Dr. Oleg V Goloshchapov - R.M.Gorbacheva Memorial Institute of Oncology, Hematology and Transplantation, Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russian Federation - Dr

Dr. Oleg V Goloshchapov

R.M.Gorbacheva Memorial Institute of Oncology, Hematology and Transplantation, Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russian Federation

Dr

Saint-Petersburg, Saint-Petersburg | Russian Federation

Main Specialties: Anesthesiology, Critical Care Medicine, Infectious Disease, Pediatric Anesthesiology, Pediatric Critical Care Medicine, Pediatric Infectious Diseases, Pediatrics

Additional Specialties: Intensive care after HSCT

ORCID logohttps://orcid.org/0000-0002-0736-1269

Dr. Oleg V Goloshchapov - R.M.Gorbacheva Memorial Institute of Oncology, Hematology and Transplantation, Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russian Federation - Dr

Dr. Oleg V Goloshchapov

Introduction

Internship in Germany (Hamburg, Idar-Oberstein), Austria (Vienna).
20 years of experience in intensive care of patients after HSCT

Primary Affiliation: R.M.Gorbacheva Memorial Institute of Oncology, Hematology and Transplantation, Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russian Federation - Saint-Petersburg, Saint-Petersburg , Russian Federation

Specialties:

Additional Specialties:

Research Interests:

Publications

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FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICE

GOLOSHCHAPOV O.V., CHURAKINA D.V., KUCHER M.А., KLEMENTEVA R.V., SIDORENKO S.V., GOSTEV V.V., KAREV V.Е., SUVOROVA М.А., SHLYK I.V., CHUKHLOVIN А.B., ZUBAROVSKAYA L.S., AFANASYEV B.V. FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICE. Messenger of ANESTHESIOLO

Messenger of Anesthesiology and Resuscitation

FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICE

O. V. GOLOSHCHAPOV1, D. V. CHURAKINA1, M. А. KUCHER1, R. V. KLEMENTEVA1, S. V. SIDORENKO2, V. V. GOSTEV2, V. Е. KAREV2,

М. А. SUVOROVA3, I. V. SHLYK1, А. B. CHUKHLOVIN1, L. S. ZUBAROVSKAYA1, B. V. AFANASYEV1

1Raisa Gorbacheva Memorial Institute for Children Oncology, Hematology and Transplantation; Pavlov First St.Petersburg State Medical

University, St.Petersburg, Russia

2Pediatric Research and Clinical Center for Infectious Diseases, St.Petersburg, Russia

3The Explana Research Laboratory, St.Petersburg, Russia

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective method to treat malignancy and some solid tumors which may be

accompanied by life-threatening immune and infectious complications refractory to standard immunosuppressive and antibacterial therapy. According to

literature data, fecal microbiota transplantation (FMT) may be applied to restore functional activity of microbiota and to overcome antibiotic resistance.

Two clinical cases of FMT in critical ill patients who had developed acute graft-versus-host disease (aGvHD) of intestine after allo-HSCT are

presented in the article.

The aim of the study was to assess FMT efficiency and safety in immunocompromised critically ill patients.

Results. Following FMT, a complete regress of aGvHD signs as well as reduction of systemic infectious process were registered, due to probable

modulation of the immune response. In one patient, elimination from respiratory ways of carbapenemase-producing Klebsiella pneumoniae positive

for NDM- and OXA-48- producing was noted, like as elimination of Pseudomonas aeruginosa synthesizing KRS-type carbapenemase.

Conclusions. FMT may be considered an alternative approach to intestinal aGvHD treatment in critically ill patients after allo-HSCT.

View Article
January 2020
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