Ola H Negm

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection.

Authors:

Ola H Negm Mohamed Hamed Tanya M Monaghan

J Vis Exp 2018 06 15(136). Epub 2018 Jun 15.

Nottingham Digestive Diseases Centre and NIHR Nottingham Digestive Diseases Biomedical Research Centre, School of Medicine, Queen's Medical Centre, University of Nottingham;

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June 2018

Characterization of Behavioral, Signaling and Cytokine Alterations in a Rat Neurodevelopmental Model for Schizophrenia, and Their Reversal by the 5-HT Receptor Antagonist SB-399885.

Authors:

Sinead E Shortall Ola H Negm Maxine Fowler Lucy C Fairclough Patrick J Tighe Peter M Wigmore Madeleine V King

Mol Neurobiol 2018 Sep 8;55(9):7413-7430. Epub 2018 Feb 8.

School of Life Sciences, Medical School, Queen's Medical Centre, The University of Nottingham, Nottingham, NG7 2UH, UK.

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September 2018

Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease.

Authors:

Reham Shindi Amna Almehairi Ola H Negm Noor Kalsheker Nichola S Gale Dennis J Shale Timothy W Harrison Charlotte E Bolton Michelle John Ian Todd Patrick J Tighe Lucy C Fairclough

Clin Immunol 2017 10 23;183:344-353. Epub 2017 Sep 23.

School of Life Sciences, The University of Nottingham, Nottingham, UK. Electronic address:

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October 2017

A signalome screening approach in the autoinflammatory disease TNF receptor associated periodic syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing.

Authors:

Ian Todd Ola H Negm Jenna Reps Paul Radford Grazziela Figueredo Elizabeth M McDermott Elizabeth Drewe Richard J Powell Susan Bainbridge Mohamed Hamed Sharon Crouch Jon Garibaldi Steve St-Gallay Lucy C Fairclough Patrick J Tighe

Pharmacol Res 2017 Nov 30;125(Pt B):188-200. Epub 2017 Aug 30.

School of Life Sciences, The University of Nottingham, Life Sciences Building, University Park, Nottingham NG7 2RD, UK.

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November 2017

High prevalence of subclass-specific binding and neutralizing antibodies against toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic infection.

Authors:

Tanya M Monaghan Ola H Negm Brendon MacKenzie Mohamed R Hamed Clifford C Shone David P Humphreys K Ravi Acharya Mark H Wilcox

Clin Exp Gastroenterol 2017 19;10:169-175. Epub 2017 Jul 19.

Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK.

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July 2017

The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs.

Authors:

Fabián Salazar Dennis Awuah Ola H Negm Farouk Shakib Amir M Ghaemmaghami

Sci Rep 2017 03 3;7:43337. Epub 2017 Mar 3.

Division of Immunology, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, United Kingdom.

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March 2017

Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction.

Authors:

Carolyn Tubby Ola H Negm Timothy Harrison Patrick J Tighe Ian Todd Lucy C Fairclough

J Asthma 2017 Jun 13;54(5):456-466. Epub 2016 Oct 13.

a School of Life Sciences, University of Nottingham , Nottingham , UK.

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June 2017

SMAD4 loss enables EGF, TGFβ1 and S100A8/A9 induced activation of critical pathways to invasion in human pancreatic adenocarcinoma cells.

Authors:

Stefania Moz Daniela Basso Dania Bozzato Paola Galozzi Filippo Navaglia Ola H Negm Giorgio Arrigoni Carlo-Federico Zambon Andrea Padoan Paddy Tighe Ian Todd Cinzia Franchin Sergio Pedrazzoli Leonardo Punzi Mario Plebani

Oncotarget 2016 Oct;7(43):69927-69944

University of Padova, Laboratory Medicine, Department of Medicine - DIMED, Padova, Italy.

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October 2016

Clinicopathological and prognostic significance of mitogen-activated protein kinases (MAPK) in breast cancers.

Authors:

Dena A J Ahmad Ola H Negm M Layth Alabdullah Sameer Mirza Mohamed R Hamed Vimla Band Andrew R Green Ian O Ellis Emad A Rakha

Breast Cancer Res Treat 2016 Oct 3;159(3):457-67. Epub 2016 Sep 3.

Division of Cancer and Stem Cells, Department of Histopathology, School of Medicine, Nottingham City Hospital, The University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK.

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October 2016

Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein.

Authors:

Alaa Tarig Alshareeda Ola H Negm Mohammed A Aleskandarany Andrew R Green Christopher Nolan Patrick J TigHhe Srinivasan Madhusudan Ian O Ellis Emad A Rakha

Breast Cancer Res Treat 2016 08 27;159(1):41-53. Epub 2016 Jul 27.

Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham, UK.

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August 2016

Human Blood Autoantibodies in the Detection of Colorectal Cancer.

Authors:

Ola H Negm Mohamed R Hamed Robert E Schoen Richard L Whelan Robert J Steele John Scholefield Elizabeth M Dilnot H M C Shantha Kumara John F R Robertson Herbert F Sewell

PLoS One 2016 6;11(7):e0156971. Epub 2016 Jul 6.

Immunology, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.

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August 2017

The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts.

Authors:

Mohammed A Aleskandarany Devika Agarwal Ola H Negm Graham Ball Ahmed Elmouna Ibraheem Ashankyty Edem Nuglozeh Mohammad F Fazaludeen Maria Diez-Rodriguez Christopher C Nolan Patrick J Tighe Andrew R Green Ian O Ellis Emad A Rakha

Breast Cancer Res Treat 2016 Feb 23;156(1):9-20. Epub 2016 Feb 23.

Division of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, NG5 1PB, UK.

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February 2016

The mannose receptor negatively modulates the Toll-like receptor 4-aryl hydrocarbon receptor-indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization.

Authors:

Fabián Salazar Laurence Hall Ola H Negm Dennis Awuah Patrick J Tighe Farouk Shakib Amir M Ghaemmaghami

J Allergy Clin Immunol 2016 06 17;137(6):1841-1851.e2. Epub 2015 Dec 17.

Division of Immunology, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom. Electronic address:

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June 2016

Clinical utility of reverse phase protein array for molecular classification of breast cancer.

Authors:

Ola H Negm Abir A Muftah Mohammed A Aleskandarany Mohamed R Hamed Dena A J Ahmad Christopher C Nolan Maria Diez-Rodriguez Patrick J Tighe Ian O Ellis Emad A Rakha Andrew R Green

Breast Cancer Res Treat 2016 Jan 9;155(1):25-35. Epub 2015 Dec 9.

Department of Histopathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham, UK.

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January 2016

Tumour necrosis factor receptor I blockade shows that TNF-dependent and TNF-independent mechanisms synergise in TNF receptor associated periodic syndrome.

Authors:

Lucy C Fairclough A Allart Stoop Ola H Negm Paul M Radford Patrick J Tighe Ian Todd

Eur J Immunol 2015 Oct 17;45(10):2937-44. Epub 2015 Aug 17.

School of Life Sciences, University of Nottingham, Nottingham, UK.

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October 2015

Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis.

Authors:

Ola H Negm Mohamed R Hamed Elizabeth M Dilnot Clifford C Shone Izabela Marszalowska Mark Lynch Christine E Loscher Laura J Edwards Patrick J Tighe Mark H Wilcox Tanya M Monaghan

Clin Vaccine Immunol 2015 Sep 15;22(9):1033-9. Epub 2015 Jul 15.

NIHR Nottingham Digestive Diseases Biomedical Research Unit, Nottingham, United Kingdom

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September 2015

The novel S59P mutation in the TNFRSF1A gene identified in an adult onset TNF receptor associated periodic syndrome (TRAPS) constitutively activates NF-κB pathway.

Authors:

Eliana Greco Ada Aita Paola Galozzi Alessandra Gava Paolo Sfriso Ola H Negm Patrick Tighe Francesco Caso Filippo Navaglia Emanuela Dazzo Marzia De Bortoli Alessandra Rampazzo Laura Obici Simona Donadei Giampaolo Merlini Mario Plebani Ian Todd Daniela Basso Leonardo Punzi

Arthritis Res Ther 2015 Apr 3;17:93. Epub 2015 Apr 3.

University of Padova, Rheumatology Unit, Department of Medicine - DIMED, Via Giustiniani 2, 35128, Padova, Italy.

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April 2015

Prognostic and biological significance of peroxisome proliferator-activated receptor-gamma in luminal breast cancer.

Authors:

Rezvan Abduljabbar Methaq Mueen Al-Kaabi Ola H Negm Dena Jerjees Abir A Muftah Abhik Mukherjee Chun F Lai Laki Buluwela Simak Ali Patrick J Tighe Andrew Green Ian Ellis Emad Rakha

Breast Cancer Res Treat 2015 Apr 21;150(3):511-22. Epub 2015 Mar 21.

Division of Cancer and Stem Cells, School of Medicine, University Of Nottingham, City Hosital Campus, Nottingham, NG5 1PB, UK,

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April 2015

Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer.

Authors:

Rezvan Abduljabbar Ola H Negm Chun-Fui Lai Dena A Jerjees Methaq Al-Kaabi Mohamed R Hamed Patrick J Tighe Lakjaya Buluwela Abhik Mukherjee Andrew R Green Simak Ali Emad A Rakha Ian O Ellis

Breast Cancer Res Treat 2015 Apr 12;150(2):335-46. Epub 2015 Mar 12.

Division of Cancer and Stem Cell, Department of Histopathology, The University of Nottingham, City Hospital Campus, Nottingham, UK,

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April 2015

The mammalian target of rapamycin complex 1 (mTORC1) in breast cancer: the impact of oestrogen receptor and HER2 pathways.

Authors:

Dena A Jerjees Ola H Negm M Layth Alabdullah Sameer Mirza Methaq Alkaabi Mohamed R Hameed Rezvan Abduljabbar Abir Muftah Chris C Nolan Andrew R Green Patrick J Tighe Vimla Band Ian O Ellis Emad A Rakha

Breast Cancer Res Treat 2015 Feb 21;150(1):91-103. Epub 2015 Feb 21.

Division of Cancer and Stem Cells, Department of Histopathology, School of Medicine, Nottingham City Hospital, The University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK,

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February 2015

Development and validation of protein microarray technology for simultaneous inflammatory mediator detection in human sera.

Authors:

Senthooran Selvarajah Ola H Negm Mohamed R Hamed Carolyn Tubby Ian Todd Patrick J Tighe Tim Harrison Lucy C Fairclough

Mediators Inflamm 2014 14;2014:820304. Epub 2014 Oct 14.

School of Life Sciences, The University of Nottingham, A Floor West Block, Queen's Medical Centre, Nottingham NG7 2UH, UK.

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July 2015

Epithelial mesenchymal transition in early invasive breast cancer: an immunohistochemical and reverse phase protein array study.

Authors:

Mohammed A Aleskandarany Ola H Negm Andrew R Green Mohamed A H Ahmed Christopher C Nolan Patrick J Tighe Ian O Ellis Emad A Rakha

Breast Cancer Res Treat 2014 Jun 26;145(2):339-48. Epub 2014 Apr 26.

Department of Histopathology, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK,

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June 2014

A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS).

Authors:

Ola H Negm Heiko A Mannsperger Elizabeth M McDermott Elizabeth Drewe Richard J Powell Ian Todd Lucy C Fairclough Patrick J Tighe

Eur J Immunol 2014 Jul 10;44(7):2096-110. Epub 2014 Jun 10.

School of Life Sciences, The University of Nottingham, UK; Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

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July 2014

SUMOylation proteins in breast cancer.

Authors:

Alaa T Alshareeda Ola H Negm Andrew R Green Christopher Nolan Paddy Tighe Nada Albarakati Rebeka Sultana Srinivasan Madhusudan Ian O Ellis Emad A Rakha

Breast Cancer Res Treat 2014 Apr 1;144(3):519-30. Epub 2014 Mar 1.

Department of Histopathology and School of Molecular Medical Sciences, The University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham, UK,

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April 2014

Clinicopathological significance of KU70/KU80, a key DNA damage repair protein in breast cancer.

Authors:

Alaa T Alshareeda Ola H Negm Nada Albarakati Andrew R Green Christopher Nolan Rebeka Sultana Srinivasan Madhusudan Ahmed Benhasouna Paddy Tighe Ian O Ellis Emad A Rakha

Breast Cancer Res Treat 2013 Jun 28;139(2):301-10. Epub 2013 Apr 28.

Department of Histopathology and School of Molecular Medical Sciences, The University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham, UK.

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June 2013

TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome.

Authors:

Mohammed A Aleskandarany Ola H Negm Emad A Rakha Mohamed A H Ahmed Christopher C Nolan Graham R Ball Carlos Caldas Andrew R Green Patrick J Tighe Ian O Ellis

Breast Cancer Res Treat 2012 Nov 4;136(2):419-27. Epub 2012 Oct 4.

Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, United Kingdom.

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November 2012

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