Ole Isacson

Ole Isacson

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Ole Isacson

Publications by authors named "Ole Isacson"

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Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells.

Stem Cells 2019 Oct 9;37(10):1293-1306. Epub 2019 Aug 9.

Department of Molecular Embryology, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1002/stem.3057DOI Listing
October 2019

Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts.

Hum Mol Genet 2019 Jul 1. Epub 2019 Jul 1.

Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1093/hmg/ddz126DOI Listing
July 2019

Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease.

J Neuroinflammation 2019 Jul 22;16(1):153. Epub 2019 Jul 22.

Neuroregeneration Research Institute, McLean Hospital/Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1186/s12974-019-1532-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647317PMC
July 2019

The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress.

Neurobiol Dis 2018 12 24;120:1-11. Epub 2018 Aug 24.

Neuroregeneration Research Institute, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont 02478, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748034PMC
December 2018

Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age.

Sci Rep 2018 10 12;8(1):15207. Epub 2018 Oct 12.

Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA, 02478, USA.

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http://www.nature.com/articles/s41598-018-33474-z
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http://dx.doi.org/10.1038/s41598-018-33474-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185981PMC
October 2018

Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain.

Neurobiol Aging 2018 07 29;67:189-200. Epub 2018 Mar 29.

Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.02.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015735PMC
July 2018

Increased motor neuron resilience by small molecule compounds that regulate IGF-II expression.

Neurobiol Dis 2018 02 4;110:218-230. Epub 2017 Nov 4.

Neuroregeneration Research Institute, McLean Hospital and Harvard Medical School, Belmont, MA, USA.

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http://dx.doi.org/10.1016/j.nbd.2017.11.002DOI Listing
February 2018

Parkinsonian monkeys with prior levodopa-induced dyskinesias followed by fetal dopamine precursor grafts do not display graft-induced dyskinesias.

J Comp Neurol 2017 02 29;525(3):498-512. Epub 2016 Aug 29.

Departments of Psychiatry and Neurosurgery, Yale University, New Haven, Connecticut, 06511.

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http://dx.doi.org/10.1002/cne.24081DOI Listing
February 2017

The Threshold Theory for Parkinson's Disease.

Trends Neurosci 2017 01 25;40(1):4-14. Epub 2016 Nov 25.

Neuroregeneration Research Institute, McLean Hospital, Belmont, MA 02478, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2016.10.008DOI Listing
January 2017

hVMAT2: A Target of Individualized Medication for Parkinson's Disease.

Neurotherapeutics 2016 07;13(3):623-34

Laboratory of Psychiatric Neurogenomics, Division of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA.

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http://dx.doi.org/10.1007/s13311-016-0435-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965405PMC
July 2016

α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.

Proc Natl Acad Sci U S A 2016 Feb 2;113(7):1931-6. Epub 2016 Feb 2.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegeneration, Charlestown, MA 02129; The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611;

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http://dx.doi.org/10.1073/pnas.1520335113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763774PMC
February 2016

Lysosomes to combat Parkinson's disease.

Authors:
Ole Isacson

Nat Neurosci 2015 Jun;18(6):792-3

Neuroregeneration Research Institute, Harvard Medical School, Harvard Stem Cell Institute and McLean Hospital, Belmont, Massachusetts, USA.

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http://dx.doi.org/10.1038/nn.4027DOI Listing
June 2015

Sorting the wheat from the chaff in dopamine neuron-based cell therapies.

Authors:
Ole Isacson

Proc Natl Acad Sci U S A 2015 Apr 6;112(15):4512-3. Epub 2015 Apr 6.

Neuroregeneration Research Institute, Center for Neuroregeneration Research, McLean Hospital/Harvard Medical School, Belmont, MA 02478

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http://dx.doi.org/10.1073/pnas.1503859112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403218PMC
April 2015

Progressive decline of glucocerebrosidase in aging and Parkinson's disease.

Ann Clin Transl Neurol 2015 Apr 6;2(4):433-8. Epub 2015 Feb 6.

Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital Belmont, Massachusetts, 02478.

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http://dx.doi.org/10.1002/acn3.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402088PMC
April 2015

Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease.

Cell Stem Cell 2015 Mar 26;16(3):269-74. Epub 2015 Feb 26.

Neuroregeneration Research Institute, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462124PMC
March 2015

Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95.

J Neurogenet 2014 Mar-Jun;28(1-2):98-111. Epub 2014 Apr 22.

New England Primate Research Center, Harvard Medical School , Southborough, Massachusetts , USA.

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http://dx.doi.org/10.3109/01677063.2014.892486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406490PMC
January 2015

ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress.

Exp Neurol 2014 Nov 4;261:217-29. Epub 2014 Jun 4.

Neuroregeneration Research Institute, McLean Hospital, Harvard Medical School, Belmont, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2014.05.024DOI Listing
November 2014

Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.

Hum Mol Genet 2014 Sep 12;23(17):4510-27. Epub 2014 Apr 12.

McLean Hospital/Harvard Medical School, Neuroregeneration Research Institute and Laboratories, Belmont, MA, USA

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http://dx.doi.org/10.1093/hmg/ddu166DOI Listing
September 2014

Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection.

Neurosci Lett 2014 Jul 29;576:73-8. Epub 2014 May 29.

Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2014.05.044DOI Listing
July 2014

Long-term health of dopaminergic neuron transplants in Parkinson's disease patients.

Cell Rep 2014 Jun 6;7(6):1755-61. Epub 2014 Jun 6.

Neuroregeneration Research Institute, Harvard University and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105701PMC
June 2014

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.

Neurobiol Dis 2014 Apr 31;64:79-87. Epub 2013 Dec 31.

Nuffield Department of Clinical Neurosciences, University of Oxford, UK; Oxford Parkinson's Disease Centre, University of Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2013.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988924PMC
April 2014

Advances in stem-cell--generated transplantation therapy for Parkinson's disease.

Expert Opin Biol Ther 2014 Apr;14(4):437-53

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http://dx.doi.org/10.1517/14712598.2014.876986DOI Listing
April 2014

Characterization and criteria of embryonic stem and induced pluripotent stem cells for a dopamine replacement therapy.

Prog Brain Res 2012 ;200:265-76

Neuroregeneration Institute, McLean Hospital, Harvard Medical School, Harvard Stem Cell Institute, Belmont, MA, USA.

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http://dx.doi.org/10.1016/B978-0-444-59575-1.00012-0DOI Listing
November 2013

The search for genetic mouse models of prodromal Parkinson's disease.

Exp Neurol 2012 Oct 14;237(2):267-73. Epub 2012 Jul 14.

Neuroregeneration Laboratories, McLean Hospital/Harvard Medical School, MA 02478, USA.

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http://dx.doi.org/10.1016/j.expneurol.2012.06.035DOI Listing
October 2012

Stem cells for Parkinson's disease: advancing science but protecting patients.

Mov Disord 2012 Oct 2;27(12):1475-7. Epub 2012 Oct 2.

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http://dx.doi.org/10.1002/mds.25170DOI Listing
October 2012

α-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits.

Neurobiol Dis 2012 Aug 19;47(2):258-67. Epub 2012 Apr 19.

Center for Neuroregeneration Research, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/j.nbd.2012.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376017PMC
August 2012

Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression.

Mol Cell Neurosci 2012 Feb 6;49(2):230-9. Epub 2011 Dec 6.

Center for Neuroregeneration Research, McLean Hospital/Harvard Medical School, Harvard University, MRC130, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/j.mcn.2011.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340908PMC
February 2012

Clinical translation of stem cells in neurodegenerative disorders.

Cell Stem Cell 2012 Feb;10(2):151-5

Wallenberg Neuroscience Center, University Hospital, SE-221 84 Lund, Sweden.

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http://dx.doi.org/10.1016/j.stem.2012.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982832PMC
February 2012

Viral and inflammatory triggers of neurodegenerative diseases.

Sci Transl Med 2012 Feb;4(121):121ps3

Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scitranslmed.3003492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982831PMC
February 2012

Using stem cells and iPS cells to discover new treatments for Parkinson's disease.

Parkinsonism Relat Disord 2012 Jan;18 Suppl 1:S14-6

Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/S1353-8020(11)70007-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982835PMC
January 2012

Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons.

PLoS One 2011 31;6(5):e19926. Epub 2011 May 31.

Center for Neuroregeneration Research, Harvard Medical School/McLean Hospital, Belmont, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019926PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104995PMC
October 2011

Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's disease.

J Neurol 2011 Aug 5;258(8):1393-405. Epub 2011 May 5.

University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1007/s00415-011-6061-6DOI Listing
August 2011

Development of histocompatible primate-induced pluripotent stem cells for neural transplantation.

Stem Cells 2011 Jul;29(7):1052-63

Center for Neuroregeneration Research, Harvard Medical School/McLean Hospital, Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.1002/stem.662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340906PMC
July 2011

The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration.

J Neurosci 2010 Dec;30(48):16091-101

Center for Neuroregeneration Research, Harvard Medical School/McLean Hospital, Belmont, Massachusetts, 02478, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2400-10.2
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http://dx.doi.org/10.1523/JNEUROSCI.2400-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075577PMC
December 2010

Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid.

Mol Cell Neurosci 2010 Nov 24;45(3):258-66. Epub 2010 Jul 24.

Neuroregeneration Laboratories, Harvard Medical School/McLean Hospital, NINDS Udall Parkinson's Disease Research Center of Excellence, 115 Mill Street, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/j.mcn.2010.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945816PMC
November 2010

[Opportunities for neurorestorative therapies in PD using iPS and stem cells].

Authors:
Isacson Ole

Rinsho Shinkeigaku 2010 Nov;50(11):891

Center for Neuroregeneration Research, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA.

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http://dx.doi.org/10.5692/clinicalneurol.50.891DOI Listing
November 2010

The hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer's disease and Down's syndrome.

J Neurochem 2010 Sep 3;114(6):1819-26. Epub 2010 Aug 3.

Neuroregeneration Laboratories, Center for Neuroregeneration Research, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06902.xDOI Listing
September 2010

Being too inclusive about synuclein inclusions.

Nat Med 2010 Sep;16(9):960-1; author reply 961

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http://dx.doi.org/10.1038/nm0910-960bDOI Listing
September 2010

High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life.

FASEB J 2010 Jul 24;24(7):2191-200. Epub 2010 Feb 24.

Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1096/fj.09-140368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887259PMC
July 2010

The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons.

Brain 2010 Jul 23;133(Pt 7):2022-31. Epub 2010 Jun 23.

Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1093/brain/awq142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892944PMC
July 2010

CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells.

Stem Cells 2009 Dec;27(12):2928-40

McLean Hospital/Harvard Medical School, Center for Neuroregeneration Research, Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.1002/stem.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322476PMC
December 2009

Isolation and culture of ventral mesencephalic precursor cells and dopaminergic neurons from rodent brains.

Curr Protoc Stem Cell Biol 2009 Dec;Chapter 2:Unit 2D.5

Freiburg University Hospital, Freiburg, Germany.

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http://dx.doi.org/10.1002/9780470151808.sc02d05s11DOI Listing
December 2009

Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression.

Proc Natl Acad Sci U S A 2009 Dec 10;106(52):22474-9. Epub 2009 Dec 10.

Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.

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http://www.pnas.org/lookup/doi/10.1073/pnas.0912193106
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http://dx.doi.org/10.1073/pnas.0912193106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791667PMC
December 2009

Cell therapy ahead for Parkinson's disease.

Authors:
Ole Isacson

Science 2009 Nov;326(5956):1060

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http://dx.doi.org/10.1126/science.326.5956.1060-bDOI Listing
November 2009

Molecular and cellular determinants for generating ES-cell derived dopamine neurons for cell therapy.

Adv Exp Med Biol 2009 ;651:112-23

Neuroregeneration Laboratories, Center for Neuroregeneration Research, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1007/978-1-4419-0322-8_11DOI Listing
October 2009

The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies.

Neurobiol Dis 2009 Sep 6;35(3):348-51. Epub 2009 Jun 6.

Harvard University and McLean Hospital, NINDS Udall Parkinson's Disease Research Center of Excellence, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/j.nbd.2009.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319396PMC
September 2009

No evidence for disease-like processes in fetal transplants.

Proc Natl Acad Sci U S A 2009 Sep 2;106(37):E104; author reply E105. Epub 2009 Sep 2.

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http://dx.doi.org/10.1073/pnas.0908169106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747238PMC
September 2009

Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients.

J Neurol 2009 Aug;256 Suppl 3:310-6

Center for Neuroregeneration Research, NINDS Udall Parkinson's Disease Research Center of Excellence, McLean Hospital, Harvard Medical School, Harvard University, MRC 130, 115 Mill Street, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1007/s00415-009-5242-zDOI Listing
August 2009

Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics.

Trends Neurosci 2009 Mar 21;32(3):142-9. Epub 2009 Jan 21.

Neuroregeneration Laboratories, Mailman Research Center, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/j.tins.2008.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954610PMC
March 2009

PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex.

J Neurosci 2009 Mar;29(9):2948-60

New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4424-08.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693913PMC
March 2009

Ole Isacson: development of new therapies for Parkinson's disease (interview).

Authors:
Ole Isacson

J Vis Exp 2007 29(3):189. Epub 2007 Apr 29.

McLean Hospital, Harvard Stem Cell Institute, Harvard Medical School, USA.

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http://dx.doi.org/10.3791/189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2535843PMC
February 2009

ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells.

Cell Stem Cell 2008 Dec;3(6):575-6

Department of Cell and Molecular Biology, Ludwig Institute for Cancer Research, Karolinska Institute, Nobelsv 3, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.stem.2008.11.004DOI Listing
December 2008

Future of cell and gene therapies for Parkinson's disease.

Ann Neurol 2008 Dec;64 Suppl 2:S122-38

Department of Neurology (Neuroscience), Center for Neuroregeneration Research and National Institute of Neurological Disorders and Stroke Udall Parkinson's Disease Research Center of Excellence, Harvard Medical School/McLean Hospital, Belmont, MA, USA.

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http://dx.doi.org/10.1002/ana.21473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982797PMC
December 2008

Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients.

Hum Mol Genet 2008 Oct 17;17(20):3144-53. Epub 2008 Jul 17.

Neuroregeneration Laboratories, Center for Neuroregeneration Research, McLean Hospital, Harvard MedicalSchool, 115 Mill Street, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1093/hmg/ddn211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556853PMC
October 2008

Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum.

Stem Cells 2008 Sep 12;26(9):2349-60. Epub 2008 Jun 12.

Udall Parkinson Disease Research Center of Excellence, Center for Neuroregeneration Research, McLean Hospital/Harvard Medical School, Belmont, Massachusetts, USA.

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http://dx.doi.org/10.1634/stemcells.2008-0080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649803PMC
September 2008

Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease.

Brain 2008 Aug 22;131(Pt 8):2127-39. Epub 2008 Jul 22.

McLean Hospital/Harvard University Udall Parkinson's Disease Research Center of Excellence, McLean Hospital, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1093/brain/awn144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724903PMC
August 2008

Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism.

Neurobiol Dis 2008 Jun 8;30(3):430-8. Epub 2008 Mar 8.

Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1016/j.nbd.2008.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605654PMC
June 2008

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years.

Nat Med 2008 May 6;14(5):507-9. Epub 2008 Apr 6.

Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Department of Anatomy & Neurobiology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.

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http://dx.doi.org/10.1038/nm1752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656682PMC
May 2008

Recent advances in cell-based therapy for Parkinson disease.

Neurosurg Focus 2008 ;24(3-4):E6

NINDS Udall Parkinson's Disease Research Center of Excellence, Harvard University and McLean Hospital, Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.3171/FOC/2008/24/3-4/E5DOI Listing
April 2008

Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease.

J Neuroinflammation 2008 Feb 27;5. Epub 2008 Feb 27.

Center for Neuroregeneration Research, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1186/1742-2094-5-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292163PMC
February 2008

Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons.

J Neurochem 2008 Jan 18;104(2):316-24. Epub 2007 Oct 18.

Udall Parkinson's Disease Research Center of Excellence, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2007.04952.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666192PMC
January 2008

Immature and neurally differentiated mouse embryonic stem cells do not express a functional Fas/Fas ligand system.

Stem Cells 2007 Oct 5;25(10):2551-8. Epub 2007 Jul 5.

Harvard Medical School, Center for Neuroregeneration Research, Udall Parkinson's Disease Center of Excellence, McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA.

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http://doi.wiley.com/10.1634/stemcells.2006-0745
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http://dx.doi.org/10.1634/stemcells.2006-0745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951385PMC
October 2007

Cell therapy and stem cells in animal models of motor neuron disorders.

Eur J Neurosci 2007 Oct;26(7):1721-37

Neuroregeneration Laboratory, Center for Neuroregeneration Research, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1111/j.1460-9568.2007.05780.xDOI Listing
October 2007

Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations.

Stem Cells 2007 Sep 21;25(9):2257-68. Epub 2007 Jun 21.

Center for Neuroregeneration Research, McLean Hospital/Harvard Medical School, Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.1634/stemcells.2006-0744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238728PMC
September 2007

Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells.

Mol Ther 2007 Sep 3;15(9):1630-9. Epub 2007 Jul 3.

Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA.

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http://dx.doi.org/10.1038/sj.mt.6300251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614215PMC
September 2007

Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.

Proc Natl Acad Sci U S A 2007 Sep 28;104(36):14430-5. Epub 2007 Aug 28.

Neuroregeneration Laboratories, Udall Parkinson's Disease Center of Excellence, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1073/pnas.0700901104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955463PMC
September 2007

In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias.

Neurobiol Dis 2007 Aug 18;27(2):220-7. Epub 2007 May 18.

McLean Hospital/Harvard University Udall Parkinson's Disease Research Center of Excellence, McLean Hospital, 115 Mill St., Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/j.nbd.2007.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674779PMC
August 2007

An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease.

J Neurosci 2007 Aug;27(31):8314-23

Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1972-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074880PMC
August 2007

Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.

PLoS Med 2007 Aug;4(8):e262

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.0040262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952204PMC
August 2007

Inhibition of the dopamine D1 receptor signaling by PSD-95.

J Biol Chem 2007 May 16;282(21):15778-89. Epub 2007 Mar 16.

Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA.

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http://dx.doi.org/10.1074/jbc.M611485200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649122PMC
May 2007

Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin.

Stem Cells 2007 Feb 12;25(2):411-8. Epub 2006 Oct 12.

Center for Neuroregeneration Research, Udall Parkinson's Disease Center of Excellence, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.1634/stemcells.2006-0380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667240PMC
February 2007

Proteasome activator enhances survival of Huntington's disease neuronal model cells.

PLoS One 2007 Feb 28;2(2):e238. Epub 2007 Feb 28.

Neuroregeneration Laboratories, Center for Neuroregeneration Research, McLean Hospital and Harvard Medical School, Belmont, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000238PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800909PMC
February 2007

Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits.

Stem Cells 2006 Nov 13;24(11):2504-13. Epub 2006 Jul 13.

Udall Parkinson's Disease Research Center of Excellence and Neuroregeneration Laboratories, Harvard Medical School/McLean Hospital, Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.1634/stemcells.2006-0119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613222PMC
November 2006

ES cell-derived neuroepithelial cell cultures.

J Vis Exp 2006 Nov 30(1):118. Epub 2006 Nov 30.

McLean Hospital, Harvard Medical School, USA.

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http://www.jove.com/index/Details.stp?ID=118
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http://dx.doi.org/10.3791/118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504447PMC
November 2006

Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft.

Eur J Neurosci 2006 Oct;24(7):1885-96

McLean Hospital/Harvard University Udall Parkinson's Disease Research Center of Excellence, 115 Mill St, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1111/j.1460-9568.2006.05093.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602801PMC
October 2006

What are the long-term effects of neural grafting in patients with Huntington's disease?

Authors:
Ole Isacson

Nat Clin Pract Neurol 2006 Sep;2(9):470-1

Harvard Medical School in Boston, USA.

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http://dx.doi.org/10.1038/ncpneuro0264DOI Listing
September 2006

Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging.

Toxicol Appl Pharmacol 2005 Sep;207(2 Suppl):251-6

McLean Hospital/Harvard University, Udall Parkinson's Disease Research Center of Excellence, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/j.taap.2005.02.039DOI Listing
September 2005

Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation.

Stem Cells 2005 Aug 7;23(7):914-22. Epub 2005 Jun 7.

McLean Hospital/Harvard University Udall Parkinson's Disease Research Center of Excellence and Neuroregeneration Laboratories, McLean Hospital, 115 Mill St., Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.1634/stemcells.2004-0172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654596PMC
August 2005