Publications by authors named "Olaf Ansorge"

98Publications

Young-onset frontotemporal dementia with FUS pathology.

Pract Neurol 2020 Dec 11. Epub 2020 Dec 11.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, UK.

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December 2020

Detection and Quantification of Novel C-terminal TDP-43 Fragments in ALS-TDP.

Brain Pathol 2020 Dec 10:e12923. Epub 2020 Dec 10.

Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.

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December 2020

A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models.

J Cereb Blood Flow Metab 2020 Nov 5:271678X20968943. Epub 2020 Nov 5.

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.

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November 2020

Amyotrophic lateral sclerosis with a heterozygous D91A SOD1 variant and classical ALS-TDP neuropathology.

Neurology 2020 09 7;95(13):595-596. Epub 2020 Aug 7.

From the Nuffield Department of Clinical Neurosciences, University of Oxford, UK.

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September 2020

Use of multi-flip angle measurements to account for transmit inhomogeneity and non-Gaussian diffusion in DW-SSFP.

Neuroimage 2020 10 1;220:117113. Epub 2020 Jul 1.

Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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October 2020

Quantitative patterns of motor cortex proteinopathy across ALS genotypes.

Acta Neuropathol Commun 2020 07 2;8(1):98. Epub 2020 Jul 2.

Nuffield Department of Clinical Neurosciences, University of Oxford, Level 1, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK.

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July 2020

Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma.

Br J Cancer 2020 03 20;122(5):624-629. Epub 2019 Dec 20.

Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.

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March 2020

Rapid intraoperative molecular genetic classification of gliomas using Raman spectroscopy.

Neurooncol Adv 2019 May-Dec;1(1):vdz008. Epub 2019 May 28.

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, UK.

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May 2019

Development of a Sensitive, Scalable Method for Spatial, Cell-Type-Resolved Proteomics of the Human Brain.

J Proteome Res 2019 04 25;18(4):1787-1795. Epub 2019 Feb 25.

Target Discovery Institute, Nuffield Department of Medicine , University of Oxford , Roosevelt Drive , Oxford , OX3 7FZ , U.K.

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April 2019

A comprehensive screening of copy number variability in dementia with Lewy bodies.

Neurobiol Aging 2019 03 24;75:223.e1-223.e10. Epub 2018 Oct 24.

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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March 2019

Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation.

Acta Neuropathol Commun 2018 09 24;6(1):99. Epub 2018 Sep 24.

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Road, Oxford, OX1 3PT, UK.

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September 2018

Somatic variants in autosomal dominant genes are a rare cause of sporadic Alzheimer's disease.

Alzheimers Dement 2018 12 13;14(12):1632-1639. Epub 2018 Aug 13.

Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.

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December 2018

Towards a TDP-43-Based Biomarker for ALS and FTLD.

Mol Neurobiol 2018 Oct 19;55(10):7789-7801. Epub 2018 Feb 19.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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October 2018

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

Lancet Neurol 2018 01 16;17(1):64-74. Epub 2017 Dec 16.

UK Dementia Research Institute, University College London, London, UK; Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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January 2018

Metastatic meningioma presenting as a malignant soft tissue tumour.

Clin Sarcoma Res 2016 30;6:23. Epub 2016 Dec 30.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, Windmill Road, Oxford, OX3 7HE UK.

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December 2016

A macroprolactinoma becoming resistant to cabergoline and developing atypical pathology.

Endocrinol Diabetes Metab Case Rep 2016 18;2016. Epub 2016 Oct 18.

Department of Endocrinology , Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford , UK.

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October 2016

Extended post-mortem delay times should not be viewed as a deterrent to the scientific investigation of human brain tissue: a study from the Brains for Dementia Research Network Neuropathology Study Group, UK.

Acta Neuropathol 2016 11 15;132(5):753-755. Epub 2016 Sep 15.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Salford Royal Hospital, University of Manchester, Salford, Manchester, M6 8HD, UK.

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November 2016

Pathogenesis of FUS-associated ALS and FTD: insights from rodent models.

Acta Neuropathol Commun 2016 09 6;4(1):99. Epub 2016 Sep 6.

Neuropathology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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September 2016

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.

Proc Natl Acad Sci U S A 2016 08 21;113(32):E4688-97. Epub 2016 Jul 21.

Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom;

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August 2016

Tocilizumab-associated multifocal cerebral thrombotic microangiopathy.

Neurol Clin Pract 2016 Jun;6(3):e24-e26

Nuffield Department of Clinical Neuroscience, University of Oxford, UK.

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June 2016

Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR.

Front Oncol 2016 2;6:98. Epub 2016 May 2.

Department of Oncology, Old Road Campus Research Building, Oxford, UK; Oxford Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

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May 2016

Dopamine transporter imaging for the diagnosis of dementia with Lewy bodies.

Cochrane Database Syst Rev 2015 Jan 30;1:CD010633. Epub 2015 Jan 30.

Oxford Health NHS Foundation Trust, Elms Centre, Oxford Road, Banbury, Oxfordshire, UK, OX16 9AL.

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January 2015

The Wnt signalling cascade and the adherens junction complex in craniopharyngioma tumorigenesis.

Endocr Pathol 2015 Mar;26(1):1-8

Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Rd, Headington, Oxford, OX3 7LE, UK,

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March 2015

Rathke's cleft cyst.

Handb Clin Neurol 2014 ;124:255-69

Department of Neuropathology, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK. Electronic address:

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July 2016

Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.

Eur J Endocrinol 2014 Dec 15;171(6):705-10. Epub 2014 Sep 15.

Nuffield Department of Clinical NeurosciencesDepartment of Neuropathology, Level 1 West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UKDepartment of EndocrinologyBarts and London School of Medicine, Queen Mary University of London, London EC1A 6BQ, UKDepartment of EndocrinologyOxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK.

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December 2014

Improving diffusion-weighted imaging of post-mortem human brains: SSFP at 7 T.

Neuroimage 2014 Nov 13;102 Pt 2:579-89. Epub 2014 Aug 13.

FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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November 2014

FTLD-ALS of TDP-43 type and SCA2 in a family with a full ataxin-2 polyglutamine expansion.

Acta Neuropathol 2014 Oct 10;128(4):597-604. Epub 2014 Apr 10.

Department of Neuropathology, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, OX3 9DU, UK.

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October 2014

BRAF V600E mutations are characteristic for papillary craniopharyngioma and may coexist with CTNNB1-mutated adamantinomatous craniopharyngioma.

Acta Neuropathol 2014 9;127(6):927-9. Epub 2014 Apr 9.

Nuffield Department of Clinical Neurosciences, Department of Neuropathology, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK.

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August 2015

Reduced C9orf72 protein levels in frontal cortex of amyotrophic lateral sclerosis and frontotemporal degeneration brain with the C9ORF72 hexanucleotide repeat expansion.

Neurobiol Aging 2014 Jul 17;35(7):1779.e5-1779.e13. Epub 2014 Jan 17.

Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cathays, Cardiff, UK.

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July 2014

Fibrillary astrocytes are decreased in the subgenual cingulate in schizophrenia.

Eur Arch Psychiatry Clin Neurosci 2014 Jun 29;264(4):357-62. Epub 2013 Dec 29.

Neuropathology Unit, Charing Cross Hospital, Imperial College London, London, W6 8RF, UK,

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June 2014

Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans.

Free Radic Biol Med 2014 Feb 18;67:41-50. Epub 2013 Oct 18.

School of Medical Science, Griffith Health Institute, Griffith University, Southport, 4222 QLD, Australia; Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic. Electronic address:

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February 2014

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.

Proc Natl Acad Sci U S A 2013 Oct 30;110(42):E4016-25. Epub 2013 Sep 30.

Oxford Parkinson's Disease Centre Department of Physiology, Anatomy and Genetics, Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, and Department of Experimental Psychology, University of Oxford, Oxford OX1 3QX, United Kingdom.

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October 2013

Whole-exome sequencing studies of nonfunctioning pituitary adenomas.

J Clin Endocrinol Metab 2013 Apr 28;98(4):E796-800. Epub 2013 Feb 28.

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, United Kingdom.

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April 2013

MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas.

Cancer Res 2012 Oct 21;72(19):5060-8. Epub 2012 Aug 21.

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, United Kingdom.

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October 2012

Pathology and pathogenesis of craniopharyngiomas.

Pituitary 2013 Mar;16(1):9-17

Nuffield Department of Clinical Neurosciences, Headley Way, Oxford, OX3 9DU, UK.

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March 2013

Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia.

Eur Arch Psychiatry Clin Neurosci 2013 Feb 4;263(1):41-52. Epub 2012 Jun 4.

Neuropathology Unit, Department of Experimental Medicine, Imperial College London, Charing Cross Hospital, UK.

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February 2013

Molecular MRI enables early and sensitive detection of brain metastases.

Proc Natl Acad Sci U S A 2012 Apr 26;109(17):6674-9. Epub 2012 Mar 26.

CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford OX3 7LJ, United Kingdom.

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April 2012

Mini-review: pheochromocytomas causing the ectopic ACTH syndrome.

Endocrine 2012 Aug 7;42(1):69-73. Epub 2012 Mar 7.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, OX3 7LE, UK.

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August 2012

Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma.

Histopathology 2012 Apr 1;60(5):740-7. Epub 2012 Feb 1.

Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.

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April 2012

Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet?

J Neuroinflammation 2012 Jan 24;9:20. Epub 2012 Jan 24.

Clinical Medical School, University of Oxford, Oxford, UK.

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January 2012

Rathke's cleft cysts.

Clin Endocrinol (Oxf) 2012 Feb;76(2):151-60

Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK.

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February 2012

Rapid development of glioblastoma at the site of atypical meningioma resection.

Br J Neurosurg 2010 Aug;24(4):471-3

Department of Neurological Surgery, The West Wing, The John Radcliffe Hospital, Oxford, England.

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August 2010

SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy.

Hum Mol Genet 2010 Nov 12;19(21):4216-28. Epub 2010 Aug 12.

Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh Medical School, Edinburgh, UK.

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November 2010

The role of RNA processing in the pathogenesis of motor neuron degeneration.

Expert Rev Mol Med 2010 Jul 20;12:e21. Epub 2010 Jul 20.

MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, OX1 3QX, UK.

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July 2010

Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.

PLoS Genet 2009 Dec 18;5(12):e1000773. Epub 2009 Dec 18.

MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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December 2009

Management of osteoblastoma and osteoid osteoma of the spine in childhood.

J Neurosurg Pediatr 2009 Nov;4(5):434-8

Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

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November 2009

The mitochondrial brain: From mitochondrial genome to neurodegeneration.

Biochim Biophys Acta 2010 Jan 6;1802(1):111-21. Epub 2009 Aug 6.

Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, NE24HH, UK.

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January 2010

Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.

Endocr Relat Cancer 2009 Dec 20;16(4):1313-27. Epub 2009 Jul 20.

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, University of Oxford, Oxford, UK.

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December 2009

The vascular basement membrane as "soil" in brain metastasis.

PLoS One 2009 Jun 10;4(6):e5857. Epub 2009 Jun 10.

Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, UK.

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June 2009

TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy.

BMC Neurosci 2008 Oct 28;9:104. Epub 2008 Oct 28.

University of Oxford, MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford, OX1 3QX, UK.

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October 2008

Extracellular acidification elicits spatially and temporally distinct Ca2+ signals.

Curr Biol 2008 May;18(10):781-785

Department of Physiology, Anatomy, and Genetics, Sherrington Building, Oxford University, Parks Road, Oxford OX1 3PT, United Kingdom. Electronic address:

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May 2008

Silent corticotroph adenomas.

Arq Bras Endocrinol Metabol 2007 Nov;51(8):1314-8

Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, UK.

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November 2007

Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation?

Pituitary 2008 ;11(3):325-30

Endocrinology Department, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, UK.

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September 2008

What are the markers of aggressiveness in prolactinomas? Changes in cell biology, extracellular matrix components, angiogenesis and genetics.

Eur J Endocrinol 2007 Feb;156(2):143-53

Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, UK.

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February 2007