Jones Natasha A Karp Hugo A Katus Sharon Kitchen Tanja Klein-Rodewald Martin Klingenspor Thomas Klopstock Valerie Lalanne Sophie Leblanc Christoph Lengger Elise le Marchand Tonia Ludwig Aline Lux Colin McKerlie Holger Maier Jean-Louis Mandel Susan Marschall Manuel Mark David G Melvin Hamid Meziane Kateryna Micklich Christophe Mittelhauser Laurent Monassier David Moulaert Stéphanie Muller Beatrix Naton Frauke Neff Patrick M Nolan Lauryl Mj Nutter Markus Ollert Guillaume Pavlovic Natalia S Pellegata Emilie Peter Benoit Petit-Demoulière Amanda Pickard Christine Podrini Paul Potter Laurent Pouilly Oliver Puk David Richardson Stephane Rousseau Leticia Quintanilla-Fend Mohamed M Quwailid Ildiko Racz Birgit Rathkolb Fabrice Riet Janet Rossant Michel Roux Jan Rozman Ed Ryder Jennifer Salisbury Luis Santos Karl-Heinz Schäble Evelyn Schiller Anja Schrewe Holger Schulz Ralf Steinkamp Michelle Simon Michelle Stewart Claudia Stöger Tobias Stöger Minxuan Sun David Sunter Lydia Teboul Isabelle Tilly Glauco P Tocchini-Valentini Monica Tost Irina Treise Laurent Vasseur Emilie Velot Daniela Vogt-Weisenhorn Christelle Wagner Alison Walling Bruno Weber Olivia Wendling Henrik Westerberg Monja Willershäuser Eckhard Wolf Anne Wolter Joe Wood Wolfgang Wurst Ali Önder Yildirim Ramona Zeh Andreas Zimmer Annemarie Zimprich Chris Holmes Karen P Steel Yann Herault Valérie Gailus-Durner Ann-Marie Mallon Steve Dm Brown

Nat Genet 2015 Sep 27;47(9):969-978. Epub 2015 Jul 27.

MRC Harwell, Medical Research Council, Harwell, UK.

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http://dx.doi.org/10.1038/ng.3360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564951PMC
September 2015

Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells.

Dis Model Mech 2015 Aug 14;8(8):877-90. Epub 2015 May 14.

Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, University Hospital, Ludwig-Maximilians University, 81377 Munich, Member of the German Center for Lung Research (DZL), Germany

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.019117
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http://dx.doi.org/10.1242/dmm.019117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527283PMC
August 2015

Multidimensional immunolabeling and 4D time-lapse imaging of vital ex vivo lung tissue.

Am J Physiol Lung Cell Mol Physiol 2015 Aug 19;309(4):L323-32. Epub 2015 Jun 19.

Comprehensive Pneumology Center, University Hospital of the Ludwig-Maximilians-University Munich and Helmholtz Zentrum München, Member of the German Center for Lung Research, Munich, Germany; and.

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http://dx.doi.org/10.1152/ajplung.00061.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538231PMC
August 2015

Validated prediction of pro-invasive growth factors using a transcriptome-wide invasion signature derived from a complex 3D invasion assay.

Sci Rep 2015 Aug 5;5:12673. Epub 2015 Aug 5.

Comprehensive Pneumology Center, University Hospital of the Ludwig-Maximilians-University Munich and Helmholtz Zentrum München, Member of the German Center for Lung Research, 81377 Munich, Germany.

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http://dx.doi.org/10.1038/srep12673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525140PMC
August 2015

In Vivo Dark-Field Radiography for Early Diagnosis and Staging of Pulmonary Emphysema.

Invest Radiol 2015 Jul;50(7):430-5

From the *Institute of Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Munich; †Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, Garching; ‡Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München and Ludwig-Maximilians-University Hospital Munich, Munich, Germany; §German Center for Lung Research (DZL), Munich, Germany; ¶Medical Radiation Physics, Lund University, Lund, Sweden; and ¶Department of Radiology, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1097/RLI.0000000000000147DOI Listing
July 2015

Time- and compartment-resolved proteome profiling of the extracellular niche in lung injury and repair.

Mol Syst Biol 2015 Jul 14;11(7):819. Epub 2015 Jul 14.

Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547847PMC
http://dx.doi.org/10.15252/msb.20156123DOI Listing
July 2015

Regulation of immunoproteasome function in the lung.

Sci Rep 2015 May 19;5:10230. Epub 2015 May 19.

Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians University, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

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http://dx.doi.org/10.1038/srep10230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437306PMC
May 2015

Hallmarks of the ageing lung.

Eur Respir J 2015 Mar 5;45(3):807-27. Epub 2015 Feb 5.

Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians-University and Helmholtz Zentrum München, Munich, Germany Member of the German Center for Lung Research (DZL).

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http://dx.doi.org/10.1183/09031936.00186914DOI Listing
March 2015

Protease-mediated release of chemotherapeutics from mesoporous silica nanoparticles to ex vivo human and mouse lung tumors.

ACS Nano 2015 Mar 2;9(3):2377-89. Epub 2015 Mar 2.

‡Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstrasse 5-13(E), 81377 Munich, Germany.

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http://dx.doi.org/10.1021/nn5070343DOI Listing
March 2015

Characteristic patterns in the fibrotic lung. Comparing idiopathic pulmonary fibrosis with chronic lung allograft dysfunction.

Ann Am Thorac Soc 2015 Mar;12 Suppl 1:S34-41

1 Comprehensive Pneumology Center, University Hospital of Ludwig Maximilians University Munich and Helmholtz Zentrum München, Member of the German Center for Lung Research, Munich, Germany; and.

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http://dx.doi.org/10.1513/AnnalsATS.201410-476MGDOI Listing
March 2015

Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface.

Sci Rep 2015 Feb 2;5:8163. Epub 2015 Feb 2.

Comprehensive Pneumology Center, Institute of Lung Biology and Disease, University Hospital, Ludwig-Maximilians-University and Helmholtz Zentrum München, Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377 Munich, Germany.

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http://dx.doi.org/10.1038/srep08163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313097PMC
February 2015

A first glimpse at the early origins of idiopathic pulmonary fibrosis.

Am J Respir Crit Care Med 2015 Feb;191(4):366-8

1 Comprehensive Pneumology Center Helmholtz Zentrum München, Member of the German Center for Lung Research Munich, Germany.

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http://dx.doi.org/10.1164/rccm.201412-2187EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351600PMC
February 2015

Cigarette smoke extract affects mitochondrial function in alveolar epithelial cells.

Am J Physiol Lung Cell Mol Physiol 2014 Dec 17;307(11):L895-907. Epub 2014 Oct 17.

Comprehensive Pneumology Center (CPC), University Hospital Ludwig-Maximilians University, Helmholtz Zentrum München, Munich, Member of the German Center for Lung Research (DZL), Germany

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http://dx.doi.org/10.1152/ajplung.00180.2014DOI Listing
December 2014