Publications by authors named "Oleg Butovsky"

59Publications

Correction to: Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy.

Acta Neuropathol Commun 2020 06 24;8(1):90. Epub 2020 Jun 24.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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June 2020

Vitamin D Regulates MerTK-Dependent Phagocytosis in Human Myeloid Cells.

J Immunol 2020 Jul 15;205(2):398-406. Epub 2020 Jun 15.

Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 0G4, Canada;

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July 2020

Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy.

Acta Neuropathol Commun 2020 05 19;8(1):72. Epub 2020 May 19.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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May 2020

Microglia, Lifestyle Stress, and Neurodegeneration.

Immunity 2020 02 7;52(2):222-240. Epub 2020 Jan 7.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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February 2020

Retinal microglia initiate neuroinflammation in ocular autoimmunity.

Proc Natl Acad Sci U S A 2019 05 25;116(20):9989-9998. Epub 2019 Apr 25.

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114;

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May 2019

Regulatory T Cells and Their Derived Cytokine, Interleukin-35, Reduce Pain in Experimental Autoimmune Encephalomyelitis.

J Neurosci 2019 03 16;39(12):2326-2346. Epub 2019 Jan 16.

School of Medical Sciences, The University of New South Wales, UNSW Sydney, Sydney, New South Wales 2052, Australia, and

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March 2019

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells.

Nat Commun 2018 11 19;9(1):4845. Epub 2018 Nov 19.

Applied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital Solna, Stockholm, 17176, Sweden.

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November 2018

Microglial signatures and their role in health and disease.

Nat Rev Neurosci 2018 10;19(10):622-635

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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October 2018

Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment.

Proc Natl Acad Sci U S A 2018 07 18;115(27):E6264-E6273. Epub 2018 Jun 18.

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114;

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July 2018

TREMendous 2 Be Social.

Immunity 2018 05;48(5):842-843

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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May 2018

Microglial Phenotypes and Functions in Multiple Sclerosis.

Cold Spring Harb Perspect Med 2018 02 1;8(2). Epub 2018 Feb 1.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

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February 2018

Laquinimod attenuates inflammation by modulating macrophage functions in traumatic brain injury mouse model.

J Neuroinflammation 2018 Jan 30;15(1):26. Epub 2018 Jan 30.

Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

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January 2018

Differential contribution of microglia and monocytes in neurodegenerative diseases.

J Neural Transm (Vienna) 2018 05 23;125(5):809-826. Epub 2017 Oct 23.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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May 2018

Microglial confetti party.

Nat Neurosci 2017 05;20(6):762-763

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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May 2017

Microglia Function in the Central Nervous System During Health and Neurodegeneration.

Annu Rev Immunol 2017 04 9;35:441-468. Epub 2017 Feb 9.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; email:

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April 2017

The brain parenchyma has a type I interferon response that can limit virus spread.

Proc Natl Acad Sci U S A 2017 01 15;114(1):E95-E104. Epub 2016 Dec 15.

Department of Genetics, Harvard Medical School, Boston, MA 02115;

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January 2017

Early life stress perturbs the maturation of microglia in the developing hippocampus.

Brain Behav Immun 2016 Oct 11;57:79-93. Epub 2016 Jun 11.

Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511, USA. Electronic address:

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October 2016

Depletion of microglia and inhibition of exosome synthesis halt tau propagation.

Nat Neurosci 2015 Nov 5;18(11):1584-93. Epub 2015 Oct 5.

Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.

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November 2015

Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency.

Glia 2015 Sep 2;63(9):1606-20. Epub 2015 Apr 2.

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven-University of Leuven, Cell Metabolism, Leuven, Belgium.

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September 2015

P2Y12 expression and function in alternatively activated human microglia.

Neurol Neuroimmunol Neuroinflamm 2015 Apr 19;2(2):e80. Epub 2015 Mar 19.

Division of BioMedical Sciences (C.S.M.), Neuroscience, Memorial University of Newfoundland and Labrador, St. John's, Newfoundland, Canada; Neuroimmunology Unit (C.S.M., A.A., A.K., V.T.S.R., M.M.-R., S.Y.L., P.S., A.B.-O., J.P.A.), Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Center for Neurologic Diseases (O.B.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Pathology and Molecular Medicine (S.K.L.), Queens University, Kingston, Ontario, Canada.

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April 2015

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

J Exp Med 2015 Mar 2;212(3):287-95. Epub 2015 Mar 2.

The Lerner Research Institute and Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH 44195 The Lerner Research Institute and Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH 44195 Case Western Reserve University, Cleveland, OH 44106

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March 2015

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

Ann Neurol 2015 Jan 27;77(1):75-99. Epub 2014 Nov 27.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02112.

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January 2015

Differential roles of microglia and monocytes in the inflamed central nervous system.

J Exp Med 2014 Jul 7;211(8):1533-49. Epub 2014 Jul 7.

Neuroinflammation Research Center and Department of Neurosciences, Lerner Research Institute; Department of Quantitative Health Sciences; and Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH 44106Neuroinflammation Research Center and Department of Neurosciences, Lerner Research Institute; Department of Quantitative Health Sciences; and Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH 44106 Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44106

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July 2014

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

J Clin Invest 2012 Sep 6;122(9):3063-87. Epub 2012 Aug 6.

Department of Neurology, Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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September 2012

Does inflammation in an autoimmune disease differ from inflammation in neurodegenerative diseases? Possible implications for therapy.

J Neuroimmune Pharmacol 2006 Mar;1(1):4-10

Department of Neurobiology, The Weizmann Institute of Science, 76100, Rehovot, Israel.

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March 2006

Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model.

Eur J Neurosci 2007 Jul 10;26(2):413-6. Epub 2007 Jul 10.

Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel.

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July 2007

Microglia can be induced by IFN-gamma or IL-4 to express neural or dendritic-like markers.

Mol Cell Neurosci 2007 Jul 1;35(3):490-500. Epub 2007 May 1.

Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel.

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July 2007

Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1.

Proc Natl Acad Sci U S A 2006 Aug 24;103(31):11784-9. Epub 2006 Jul 24.

Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.

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August 2006

Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood.

Nat Neurosci 2006 Feb 15;9(2):268-75. Epub 2006 Jan 15.

Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel.

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February 2006

Microglial phenotype: is the commitment reversible?

Trends Neurosci 2006 Feb 6;29(2):68-74. Epub 2006 Jan 6.

The Weizmann Institute of Science, POB 26, Rehovot, 76100, Israel.

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February 2006

The therapeutic window after spinal cord injury can accommodate T cell-based vaccination and methylprednisolone in rats.

Eur J Neurosci 2004 Jun;19(11):2984-90

Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel.

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June 2004