Olga Millán

Monitoring of gene expression in tacrolimus-treated de novo renal allograft recipients facilitates individualized immunosuppression - results of the IMAGEN study.

Authors:

Claudia Sommerer Mercè Brunet Klemens Budde Olga Millán Lluis Guirado Perich Petra Glander Stefan Meuer Martin Zeier Thomas Giese

Br J Clin Pharmacol 2021 Feb 23. Epub 2021 Feb 23.

Institute of Immunology, University Hospital Heidelberg, Heidelberg, Germany.

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February 2021

Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients.

Authors:

Luis Quintairos Helena Colom Olga Millán Virginia Fortuna Cristina Espinosa Lluis Guirado Klemens Budde Claudia Sommerer Ana Lizana Yolanda López-Púa Mercè Brunet

PLoS One 2021 22;16(1):e0245880. Epub 2021 Jan 22.

Pharmacology and Toxicology Laboratory, Biochemistry and Molecular Genetics, Biomedical Diagnostic Center (CDB), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.

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January 2021

Pharmacokinetics and pharmacogenetics of sorafenib in patients with hepatocellular carcinoma: Implications for combination trials.

Authors:

Álvaro Díaz-González Víctor Sapena Loreto Boix Mercè Brunet Ferrán Torres Neus LLarch Esther Samper Olga Millán Josep Corominas Gemma Iserte Marco Sanduzzi-Zamparelli Leonardo G da Fonseca Anna Darnell Ernest Belmonte Alejandro Forner Carmen Ayuso Jordi Bruix María Reig

Liver Int 2020 10 25;40(10):2476-2488. Epub 2020 Jul 25.

BCLC group. Liver Unit, Hospital Clínic de Barcelona. IDIBAPS. CIBERehd, University of Barcelona, Barcelona, Spain.

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October 2020

MicroRNAs 155-5p, 122-5p, and 181a-5p Identify Patients With Graft Dysfunction Due to T Cell-Mediated Rejection After Liver Transplantation.

Authors:

Pablo Ruiz Olga Millán Jose Ríos Alba Díaz Lydia Sastre Jordi Colmenero Gonzalo Crespo Mercè Brunet Miquel Navasa

Liver Transpl 2020 10 2;26(10):1275-1286. Epub 2020 Sep 2.

Liver Transplant Unit, Hospital Clínic Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain.

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October 2020

Nuclear factor of activated T cells as potential pharmacodynamic biomarker for the risk of acute and subclinical rejection in de novo liver recipients.

Authors:

Olga Millán Pablo Ruiz Virginia Fortuna Miquel Navasa Mercè Brunet

Liver Int 2020 04 22;40(4):931-946. Epub 2020 Jan 22.

Biomedical Research Centre in Hepatic and Digestive Diseases (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.

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April 2020

Monitoring of miR-181a-5p and miR-155-5p Plasmatic Expression as Prognostic Biomarkers for Acute and Subclinical Rejection in Adult Liver Transplant Recipients.

Authors:

Olga Millán Pablo Ruiz Lara Orts Paula Ferré Gonzalo Crespo Miguel Santana Virginia Fortuna Luís Quintairos Miguel Navasa Mercè Brunet

Front Immunol 2019 24;10:873. Epub 2019 Apr 24.

Biomedical Research Center in Hepatic and Digestive Diseases (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.

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October 2020

Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report.

Ther Drug Monit 2019 06;41(3):261-307

Department of Pharmacology, Oslo University Hospital, Oslo, Norway.

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June 2019

Pharmacodynamic Monitoring of mTOR Inhibitors.

Authors:

Olga Millán Eberhard Wieland Pierre Marquet Mercè Brunet

Ther Drug Monit 2019 04;41(2):160-167

Pharmacology and Toxicology Laboratory, Biomedical Diagnostic Center (CDB), CIBERehd, IDIBAPS, Hospital Clínic of Barcelona, University of Barcelona, Barcelona, Spain.

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April 2019

Influence of donor liver CYP3A4*20 loss-of-function genotype on tacrolimus pharmacokinetics in transplanted patients.

Authors:

Miguel A Gómez-Bravo María Apellaniz-Ruiz Magdalena Salcedo Constantino Fondevila Francisco Suarez José Castellote Sebastián Rufian José A Pons Itxarone Bilbao José M Alamo Olga Millán Mercè Brunet Cristina Rodríguez-Antona

Pharmacogenet Genomics 2018 02;28(2):41-48

Rare Diseases Networking Biomedical Research Centre (CIBERER).

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February 2018

Urinary miR-155-5p and CXCL10 as prognostic and predictive biomarkers of rejection, graft outcome and treatment response in kidney transplantation.

Authors:

Olga Millán Klemens Budde Claudia Sommerer Irene Aliart Olesja Rissling Beatriz Bardaji Maaren Matz Martin Zeier Irene Silva Lluis Guirado Mercè Brunet

Br J Clin Pharmacol 2017 12 21;83(12):2636-2650. Epub 2017 Sep 21.

Pharmacology and Toxicology Laboratory, CDB, IDIBAPS, Hospital Clinic of Barcelona, University of Barcelona, Spain.

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December 2017

Pharmacodynamics of T cell function for monitoring pharmacologic immunosuppression after allogeneic hematopoietic stem cell transplantation.

Authors:

Carmen Martínez Olga Millán Montserrat Rovira Francesc Fernández-Avilés Anna López María Suárez-Lledó Enric Carreras Álvaro Urbano-Ispízua Mercè Brunet

Int J Hematol 2017 Apr 23;105(4):497-505. Epub 2016 Nov 23.

Pharmacology and Toxicology Department, Biomedical Diagnostic Center, Hospital Clínic, University of Barcelona, Barcelona, Spain.

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April 2017

High expression of CD38, CD69, CD95 and CD154 biomarkers in cultured peripheral T lymphocytes correlates with an increased risk of acute rejection in liver allograft recipients.

Authors:

Francisco Boix Olga Millan David San Segundo Esther Mancebo Antoni Rimola Emilio Fabrega Virginia Fortuna Anna Mrowiec Maria J Castro-Panete Jesus de la Peña Santiago Llorente Alfredo Minguela Jose M Bolarin Estela Paz-Artal Marcos Lopez-Hoyos Mercé Brunet Manuel Muro

Immunobiology 2016 May 25;221(5):595-603. Epub 2016 Jan 25.

Immunology Service, Clinical University Hospital ́Virgen de la Arrixacá-IMIB (Murcian Institute of Biomedical Investigation), Murcia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain. Electronic address:

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May 2016

High proportion of CD95(+) and CD38(+) in cultured CD8(+) T cells predicts acute rejection and infection, respectively, in kidney recipients.

Authors:

Esther Mancebo María José Castro Luís M Allende Paloma Talayero Mercè Brunet Olga Millán Luís Guirado Marcos López-Hoyos David San Segundo Emilio Rodrigo Pedro Muñoz Francisco Boix Giner Santiago Llorente Viñas Manuel Muro-Amador Estela Paz-Artal

Transpl Immunol 2016 Feb 7;34:33-41. Epub 2016 Jan 7.

Immunology Department, Hospital Universitario 12 de Octubre, Madrid, Spain; Research Institute, Hospital Universitario 12 de Octubre, Madrid, Spain.

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February 2016

High frequency of central memory regulatory T cells allows detection of liver recipients at risk of early acute rejection within the first month after transplantation.

Authors:

Francisco Boix-Giner Olga Millan David San Segundo Pedro Muñoz-Cacho Esther Mancebo Santiago Llorente Lourdes Rafael-Valdivia Antoni Rimola Emilio Fábrega Anna Mrowiec Luis Allende Alfredo Minguela Jose M Bolarín Estela Paz-Artal Marcos López-Hoyos Mercé Brunet Manuel Muro

Int Immunol 2016 Feb 12;28(2):55-64. Epub 2015 Aug 12.

Servicio de Inmunología, Hospital Clínico Universitario Virgen de la Arrixaca, IMIB, Murcia, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain

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February 2016

High proportion of pretransplantation activated regulatory T cells (CD4+CD25highCD62L+CD45RO+) predicts acute rejection in kidney transplantation: results of a multicenter study.

Authors:

David San Segundo Olga Millán Pedro Muñoz-Cacho Francisco Boix Estela Paz-Artal Paloma Talayero José María Morales Manuel Muro María Ángeles De Cos Lluis Guirado Santiago Llorente Julio Pascual Manuel Arias Mercè Brunet Marcos López-Hoyos

Transplantation 2014 Dec;98(11):1213-8

1 Servicio de Inmunología, Hospital Universitario Marqués de Valdecilla-IFIMAV, Santander, Spain. 2 Farmacología y Toxicología, Centro de Diagnóstico Biomédico, IDIBAPS, Hospital Clínico, Universidad de Barcelona, Barcelona, Spain. 3 Servicio de Epidemiología, Gerencia de Atención Primaria-IFIMAV, Santander, Spain. 4 Servicio de Inmunología, Hospital Universitario Virgen Arrixaca, Murcia, Spain. 5 Instituto de Investigación del Hospital 12 de Octubre, Servicio de Inmunología Hospital 12 de Octubre, Facultad de Medicina Universidad Complutense de Madrid, Universidad CEU San Pablo, Madrid, Spain. 6 Instituto de Investigación del Hospital 12 de Octubre, Servicio de Inmunología Hospital 12 de Octubre, Madrid, Spain. 7 Instituto de Investigación del Hospital 12 de Octubre, Servicio de Nefrología Hospital 12 de Octubre, Facultad de Medicina Universidad Complutense de Madrid, Madrid, Spain. 8 Farmacología Clínica, Hospital Universitario Marqués de Valdecilla-IFIMAV, Santander, Spain. 9 Unidad de Trasplante Renal, Servicio de Nefrologia, Fundació Puigvert, Barcelona, Spain. 10 Servicio de Nefrologia, Hospital Universitario Virgen Arrixaca, Murcia, Spain. 11 Servicio de Nefrología, Hospital del Mar, Barcelona, Spain. 12 Servicio de Nefrología, Hospital Universitario Marqués de Valdecilla-IFIMAV, Santander, Spain. 13 Address correspondence to: Marcos López-Hoyos, M.D., Ph.D., Servicio de Inmunología. Hospital Universitario Marqués de Valdecilla. Avenida Valdecilla s/n. CP 39008. Santander, Cantabria, Spain.

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December 2014