Olav B Smeland

Olav B Smeland

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Olav B Smeland

Olav B Smeland

Publications by authors named "Olav B Smeland"

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The polygenic architecture of schizophrenia - rethinking pathogenesis and nosology.

Nat Rev Neurol 2020 Jul 11;16(7):366-379. Epub 2020 Jun 11.

NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1038/s41582-020-0364-0DOI Listing
July 2020

Understanding the genetic determinants of the brain with MOSTest.

Nat Commun 2020 Jul 14;11(1):3512. Epub 2020 Jul 14.

NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1038/s41467-020-17368-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360598PMC
July 2020

Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model.

PLoS Genet 2020 05 19;16(5):e1008612. Epub 2020 May 19.

Center for Multimodal Imaging and Genetics, University of California at San Diego, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272101PMC
May 2020

Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence.

Mol Psychiatry 2020 04 4;25(4):844-853. Epub 2019 Jan 4.

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, 0407, Oslo, Norway.

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http://www.nature.com/articles/s41380-018-0332-x
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http://dx.doi.org/10.1038/s41380-018-0332-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609490PMC
April 2020

Correction: Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence.

Mol Psychiatry 2020 Apr;25(4):914

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, 0407, Oslo, Norway.

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http://dx.doi.org/10.1038/s41380-019-0456-7DOI Listing
April 2020

Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders.

Psychol Med 2020 03 14;50(4):595-606. Epub 2019 Mar 14.

NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1017/S0033291719000400DOI Listing
March 2020

Publisher Correction: Common brain disorders are associated with heritable patterns of apparent aging of the brain.

Nat Neurosci 2020 Feb;23(2):295

NORMENT, Division of Mental Health and Addiction Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1038/s41593-019-0553-6DOI Listing
February 2020

Discovery of shared genomic loci using the conditional false discovery rate approach.

Hum Genet 2020 Jan 13;139(1):85-94. Epub 2019 Sep 13.

NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Kirkeveien 166, 0424, Oslo, Norway.

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http://dx.doi.org/10.1007/s00439-019-02060-2DOI Listing
January 2020

The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges.

Psychiatr Genet 2019 10;29(5):152-159

NORMENT Centre, Institute of Clinical Medicine, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1097/YPG.0000000000000234DOI Listing
October 2019

Common brain disorders are associated with heritable patterns of apparent aging of the brain.

Nat Neurosci 2019 10 24;22(10):1617-1623. Epub 2019 Sep 24.

NORMENT, Division of Mental Health and Addiction Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1038/s41593-019-0471-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823048PMC
October 2019

Correction: Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence.

Mol Psychiatry 2020 Apr;25(4):914

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, 0407, Oslo, Norway.

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http://dx.doi.org/10.1038/s41380-019-0456-7DOI Listing
April 2020

Genome-wide association study identifies 30 loci associated with bipolar disorder.

Authors:
Eli A Stahl Gerome Breen Andreas J Forstner Andrew McQuillin Stephan Ripke Vassily Trubetskoy Manuel Mattheisen Yunpeng Wang Jonathan R I Coleman Héléna A Gaspar Christiaan A de Leeuw Stacy Steinberg Jennifer M Whitehead Pavlides Maciej Trzaskowski Enda M Byrne Tune H Pers Peter A Holmans Alexander L Richards Liam Abbott Esben Agerbo Huda Akil Diego Albani Ney Alliey-Rodriguez Thomas D Als Adebayo Anjorin Verneri Antilla Swapnil Awasthi Judith A Badner Marie Bækvad-Hansen Jack D Barchas Nicholas Bass Michael Bauer Richard Belliveau Sarah E Bergen Carsten Bøcker Pedersen Erlend Bøen Marco P Boks James Boocock Monika Budde William Bunney Margit Burmeister Jonas Bybjerg-Grauholm William Byerley Miquel Casas Felecia Cerrato Pablo Cervantes Kimberly Chambert Alexander W Charney Danfeng Chen Claire Churchhouse Toni-Kim Clarke William Coryell David W Craig Cristiana Cruceanu David Curtis Piotr M Czerski Anders M Dale Simone de Jong Franziska Degenhardt Jurgen Del-Favero J Raymond DePaulo Srdjan Djurovic Amanda L Dobbyn Ashley Dumont Torbjørn Elvsåshagen Valentina Escott-Price Chun Chieh Fan Sascha B Fischer Matthew Flickinger Tatiana M Foroud Liz Forty Josef Frank Christine Fraser Nelson B Freimer Louise Frisén Katrin Gade Diane Gage Julie Garnham Claudia Giambartolomei Marianne Giørtz Pedersen Jaqueline Goldstein Scott D Gordon Katherine Gordon-Smith Elaine K Green Melissa J Green Tiffany A Greenwood Jakob Grove Weihua Guan José Guzman-Parra Marian L Hamshere Martin Hautzinger Urs Heilbronner Stefan Herms Maria Hipolito Per Hoffmann Dominic Holland Laura Huckins Stéphane Jamain Jessica S Johnson Anders Juréus Radhika Kandaswamy Robert Karlsson James L Kennedy Sarah Kittel-Schneider James A Knowles Manolis Kogevinas Anna C Koller Ralph Kupka Catharina Lavebratt Jacob Lawrence William B Lawson Markus Leber Phil H Lee Shawn E Levy Jun Z Li Chunyu Liu Susanne Lucae Anna Maaser Donald J MacIntyre Pamela B Mahon Wolfgang Maier Lina Martinsson Steve McCarroll Peter McGuffin Melvin G McInnis James D McKay Helena Medeiros Sarah E Medland Fan Meng Lili Milani Grant W Montgomery Derek W Morris Thomas W Mühleisen Niamh Mullins Hoang Nguyen Caroline M Nievergelt Annelie Nordin Adolfsson Evaristus A Nwulia Claire O'Donovan Loes M Olde Loohuis Anil P S Ori Lilijana Oruc Urban Ösby Roy H Perlis Amy Perry Andrea Pfennig James B Potash Shaun M Purcell Eline J Regeer Andreas Reif Céline S Reinbold John P Rice Fabio Rivas Margarita Rivera Panos Roussos Douglas M Ruderfer Euijung Ryu Cristina Sánchez-Mora Alan F Schatzberg William A Scheftner Nicholas J Schork Cynthia Shannon Weickert Tatyana Shehktman Paul D Shilling Engilbert Sigurdsson Claire Slaney Olav B Smeland Janet L Sobell Christine Søholm Hansen Anne T Spijker David St Clair Michael Steffens John S Strauss Fabian Streit Jana Strohmaier Szabolcs Szelinger Robert C Thompson Thorgeir E Thorgeirsson Jens Treutlein Helmut Vedder Weiqing Wang Stanley J Watson Thomas W Weickert Stephanie H Witt Simon Xi Wei Xu Allan H Young Peter Zandi Peng Zhang Sebastian Zöllner Rolf Adolfsson Ingrid Agartz Martin Alda Lena Backlund Bernhard T Baune Frank Bellivier Wade H Berrettini Joanna M Biernacka Douglas H R Blackwood Michael Boehnke Anders D Børglum Aiden Corvin Nicholas Craddock Mark J Daly Udo Dannlowski Tõnu Esko Bruno Etain Mark Frye Janice M Fullerton Elliot S Gershon Michael Gill Fernando Goes Maria Grigoroiu-Serbanescu Joanna Hauser David M Hougaard Christina M Hultman Ian Jones Lisa A Jones René S Kahn George Kirov Mikael Landén Marion Leboyer Cathryn M Lewis Qingqin S Li Jolanta Lissowska Nicholas G Martin Fermin Mayoral Susan L McElroy Andrew M McIntosh Francis J McMahon Ingrid Melle Andres Metspalu Philip B Mitchell Gunnar Morken Ole Mors Preben Bo Mortensen Bertram Müller-Myhsok Richard M Myers Benjamin M Neale Vishwajit Nimgaonkar Merete Nordentoft Markus M Nöthen Michael C O'Donovan Ketil J Oedegaard Michael J Owen Sara A Paciga Carlos Pato Michele T Pato Danielle Posthuma Josep Antoni Ramos-Quiroga Marta Ribasés Marcella Rietschel Guy A Rouleau Martin Schalling Peter R Schofield Thomas G Schulze Alessandro Serretti Jordan W Smoller Hreinn Stefansson Kari Stefansson Eystein Stordal Patrick F Sullivan Gustavo Turecki Arne E Vaaler Eduard Vieta John B Vincent Thomas Werge John I Nurnberger Naomi R Wray Arianna Di Florio Howard J Edenberg Sven Cichon Roel A Ophoff Laura J Scott Ole A Andreassen John Kelsoe Pamela Sklar

Nat Genet 2019 05 1;51(5):793-803. Epub 2019 May 1.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://www.nature.com/articles/s41588-019-0397-8
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http://dx.doi.org/10.1038/s41588-019-0397-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956732PMC
May 2019

Cross-tissue eQTL enrichment of associations in schizophrenia.

PLoS One 2018 6;13(9):e0202812. Epub 2018 Sep 6.

NORMENT, KG Jebsen Centre for Psychosis Research, University of Oslo, 0424 Oslo, Norway - Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202812PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126834PMC
February 2019

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

Authors:
Jeanne E Savage Philip R Jansen Sven Stringer Kyoko Watanabe Julien Bryois Christiaan A de Leeuw Mats Nagel Swapnil Awasthi Peter B Barr Jonathan R I Coleman Katrina L Grasby Anke R Hammerschlag Jakob A Kaminski Robert Karlsson Eva Krapohl Max Lam Marianne Nygaard Chandra A Reynolds Joey W Trampush Hannah Young Delilah Zabaneh Sara Hägg Narelle K Hansell Ida K Karlsson Sten Linnarsson Grant W Montgomery Ana B Muñoz-Manchado Erin B Quinlan Gunter Schumann Nathan G Skene Bradley T Webb Tonya White Dan E Arking Dimitrios Avramopoulos Robert M Bilder Panos Bitsios Katherine E Burdick Tyrone D Cannon Ornit Chiba-Falek Andrea Christoforou Elizabeth T Cirulli Eliza Congdon Aiden Corvin Gail Davies Ian J Deary Pamela DeRosse Dwight Dickinson Srdjan Djurovic Gary Donohoe Emily Drabant Conley Johan G Eriksson Thomas Espeseth Nelson A Freimer Stella Giakoumaki Ina Giegling Michael Gill David C Glahn Ahmad R Hariri Alex Hatzimanolis Matthew C Keller Emma Knowles Deborah Koltai Bettina Konte Jari Lahti Stephanie Le Hellard Todd Lencz David C Liewald Edythe London Astri J Lundervold Anil K Malhotra Ingrid Melle Derek Morris Anna C Need William Ollier Aarno Palotie Antony Payton Neil Pendleton Russell A Poldrack Katri Räikkönen Ivar Reinvang Panos Roussos Dan Rujescu Fred W Sabb Matthew A Scult Olav B Smeland Nikolaos Smyrnis John M Starr Vidar M Steen Nikos C Stefanis Richard E Straub Kjetil Sundet Henning Tiemeier Aristotle N Voineskos Daniel R Weinberger Elisabeth Widen Jin Yu Goncalo Abecasis Ole A Andreassen Gerome Breen Lene Christiansen Birgit Debrabant Danielle M Dick Andreas Heinz Jens Hjerling-Leffler M Arfan Ikram Kenneth S Kendler Nicholas G Martin Sarah E Medland Nancy L Pedersen Robert Plomin Tinca J C Polderman Stephan Ripke Sophie van der Sluis Patrick F Sullivan Scott I Vrieze Margaret J Wright Danielle Posthuma

Nat Genet 2018 07 25;50(7):912-919. Epub 2018 Jun 25.

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41588-018-0152-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411041PMC
July 2018

Genetic Overlap Between Schizophrenia and Volumes of Hippocampus, Putamen, and Intracranial Volume Indicates Shared Molecular Genetic Mechanisms.

Schizophr Bull 2018 06;44(4):854-864

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1093/schbul/sbx148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007549PMC
June 2018

Beyond heritability: improving discoverability in imaging genetics.

Hum Mol Genet 2018 05;27(R1):R22-R28

Center for Multimodal Imaging and Genetics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1093/hmg/ddy082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946904PMC
May 2018

How can genetics help understand the relationship between cognitive dysfunction and schizophrenia?

Scand J Psychol 2018 Feb;59(1):26-31

NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1111/sjop.12407DOI Listing
February 2018

Novel Loci Associated With Attention-Deficit/Hyperactivity Disorder Are Revealed by Leveraging Polygenic Overlap With Educational Attainment.

J Am Acad Child Adolesc Psychiatry 2018 02 26;57(2):86-95. Epub 2017 Nov 26.

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1016/j.jaac.2017.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806128PMC
February 2018

Modeling prior information of common genetic variants improves gene discovery for neuroticism.

Hum Mol Genet 2017 11;26(22):4530-4539

Department of Radiology, Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1093/hmg/ddx340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886256PMC
November 2017

Identification of genetic loci shared between schizophrenia and the Big Five personality traits.

Sci Rep 2017 05 22;7(1):2222. Epub 2017 May 22.

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, 0407, Oslo, Norway.

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http://dx.doi.org/10.1038/s41598-017-02346-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440373PMC
May 2017

Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-L-Carnitine.

Neurochem Res 2016 Feb 3;41(1-2):86-95. Epub 2015 Oct 3.

Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Olav Kyrresgt. 3, 7489, Trondheim, Norway.

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http://link.springer.com/10.1007/s11064-015-1728-5
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http://dx.doi.org/10.1007/s11064-015-1728-5DOI Listing
February 2016

Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy.

J Neurochem 2014 Apr 2;129(1):107-19. Epub 2013 Dec 2.

Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1111/jnc.12610DOI Listing
April 2014

Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice.

J Cereb Blood Flow Metab 2013 Jul 24;33(7):1090-7. Epub 2013 Apr 24.

Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1038/jcbfm.2013.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705438PMC
July 2013

Dietary supplementation with acetyl-l-carnitine in seizure treatment of pentylenetetrazole kindled mice.

Neurochem Int 2012 Sep 16;61(4):444-54. Epub 2012 Jun 16.

Dept. of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1016/j.neuint.2012.06.008DOI Listing
September 2012

Chronic acetyl-L-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice.

Neurochem Int 2012 Jul 23;61(1):100-7. Epub 2012 Apr 23.

Dept. of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1016/j.neuint.2012.04.008DOI Listing
July 2012

Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine.

J Cereb Blood Flow Metab 2011 Feb 28;31(2):494-503. Epub 2010 Jul 28.

Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

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http://dx.doi.org/10.1038/jcbfm.2010.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049505PMC
February 2011