Publications by authors named "Olga N Kozyreva"

4 Publications

  • Page 1 of 1

Hyperammonemic Encephalopathy Associated With Fibrolamellar Hepatocellular Carcinoma: Case Report, Literature Review, and Proposed Treatment Algorithm.

Oncologist 2016 Apr 14;21(4):514-20. Epub 2016 Mar 14.

Dana-Farber Cancer Institute at St. Elizabeth's Medical Center, Boston, Massachusetts, USA

Unlabelled: We report a case of a 31-year-old man with metastatic fibrolamellar hepatocellular carcinoma (FLHCC) treated with gemcitabine and oxaliplatin complicated by hyperammonemic encephalopathy biochemically consistent with acquired ornithine transcarbamylase deficiency. Awareness of FLHCC-associated hyperammonemic encephalopathy and a pathophysiology-based management approach can optimize patient outcome and prevent serious complications. A discussion of the management, literature review, and proposed treatment algorithm of this rare metabolic complication are presented.

Implications For Practice: Pathophysiology-guided management of cancer-associated hyperammonemic encephalopathy can improve patient outcome and prevent life-threatening complications. Community and academic oncologists should be aware of this serious metabolic complication of cancer and be familiar with its management.
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http://dx.doi.org/10.1634/theoncologist.2015-0267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828114PMC
April 2016

Skeletal Muscle Metastases in a Patient With Neuroendocrine Tumor.

World J Oncol 2013 Apr 6;4(2):114-117. Epub 2013 May 6.

St. Elizabeth Medical Center, 736 Cambridge St, Boston, MA 02135, USA.

Carcinoid tumors are rare but diverse group of malignancies that arise from neuroendocrine cells. Skeletal muscle metastasis is exceedingly rare and is associated with a poor prognosis. We report a case of carcinoid tumor of the ileocecal with skeletal muscle metastasis. We also review available case reports of carcinoid tumors metastasizing to the muscle.
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http://dx.doi.org/10.4021/wjon609wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649678PMC
April 2013

A multicenter retrospective study on clinical characteristics, treatment patterns, and outcome in elderly patients with hepatocellular carcinoma.

Oncologist 2011 24;16(3):310-8. Epub 2011 Feb 24.

Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

Background: There is a paucity of information on the clinical presentation and outcome of elderly hepatocellular carcinoma (HCC) patients. We performed a multicenter retrospective comparative study to assess the impact of age on potential differences in clinical characteristics, treatment patterns, and outcome in HCC patients.

Methods: We retrospectively analyzed HCC patients treated at two U.S. tertiary institutions from 1998 to 2008. Demographics, tumor parameters, etiology and severity of cirrhosis, treatment, and survival from diagnosis were collected and analyzed. After exclusion of transplanted patients, survival analyses were performed using the Kaplan-Meier method with log-rank tests and Cox proportional hazards models.

Results: Three hundred thirty-five HCC patients were divided into two groups: "elderly" (95 patients, age ≥ 70 years) and "younger" (240 patients, aged <70 years). The male/female (M/F) ratio was 5.8:1 and 1.7:1 in the younger and elderly groups, respectively (p < .0001). Hepatitis C virus (HCV) infection rate was 48.3% in younger and 21.1% in elderly patients (p < .0001); Child class B and C cirrhosis accounted for 35.8% in younger and 25.3% in elderly patients (p = .063). Compared with younger patients, the elderly received transplant less frequently (19.6% versus 5.3%, p = .0002) and were more likely to receive supportive care only (22.9% versus 36.8%, p = .01). No significant differences between the two age groups were seen in tumor parameters or other treatments received. Overall (p = .47) and HCC-specific survival rates (p = .38) were similar in both age groups.

Conclusions: Characteristics that distinguish elderly from younger HCC patients include lower M/F ratio, worse performance status, lower rate of HCV infection, and less advanced underlying cirrhosis. Elderly patients were less likely to have a liver transplant and more likely to receive supportive care only. However, overall and HCC-specific survival were similar between the two groups.
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http://dx.doi.org/10.1634/theoncologist.2010-0223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228108PMC
August 2011

Asymptomatic muscle metastases from esophageal adenocarcinoma.

J Clin Oncol 2007 Aug;25(24):3780-3

Division of Hematology and Oncology, Sylvester Comprehensive Cancer Center, Miami, FL, USA.

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http://dx.doi.org/10.1200/JCO.2007.12.1962DOI Listing
August 2007