Ole Ammerpohl

Ole Ammerpohl

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Ole Ammerpohl

Ole Ammerpohl

Publications by authors named "Ole Ammerpohl"

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Reduced Androgen Receptor Expression in Genital Skin Fibroblasts From Patients With 45,X/46,XY Mosaicism.

J Clin Endocrinol Metab 2019 Oct;104(10):4630-4638

Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1210/jc.2019-00108DOI Listing
October 2019

Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease.

Int J Chron Obstruct Pulmon Dis 2018 26;13:2255-2259. Epub 2018 Jul 26.

Pathology of the University Medical Center Schleswig-Holstein (UKSH), Campus Luebeck and Research Center Borstel, Borstel, Germany,

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http://dx.doi.org/10.2147/COPD.S161958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065552PMC
January 2019

Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression.

Clin Epigenetics 2017 28;9:123. Epub 2017 Nov 28.

Pathology of the University Medical Center Schleswig-Holstein (UKSH), Campus Lübeck and the Research Center Borstel Parkallee 3, 23845 Borstel, Germany.

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https://clinicalepigeneticsjournal.biomedcentral.com/article
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http://dx.doi.org/10.1186/s13148-017-0423-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704452PMC
July 2018

Epigenetic modifications of the immune-checkpoint genes and in non-small cell lung cancer results in increased expression.

Clin Epigenetics 2017 11;9:51. Epub 2017 May 11.

Campus Luebeck and the Research Center Borstel, Leibniz Center for Medicine and Biosciences, Pathology of the University Medical Center Schleswig-Holstein, 23538 Luebeck, Germany.

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http://dx.doi.org/10.1186/s13148-017-0354-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426039PMC
March 2018

MicroRNA-212/ABCG2-axis contributes to development of imatinib-resistance in leukemic cells.

Oncotarget 2017 Nov 26;8(54):92018-92031. Epub 2017 Sep 26.

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.18632/oncotarget.21272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696160PMC
November 2017

Dynamics of epigenetic age following hematopoietic stem cell transplantation.

Haematologica 2017 08 26;102(8):e321-e323. Epub 2017 May 26.

Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Germany.

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http://dx.doi.org/10.3324/haematol.2016.160481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541887PMC
August 2017

DNA methylation profiling of pediatric B-cell lymphoblastic leukemia with KMT2A rearrangement identifies hypomethylation at enhancer sites.

Pediatr Blood Cancer 2017 03 27;64(3). Epub 2016 Oct 27.

Institute of Human Genetics, Christian-Albrechts-University Kiel & University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1002/pbc.26251DOI Listing
March 2017

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.

Authors:
Simone Wahl Alexander Drong Benjamin Lehne Marie Loh William R Scott Sonja Kunze Pei-Chien Tsai Janina S Ried Weihua Zhang Youwen Yang Sili Tan Giovanni Fiorito Lude Franke Simonetta Guarrera Silva Kasela Jennifer Kriebel Rebecca C Richmond Marco Adamo Uzma Afzal Mika Ala-Korpela Benedetta Albetti Ole Ammerpohl Jane F Apperley Marian Beekman Pier Alberto Bertazzi S Lucas Black Christine Blancher Marc-Jan Bonder Mario Brosch Maren Carstensen-Kirberg Anton J M de Craen Simon de Lusignan Abbas Dehghan Mohamed Elkalaawy Krista Fischer Oscar H Franco Tom R Gaunt Jochen Hampe Majid Hashemi Aaron Isaacs Andrew Jenkinson Sujeet Jha Norihiro Kato Vittorio Krogh Michael Laffan Christa Meisinger Thomas Meitinger Zuan Yu Mok Valeria Motta Hong Kiat Ng Zacharoula Nikolakopoulou Georgios Nteliopoulos Salvatore Panico Natalia Pervjakova Holger Prokisch Wolfgang Rathmann Michael Roden Federica Rota Michelle Ann Rozario Johanna K Sandling Clemens Schafmayer Katharina Schramm Reiner Siebert P Eline Slagboom Pasi Soininen Lisette Stolk Konstantin Strauch E-Shyong Tai Letizia Tarantini Barbara Thorand Ettje F Tigchelaar Rosario Tumino Andre G Uitterlinden Cornelia van Duijn Joyce B J van Meurs Paolo Vineis Ananda Rajitha Wickremasinghe Cisca Wijmenga Tsun-Po Yang Wei Yuan Alexandra Zhernakova Rachel L Batterham George Davey Smith Panos Deloukas Bastiaan T Heijmans Christian Herder Albert Hofman Cecilia M Lindgren Lili Milani Pim van der Harst Annette Peters Thomas Illig Caroline L Relton Melanie Waldenberger Marjo-Riitta Järvelin Valentina Bollati Richie Soong Tim D Spector James Scott Mark I McCarthy Paul Elliott Jordana T Bell Giuseppe Matullo Christian Gieger Jaspal S Kooner Harald Grallert John C Chambers

Nature 2017 01 21;541(7635):81-86. Epub 2016 Dec 21.

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.

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http://dx.doi.org/10.1038/nature20784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570525PMC
January 2017

Quantitative DNA Methylation Profiling in Cancer.

Methods Mol Biol 2016 ;1381:75-92

Institute of Human Genetics, University of Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Schwanenweg 24, Kiel, 24105, Germany.

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http://dx.doi.org/10.1007/978-1-4939-3204-7_5DOI Listing
October 2016

Target Gene Discovery for Novel Therapeutic Agents in Cancer Treatment.

Methods Mol Biol 2016 ;1381:181-200

Institute for Experimental Cancer Research, Section for Molecular Oncology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, House 17, 24105, Kiel, Germany.

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http://dx.doi.org/10.1007/978-1-4939-3204-7_10DOI Listing
October 2016

PLAGL1 epimutation and bladder exstrophy: Coincidence or concurrent etiology?

Birth Defects Res A Clin Mol Teratol 2016 Aug 25;106(8):724-8. Epub 2016 May 25.

Institute of Human Genetics, Christian-Albrechts-University Kiel, Kiel, Germany.

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http://dx.doi.org/10.1002/bdra.23521DOI Listing
August 2016

Downregulation of the TGFβ Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion.

Cancer Res 2016 07 17;76(13):3785-801. Epub 2016 May 17.

Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany. BIOQUANT, University of Heidelberg, Heidelberg, Germany. Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1326DOI Listing
July 2016

The differentially methylated region of MEG8 is hypermethylated in patients with Temple syndrome.

Epigenomics 2015 Oct 6;7(7):1089-97. Epub 2015 Nov 6.

Institute of Human Genetics, Christian-Albrechts-University Kiel & University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.2217/epi.15.73DOI Listing
October 2015

Array-based DNA methylation analysis in individuals with developmental delay/intellectual disability and normal molecular karyotype.

Eur J Med Genet 2015 Aug 21;58(8):419-25. Epub 2015 May 21.

Institute of Human Genetics, Christian-Albrechts-University Kiel & University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejmg.2015.05.001DOI Listing
August 2015

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study.

Lancet Diabetes Endocrinol 2015 Jul 18;3(7):526-534. Epub 2015 Jun 18.

​ (J C Chambers PhD, M Loh PhD, B Lehne PhD, W R Scott MRCP, W Zhang PhD, G Campanella MSc, M Chadeau-Hyam PhD, U Afzal MRCP, Prof P Froguel PhD, Prof P Vineis MD, Prof M-R Jarvelin PhD, Prof P Elliott PhD) (J C Chambers, Prof M-R Jarvelin, Prof P Elliott, Prof J S Kooner FRCP) (W R Scott, S-T Tan MRCP, Prof J Scott PhD, Prof J S Kooner) (J Abbott PhD) (J C Chambers, W Zhang, S-T Tan, U Afzal, Prof J S Kooner) (J C Chambers, P Punjabi FRCS, Prof J S Kooner) (M Loh) (C Blancher PhD) (A Drong PhD, Prof M I McCarthy MD) (Prof M I McCarthy) (J Kriebel PhD, S Wahl MSc, C Gieger PhD, H Grallert PhD) (C Gieger) (J Kriebel, S Wahl, C Gieger, B Thorand PhD, H Grallert) (H Prokisch PhD) (J Kriebel, S Wahl, B Thorand, H Grallert) (V Motta PhD, F Rota PhD, L Tarantini PhD, B Albetti PhD, Prof P A Bertazzi MD, V Bollati PhD) (Prof M Ala-Korpela PhD) (H R Elliott Dip Biol, R C Richmond BA, R Caiazzo PhD, T R Gaunt FRCP, Prof C L Relton PhD) (L Yengo PhD, Prof F Pattou PhD, R Caiazzo, S Cauchi PhD, Prof P Froguel) (L Yengo, S Cauchi, Prof P Froguel) (L Yengo, Prof F Pattou, S Cauchi, Prof P Froguel) (M Adamowicz-Brice PhD, Prof T J Aitman PhD) (K Bozaoglu PhD, R Caiazzo, J Jowett PhD) (Z Y Mok BSc, H K Ng BSc, M A Rozario BSc, R Soong PhD) (E-S Tai PhD) (E-S Tai) (Prof F Pattou) (H Prokisch) (Prof M Ala-Korpela, A J Kangas MSc, P Soininen PhD) (M Loh, Prof M-R Jarvelin) (Prof M-R Jarvelin) (Prof M Ala-Korpela, P Soininen) (Prof M-R Jarvelin) (Prof M Ala-Korpela) (Prof O Ammerpohl PhD) (Prof C Schafmayer MD) (Prof J Danesh FRCP) (Prof S de Lusignan PhD, Prof S Jones PhD) (Prof T Illig PhD) (S Jha MRCP) (A Kasturiratne MD, Prof A R Wickremasinghe PhD) (N Kato PhD) (N Kotea PhD) (S Kowlessur Dip Pub Health Admin) (J Pitkäniemi PhD) (Prof J Tuomilehto PhD) (J Pitkäniemi) (D Saleheen PhD) (D Saleheen) (D Saleheen) (E-S Tai) (Prof S A Kyrtopoulos PhD) (C Herder PhD) (C Herder) (Prof J Hampe MD) (R Soong) (Prof P Vineis) (Prof M I McCarthy).

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http://dx.doi.org/10.1016/S2213-8587(15)00127-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724884PMC
July 2015

Obesity accelerates epigenetic aging of human liver.

Proc Natl Acad Sci U S A 2014 Oct 13;111(43):15538-43. Epub 2014 Oct 13.

Medical Department 1, University Hospital Dresden, Technical University Dresden, 01307 Dresden, Germany;

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http://dx.doi.org/10.1073/pnas.1412759111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217403PMC
October 2014

The tissue is the issue: improved methylome analysis from paraffin-embedded tissues by application of the HOPE technique.

Lab Invest 2014 Aug 16;94(8):927-33. Epub 2014 Jun 16.

1] Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany [2] Institute of Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.

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http://www.nature.com/articles/labinvest201479
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http://dx.doi.org/10.1038/labinvest.2014.79DOI Listing
August 2014

A familial disorder of altered DNA-methylation.

J Med Genet 2014 Jun 10;51(6):407-12. Epub 2014 Apr 10.

Institute of Human Genetics, University Hospital Schleswig-Holstein Campus Kiel/Christian-Albrechts University Kiel, Kiel, Germany.

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http://dx.doi.org/10.1136/jmedgenet-2013-102149DOI Listing
June 2014

Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia.

Genes Chromosomes Cancer 2014 Apr 21;53(4):309-16. Epub 2014 Jan 21.

Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany; Department of Pediatrics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1002/gcc.22141DOI Listing
April 2014

Array-based DNA methylation profiling in male infertility reveals allele-specific DNA methylation in PIWIL1 and PIWIL2.

Fertil Steril 2014 Apr 10;101(4):1097-1103.e1. Epub 2014 Feb 10.

Institute of Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.fertnstert.2013.12.054DOI Listing
April 2014

Janus--a comprehensive tool investigating the two faces of transcription.

Bioinformatics 2013 Jul 24;29(13):1600-6. Epub 2013 Apr 24.

Institute for Clinical Molecular Biology, Christian-Albrechts-University, 24105 Kiel, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btt185DOI Listing
July 2013

Quantitative cross-validation and content analysis of the 450k DNA methylation array from Illumina, Inc.

BMC Res Notes 2012 Apr 30;5:210. Epub 2012 Apr 30.

Institute of Pathology, Medizinische Hochschule Hannover, Carl-Neuberg-Str, 1, D-30625, Hannover, Germany.

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http://dx.doi.org/10.1186/1756-0500-5-210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420245PMC
April 2012

A putative "hepitype" in the ATM gene associated with chronic lymphocytic leukemia risk.

Genes Chromosomes Cancer 2011 Nov 24;50(11):887-95. Epub 2011 Aug 24.

Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Bizkaia, Spain.

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http://dx.doi.org/10.1002/gcc.20912DOI Listing
November 2011

Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles.

Oncology 2011 16;80(1-2):12-20. Epub 2011 May 16.

Department of Gynecology, University Medical Center Aachen, RWTH, Aachen, Germany.

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http://dx.doi.org/10.1159/000327746DOI Listing
September 2011

Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance.

J Pathol 2010 Aug;221(4):433-42

Department of Pathology, Erasmus MC-Erasmus University Medical Center, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/path.2725DOI Listing
August 2010

Target gene discovery for novel therapeutic agents in cancer treatment.

Methods Mol Biol 2010 ;576:427-45

Clinic for General Surgery and Thoracic Surgery, Division Molecular Oncology, University Hospital of Schleswig, Kiel, Germany.

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http://dx.doi.org/10.1007/978-1-59745-545-9_22DOI Listing
January 2010

Array-based DNA methylation profiling of primary lymphomas of the central nervous system.

BMC Cancer 2009 Dec 21;9:455. Epub 2009 Dec 21.

Institute of Human Genetics, University Hospital Schleswig-Holstein Campus Kiel/Christian-Albrechts University Kiel, Germany.

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http://dx.doi.org/10.1186/1471-2407-9-455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807878PMC
December 2009

The human retinoblastoma gene is imprinted.

PLoS Genet 2009 Dec 24;5(12):e1000790. Epub 2009 Dec 24.

Institut für Humangenetik, Universitätsklinikum Essen, Essen, Germany.

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http://dx.plos.org/10.1371/journal.pgen.1000790
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http://dx.doi.org/10.1371/journal.pgen.1000790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791201PMC
December 2009

Hunting for the 5th base: Techniques for analyzing DNA methylation.

Biochim Biophys Acta 2009 Sep 9;1790(9):847-62. Epub 2009 Feb 9.

Institute of Human Genetics, Christian-Albrechts University Kiel, University Hospital Schleswig-Holstein Campus Kiel, Germany.

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http://dx.doi.org/10.1016/j.bbagen.2009.02.001DOI Listing
September 2009

Role of myofibroblasts in innate chemoresistance of pancreatic carcinoma--epigenetic downregulation of caspases.

Int J Cancer 2008 Oct;123(8):1751-60

Clinic of General Internal Medicine, Laboratory of Molecular Gastroenterology and Hepatology, UKSH-Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1002/ijc.23703DOI Listing
October 2008

Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer.

Cancer Res 2007 Sep;67(17):8344-50

Division Molecular Oncology, Department for General Surgery, Institute of Immunology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3304DOI Listing
September 2007

The role of protein kinases in pancreatic carcinogenesis.

Clin Chim Acta 2007 May 21;381(1):56-62. Epub 2007 Feb 21.

University Hospital of Schlewig-Holstein, Campus Kiel, Clinic for General Surgery and Thoracic Surgery, Division of Molecular Oncology, Arnold-Heller-Strasse 7, 24105 Kiel, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S000989810700093
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http://dx.doi.org/10.1016/j.cca.2007.02.024DOI Listing
May 2007

p21waf1/Cip1 partially mediates apoptosis in hepatocellular carcinoma cells.

Biochem Biophys Res Commun 2007 Mar 10;354(2):466-71. Epub 2007 Jan 10.

Department of Woman and Child Health, Pediatric Endocrinology Unit, Karolinska Institute & University Hospital, Q2:08, SE-171 76 Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0700011
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http://dx.doi.org/10.1016/j.bbrc.2006.12.222DOI Listing
March 2007

Detection of tumor stem cell markers in pancreatic carcinoma cell lines.

Hepatobiliary Pancreat Dis Int 2007 Feb;6(1):92-7

Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Arnold Heller Str. 7, 24 105 Kiel, Germany.

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February 2007

Combination phenylbutyrate/gemcitabine therapy effectively inhibits in vitro and in vivo growth of NSCLC by intrinsic apoptotic pathways.

J Carcinog 2006 Nov 23;5:25. Epub 2006 Nov 23.

Hospital for General and Thoracic Surgery, Schleswig-Holstein University Hospitals, Campus Kiel, Arnold-Heller-Str 7, Kiel, Germany.

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http://dx.doi.org/10.1186/1477-3163-5-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665446PMC
November 2006

Meta-analysis of microarray data on pancreatic cancer defines a set of commonly dysregulated genes.

Oncogene 2005 Jul;24(32):5079-88

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany.

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http://dx.doi.org/10.1038/sj.onc.1208696DOI Listing
July 2005

HDACi phenylbutyrate increases bystander killing of HSV-tk transfected glioma cells.

Biochem Biophys Res Commun 2004 Nov;324(1):8-14

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2004.09.016DOI Listing
November 2004

HDACi phenylbutyrate increases bystander killing of HSV-tk transfected glioma cells.

Biochem Biophys Res Commun 2004 Nov;324(1):8-14

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2004.09.016DOI Listing
November 2004