Olaf Rotzschke

Olaf Rotzschke

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Olaf Rotzschke

Olaf Rotzschke

Publications by authors named "Olaf Rotzschke"

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60Publications

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Biomarker Signatures Predicting 10-Year All-Cause and Disease-Specific Mortality.

J Gerontol A Biol Sci Med Sci 2019 Mar;74(4):469-479

Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Biopolis, Singapore.

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http://dx.doi.org/10.1093/gerona/gly138DOI Listing
March 2019

Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study.

Int J Nephrol 2017 15;2017:3095425. Epub 2017 Aug 15.

Singapore Immunology Network (SIGN), Agency for Science, Technology and Research (ASTAR), Biopolis, Singapore.

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http://dx.doi.org/10.1155/2017/3095425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574215PMC
August 2017

Systematic characterization of basophil anergy.

Allergy 2017 Mar 8;72(3):373-384. Epub 2016 Aug 8.

Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.

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http://dx.doi.org/10.1111/all.12952DOI Listing
March 2017

Fingolimod treatment abrogates chikungunya virus-induced arthralgia.

Sci Transl Med 2017 02;9(375)

Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore, Singapore.

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http://dx.doi.org/10.1126/scitranslmed.aal1333DOI Listing
February 2017

Immune Modulation and Prevention of Autoimmune Disease by Repeated Sequences from Parasites Linked to Self Antigens.

J Neuroimmune Pharmacol 2016 12 12;11(4):749-762. Epub 2016 Aug 12.

Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany.

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http://dx.doi.org/10.1007/s11481-016-9701-xDOI Listing
December 2016

Virus infection drives IL-2 antibody complexes into pro-inflammatory agonists in mice.

Sci Rep 2016 11 25;6:37603. Epub 2016 Nov 25.

Singapore Immunology Network, Agency for Science, Technology and Research, Singapore (A*STAR), Singapore 138648, Singapore.

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http://dx.doi.org/10.1038/srep37603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122839PMC
November 2016

Neuropeptide Y associated with asthma in young adults.

Neuropeptides 2016 Oct 20;59:117-121. Epub 2016 Jul 20.

Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01434179163001
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http://dx.doi.org/10.1016/j.npep.2016.07.003DOI Listing
October 2016

Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis.

J Allergy Clin Immunol 2016 Mar 23;137(3):758-66.e3. Epub 2015 Oct 23.

Department of Biological Sciences, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.08.038DOI Listing
March 2016

Large-scale Isolation of Highly Pure "Untouched" Regulatory T Cells in a GMP Environment for Adoptive Cell Therapy.

J Immunother 2015 Jul-Aug;38(6):250-8

*Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis †Cell Therapy Facility, Blood Services Group, Health Science Authority (HSA) Departments of ‡Hematology ∥Pathology, Singapore General Hospital (SGH), Singapore, Singapore §Department of Haematology, St George's Hospital and Medical School, London, United Kingdom.

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http://dx.doi.org/10.1097/CJI.0000000000000083DOI Listing
February 2016

Expanding regulatory T cells alleviates chikungunya virus-induced pathology in mice.

J Virol 2015 08 20;89(15):7893-7904. Epub 2015 May 20.

Singapore Immunology Network, Agency for Science, Technology and Research, Singapore (A*STAR), Singapore Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Institute of Infection and Global Health, University of Liverpool, United Kingdom

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http://jvi.asm.org/content/early/2015/05/15/JVI.00998-15.ful
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http://jvi.asm.org/content/89/15/7893.full.pdf
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http://jvi.asm.org/lookup/doi/10.1128/JVI.00998-15
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http://dx.doi.org/10.1128/JVI.00998-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505607PMC
August 2015

Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.

Nat Genet 2015 Mar 2;47(3):267-71. Epub 2015 Feb 2.

1] Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, China. [2] School of Medicine, Shandong University, Jinan, China. [3] Shandong Provincial Key Laboratory for Dermatovenereology, Jinan, China. [4] National Clinical Key Project of Dermatology and Venereology, Jinan, China.

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http://dx.doi.org/10.1038/ng.3212DOI Listing
March 2015

Evaluation of the applicability of the Immuno-solid-phase allergen chip (ISAC) assay in atopic patients in Singapore.

Clin Transl Allergy 2015 27;5. Epub 2015 Feb 27.

Division of Rheumatology, University Medicine Cluster, National University Health System, Singapore, Level 10 Tower Block, 1E Kent Ridge Road, Singapore, 119228 Singapore ; IMB (Institute of Medical Biology), ASTAR (Agency for Science, Technology and Research), Singapore, Singapore.

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http://dx.doi.org/10.1186/s13601-015-0053-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349609PMC
March 2015

γ/δ T cell subsets in human aging using the classical α/β T cell model.

J Leukoc Biol 2014 Oct 7;96(4):647-55. Epub 2014 Jul 7.

Singapore Immunology Network, Biopolis, Agency for Science, Technology and Research, Singapore;

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http://dx.doi.org/10.1189/jlb.5A1213-650RRDOI Listing
October 2014

ArchiLD: hierarchical visualization of linkage disequilibrium in human populations.

PLoS One 2014 21;9(1):e86761. Epub 2014 Jan 21.

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086761PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897757PMC
September 2014

Association of interleukin-13 SNP rs20541 (Arg>Gln) to allergic rhinitis in an Asian population of ethnic Chinese in Singapore.

Gene 2013 Oct 15;529(2):357-8. Epub 2013 Aug 15.

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

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https://linkinghub.elsevier.com/retrieve/pii/S03781119130104
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http://dx.doi.org/10.1016/j.gene.2013.08.014DOI Listing
October 2013

Immune modulation of inflammatory conditions: regulatory T cells for treatment of GvHD.

Immunol Res 2012 Sep;53(1-3):200-12

Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #03/04 Immunos, Biopolis, Singapore.

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http://link.springer.com/10.1007/s12026-012-8267-9
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http://dx.doi.org/10.1007/s12026-012-8267-9DOI Listing
September 2012

Are we ready for the use of foxp3(+) regulatory T cells for immunodiagnosis and immunotherapy in kidney transplantation?

J Transplant 2012 29;2012:397952. Epub 2012 May 29.

Tregs and HLA Research Force, Department of Renal Medicine, Singapore General Hospital, Outram Road, Singapore 169608.

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http://dx.doi.org/10.1155/2012/397952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368592PMC
August 2012

The lymph as a pool of self-antigens.

Trends Immunol 2011 Jan 1;32(1):6-11. Epub 2010 Dec 1.

Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave., New York, 10461, USA.

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http://www.cell.com/trends/immunology/pdf/S1471-4906(10)0015
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http://linkinghub.elsevier.com/retrieve/pii/S147149061000151
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http://dx.doi.org/10.1016/j.it.2010.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052980PMC
January 2011

Bidirectional binding of invariant chain peptides to an MHC class II molecule.

Proc Natl Acad Sci U S A 2010 Dec 29;107(51):22219-24. Epub 2010 Nov 29.

Leibniz-Institute for Molecular Pharmacology and Freie Universität Berlin, 13125 Berlin, Germany.

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http://dx.doi.org/10.1073/pnas.1014708107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009805PMC
December 2010

Bose-Einstein distribution, condensation transition, and multiple stationary states in multiloci evolution of diploid populations.

Phys Rev E Stat Nonlin Soft Matter Phys 2010 Sep 16;82(3 Pt 2):036109. Epub 2010 Sep 16.

Physics Department, Northeastern University, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1103/PhysRevE.82.036109DOI Listing
September 2010

Regulatory T cells in transplantation: does extracellular adenosine triphosphate metabolism through CD39 play a crucial role?

Transplant Rev (Orlando) 2010 Apr 11;24(2):52-66. Epub 2010 Feb 11.

Renal Medicine Department, Singapore General Hospital, Singapore.

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http://dx.doi.org/10.1016/j.trre.2010.01.002DOI Listing
April 2010

CD49d provides access to "untouched" human Foxp3+ Treg free of contaminating effector cells.

Blood 2009 Jan 21;113(4):827-36. Epub 2008 Oct 21.

Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1182/blood-2008-04-150524DOI Listing
January 2009

Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant tolerance.

Proc Natl Acad Sci U S A 2007 May 16;104(22):9393-8. Epub 2007 May 16.

Institut National de la Santé et de la Recherche Médicale Unité 563, Centre de Physiopathologie de Toulouse Purpan, F-31300 Toulouse, France.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0610423104
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http://dx.doi.org/10.1073/pnas.0610423104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890505PMC
May 2007

CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset.

Blood 2005 Apr 21;105(7):2877-86. Epub 2004 Dec 21.

Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str 10, 13125 Berlin, Germany.

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http://dx.doi.org/10.1182/blood-2004-07-2505DOI Listing
April 2005

"Chemical analogues" of HLA-DM can induce a peptide-receptive state in HLA-DR molecules.

J Biol Chem 2004 Dec 20;279(49):50684-90. Epub 2004 Sep 20.

Max Delbrück Center for Molecular Medicine, Robert Rösslestrasse 10, 13125 Berlin, Germany.

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http://dx.doi.org/10.1074/jbc.M407598200DOI Listing
December 2004

Production of neuroprotective NGF in astrocyte-T helper cell cocultures is upregulated following antigen recognition.

J Neuroimmunol 2004 Apr;149(1-2):59-65

Max Delbrück Center for Molecular Medicine, Robert-Rössle-Strasse 10, Berlin D-13125, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S016557280300565
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http://dx.doi.org/10.1016/j.jneuroim.2003.12.009DOI Listing
April 2004

Small-molecular compounds enhance the loading of APC with encephalitogenic MBP protein.

J Autoimmun 2003 Feb;20(1):63-9

Max-Delbrück-Center for Molecular Medicine, Berlin-Buch, Robert-Rössle-Strasse 10, 13125 Berlin, Germany.

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February 2003

The final cut: how ERAP1 trims MHC ligands to size.

Nat Immunol 2002 Dec;3(12):1121-2

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http://dx.doi.org/10.1038/ni1202-1121DOI Listing
December 2002

A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules.

Proc Natl Acad Sci U S A 2002 Dec 5;99(26):16946-50. Epub 2002 Dec 5.

Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.212643999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139249PMC
December 2002

Ligand exchange of major histocompatibility complex class II proteins is triggered by H-bond donor groups of small molecules.

J Biol Chem 2002 Jan 15;277(4):2709-15. Epub 2001 Oct 15.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1074/jbc.M109098200DOI Listing
January 2002