Publications by authors named "Oleg V Tsodikov"

81Publications

Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer.

Biomedicines 2021 Jan 12;9(1). Epub 2021 Jan 12.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Lexington, University of Kentucky Markey Cancer Center, Lexington, KY 40536, USA.

View Article and Find Full Text PDF
January 2021

Allosteric Interference in Oncogenic FLI1 and ERG Transactions by Mithramycins.

Structure 2020 Dec 2. Epub 2020 Dec 2.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

View Article and Find Full Text PDF
December 2020

Mithramycin 2'-Oximes with Improved Selectivity, Pharmacokinetics, and Ewing Sarcoma Antitumor Efficacy.

J Med Chem 2020 11 16;63(22):14067-14086. Epub 2020 Nov 16.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.

View Article and Find Full Text PDF
November 2020

Structural Insight into the DNA Binding Function of Transcription Factor ERF.

Biochemistry 2020 Nov 11. Epub 2020 Nov 11.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.

View Article and Find Full Text PDF
November 2020

Unimodular Methylation by Adenylation-Thiolation Domains Containing an Embedded Methyltransferase.

J Mol Biol 2020 Oct 11;432(21):5802-5808. Epub 2020 Sep 11.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, USA. Electronic address:

View Article and Find Full Text PDF
October 2020

Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from .

ACS Chem Biol 2020 06 18;15(6):1581-1594. Epub 2020 May 18.

Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536-0596, United States.

View Article and Find Full Text PDF
June 2020

Combining Chalcones with Donepezil to Inhibit Both Cholinesterases and Aβ Fibril Assembly.

Molecules 2019 Dec 24;25(1). Epub 2019 Dec 24.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, USA.

View Article and Find Full Text PDF
December 2019

Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis.

Angew Chem Int Ed Engl 2020 01 27;59(2):826-832. Epub 2019 Nov 27.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536-0596, USA.

View Article and Find Full Text PDF
January 2020

Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis.

ACS Infect Dis 2019 10 21;5(10):1772-1778. Epub 2019 Aug 21.

Department of Pharmaceutical Sciences, College of Pharmacy , University of Kentucky , 789 South Limestone Street , Lexington , Kentucky 40536-0596 , United States.

View Article and Find Full Text PDF
October 2019

How mithramycin stereochemistry dictates its structure and DNA binding function.

Medchemcomm 2019 May 28;10(5):735-741. Epub 2019 Mar 28.

University of Kentucky , Department of Pharmaceutical Sciences , College of Pharmacy , Lexington , KY 40536-0596 , USA . Email: ; Email:

View Article and Find Full Text PDF
May 2019

Publisher Correction: Unusual substrate and halide versatility of phenolic halogenase PltM.

Nat Commun 2019 Apr 30;10(1):2053. Epub 2019 Apr 30.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA.

View Article and Find Full Text PDF
April 2019

Unusual substrate and halide versatility of phenolic halogenase PltM.

Nat Commun 2019 03 19;10(1):1255. Epub 2019 Mar 19.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA.

View Article and Find Full Text PDF
March 2019

Utilizing guanine-coordinated Zn ions to determine DNA crystal structures by single-wavelength anomalous diffraction.

Acta Crystallogr D Struct Biol 2019 Jan 7;75(Pt 1):32-40. Epub 2019 Jan 7.

Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536, USA.

View Article and Find Full Text PDF
January 2019

Nucleoside triphosphate cosubstrates control the substrate profile and efficiency of aminoglycoside 3'--phosphotransferase type IIa.

Medchemcomm 2018 Aug 16;9(8):1332-1339. Epub 2018 Jul 16.

Department of Pharmaceutical Sciences , College of Pharmacy , University of Kentucky , Lexington , KY 40536-0596 , USA . Email: ; Email: ; ; Tel: +859 218 1686.

View Article and Find Full Text PDF
August 2018

A crystal structure of coil 1B of vimentin in the filamentous form provides a model of a high-order assembly of a vimentin filament.

FEBS J 2018 08 25;285(15):2888-2899. Epub 2018 Jun 25.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA.

View Article and Find Full Text PDF
August 2018

Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.

ACS Infect Dis 2018 06 30;4(6):1030-1040. Epub 2018 Mar 30.

Department of Pharmaceutical Sciences , University of Kentucky , Lee T. Todd, Jr. Building, 789 South Limestone Street , Lexington , Kentucky 40536-0596 , United States.

View Article and Find Full Text PDF
June 2018

Structures of the Catalytic Domain of Bacterial Primase DnaG in Complexes with DNA Provide Insight into Key Priming Events.

Biochemistry 2018 04 23;57(14):2084-2093. Epub 2018 Mar 23.

Department of Pharmaceutical Sciences, College of Pharmacy , University of Kentucky , Lexington , Kentucky 40536 , United States.

View Article and Find Full Text PDF
April 2018

Structural basis for backbone N-methylation by an interrupted adenylation domain.

Nat Chem Biol 2018 05 19;14(5):428-430. Epub 2018 Mar 19.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA.

View Article and Find Full Text PDF
May 2018

Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight.

Biochemistry 2018 02 18;57(5):781-790. Epub 2018 Jan 18.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky , Lexington, Kentucky 40536-0596, United States.

View Article and Find Full Text PDF
February 2018

Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents.

J Med Chem 2018 01 19;61(1):158-173. Epub 2017 Dec 19.

Department of Pharmaceutical Sciences, University of Kentucky , Lexington, Kentucky 40536-0596, United States.

View Article and Find Full Text PDF
January 2018

Deciphering Nature's Intricate Way of N,S-Dimethylating l-Cysteine: Sequential Action of Two Bifunctional Adenylation Domains.

Biochemistry 2017 11 7;56(46):6087-6097. Epub 2017 Nov 7.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky , Lexington, Kentucky 40536-0596, United States.

View Article and Find Full Text PDF
November 2017

Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors.

ACS Infect Dis 2017 04 17;3(4):302-309. Epub 2017 Feb 17.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky , 789 South Limestone Street, Lexington, Kentucky 40536-0596, United States.

View Article and Find Full Text PDF
April 2017

Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant .

ACS Med Chem Lett 2016 Dec 15;7(12):1219-1221. Epub 2016 Sep 15.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky , Lexington, Kentucky 40536, United States.

View Article and Find Full Text PDF
December 2016

Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis.

J Med Chem 2016 12 22;59(23):10619-10628. Epub 2016 Nov 22.

University of Kentucky , Department of Pharmaceutical Sciences, College of Pharmacy, 789 South Limestone St., Lexington, Kentucky 40536-0596, United States.

View Article and Find Full Text PDF
December 2016

In Vitro Assays to Identify Antibiotics Targeting DNA Metabolism.

Methods Mol Biol 2017 ;1520:175-200

Department of Pharmaceutical Sciences, University of Kentucky, 789 S. Limestone Street, Lexington, KY, 40536, USA.

View Article and Find Full Text PDF
January 2018

Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis.

ACS Chem Biol 2016 11 26;11(11):3084-3092. Epub 2016 Sep 26.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky , 789 South Limestone Street, Lexington, Kentucky 40536-0596, United States.

View Article and Find Full Text PDF
November 2016

Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.

Nucleic Acids Res 2016 Oct 1;44(18):8990-9004. Epub 2016 Sep 1.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA

View Article and Find Full Text PDF
October 2016

Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis.

ACS Chem Biol 2016 06 7;11(6):1639-46. Epub 2016 Apr 7.

Department of Pharmaceutical Sciences, University of Kentucky , Lexington, Kentucky 40536-0596, United States.

View Article and Find Full Text PDF
June 2016

Dimerization and DNA recognition rules of mithramycin and its analogues.

J Inorg Biochem 2016 Mar 18;156:40-7. Epub 2015 Dec 18.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

View Article and Find Full Text PDF
March 2016

Structural Basis for Dimerization and DNA Binding of Transcription Factor FLI1.

Biochemistry 2015 Dec 10;54(50):7365-74. Epub 2015 Dec 10.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky , 789 South Limestone Street, Lexington, Kentucky 40536-0596, United States.

View Article and Find Full Text PDF
December 2015

Par-4 secretion: stoichiometry of 3-arylquinoline binding to vimentin.

Org Biomol Chem 2016 Jan;14(1):74-84

Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536-0509, USA. and Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, USA.

View Article and Find Full Text PDF
January 2016

Crystal structure of halogenase PltA from the pyoluteorin biosynthetic pathway.

J Struct Biol 2015 Dec 28;192(3):349-357. Epub 2015 Sep 28.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536-0596, USA. Electronic address:

View Article and Find Full Text PDF
December 2015

Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis.

J Struct Biol 2015 Oct 19;192(1):76-87. Epub 2015 Aug 19.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

View Article and Find Full Text PDF
October 2015

Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones.

Org Biomol Chem 2015 Sep 6;13(36):9418-26. Epub 2015 Aug 6.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536-0596, USA.

View Article and Find Full Text PDF
September 2015

Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution.

BMC Struct Biol 2015 Jul 15;15:13. Epub 2015 Jul 15.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, 40536-0596, Lexington, KY, USA.

View Article and Find Full Text PDF
July 2015

Ambiguity of structure determination from a minimum of diffraction intensities.

Acta Crystallogr A Found Adv 2014 Jul 28;70(Pt 4):354-7. Epub 2014 May 28.

Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536, USA.

View Article and Find Full Text PDF
July 2014

Determination of small crystal structures from a minimum set of diffraction intensities by homotopy continuation.

Acta Crystallogr A Found Adv 2015 May 25;71(Pt 3):319-24. Epub 2015 Apr 25.

Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536, USA.

View Article and Find Full Text PDF
May 2015

Structural insight into MtmC, a bifunctional ketoreductase-methyltransferase involved in the assembly of the mithramycin trisaccharide chain.

Biochemistry 2015 Apr 7;54(15):2481-9. Epub 2015 Apr 7.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, Kentucky 40536-0596, United States.

View Article and Find Full Text PDF
April 2015

Structure of inorganic pyrophosphatase from Staphylococcus aureus reveals conformational flexibility of the active site.

J Struct Biol 2015 Feb 7;189(2):81-6. Epub 2015 Jan 7.

Department of Pharmaceutical Sciences, University of Kentucky, College of Pharmacy, 789 S. Limestone St., Lexington, KY 40536, United States. Electronic address:

View Article and Find Full Text PDF
February 2015

Antimycobacterial activity of DNA intercalator inhibitors of Mycobacterium tuberculosis primase DnaG.

J Antibiot (Tokyo) 2015 Mar 24;68(3):153-7. Epub 2014 Sep 24.

Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA.

View Article and Find Full Text PDF
March 2015

2',6'-Dihalostyrylanilines, pyridines, and pyrimidines for the inhibition of the catalytic subunit of methionine S-adenosyltransferase-2.

J Med Chem 2014 Jul 9;57(14):6083-91. Epub 2014 Jul 9.

Department of Molecular and Cellular Biochemistry, ‡Department of Pharmaceutical Sciences, College of Pharmacy, §Center for Pharmaceutical Research and Innovation, and ∥Markey Cancer Center, University of Kentucky , Lexington, Kentucky 40506-0509, United States.

View Article and Find Full Text PDF
July 2014

A random sequential mechanism of aminoglycoside acetylation by Mycobacterium tuberculosis Eis protein.

PLoS One 2014 3;9(4):e92370. Epub 2014 Apr 3.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, BioPharm Complex, Lexington, Kentucky, United States of America.

View Article and Find Full Text PDF
January 2015

Chemical and structural insights into the regioversatility of the aminoglycoside acetyltransferase Eis.

Chembiochem 2013 Nov 17;14(16):2127-35. Epub 2013 Sep 17.

Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109 (USA); Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 (USA).

View Article and Find Full Text PDF
November 2013

Probing the protein-folding mechanism using denaturant and temperature effects on rate constants.

Proc Natl Acad Sci U S A 2013 Oct 16;110(42):16784-9. Epub 2013 Sep 16.

Departments of Chemistry, Biochemistry, and Bacteriology, University of Wisconsin, Madison, WI 53706.

View Article and Find Full Text PDF
October 2013

Discovery of inhibitors of Bacillus anthracis primase DnaG.

Biochemistry 2013 Oct 19;52(39):6905-10. Epub 2013 Sep 19.

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan , Ann Arbor, Michigan 48109, United States.

View Article and Find Full Text PDF
October 2013

Quantifying additive interactions of the osmolyte proline with individual functional groups of proteins: comparisons with urea and glycine betaine, interpretation of m-values.

Biochemistry 2013 Sep 21;52(35):5997-6010. Epub 2013 Aug 21.

Department of Biochemistry and ‡Department of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States.

View Article and Find Full Text PDF
September 2013

Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis.

Proc Natl Acad Sci U S A 2013 Jul 25;110(28):11320-5. Epub 2013 Jun 25.

Division of Mycobacterial Research, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom.

View Article and Find Full Text PDF
July 2013

DksA2, a zinc-independent structural analog of the transcription factor DksA.

FEBS Lett 2013 Mar 14;587(6):614-9. Epub 2013 Feb 14.

Department of Microbiology, The Ohio State University, Columbus, OH, USA.

View Article and Find Full Text PDF
March 2013

A novel non-radioactive primase-pyrophosphatase activity assay and its application to the discovery of inhibitors of Mycobacterium tuberculosis primase DnaG.

Nucleic Acids Res 2013 Feb 24;41(4):e56. Epub 2012 Dec 24.

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
February 2013

An insertion in the catalytic trigger loop gates the secondary channel of RNA polymerase.

J Mol Biol 2013 Jan 9;425(1):82-93. Epub 2012 Nov 9.

Department of Microbiology and The Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
January 2013

New insights into fluoroquinolone resistance in Mycobacterium tuberculosis: functional genetic analysis of gyrA and gyrB mutations.

PLoS One 2012 28;7(6):e39754. Epub 2012 Jun 28.

Laboratory Branch, Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.

View Article and Find Full Text PDF
January 2013

Aminoglycoside multiacetylating activity of the enhanced intracellular survival protein from Mycobacterium smegmatis and its inhibition.

Biochemistry 2012 Jun 5;51(24):4959-67. Epub 2012 Jun 5.

Life Sciences Institute, 210 Washtenaw Avenue, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

View Article and Find Full Text PDF
June 2012

Enumeration of one-dimensional crystal structures obtained from a minimum of diffraction intensities.

Acta Crystallogr A 2012 May 6;68(Pt 3):313-8. Epub 2012 Mar 6.

Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
May 2012

The structural basis for substrate versatility of chloramphenicol acetyltransferase CATI.

Protein Sci 2012 Apr 6;21(4):520-30. Epub 2012 Mar 6.

Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

View Article and Find Full Text PDF
April 2012

Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB.

Proc Natl Acad Sci U S A 2011 Jun 31;108(24):9804-8. Epub 2011 May 31.

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
June 2011

Structural and thermodynamic signatures of DNA recognition by Mycobacterium tuberculosis DnaA.

J Mol Biol 2011 Jul 18;410(3):461-76. Epub 2011 May 18.

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
July 2011

Conditional ambiguity of one-dimensional crystal structures determined from a minimum of diffraction intensity data.

Acta Crystallogr A 2011 May 25;67(Pt 3):292-6. Epub 2011 Mar 25.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.

View Article and Find Full Text PDF
May 2011

Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.

Structure 2010 Oct;18(10):1353-63

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
October 2010

An easy-to-use tool for planning and modeling a calorimetric titration.

Anal Biochem 2010 Nov 6;406(1):91-3. Epub 2010 Jul 6.

Department of Medicinal Chemistry, University of Michigan, Ann Arbor, 48109, USA.

View Article and Find Full Text PDF
November 2010

A new scaffold of an old protein fold ensures binding to the bisintercalator thiocoraline.

J Mol Biol 2010 Mar 1;397(2):495-507. Epub 2010 Feb 1.

Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
March 2010

The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways.

J Biol Chem 2010 Feb 23;285(6):3705-12. Epub 2009 Nov 23.

Department of Pharmacological Sciences and Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA.

View Article and Find Full Text PDF
February 2010

The tail of KdsC: conformational changes control the activity of a haloacid dehalogenase superfamily phosphatase.

J Biol Chem 2009 Oct 2;284(44):30594-603. Epub 2009 Sep 2.

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA.

View Article and Find Full Text PDF
October 2009

Exact and user-friendly kinetic analysis of the two-step rapid equilibrium Michaelis-Menten mechanism.

Anal Biochem 2009 Apr 21;387(2):276-9. Epub 2009 Jan 21.

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
April 2009

DNA-dependent ATPase activity of bacterial XPB helicases.

Biochemistry 2009 Mar;48(12):2839-48

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065, USA.

View Article and Find Full Text PDF
March 2009

A nonradioactive high-throughput assay for screening and characterization of adenylation domains for nonribosomal peptide combinatorial biosynthesis.

Anal Biochem 2009 Mar 24;386(2):244-50. Epub 2008 Dec 24.

Center for Chemical Genomics, High-Throughput Screening Laboratory, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
March 2009

Hexameric ring structure of the N-terminal domain of Mycobacterium tuberculosis DnaB helicase.

FEBS J 2008 Jun 8;275(12):3064-71. Epub 2008 May 8.

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
June 2008

Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA.

EMBO J 2007 Nov 18;26(22):4768-76. Epub 2007 Oct 18.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
November 2007

Domain-swapped dimerization of the HIV-1 capsid C-terminal domain.

Proc Natl Acad Sci U S A 2007 Mar 5;104(11):4353-8. Epub 2007 Mar 5.

Department of Pathology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA.

View Article and Find Full Text PDF
March 2007

A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.

Mol Cell 2006 Oct;24(2):279-91

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article and Find Full Text PDF
October 2006

Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1.

Proc Natl Acad Sci U S A 2005 Aug 2;102(32):11236-41. Epub 2005 Aug 2.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

View Article and Find Full Text PDF
August 2005

Organized unidirectional waves of ATP hydrolysis within a RecA filament.

PLoS Biol 2005 Feb 8;3(2):e52. Epub 2005 Feb 8.

Department of Biochemistry, University of Wisconsin, Madison, USA.

View Article and Find Full Text PDF
February 2005

Rapid quench mixing to quantify kinetics of steps in association of Escherichia coli RNA polymerase with promoter DNA.

Methods Enzymol 2003 ;370:535-46

Department of Chemistry, University of Wisconsin, 433 Babcock Drive, Madison, Wisconsin 53706-1544, USA.

View Article and Find Full Text PDF
February 2004

Interaction of RNA polymerase with forked DNA: evidence for two kinetically significant intermediates on the pathway to the final complex.

Proc Natl Acad Sci U S A 2002 Mar 12;99(6):3493-8. Epub 2002 Mar 12.

Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106-4935, USA.

View Article and Find Full Text PDF
March 2002