Publications by authors named "Oleksandra Havryliuk"

4 Publications

  • Page 1 of 1

Effectiveness of psychopharmacotherapy in psoriasis patients with associated anxiety and depression.

Dermatol Ther 2020 11 20;33(6):e14292. Epub 2020 Sep 20.

Central Michigan University, College of Medicine, Saginaw, Michigan, USA.

Psoriasis is associated with psychological comorbidities. We evaluated the effectiveness of additional psychopharmacotherapy on the clinical severity and associated anxiety and depression in psoriasis. 173 patients were enrolled with psoriasis and associated anxiety and depression. Spielberger State-Trait Anxiety Inventory (STAI) and The Beck Depression Scale (BDI) were used to assess anxiety and depression parameters. The IA main group included patients with anxiety disorders who received Mebicar. The IB main group consisted of patients with anxiety and depressive disorders who received Mianserin. The II group comprised patients with anxiety disorders (IIA comparison group) and patients with anxiety and depressive disorders (IIB comparison group), who received only traditional therapy. The level of anxiety in patients of the IA and IB main groups decreased by 2.1 times. The level of depression in the IB main group significantly decreased by 1.7 times, while in the IIB comparison group, this indicator remained almost at the same level. Patients of the IA and IB main groups had PASI50 on average on 15 to 16 days of treatment. PASI50 was achieved in the both comparison groups only at 21 to 22 days. PASI75 occurred in the IA and IIB main groups almost simultaneously on 28 to 29 days of treatment. But in the IIA and IIB comparison groups, these positive changes occurred significantly later than in patients of the main groups (on 34-35 days of treatment). Additional psychopharmacotherapy significantly reduced anxiety and depression in both groups IA and IB, as compared to patients in groups IIA and IIB who received only traditional therapy.
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http://dx.doi.org/10.1111/dth.14292DOI Listing
November 2020

Possible role of vitamin d in pathogenesis of lichenoid dermatoses (a review of literature).

Wiad Lek 2020 ;73(2):365-369

Kharkiv National Medical University, Kharkiv, Ukraine.

Objective: The aim of the study was search and analysis of the data of review, experimental and clinical scientific and medical publications on the issues of the possible role of VD inpathogenesis of lichenoid dermatoses.

Patients And Methods: Materials and methods: An analysis of the studying of the scientific and medical literature was shown. Searching was carried out through the PubMed/MEDLINE portal from the databases of the National Center Biotechnology Information, Web of Science Core Collection, U. S. National Library of Medicine, National Institute for Health and Clinical Excellence, as well as the portals «Scientific Electronic Library eLIBRARY.RU», «Russian Science Citation Index (RSCI)» and «Index Copernicus».

Conclusion: Conclusions: The results of studies had convincingly demonstrated that deficiency of VD in the blood, decrease vitamin D receptors activity can lead to development of lichenoid dermatoses.
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May 2020

Psychodermatology in Ukraine and Belarus: an Eastern European perspective.

Int J Dermatol 2020 May 24;59(5):e151-e153. Epub 2019 Oct 24.

Department of Dermatology and Venereology, Vitebsk State Medical University, Vitebsk, Belarus.

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http://dx.doi.org/10.1111/ijd.14677DOI Listing
May 2020

LICHEN PLANUS AND COMORBID CONDITIONS (A REVIEW OF LITERATURE) LISZAJ PŁASKI I CHOROBY WSPÓŁISTNIEJĄCE (PRZEGLĄD LITERATURY).

Wiad Lek 2019 ;72(3):447-451

Kharkiv National Medical University, Kharkiv, Ukraine.

Objective: Introduction: The studying of the comorbidity of skin diseases is a priority scientific direction in modern dermatology. Comorbid conditions aggravate the course of the underlying disease, reduce the effectiveness of diagnosis and treatment can lead to chronization of the process, disability of patients. Understanding of the commonality of pathogenesis and the mutually complicating nature of comorbidity makes a possible to prescribe individual rational treatment. The aim of the study was search and analysis of the data of review, experimental and clinical scientific and medical publications on the issues of the comorbidity of LP.

Patients And Methods: Materials and methods: an analysis of the studying of the scientific and medical literature was shown. Searching was carried out through the PubMed/MEDLINE portal from the databases of the National Center Biotechnology Information, U. S. National Library of Medicine, National Institute for Health and Clinical Excellence, as well as the portals «Scientific Electronic Library eLIBRARY.RU», «Russian Science Citation Index (RSCI)» and «Index Copernicus».

Conclusion: Conclusions: The main global trends of comorbidity of LP are determined. The results of these studies can form the basis for updating of clinical guidelines for the management of patients with LP at the international and local levels.
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August 2019
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