Olaf Ansorge

Olaf Ansorge

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Olaf Ansorge

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Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing.

Authors:
Istvan Adorjan Teadora Tyler Aparna Bhaduri Samuel Demharter Cintia Klaudia Finszter Maria Bako Oliver Marcell Sebok Tomasz J Nowakowski Konstantin Khodosevich Kjeld Møllgård Arnold R Kriegstein Lei Shi Anna Hoerder-Suabedissen Olaf Ansorge Zoltán Molnár

J Anat 2019 Sep 15;235(3):543-554. Epub 2019 Jan 15.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/joa.12931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704272PMC
September 2019

Heritability and genetic variance of dementia with Lewy bodies.

Authors:
Rita Guerreiro Valentina Escott-Price Dena G Hernandez Celia Kun-Rodrigues Owen A Ross Tatiana Orme Joao Luis Neto Susana Carmona Nadia Dehghani John D Eicher Claire Shepherd Laura Parkkinen Lee Darwent Michael G Heckman Sonja W Scholz Juan C Troncoso Olga Pletnikova Ted Dawson Liana Rosenthal Olaf Ansorge Jordi Clarimon Alberto Lleo Estrella Morenas-Rodriguez Lorraine Clark Lawrence S Honig Karen Marder Afina Lemstra Ekaterina Rogaeva Peter St George-Hyslop Elisabet Londos Henrik Zetterberg Imelda Barber Anne Braae Kristelle Brown Kevin Morgan Claire Troakes Safa Al-Sarraj Tammaryn Lashley Janice Holton Yaroslau Compta Vivianna Van Deerlin Geidy E Serrano Thomas G Beach Suzanne Lesage Douglas Galasko Eliezer Masliah Isabel Santana Pau Pastor Monica Diez-Fairen Miquel Aguilar Pentti J Tienari Liisa Myllykangas Minna Oinas Tamas Revesz Andrew Lees Brad F Boeve Ronald C Petersen Tanis J Ferman Neill Graff-Radford Nigel J Cairns John C Morris Stuart Pickering-Brown David Mann Glenda M Halliday John Hardy John Q Trojanowski Dennis W Dickson Andrew Singleton David J Stone Jose Bras

Neurobiol Dis 2019 07 3;127:492-501. Epub 2019 Apr 3.

Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588425PMC
July 2019

Rapid intraoperative molecular genetic classification of gliomas using Raman spectroscopy.

Authors:
Laurent James Livermore Martin Isabelle Ian Mac Bell Connor Scott John Walsby-Tickle Joan Gannon Puneet Plaha Claire Vallance Olaf Ansorge

Neurooncol Adv 2019 May-Dec;1(1):vdz008. Epub 2019 May 28.

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, UK.

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http://dx.doi.org/10.1093/noajnl/vdz008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777649PMC
May 2019

Frequency and signature of somatic variants in 1461 human brain exomes.

Authors:
Wei Wei Michael J Keogh Juvid Aryaman Zoe Golder Peter J Kullar Ian Wilson Kevin Talbot Martin R Turner Chris-Anne McKenzie Claire Troakes Johannes Attems Colin Smith Safa Al Sarraj Chris M Morris Olaf Ansorge Nick S Jones James W Ironside Patrick F Chinnery

Genet Med 2019 04 14;21(4):904-912. Epub 2018 Sep 14.

Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/s41436-018-0274-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544539PMC
April 2019

Development of a Sensitive, Scalable Method for Spatial, Cell-Type-Resolved Proteomics of the Human Brain.

Authors:
Simon Davis Connor Scott Olaf Ansorge Roman Fischer

J Proteome Res 2019 Apr 25;18(4):1787-1795. Epub 2019 Feb 25.

Target Discovery Institute, Nuffield Department of Medicine , University of Oxford , Roosevelt Drive , Oxford , OX3 7FZ , U.K.

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http://dx.doi.org/10.1021/acs.jproteome.8b00981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456870PMC
April 2019

A comprehensive screening of copy number variability in dementia with Lewy bodies.

Authors:
Celia Kun-Rodrigues Tatiana Orme Susana Carmona Dena G Hernandez Owen A Ross John D Eicher Claire Shepherd Laura Parkkinen Lee Darwent Michael G Heckman Sonja W Scholz Juan C Troncoso Olga Pletnikova Ted Dawson Liana Rosenthal Olaf Ansorge Jordi Clarimon Alberto Lleo Estrella Morenas-Rodriguez Lorraine Clark Lawrence S Honig Karen Marder Afina Lemstra Ekaterina Rogaeva Peter St George-Hyslop Elisabet Londos Henrik Zetterberg Imelda Barber Anne Braae Kristelle Brown Kevin Morgan Claire Troakes Safa Al-Sarraj Tammaryn Lashley Janice Holton Yaroslau Compta Vivianna Van Deerlin Geidy E Serrano Thomas G Beach Suzanne Lesage Douglas Galasko Eliezer Masliah Isabel Santana Pau Pastor Monica Diez-Fairen Miquel Aguilar Pentti J Tienari Liisa Myllykangas Minna Oinas Tamas Revesz Andrew Lees Brad F Boeve Ronald C Petersen Tanis J Ferman Valentina Escott-Price Neill Graff-Radford Nigel J Cairns John C Morris Stuart Pickering-Brown David Mann Glenda M Halliday John Hardy John Q Trojanowski Dennis W Dickson Andrew Singleton David J Stone Rita Guerreiro Jose Bras

Neurobiol Aging 2019 03 24;75:223.e1-223.e10. Epub 2018 Oct 24.

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183038
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541211PMC
March 2019

A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy.

Authors:
Xin Shen Natalie L Voets Sarah J Larkin Nick de Pennington Puneet Plaha Richard Stacey James S O McCullagh Christopher J Schofield Stuart Clare Peter Jezzard Tom Cadoux-Hudson Olaf Ansorge Uzay E Emir

Metabolites 2019 Feb 20;9(2). Epub 2019 Feb 20.

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.3390/metabo9020035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409728PMC
February 2019

Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.

Authors:
David Gordon Ruxandra Dafinca Jakub Scaber Javier Alegre-Abarrategui Lucy Farrimond Connor Scott Daniel Biggs Louisa Kent Peter L Oliver Benjamin Davies Olaf Ansorge Richard Wade-Martins Kevin Talbot

Neurobiol Dis 2019 01 2;121:148-162. Epub 2018 Oct 2.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09699961183066
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http://dx.doi.org/10.1016/j.nbd.2018.09.024DOI Listing
January 2019

Group II Metabotropic Glutamate Receptors Mediate Presynaptic Inhibition of Excitatory Transmission in Pyramidal Neurons of the Human Cerebral Cortex.

Authors:
Marco Bocchio Istvan P Lukacs Richard Stacey Puneet Plaha Vasileios Apostolopoulos Laurent Livermore Arjune Sen Olaf Ansorge Martin J Gillies Peter Somogyi Marco Capogna

Front Cell Neurosci 2018 8;12:508. Epub 2019 Jan 8.

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.3389/fncel.2018.00508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333023PMC
January 2019

Somatic variants in autosomal dominant genes are a rare cause of sporadic Alzheimer's disease.

Authors:
Gaël Nicolas Rocío Acuña-Hidalgo Michael J Keogh Olivier Quenez Marloes Steehouwer Stefan Lelieveld Stéphane Rousseau Anne-Claire Richard Manon S Oud Florent Marguet Annie Laquerrière Chris M Morris Johannes Attems Colin Smith Olaf Ansorge Safa Al Sarraj Thierry Frebourg Dominique Campion Didier Hannequin David Wallon Christian Gilissen Patrick F Chinnery Joris A Veltman Alexander Hoischen

Alzheimers Dement 2018 12 13;14(12):1632-1639. Epub 2018 Aug 13.

Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.jalz.2018.06.3056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544509PMC
December 2018

Towards a TDP-43-Based Biomarker for ALS and FTLD.

Authors:
Emily Feneberg Elizabeth Gray Olaf Ansorge Kevin Talbot Martin R Turner

Mol Neurobiol 2018 Oct 19;55(10):7789-7801. Epub 2018 Feb 19.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1007/s12035-018-0947-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132775PMC
October 2018

Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation.

Authors:
Maggie M K Wong Stephanie D Hoekstra Jane Vowles Lauren M Watson Geraint Fuller Andrea H Németh Sally A Cowley Olaf Ansorge Kevin Talbot Esther B E Becker

Acta Neuropathol Commun 2018 09 24;6(1):99. Epub 2018 Sep 24.

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Road, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1186/s40478-018-0600-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151931PMC
September 2018

Oligogenic genetic variation of neurodegenerative disease genes in 980 postmortem human brains.

Authors:
Michael J Keogh Wei Wei Juvid Aryaman Ian Wilson Kevin Talbot Martin R Turner Chris-Anne McKenzie Claire Troakes Johannes Attems Colin Smith Safa Al Sarraj Chris M Morris Olaf Ansorge Stuart Pickering-Brown Nick Jones James W Ironside Patrick F Chinnery

J Neurol Neurosurg Psychiatry 2018 08 13;89(8):813-816. Epub 2018 Jan 13.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1136/jnnp-2017-317234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204946PMC
August 2018

Autism BrainNet: A network of postmortem brain banks established to facilitate autism research.

Authors:
David G Amaral Matthew P Anderson Olaf Ansorge Steven Chance Carolyn Hare Patrick R Hof Melissa Miller Ikue Nagakura Jane Pickett Cynthia Schumann Carol Tamminga

Handb Clin Neurol 2018 ;150:31-39

Department of Psychiatry, UT Southwestern, Dallas, TX, United States.

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https://linkinghub.elsevier.com/retrieve/pii/B97804446363930
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http://dx.doi.org/10.1016/B978-0-444-63639-3.00003-7DOI Listing
August 2018

A comparison of 2-hydroxyglutarate detection at 3 and 7 T with long-TE semi-LASER.

Authors:
Adam Berrington Natalie L Voets Sarah J Larkin Nick de Pennington James Mccullagh Richard Stacey Christopher J Schofield Peter Jezzard Stuart Clare Tom Cadoux-Hudson Puneet Plaha Olaf Ansorge Uzay E Emir

NMR Biomed 2018 03 5;31(3). Epub 2018 Jan 5.

FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1002/nbm.3886DOI Listing
March 2018

Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology.

Authors:
Menuka Pallebage-Gamarallage Sean Foxley Ricarda A L Menke Istvan N Huszar Mark Jenkinson Benjamin C Tendler Chaoyue Wang Saad Jbabdi Martin R Turner Karla L Miller Olaf Ansorge

BMC Neurosci 2018 03 13;19(1):11. Epub 2018 Mar 13.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/s12868-018-0416-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848544PMC
March 2018

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

Authors:
Rita Guerreiro Owen A Ross Celia Kun-Rodrigues Dena G Hernandez Tatiana Orme John D Eicher Claire E Shepherd Laura Parkkinen Lee Darwent Michael G Heckman Sonja W Scholz Juan C Troncoso Olga Pletnikova Olaf Ansorge Jordi Clarimon Alberto Lleo Estrella Morenas-Rodriguez Lorraine Clark Lawrence S Honig Karen Marder Afina Lemstra Ekaterina Rogaeva Peter St George-Hyslop Elisabet Londos Henrik Zetterberg Imelda Barber Anne Braae Kristelle Brown Kevin Morgan Claire Troakes Safa Al-Sarraj Tammaryn Lashley Janice Holton Yaroslau Compta Vivianna Van Deerlin Geidy E Serrano Thomas G Beach Suzanne Lesage Douglas Galasko Eliezer Masliah Isabel Santana Pau Pastor Monica Diez-Fairen Miquel Aguilar Pentti J Tienari Liisa Myllykangas Minna Oinas Tamas Revesz Andrew Lees Brad F Boeve Ronald C Petersen Tanis J Ferman Valentina Escott-Price Neill Graff-Radford Nigel J Cairns John C Morris Stuart Pickering-Brown David Mann Glenda M Halliday John Hardy John Q Trojanowski Dennis W Dickson Andrew Singleton David J Stone Jose Bras

Lancet Neurol 2018 01 16;17(1):64-74. Epub 2017 Dec 16.

UK Dementia Research Institute, University College London, London, UK; Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30400-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805394PMC
January 2018

In-frame seven amino-acid duplication in arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism.

Authors:
Roberto Salvatori Serban Radian Yoan Diekmann Donato Iacovazzo Alessia David Plamena Gabrovska Giorgia Grassi Anna-Marie Bussell Karen Stals Astrid Weber Richard Quinton Elizabeth C Crowne Valentina Corazzini Lou Metherell Tara Kearney Daniel Du Plessis Ajay Kumar Sinha Atik Baborie Anne-Lise Lecoq Philippe Chanson Olaf Ansorge Sian Ellard Peter J Trainer David Balding Mark G Thomas Márta Korbonits

Eur J Endocrinol 2017 Sep 20;177(3):257-266. Epub 2017 Jun 20.

William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1530/EJE-17-0293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510572PMC
September 2017

Evaluating fibre orientation dispersion in white matter: Comparison of diffusion MRI, histology and polarized light imaging.

Authors:
Jeroen Mollink Michiel Kleinnijenhuis Anne-Marie van Cappellen van Walsum Stamatios N Sotiropoulos Michiel Cottaar Christopher Mirfin Mattias P Heinrich Mark Jenkinson Menuka Pallebage-Gamarallage Olaf Ansorge Saad Jbabdi Karla L Miller

Neuroimage 2017 08 8;157:561-574. Epub 2017 Jun 8.

FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.neuroimage.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607356PMC
August 2017

Functional expression of calcium-permeable canonical transient receptor potential 4-containing channels promotes migration of medulloblastoma cells.

Authors:
Wei-Chun Wei Wan-Chen Huang Yu-Ping Lin Esther B E Becker Olaf Ansorge Veit Flockerzi Daniele Conti Giovanna Cenacchi Maike D Glitsch

J Physiol 2017 08 20;595(16):5525-5544. Epub 2017 Jul 20.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1113/JP274659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556167PMC
August 2017

Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains.

Authors:
Wei Wei Michael J Keogh Ian Wilson Jonathan Coxhead Sarah Ryan Sara Rollinson Helen Griffin Marzena Kurzawa-Akanbi Mauro Santibanez-Koref Kevin Talbot Martin R Turner Chris-Anne McKenzie Claire Troakes Johannes Attems Colin Smith Safa Al Sarraj Christopher M Morris Olaf Ansorge Stuart Pickering-Brown James W Ironside Patrick F Chinnery

Acta Neuropathol Commun 2017 Feb 2;5(1):13. Epub 2017 Feb 2.

Institute of Genetic Medicine, Central Parkway, Newcastle University, Newcastle Upon Tyne, NE1 3BZ, UK.

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http://dx.doi.org/10.1186/s40478-016-0404-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290662PMC
February 2017

Erratum to: Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains.

Authors:
Wei Wei Michael J Keogh Ian Wilson Jonathan Coxhead Sarah Ryan Sara Rollinson Helen Griffin Marzena Kurzawa-Akanbi Mauro Santibanez-Koref Kevin Talbot Martin R Turner Chris-Anne McKenzie Claire Troakes Johannes Attems Colin Smith Safa Al Sarraj Christopher M Morris Olaf Ansorge Stuart Pickering-Brown James W Ironside Patrick F Chinnery

Acta Neuropathol Commun 2017 02 22;5(1):17. Epub 2017 Feb 22.

Institute of Genetic Medicine, Central Parkway, Newcastle University, Newcastle Upon Tyne, NE1 3BZ, UK.

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http://dx.doi.org/10.1186/s40478-017-0419-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322681PMC
February 2017

Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

Authors:
Celia Kun-Rodrigues Owen A Ross Tatiana Orme Claire Shepherd Laura Parkkinen Lee Darwent Dena Hernandez Olaf Ansorge Lorraine N Clark Lawrence S Honig Karen Marder Afina Lemstra Philippe Scheltens Wiesje van der Flier Eva Louwersheimer Henne Holstege Ekaterina Rogaeva Peter St George-Hyslop Elisabet Londos Henrik Zetterberg Imelda Barber Anne Braae Kristelle Brown Kevin Morgan Walter Maetzler Daniela Berg Claire Troakes Safa Al-Sarraj Tammaryn Lashley Janice Holton Yaroslau Compta Vivianna Van Deerlin John Q Trojanowski Geidy E Serrano Thomas G Beach Jordi Clarimon Alberto Lleó Estrella Morenas-Rodríguez Suzanne Lesage Douglas Galasko Eliezer Masliah Isabel Santana Monica Diez Pau Pastor Pentti J Tienari Liisa Myllykangas Minna Oinas Tamas Revesz Andrew Lees Brad F Boeve Ronald C Petersen Tanis J Ferman Valentina Escott-Price Neill Graff-Radford Nigel J Cairns John C Morris David J Stone Stuart Pickering-Brown David Mann Dennis W Dickson Glenda M Halliday Andrew Singleton Rita Guerreiro Jose Bras

Neurobiol Aging 2017 01 2;49:214.e13-214.e15. Epub 2016 Sep 2.

Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Department of Medical Sciences and Institute of Biomedicine-iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154872PMC
January 2017

Genetic compendium of 1511 human brains available through the UK Medical Research Council Brain Banks Network Resource.

Authors:
Michael J Keogh Wei Wei Ian Wilson Jon Coxhead Sarah Ryan Sara Rollinson Helen Griffin Marzena Kurzawa-Akanbi Mauro Santibanez-Koref Kevin Talbot Martin R Turner Chris-Anne McKenzie Claire Troakes Johannes Attems Colin Smith Safa Al Sarraj Chris M Morris Olaf Ansorge Stuart Pickering-Brown James W Ironside Patrick F Chinnery

Genome Res 2017 01 21;27(1):165-173. Epub 2016 Dec 21.

Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1101/gr.210609.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204341PMC
January 2017

Metastatic meningioma presenting as a malignant soft tissue tumour.

Authors:
Catherine McCarthy Monika Hofer Marianna Vlychou Robar Khundkar Paul Critchley Simon Cudlip Olaf Ansorge Nick A Athanasou

Clin Sarcoma Res 2016 30;6:23. Epub 2016 Dec 30.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, Windmill Road, Oxford, OX3 7HE UK.

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http://dx.doi.org/10.1186/s13569-016-0063-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200959PMC
December 2016

Extended post-mortem delay times should not be viewed as a deterrent to the scientific investigation of human brain tissue: a study from the Brains for Dementia Research Network Neuropathology Study Group, UK.

Authors:
Andrew C Robinson Laura Palmer Seth Love Marie Hamard Margaret Esiri Olaf Ansorge Debbie Lett Johannes Attems Chris Morris Claire Troakes Sashika Selvackadunco Andrew King Safa Al-Sarraj David M A Mann

Acta Neuropathol 2016 11 15;132(5):753-755. Epub 2016 Sep 15.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Salford Royal Hospital, University of Manchester, Salford, Manchester, M6 8HD, UK.

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http://dx.doi.org/10.1007/s00401-016-1617-2DOI Listing
November 2016

Expression of Idh1 in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.

Authors:
Chiara Bardella Osama Al-Dalahmah Daniel Krell Pijus Brazauskas Khalid Al-Qahtani Marketa Tomkova Julie Adam Sébastien Serres Helen Lockstone Luke Freeman-Mills Inga Pfeffer Nicola Sibson Robert Goldin Benjamin Schuster-Böeckler Patrick J Pollard Tomoyoshi Soga James S McCullagh Christopher J Schofield Paul Mulholland Olaf Ansorge Skirmantas Kriaucionis Peter J Ratcliffe Francis G Szele Ian Tomlinson

Cancer Cell 2016 10 29;30(4):578-594. Epub 2016 Sep 29.

Molecular & Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064912PMC
October 2016

A macroprolactinoma becoming resistant to cabergoline and developing atypical pathology.

Authors:
Emilia Sbardella George Farah Ahmed Fathelrahman Simon Cudlip Olaf Ansorge Niki Karavitaki Ashley B Grossman

Endocrinol Diabetes Metab Case Rep 2016 18;2016. Epub 2016 Oct 18.

Department of Endocrinology , Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford , UK.

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http://dx.doi.org/10.1530/EDM-16-0038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093397PMC
October 2016

Pathogenesis of FUS-associated ALS and FTD: insights from rodent models.

Authors:
Matthew Nolan Kevin Talbot Olaf Ansorge

Acta Neuropathol Commun 2016 09 6;4(1):99. Epub 2016 Sep 6.

Neuropathology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/s40478-016-0358-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011941PMC
September 2016

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.

Authors:
Zoi Alexopoulou Johannes Lang Rebecca M Perrett Myriam Elschami Madeleine E D Hurry Hyoung Tae Kim Dimitra Mazaraki Aron Szabo Benedikt M Kessler Alfred Lewis Goldberg Olaf Ansorge Tudor A Fulga George K Tofaris

Proc Natl Acad Sci U S A 2016 08 21;113(32):E4688-97. Epub 2016 Jul 21.

Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1523597113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987833PMC
August 2016

Rathke's cleft cyst.

Authors:
Sarah Larkin Niki Karavitaki Olaf Ansorge

Handb Clin Neurol 2014 ;124:255-69

Department of Neuropathology, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-59602-4.00017-4DOI Listing
July 2016

Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study.

Authors:
Donato Iacovazzo Richard Caswell Benjamin Bunce Sian Jose Bo Yuan Laura C Hernández-Ramírez Sonal Kapur Francisca Caimari Jane Evanson Francesco Ferraù Mary N Dang Plamena Gabrovska Sarah J Larkin Olaf Ansorge Celia Rodd Mary L Vance Claudia Ramírez-Renteria Moisés Mercado Anthony P Goldstone Michael Buchfelder Christine P Burren Alper Gurlek Pinaki Dutta Catherine S Choong Timothy Cheetham Giampaolo Trivellin Constantine A Stratakis Maria-Beatriz Lopes Ashley B Grossman Jacqueline Trouillas James R Lupski Sian Ellard Julian R Sampson Federico Roncaroli Márta Korbonits

Acta Neuropathol Commun 2016 06 1;4(1):56. Epub 2016 Jun 1.

Centre for Endocrinology, Barts and The London School of Medicine, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1186/s40478-016-0328-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888203PMC
June 2016

Tocilizumab-associated multifocal cerebral thrombotic microangiopathy.

Authors:
Paul Jewell Olaf Ansorge Wilhelm Kuker Sarosh R Irani Giovanna Zamboni

Neurol Clin Pract 2016 Jun;6(3):e24-e26

Nuffield Department of Clinical Neuroscience, University of Oxford, UK.

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http://dx.doi.org/10.1212/CPJ.0000000000000220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909526PMC
June 2016

Improved localisation for 2-hydroxyglutarate detection at 3T using long-TE semi-LASER.

Authors:
Adam Berrington Natalie L Voets Puneet Plaha Sarah J Larkin James Mccullagh Richard Stacey Muhammed Yildirim Christopher J Schofield Peter Jezzard Tom Cadoux-Hudson Olaf Ansorge Uzay E Emir

Tomography 2016 Jun;2(2):94-105

FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.18383/j.tom.2016.00139DOI Listing
June 2016

Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR.

Authors:
Tamara Aleksic Lisa Browning Martha Woodward Rachel Phillips Suzanne Page Shirley Henderson Nicholas Athanasou Olaf Ansorge Duncan Whitwell Sarah Pratap A Bassim Hassan Mark R Middleton Valentine M Macaulay

Front Oncol 2016 2;6:98. Epub 2016 May 2.

Department of Oncology, Old Road Campus Research Building, Oxford, UK; Oxford Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

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http://dx.doi.org/10.3389/fonc.2016.00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852191PMC
May 2016

Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.

Authors:
Marc Suárez-Calvet Manuela Neumann Thomas Arzberger Claudia Abou-Ajram Eva Funk Hannelore Hartmann Dieter Edbauer Elisabeth Kremmer Christoph Göbl Moritz Resch Benjamin Bourgeois Tobias Madl Stefan Reber Daniel Jutzi Marc-David Ruepp Ian R A Mackenzie Olaf Ansorge Dorothee Dormann Christian Haass

Acta Neuropathol 2016 Apr 19;131(4):587-604. Epub 2016 Feb 19.

Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich, Feodor-Lynen Strasse 17, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-016-1544-2DOI Listing
April 2016

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases.

Authors:
Rita Guerreiro Valentina Escott-Price Lee Darwent Laura Parkkinen Olaf Ansorge Dena G Hernandez Michael A Nalls Lorraine Clark Lawrence Honig Karen Marder Wiesje van der Flier Henne Holstege Eva Louwersheimer Afina Lemstra Philip Scheltens Ekaterina Rogaeva Peter St George-Hyslop Elisabet Londos Henrik Zetterberg Sara Ortega-Cubero Pau Pastor Tanis J Ferman Neill R Graff-Radford Owen A Ross Imelda Barber Anne Braae Kristelle Brown Kevin Morgan Walter Maetzler Daniela Berg Claire Troakes Safa Al-Sarraj Tammaryn Lashley Yaroslau Compta Tamas Revesz Andrew Lees Nigel J Cairns Glenda M Halliday David Mann Stuart Pickering-Brown John Powell Katie Lunnon Michelle K Lupton Dennis Dickson John Hardy Andrew Singleton Jose Bras

Neurobiol Aging 2016 Feb 2;38:214.e7-214.e10. Epub 2015 Nov 2.

Department of Molecular Neuroscience, Institute of Neurology, UCL, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759606PMC
February 2016

Establishment of human iPSC-based models for the study and targeting of glioma initiating cells.

Authors:
Ignacio Sancho-Martinez Emmanuel Nivet Yun Xia Tomoaki Hishida Aitor Aguirre Alejandro Ocampo Li Ma Robert Morey Marie N Krause Andreas Zembrzycki Olaf Ansorge Eric Vazquez-Ferrer Ilir Dubova Pradeep Reddy David Lam Yuriko Hishida Min-Zu Wu Concepcion Rodriguez Esteban Dennis O'Leary Geoffrey M Wahl Inder M Verma Louise C Laurent Juan Carlos Izpisua Belmonte

Nat Commun 2016 Feb 22;7:10743. Epub 2016 Feb 22.

Gene Expression Laboratory Belmonte, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/ncomms10743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764898PMC
February 2016

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.

Authors:
Gabor G Kovacs Isidro Ferrer Lea T Grinberg Irina Alafuzoff Johannes Attems Herbert Budka Nigel J Cairns John F Crary Charles Duyckaerts Bernardino Ghetti Glenda M Halliday James W Ironside Seth Love Ian R Mackenzie David G Munoz Melissa E Murray Peter T Nelson Hitoshi Takahashi John Q Trojanowski Olaf Ansorge Thomas Arzberger Atik Baborie Thomas G Beach Kevin F Bieniek Eileen H Bigio Istvan Bodi Brittany N Dugger Mel Feany Ellen Gelpi Stephen M Gentleman Giorgio Giaccone Kimmo J Hatanpaa Richard Heale Patrick R Hof Monika Hofer Tibor Hortobágyi Kurt Jellinger Gregory A Jicha Paul Ince Julia Kofler Enikö Kövari Jillian J Kril David M Mann Radoslav Matej Ann C McKee Catriona McLean Ivan Milenkovic Thomas J Montine Shigeo Murayama Edward B Lee Jasmin Rahimi Roberta D Rodriguez Annemieke Rozemüller Julie A Schneider Christian Schultz William Seeley Danielle Seilhean Colin Smith Fabrizio Tagliavini Masaki Takao Dietmar Rudolf Thal Jon B Toledo Markus Tolnay Juan C Troncoso Harry V Vinters Serge Weis Stephen B Wharton Charles L White Thomas Wisniewski John M Woulfe Masahito Yamada Dennis W Dickson

Acta Neuropathol 2016 Jan 10;131(1):87-102. Epub 2015 Dec 10.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-015-1509-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879001PMC
January 2016

Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations.

Authors:
Uzay E Emir Sarah J Larkin Nick de Pennington Natalie Voets Puneet Plaha Richard Stacey Khalid Al-Qahtani James Mccullagh Christopher J Schofield Stuart Clare Peter Jezzard Tom Cadoux-Hudson Olaf Ansorge

Cancer Res 2016 Jan 15;76(1):43-9. Epub 2015 Dec 15.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704134PMC
January 2016

BRAF V600E mutations are characteristic for papillary craniopharyngioma and may coexist with CTNNB1-mutated adamantinomatous craniopharyngioma.

Authors:
Sarah Jane Larkin Veronica Preda Niki Karavitaki Ashley Grossman Olaf Ansorge

Acta Neuropathol 2014 9;127(6):927-9. Epub 2014 Apr 9.

Nuffield Department of Clinical Neurosciences, Department of Neuropathology, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1007/s00401-014-1270-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024131PMC
August 2015

The Wnt signalling cascade and the adherens junction complex in craniopharyngioma tumorigenesis.

Authors:
Veronica Preda Sarah J Larkin Niki Karavitaki Olaf Ansorge Ashley B Grossman

Endocr Pathol 2015 Mar;26(1):1-8

Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Rd, Headington, Oxford, OX3 7LE, UK,

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http://dx.doi.org/10.1007/s12022-014-9341-8DOI Listing
March 2015

Dopamine transporter imaging for the diagnosis of dementia with Lewy bodies.

Authors:
Jenny McCleery Shirlony Morgan Kevin M Bradley Anna H Noel-Storr Olaf Ansorge Chris Hyde

Cochrane Database Syst Rev 2015 Jan 30;1:CD010633. Epub 2015 Jan 30.

Oxford Health NHS Foundation Trust, Elms Centre, Oxford Road, Banbury, Oxfordshire, UK, OX16 9AL.

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http://dx.doi.org/10.1002/14651858.CD010633.pub2DOI Listing
January 2015

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.

Authors:
Jose Bras Rita Guerreiro Lee Darwent Laura Parkkinen Olaf Ansorge Valentina Escott-Price Dena G Hernandez Michael A Nalls Lorraine N Clark Lawrence S Honig Karen Marder Wiesje M Van Der Flier Afina Lemstra Philip Scheltens Ekaterina Rogaeva Peter St George-Hyslop Elisabet Londos Henrik Zetterberg Sara Ortega-Cubero Pau Pastor Tanis J Ferman Neill R Graff-Radford Owen A Ross Imelda Barber Anne Braae Kristelle Brown Kevin Morgan Walter Maetzler Daniela Berg Claire Troakes Safa Al-Sarraj Tammaryn Lashley Yaroslau Compta Tamas Revesz Andrew Lees Nigel Cairns Glenda M Halliday David Mann Stuart Pickering-Brown Dennis W Dickson Andrew Singleton John Hardy

Hum Mol Genet 2014 Dec 27;23(23):6139-46. Epub 2014 Jun 27.

Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.

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http://dx.doi.org/10.1093/hmg/ddu334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222357PMC
December 2014

Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.

Authors:
Sarah J Larkin Francesco Ferraù Niki Karavitaki Laura C Hernández-Ramírez Olaf Ansorge Ashley B Grossman Márta Korbonits

Eur J Endocrinol 2014 Dec 15;171(6):705-10. Epub 2014 Sep 15.

Nuffield Department of Clinical NeurosciencesDepartment of Neuropathology, Level 1 West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UKDepartment of EndocrinologyBarts and London School of Medicine, Queen Mary University of London, London EC1A 6BQ, UKDepartment of EndocrinologyOxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK.

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http://dx.doi.org/10.1530/EJE-14-0545DOI Listing
December 2014

Improving diffusion-weighted imaging of post-mortem human brains: SSFP at 7 T.

Authors:
Sean Foxley Saad Jbabdi Stuart Clare Wilfred Lam Olaf Ansorge Gwenaelle Douaud Karla Miller

Neuroimage 2014 Nov 13;102 Pt 2:579-89. Epub 2014 Aug 13.

FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2014.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229505PMC
November 2014

FTLD-ALS of TDP-43 type and SCA2 in a family with a full ataxin-2 polyglutamine expansion.

Authors:
Dirk Bäumer Simon Z East Bing Tseu Adam Zeman David Hilton Kevin Talbot Olaf Ansorge

Acta Neuropathol 2014 Oct 10;128(4):597-604. Epub 2014 Apr 10.

Department of Neuropathology, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1007/s00401-014-1277-zDOI Listing
October 2014

Reduced C9orf72 protein levels in frontal cortex of amyotrophic lateral sclerosis and frontotemporal degeneration brain with the C9ORF72 hexanucleotide repeat expansion.

Authors:
Adrian J Waite Dirk Bäumer Simon East James Neal Huw R Morris Olaf Ansorge Derek J Blake

Neurobiol Aging 2014 Jul 17;35(7):1779.e5-1779.e13. Epub 2014 Jan 17.

Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cathays, Cardiff, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988882PMC
July 2014

STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression.

Authors:
Casmir Turnquist Yihua Wang David T Severson Shan Zhong Bin Sun Jingyi Ma Stefan N Constaninescu Olaf Ansorge Helen B Stolp Zoltán Molnár Francis G Szele Xin Lu

Proc Natl Acad Sci U S A 2014 Jul 23;111(27):9834-9. Epub 2014 Jun 23.

Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine and

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http://www.pnas.org/lookup/doi/10.1073/pnas.1407898111
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http://dx.doi.org/10.1073/pnas.1407898111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103354PMC
July 2014

Fibrillary astrocytes are decreased in the subgenual cingulate in schizophrenia.

Authors:
Matthew Williams Ronald K B Pearce Steven R Hirsch Olaf Ansorge Maria Thom Michael Maier

Eur Arch Psychiatry Clin Neurosci 2014 Jun 29;264(4):357-62. Epub 2013 Dec 29.

Neuropathology Unit, Charing Cross Hospital, Imperial College London, London, W6 8RF, UK,

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http://dx.doi.org/10.1007/s00406-013-0482-4DOI Listing
June 2014

Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.

Authors:
Tonya N Taylor Dawid Potgieter Sabina Anwar Steven L Senior Stephanie Janezic Sarah Threlfell Brent Ryan Laura Parkkinen Thierry Deltheil Milena Cioroch Achilleas Livieratos Peter L Oliver Katie A Jennings Kay E Davies Olaf Ansorge David M Bannerman Stephanie J Cragg Richard Wade-Martins

Neurobiol Dis 2014 Feb 10;62:193-207. Epub 2013 Oct 10.

Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK; Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2013.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898275PMC
February 2014

Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans.

Authors:
Michael Stapelberg Renata Zobalova Maria Nga Nguyen Tom Walker Marina Stantic Jacob Goodwin Elham Alizadeh Pasdar Thuan Thai Katerina Prokopova Bing Yan Susan Hall Nicholas de Pennington Shane R Thomas Gary Grant Jan Stursa Martina Bajzikova Adrian C B Meedeniya Jaroslav Truksa Stephen J Ralph Olaf Ansorge Lan-Feng Dong Jiri Neuzil

Free Radic Biol Med 2014 Feb 18;67:41-50. Epub 2013 Oct 18.

School of Medical Science, Griffith Health Institute, Griffith University, Southport, 4222 QLD, Australia; Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.003DOI Listing
February 2014

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.

Authors:
Stephanie Janezic Sarah Threlfell Paul D Dodson Megan J Dowie Tonya N Taylor Dawid Potgieter Laura Parkkinen Steven L Senior Sabina Anwar Brent Ryan Thierry Deltheil Polina Kosillo Milena Cioroch Katharina Wagner Olaf Ansorge David M Bannerman J Paul Bolam Peter J Magill Stephanie J Cragg Richard Wade-Martins

Proc Natl Acad Sci U S A 2013 Oct 30;110(42):E4016-25. Epub 2013 Sep 30.

Oxford Parkinson's Disease Centre Department of Physiology, Anatomy and Genetics, Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, and Department of Experimental Psychology, University of Oxford, Oxford OX1 3QX, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1309143110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801069PMC
October 2013

Confusing genes: a patient with MEN2A and Cushing's disease.

Authors:
Auditi Naziat Niki Karavitaki Rajesh Thakker Olaf Ansorge Greg Sadler Fergus Gleeson Treena Cranston Ann McCormack Ashley B Grossman Brian Shine

Clin Endocrinol (Oxf) 2013 Jun 6;78(6):966-8. Epub 2013 Apr 6.

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http://dx.doi.org/10.1111/cen.12072DOI Listing
June 2013

Granulation pattern, but not GSP or GHR mutation, is associated with clinical characteristics in somatostatin-naive patients with somatotroph adenomas.

Authors:
Sarah Larkin Raghava Reddy Niki Karavitaki Simon Cudlip John Wass Olaf Ansorge

Eur J Endocrinol 2013 Apr 15;168(4):491-9. Epub 2013 Mar 15.

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.

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https://eje.bioscientifica.com/view/journals/eje/168/4/491.x
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http://dx.doi.org/10.1530/EJE-12-0864DOI Listing
April 2013

Whole-exome sequencing studies of nonfunctioning pituitary adenomas.

Authors:
Paul J Newey M Andrew Nesbit Andrew J Rimmer Rosie A Head Caroline M Gorvin Moustafa Attar Lorna Gregory John A H Wass David Buck Niki Karavitaki Ashley B Grossman Gilean McVean Olaf Ansorge Rajesh V Thakker

J Clin Endocrinol Metab 2013 Apr 28;98(4):E796-800. Epub 2013 Feb 28.

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, United Kingdom.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2012-4028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447855PMC
April 2013

Pathology and pathogenesis of craniopharyngiomas.

Authors:
Sarah J Larkin Olaf Ansorge

Pituitary 2013 Mar;16(1):9-17

Nuffield Department of Clinical Neurosciences, Headley Way, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1007/s11102-012-0418-4DOI Listing
March 2013

Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia.

Authors:
Matthew Roy Williams Thomas Hampton Ronald K B Pearce Steven Richard Hirsch Olaf Ansorge Maria Thom Michael Maier

Eur Arch Psychiatry Clin Neurosci 2013 Feb 4;263(1):41-52. Epub 2012 Jun 4.

Neuropathology Unit, Department of Experimental Medicine, Imperial College London, Charing Cross Hospital, UK.

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http://dx.doi.org/10.1007/s00406-012-0328-5DOI Listing
February 2013

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.

Authors:
Manuela Neumann Chiara F Valori Olaf Ansorge Hans A Kretzschmar David G Munoz Hirofumi Kusaka Osamu Yokota Kenji Ishihara Lee-Cyn Ang Juan M Bilbao Ian R A Mackenzie

Acta Neuropathol 2012 Nov 28;124(5):705-16. Epub 2012 Jul 28.

Institute of Neuropathology, University Hospital Zurich, Switzerland.

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http://link.springer.com/10.1007/s00401-012-1020-6
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November 2012

Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.

Authors:
Dorothee Dormann Tobias Madl Chiara F Valori Eva Bentmann Sabina Tahirovic Claudia Abou-Ajram Elisabeth Kremmer Olaf Ansorge Ian R A Mackenzie Manuela Neumann Christian Haass

EMBO J 2012 Nov 11;31(22):4258-75. Epub 2012 Sep 11.

Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1038/emboj.2012.261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501225PMC
November 2012

MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas.

Authors:
Gerard V Walls Manuel C Lemos Mahsa Javid Miriam Bazan-Peregrino Jeshmi Jeyabalan Anita A C Reed Brian Harding Damian J Tyler Daniel J Stuckey Sian Piret Paul T Christie Olaf Ansorge Kieran Clarke Len Seymour Rajesh V Thakker

Cancer Res 2012 Oct 21;72(19):5060-8. Epub 2012 Aug 21.

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463502PMC
October 2012

Mini-review: pheochromocytomas causing the ectopic ACTH syndrome.

Authors:
Chitrabhanu Ballav Auditi Naziat Radu Mihai Niki Karavitaki Olaf Ansorge Ashley B Grossman

Endocrine 2012 Aug 7;42(1):69-73. Epub 2012 Mar 7.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, OX3 7LE, UK.

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http://dx.doi.org/10.1007/s12020-012-9646-7DOI Listing
August 2012

Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide.

Authors:
Iain R Thompson Annisa N Chand Peter J King Olaf Ansorge Niki Karavitaki Ceri Alexander Jones Dolkun Rahmutula David G Gardner Vladimir Zivkovic Caroline P Wheeler-Jones Imelda M McGonnell Márta Korbonits Richard A Anderson John A H Wass Alan S McNeilly Robert C Fowkes

Endocr Relat Cancer 2012 Aug 22;19(4):497-508. Epub 2012 Jul 22.

Endocrine Signalling Group, Veterinary Basic Sciences, University of London, Royal College Street, London NW1 0TU, UK.

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http://dx.doi.org/10.1530/ERC-12-0129DOI Listing
August 2012

Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway.

Authors:
Harvinder S Chahal Giampaolo Trivellin Chrysanthia A Leontiou Neda Alband Robert C Fowkes Asil Tahir Susana C Igreja J Paul Chapple Susan Jordan Amelie Lupp Stefan Schulz Olaf Ansorge Niki Karavitaki Eivind Carlsen John A H Wass Ashley B Grossman Márta Korbonits

J Clin Endocrinol Metab 2012 Aug 1;97(8):E1411-20. Epub 2012 Jun 1.

Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2012-1111DOI Listing
August 2012

Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma.

Authors:
Adrian M Jubb Lisa Browning Leticia Campo Helen Turley Graham Steers Gavin Thurston Adrian L Harris Olaf Ansorge

Histopathology 2012 Apr 1;60(5):740-7. Epub 2012 Feb 1.

Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/j.1365-2559.2011.04138.xDOI Listing
April 2012

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study.

Authors:
Elisa Majounie Alan E Renton Kin Mok Elise G P Dopper Adrian Waite Sara Rollinson Adriano Chiò Gabriella Restagno Nayia Nicolaou Javier Simon-Sanchez John C van Swieten Yevgeniya Abramzon Janel O Johnson Michael Sendtner Roger Pamphlett Richard W Orrell Simon Mead Katie C Sidle Henry Houlden Jonathan D Rohrer Karen E Morrison Hardev Pall Kevin Talbot Olaf Ansorge Dena G Hernandez Sampath Arepalli Mario Sabatelli Gabriele Mora Massimo Corbo Fabio Giannini Andrea Calvo Elisabet Englund Giuseppe Borghero Gian Luca Floris Anne M Remes Hannu Laaksovirta Leo McCluskey John Q Trojanowski Vivianna M Van Deerlin Gerard D Schellenberg Michael A Nalls Vivian E Drory Chin-Song Lu Tu-Hsueh Yeh Hiroyuki Ishiura Yuji Takahashi Shoji Tsuji Isabelle Le Ber Alexis Brice Carsten Drepper Nigel Williams Janine Kirby Pamela Shaw John Hardy Pentti J Tienari Peter Heutink Huw R Morris Stuart Pickering-Brown Bryan J Traynor

Lancet Neurol 2012 Apr 9;11(4):323-30. Epub 2012 Mar 9.

Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/S1474-4422(12)70043-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322422PMC
April 2012

Molecular MRI enables early and sensitive detection of brain metastases.

Authors:
Sébastien Serres Manuel Sarmiento Soto Alastair Hamilton Martina A McAteer W Shawn Carbonell Matthew D Robson Olaf Ansorge Alexandre Khrapitchev Claire Bristow Lukxmi Balathasan Thomas Weissensteiner Daniel C Anthony Robin P Choudhury Ruth J Muschel Nicola R Sibson

Proc Natl Acad Sci U S A 2012 Apr 26;109(17):6674-9. Epub 2012 Mar 26.

CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford OX3 7LJ, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1117412109
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http://dx.doi.org/10.1073/pnas.1117412109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340084PMC
April 2012

Rathke's cleft cysts.

Authors:
Raluca Trifanescu Olaf Ansorge John A H Wass Ashley B Grossman Niki Karavitaki

Clin Endocrinol (Oxf) 2012 Feb;76(2):151-60

Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK.

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http://dx.doi.org/10.1111/j.1365-2265.2011.04235.xDOI Listing
February 2012

Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet?

Authors:
Grace Li Margaret M Esiri Olaf Ansorge Gabriele C DeLuca

J Neuroinflammation 2012 Jan 24;9:20. Epub 2012 Jan 24.

Clinical Medical School, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/1742-2094-9-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308920PMC
January 2012

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.

Authors:
Manuela Neumann Eva Bentmann Dorothee Dormann Ali Jawaid Mariely DeJesus-Hernandez Olaf Ansorge Sigrun Roeber Hans A Kretzschmar David G Munoz Hirofumi Kusaka Osamu Yokota Lee-Cyn Ang Juan Bilbao Rosa Rademakers Christian Haass Ian R A Mackenzie

Brain 2011 Sep 19;134(Pt 9):2595-609. Epub 2011 Aug 19.

Institute of Neuropathology, Schmelzbergstr. 12, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1093/brain/awr201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170539PMC
September 2011

Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation.

Authors:
Ian R A Mackenzie Olaf Ansorge Michael Strong Juan Bilbao Lorne Zinman Lee-Cyn Ang Matt Baker Heather Stewart Andrew Eisen Rosa Rademakers Manuela Neumann

Acta Neuropathol 2011 Jul 21;122(1):87-98. Epub 2011 May 21.

Department of Pathology, University of British Columbia and Vancouver General Hospital, Vancouver, BC V5Z 1M9, Canada.

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http://dx.doi.org/10.1007/s00401-011-0838-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319073PMC
July 2011

SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy.

Authors:
Thomas M Wishart Jack P-W Huang Lyndsay M Murray Douglas J Lamont Chantal A Mutsaers Jenny Ross Pascal Geldsetzer Olaf Ansorge Kevin Talbot Simon H Parson Thomas H Gillingwater

Hum Mol Genet 2010 Nov 12;19(21):4216-28. Epub 2010 Aug 12.

Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh Medical School, Edinburgh, UK.

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http://dx.doi.org/10.1093/hmg/ddq340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951867PMC
November 2010

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.

Authors:
Ronald G Lafrenière M Zameel Cader Jean-François Poulin Isabelle Andres-Enguix Maryse Simoneau Namrata Gupta Karine Boisvert François Lafrenière Shannon McLaughlan Marie-Pierre Dubé Martin M Marcinkiewicz Sreeram Ramagopalan Olaf Ansorge Bernard Brais Jorge Sequeiros Jose Maria Pereira-Monteiro Lyn R Griffiths Stephen J Tucker George Ebers Guy A Rouleau

Nat Med 2010 Oct 26;16(10):1157-60. Epub 2010 Sep 26.

Centre of Excellence in Neuromics and Department of Medicine, Université de Montréal, Centre Hospitalier de l'Université de Montréal, Research Centre, Notre-Dame Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/nm.2216DOI Listing
October 2010

Rapid development of glioblastoma at the site of atypical meningioma resection.

Authors:
Erlick A C Pereira Bassam Dabbous Hammad U Qureshi Olaf Ansorge Stana Bojanic

Br J Neurosurg 2010 Aug;24(4):471-3

Department of Neurological Surgery, The West Wing, The John Radcliffe Hospital, Oxford, England.

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August 2010

The role of RNA processing in the pathogenesis of motor neuron degeneration.

Authors:
Dirk Bäumer Olaf Ansorge Mara Almeida Kevin Talbot

Expert Rev Mol Med 2010 Jul 20;12:e21. Epub 2010 Jul 20.

MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, OX1 3QX, UK.

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http://dx.doi.org/10.1017/S1462399410001523DOI Listing
July 2010

The mitochondrial brain: From mitochondrial genome to neurodegeneration.

Authors:
Helen E Turnbull Nichola Z Lax Daria Diodato Olaf Ansorge Doug M Turnbull

Biochim Biophys Acta 2010 Jan 6;1802(1):111-21. Epub 2009 Aug 6.

Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, NE24HH, UK.

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http://dx.doi.org/10.1016/j.bbadis.2009.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795853PMC
January 2010

Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.

Authors:
Brian Harding Manuel C Lemos Anita A C Reed Gerard V Walls Jeshmi Jeyabalan Michael R Bowl Hilda Tateossian Nicky Sullivan Tertius Hough William D Fraser Olaf Ansorge Michael T Cheeseman Rajesh V Thakker

Endocr Relat Cancer 2009 Dec 20;16(4):1313-27. Epub 2009 Jul 20.

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1677/ERC-09-0082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439740PMC
December 2009

Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.

Authors:
Dirk Bäumer Sheena Lee George Nicholson Joanna L Davies Nicholas J Parkinson Lyndsay M Murray Thomas H Gillingwater Olaf Ansorge Kay E Davies Kevin Talbot

PLoS Genet 2009 Dec 18;5(12):e1000773. Epub 2009 Dec 18.

MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1000773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787017PMC
December 2009

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model.

Authors:
Javier Alegre-Abarrategui Helen Christian Michele M P Lufino Ruxandra Mutihac Lara Lourenço Venda Olaf Ansorge Richard Wade-Martins

Hum Mol Genet 2009 Nov 29;18(21):4022-34. Epub 2009 Jul 29.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.

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http://dx.doi.org/10.1093/hmg/ddp346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758136PMC
November 2009

Management of osteoblastoma and osteoid osteoma of the spine in childhood.

Authors:
Sasha C Burn Olaf Ansorge Reinhard Zeller James M Drake

J Neurosurg Pediatr 2009 Nov;4(5):434-8

Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/2009.6.PEDS08450DOI Listing
November 2009

The vascular basement membrane as "soil" in brain metastasis.

Authors:
W Shawn Carbonell Olaf Ansorge Nicola Sibson Ruth Muschel

PLoS One 2009 Jun 10;4(6):e5857. Epub 2009 Jun 10.

Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689678PMC
June 2009

Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation.

Authors:
Alexander F Jeans Ian Frayling Bharat Jasani Lucy Side Claire Blesing Olaf Ansorge

Nat Rev Clin Oncol 2009 May;6(5):295-9

Department of Neuropathology, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1038/nrclinonc.2009.35DOI Listing
May 2009

TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy.

Authors:
Bradley J Turner Dirk Bäumer Nicholas J Parkinson Jakub Scaber Olaf Ansorge Kevin Talbot

BMC Neurosci 2008 Oct 28;9:104. Epub 2008 Oct 28.

University of Oxford, MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford, OX1 3QX, UK.

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http://dx.doi.org/10.1186/1471-2202-9-104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583980PMC
October 2008

Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation?

Authors:
Alberto Fernandez Niki Karavitaki Olaf Ansorge Violet Fazal-Sanderson John A H Wass

Pituitary 2008 ;11(3):325-30

Endocrinology Department, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, UK.

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http://dx.doi.org/10.1007/s11102-007-0074-2DOI Listing
September 2008

Extracellular acidification elicits spatially and temporally distinct Ca2+ signals.

Authors:
Wan-Chen Huang Pawel Swietach Richard D Vaughan-Jones Olaf Ansorge Maike D Glitsch

Curr Biol 2008 May;18(10):781-785

Department of Physiology, Anatomy, and Genetics, Sherrington Building, Oxford University, Parks Road, Oxford OX1 3PT, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2008.04.049DOI Listing
May 2008

Silent corticotroph adenomas.

Authors:
Niki Karavitaki Olaf Ansorge John A H Wass

Arq Bras Endocrinol Metabol 2007 Nov;51(8):1314-8

Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, UK.

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http://dx.doi.org/10.1590/s0004-27302007000800017DOI Listing
November 2007

What are the markers of aggressiveness in prolactinomas? Changes in cell biology, extracellular matrix components, angiogenesis and genetics.

Authors:
Alper Gürlek Niki Karavitaki Olaf Ansorge John A H Wass

Eur J Endocrinol 2007 Feb;156(2):143-53

Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, UK.

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http://dx.doi.org/10.1530/eje.1.02339DOI Listing
February 2007

Do the limits of serum prolactin in disconnection hyperprolactinaemia need re-definition? A study of 226 patients with histologically verified non-functioning pituitary macroadenoma.

Authors:
Niki Karavitaki Gaya Thanabalasingham Helena C A Shore Raluca Trifanescu Olaf Ansorge Niki Meston Helen E Turner John A H Wass

Clin Endocrinol (Oxf) 2006 Oct;65(4):524-9

Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, UK.

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http://dx.doi.org/10.1111/j.1365-2265.2006.02627.xDOI Listing
October 2006

Recent advances in the genetics of amyotrophic lateral sclerosis and frontotemporal dementia: common pathways in neurodegenerative disease.

Authors:
Kevin Talbot Olaf Ansorge

Hum Mol Genet 2006 Oct;15 Spec No 2:R182-7

Department of Physiology, Anatomy and Genetics , University of Oxford, Henry Wellcome Building of Gene Function, South Parks Road, Oxford OX1 3QX, UK.

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http://dx.doi.org/10.1093/hmg/ddl202DOI Listing
October 2006

Autopsy: not dead.

Authors:
Margaret Esiri Olaf Ansorge

Lancet 2006 Feb;367(9510):568

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http://dx.doi.org/10.1016/S0140-6736(06)68221-4DOI Listing
February 2006

Ataxin-7 aggregation and ubiquitination in infantile SCA7 with 180 CAG repeats.

Authors:
Olaf Ansorge Paola Giunti Andrej Michalik Christine Van Broeckhoven Brian Harding Nicholas Wood Francesco Scaravilli

Ann Neurol 2004 Sep;56(3):448-52

Division of Neuropathology, Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1002/ana.20230DOI Listing
September 2004

Neuronal intranuclear inclusions in SCA2: a genetic, morphological and immunohistochemical study of two cases.

Authors:
Joanna T Pang Paola Giunti Susan Chamberlain Shu F An Roberta Vitaliani Tomaso Scaravilli Lillian Martinian Nicholas W Wood Francesco Scaravilli Olaf Ansorge

Brain 2002 Mar;125(Pt 3):656-63

Hereditary Ataxia Research Group, Imperial College, Departments of Neurology. and. Neuropathology, Institute of Neurology, University College London, London, UK and. Clinica Neurologica 2, Università di Padova, Italy.

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http://dx.doi.org/10.1093/brain/awf060DOI Listing
March 2002