Olaf Witt

Olaf Witt

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Olaf Witt

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Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Eur J Cancer 2019 Jun 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049193022
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http://dx.doi.org/10.1016/j.ejca.2019.03.019DOI Listing
June 2019

Monitoring futility and efficacy in phase II trials with Bayesian posterior distributions-A calibration approach.

Biom J 2019 05 2;61(3):488-502. Epub 2018 Sep 2.

Clinical Trial Center, National Center for Tumor Diseases, Heidelberg, Germany.

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http://dx.doi.org/10.1002/bimj.201700209DOI Listing
May 2019

The enzyme activity of histone deacetylase 8 is modulated by a redox-switch.

Redox Biol 2019 01 27;20:60-67. Epub 2018 Sep 27.

Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Haardtring 100, 64295 Darmstadt, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183052
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http://dx.doi.org/10.1016/j.redox.2018.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174833PMC
January 2019

Klinischer Nutzen der molekularen Diagnostik pädiatrischer Hirntumore.

Klin Padiatr 2018 10 6;230(6):289-290. Epub 2018 Nov 6.

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http://dx.doi.org/10.1055/a-0750-8353DOI Listing
October 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

Response in a child with a BRAF V600E mutated desmoplastic infantile astrocytoma upon retreatment with vemurafenib.

Pediatr Blood Cancer 2018 03 12;65(3). Epub 2017 Dec 12.

Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/pbc.26893DOI Listing
March 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

BRAF V600E Status Alone Is Not Sufficient as a Prognostic Biomarker in Pediatric Low-Grade Glioma.

J Clin Oncol 2018 01 15;36(1):96. Epub 2017 Nov 15.

David T.W. Jones, German Cancer Research Center and Hopp Children's Cancer Center at the National Center for Tumor Diseases Heidelberg, Heidelberg, Germany; and Olaf Witt and Stefan M. Pfister, German Cancer Research Center, Hopp Children's Cancer Center at the National Center for Tumor Diseases Heidelberg, and Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1200/JCO.2017.75.8987DOI Listing
January 2018

Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients.

Neuro Oncol 2017 Nov;19(12):1607-1617

Division of Pediatric Neurooncology, German Cancer Research Center, Heidelberg, Germany; Cancer Consortium, Core Center Heidelberg, Heidelberg, Germany; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada; Alberta Children's Hospital Research Institute and Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, Section of Pediatric Brain Tumors, University Hospital Heidelberg, Heidelberg, Germany; National Center for Tumor Diseases, Clinical Trial Center, Heidelberg, Germany; Division of Neurosurgical Research, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center, Heidelberg, Germany; Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1093/neuonc/nox093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716199PMC
November 2017

Three-dimensional tumor cell growth stimulates autophagic flux and recapitulates chemotherapy resistance.

Cell Death Dis 2017 08 24;8(8):e3013. Epub 2017 Aug 24.

Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), INF 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/cddis.2017.398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596581PMC
August 2017

The whole-genome landscape of medulloblastoma subtypes.

Nature 2017 07;547(7663):311-317

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature22973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905700PMC
July 2017

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Am J Med Genet A 2017 Apr 7;173(4):1017-1037. Epub 2017 Feb 7.

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ajmg.a.38142DOI Listing
April 2017

Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival.

Cell Death Dis 2017 03 2;8(3):e2635. Epub 2017 Mar 2.

Department of Pediatric Hematology, Oncology and SCT, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, Berlin 13353, Germany.

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http://dx.doi.org/10.1038/cddis.2017.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386552PMC
March 2017

Hematologic Response to Vorinostat Treatment in Relapsed Myeloid Leukemia of Down Syndrome.

Pediatr Blood Cancer 2016 09 18;63(9):1677-9. Epub 2016 May 18.

Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/pbc.26062DOI Listing
September 2016

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.

Eur J Cancer 2016 09 29;65:91-101. Epub 2016 Jul 29.

Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.06.009DOI Listing
September 2016

Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases.

Future Med Chem 2016 09 30;8(13):1609-34. Epub 2016 Aug 30.

Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.4155/fmc-2016-0117DOI Listing
September 2016

Minichromosome Maintenance Complex Is a Critical Node in the miR-183 Signaling Network of MYCN-Amplified Neuroblastoma Cells.

J Proteome Res 2016 07 9;15(7):2178-86. Epub 2016 Jun 9.

Department of Pediatric Hematology/Oncology/Stem Cell Transplantation Charité - Universitätsmedizin Berlin , Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1021/acs.jproteome.6b00134DOI Listing
July 2016

No correlation between NF1 mutation position and risk of optic pathway glioma in 77 unrelated NF1 patients.

Hum Genet 2016 May 11;135(5):469-475. Epub 2016 Mar 11.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00439-016-1646-xDOI Listing
May 2016

Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1.

Viruses 2016 05 19;8(5). Epub 2016 May 19.

Research Program Infection, Inflammation and Cancer, Division of Tumor Virology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/v8050138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885093PMC
May 2016

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.

J Med Chem 2016 Feb 22;59(4):1545-55. Epub 2015 Dec 22.

Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg , Albertstraße 25, 79104 Freiburg, Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01493DOI Listing
February 2016

Treatment tolerance of particle therapy in pediatric patients.

Acta Oncol 2015 Jul 23;54(7):1049-55. Epub 2015 Jan 23.

Department of Radiation Oncology, University Hospital Heidelberg , Heidelberg , Germany.

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http://dx.doi.org/10.3109/0284186X.2014.998273DOI Listing
July 2015

HDAC8: a multifaceted target for therapeutic interventions.

Trends Pharmacol Sci 2015 Jul 23;36(7):481-92. Epub 2015 May 23.

Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany. Electronic address:

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http://www.cell.com/trends/pharmacological-sciences/pdf/S016
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http://linkinghub.elsevier.com/retrieve/pii/S016561471500089
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http://dx.doi.org/10.1016/j.tips.2015.04.013DOI Listing
July 2015

HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities.

Cells 2015 Apr 23;4(2):135-68. Epub 2015 Apr 23.

Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/cells4020135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493453PMC
April 2015

Quantification of vorinostat and its main metabolites in plasma and intracellular vorinostat in PBMCs by liquid chromatography coupled to tandem mass spectrometry and its relation to histone deacetylase activity in human blood.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Aug 18;964:212-21. Epub 2014 Feb 18.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15700232140009
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http://dx.doi.org/10.1016/j.jchromb.2014.02.014DOI Listing
August 2014

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Nature 2014 Jul 22;511(7510):428-34. Epub 2014 Jun 22.

1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.

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http://www.abta.org/resources/enhancers-hijacking-activates.
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http://www.nature.com/doifinder/10.1038/nature13379
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http://dx.doi.org/10.1038/nature13379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201514PMC
July 2014

GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.

Cancer Res 2014 May 13;74(9):2604-16. Epub 2014 Jan 13.

Authors' Affiliations: Clinical Cooperation Unit Pediatric Oncology; Departments of Biostatistics and Tumor Genetics; Clinical Cooperation Unit Neuropathology; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ); Departments of Neuropathology and Pediatric Hematology and Oncology, University of Heidelberg, Heidelberg; Transcriptome Analysis Laboratory, University of Goettingen, Goettingen; St. Lukas Klinik Solingen, Solingen; Department of Pediatric Hematology and Oncology; and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1904DOI Listing
May 2014

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Cancer Cell 2014 Mar;25(3):393-405

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493053PMC
March 2014

Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis.

Int J Cancer 2014 Feb 2;134(3):703-16. Epub 2013 Sep 2.

Division of Tumor Virology, Program Infection and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, Heidelberg, Germany; Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.28386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232887PMC
February 2014

Adaptive designs with arbitrary dependence structure.

Biom J 2014 Jan 11;56(1):86-106. Epub 2013 Nov 11.

Institute of Biostatistics and Clinical Research, University of Münster, Schmeddingstraße 56, 48149, Münster, Germany.

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http://dx.doi.org/10.1002/bimj.201200234DOI Listing
January 2014

Histone deacetylase 10-promoted autophagy as a druggable point of interference to improve the treatment response of advanced neuroblastomas.

Autophagy 2013 Dec 8;9(12):2163-5. Epub 2013 Oct 8.

Clinical Cooperation Unit Pediatric Oncology; German Cancer Research Center (DKFZ); Heidelberg, Germany.

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http://dx.doi.org/10.4161/auto.26450DOI Listing
December 2013

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Nat Genet 2013 Aug 30;45(8):927-32. Epub 2013 Jun 30.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://pubman.mpdl.mpg.de/pubman/item/escidoc:1982973/compon
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http://www.nature.com/doifinder/10.1038/ng.2682
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http://dx.doi.org/10.1038/ng.2682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951336PMC
August 2013

Targeting of histone deacetylases in brain tumors.

CNS Oncol 2013 Jul;2(4):359-76

Clinical Cooperation Unit Pediatric Oncology (G340), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.2217/cns.13.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166540PMC
July 2013

HDAC11 is a novel drug target in carcinomas.

Int J Cancer 2013 May 25;132(9):2200-8. Epub 2012 Oct 25.

Clinical Cooperation Unit Pediatric Oncology (G340), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.27876DOI Listing
May 2013

Nestin expression identifies ependymoma patients with poor outcome.

Brain Pathol 2012 Nov 30;22(6):848-60. Epub 2012 May 30.

Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1750-3639.2012.00600.xDOI Listing
November 2012

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

Cancer Cell 2012 Oct;22(4):425-37

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2012.08.024DOI Listing
October 2012

Dissecting the genomic complexity underlying medulloblastoma.

Nature 2012 Aug;488(7409):100-5

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1038/nature11284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662966PMC
August 2012

MAPK pathway activation in pilocytic astrocytoma.

Cell Mol Life Sci 2012 Jun 13;69(11):1799-811. Epub 2011 Dec 13.

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00018-011-0898-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350769PMC
June 2012

Outcome and prognostic factors of radiation therapy for medulloblastoma.

Int J Radiat Oncol Biol Phys 2011 Nov 23;81(3):e7-e13. Epub 2011 Feb 23.

Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ijrobp.2010.12.042DOI Listing
November 2011

Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibition.

Int J Radiat Oncol Biol Phys 2010 Sep 18;78(1):237-45. Epub 2010 Jun 18.

Department of Pediatric Oncology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ijrobp.2010.03.010DOI Listing
September 2010

Sorafenib plus valproic acid for infant spinal glioblastoma.

J Pediatr Hematol Oncol 2010 Aug;32(6):511-4

Children's Cancer Hospital, The University of Texas MD Anderson Cancer Center, Houstan, TX 77030, USA.

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http://dx.doi.org/10.1097/MPH.0b013e3181d74702DOI Listing
August 2010

Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept.

BMC Cancer 2010 Aug 23;10:450. Epub 2010 Aug 23.

Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1186/1471-2407-10-450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939548PMC
August 2010

HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth.

Clin Cancer Res 2010 Jun 22;16(12):3240-52. Epub 2010 Apr 22.

Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0395DOI Listing
June 2010