Publications by authors named "Ola Didrik Saugstad"

215 Publications

50 Years Ago in TheJournalofPediatrics: The Oxygen Dilemma.

J Pediatr 2021 Apr;231:130

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.11.036DOI Listing
April 2021

Oxygen saturation (SpO2) targeting for newborn infants at delivery: Are we reaching for an impossible unknown?

Semin Fetal Neonatal Med 2021 Feb 24:101220. Epub 2021 Feb 24.

School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Kensington, NSW, Australia; Department of Newborn Care, The Royal Hospital for Women, Randwick, NSW, Australia. Electronic address:

For more than 200 years, pure oxygen was given ad libitum to newborn infants requiring resuscitation. Due to oxidative stress and injury concerns, a paradigm shift towards using "less" oxygen, including air (21% oxygen) instead of pure (100%) oxygen, occurred about twenty years ago. A decade later, clinicians were advised to adjust fractional inspired oxygen (FiO) to target oxygen saturations (SpO) that were derived from spontaneously breathing, healthy, mature infants. Whether these recommendations are achievable, beneficial, harmful or redundant is uncertain. The underlying pathology leading to resuscitation varies between infants and may considerably alter an infant's response to supplemental oxygen. In this review, we summarize available evidence for the use of SpO monitoring at delivery for newborn infants, elucidate existing knowledge and service gaps, and suggest future research recommendations that will lead to the safest clinical strategies for this standard and important practice.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.siny.2021.101220DOI Listing
February 2021

50 Years Ago in TheJournalofPediatrics: Vigorous and Repeated Nasopharyngeal Suctioning.

J Pediatr 2021 Mar;230:99

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago; Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.10.052DOI Listing
March 2021

50 Years Ago in TheJournalofPediatrics: Sixth Cranial Nerve Palsy in the Neonate.

J Pediatr 2021 Mar;230:125

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago; Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.10.054DOI Listing
March 2021

50 Years Ago in TheJournalofPediatrics: Hepatopulmonary Syndrome: Transplantation Is the Big Difference.

J Pediatr 2021 Feb;229:69

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.08.074DOI Listing
February 2021

50 Years Ago in TheJournalofPediatrics: Diagnostic Utility of the Newborn Electrocardiogram.

J Pediatr 2021 Feb;229:32

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.08.073DOI Listing
February 2021

50 Years Ago in TheJournalofPediatrics: The Newborn Electrocardiogram.

J Pediatr 2021 01;228:52

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.07.074DOI Listing
January 2021

50 Years Ago in TheJournalofPediatrics: The Oxygen-Hemoglobin Equilibrium Curve and Tissue Oxygen Release.

J Pediatr 2020 12;227:93

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.06.085DOI Listing
December 2020

50 Years Ago in TheJournalofPediatrics: Magnesium and Birth Asphyxia.

J Pediatr 2020 12;227:190

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Ilinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.10.015DOI Listing
December 2020

50 Years Ago in TheJournalofPediatrics: Umbilical Catheters-Then and Now.

J Pediatr 2020 12;227:156

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.06.082DOI Listing
December 2020

Reply.

J Pediatr 2021 Feb 13;229:309-310. Epub 2020 Nov 13.

University of Oslo and Oslo University Hospital, Department of Pediatric Research, Oslo, Norway; Division of Neonatology, Department of Pediatrics, University of California, Davis, Davis, California; Division of Neonatology, University and Polytechnic Hospital La Fe, Valencia, Spain.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.11.018DOI Listing
February 2021

Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates.

Neonatology 2020 19;117(5):545-554. Epub 2020 Oct 19.

Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland,

Infection and persistent inflammation have a prominent role in the pathogenesis of brain injury and cerebral palsy, as well as other conditions associated with prematurity such as bronchopulmonary dysplasia. The NLRP3 inflammasome-interleukin (IL)-1β pathway has been extensively studied in adults and pre-clinical models, improving our understanding of innate immunity and offering an attractive therapeutic target that is already contributing to clinical management in many auto-inflammatory disorders. IL-1 blockade has transformed the course and outcome of conditions such as chronic infantile neurological, cutaneous, articular (CINCA/NOMID) syndrome. Inflammasome activation and upregulation has recently been implicated in neonatal brain and lung inflammatory disease and may be a novel therapeutic target.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1159/000507584DOI Listing
October 2020

50 Years Ago in The Journal of Pediatrics: Neonatal Seizures: 50 Years of Progress.

J Pediatr 2020 10;225:50

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.04.014DOI Listing
October 2020

50 Years Ago in The Journal of Pediatrics: Neonatal Seizures: 50 Years of Progress.

J Pediatr 2020 10;225:230

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.03.058DOI Listing
October 2020

50 Years Ago in The Journal of Pediatrics: When the Newborn Remains Blue.

J Pediatr 2020 09;224:78

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine Chicago Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.03.030DOI Listing
September 2020

50 Years Ago in TheJournalofPediatrics: Light Exposure to the Immature Eye.

J Pediatr 2020 08;223:119

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.02.011DOI Listing
August 2020

Acetaminophen and the Developing Brain: Reason for Concern?

Neonatology 2020 2;117(2):245-248. Epub 2020 Jul 2.

Department of Pediatric Research, University of Oslo, Oslo, Norway,

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1159/000505954DOI Listing
July 2020

50 Years Ago in The Journal of Pediatrics: Wilson-Mikity Syndrome.

J Pediatr 2020 07;222:173

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2020.01.037DOI Listing
July 2020

More Details Needed on Association of Placental Weight With Risk of Neonatal Death-Reply.

JAMA Pediatr 2020 09;174(9):906

Department of Obstetrics and Gynecology, Akershus University Hospital, Lørenskog, Norway.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamapediatrics.2020.0975DOI Listing
September 2020

50 Years Ago in TheJournalofPediatrics: Developmental Outcome for Trisomy 21 Mosaicism.

J Pediatr 2020 06;221:38

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2019.12.011DOI Listing
June 2020

50 Years Ago in TheJournalofPediatrics: Birth Weight Is More Important than Gestational Age for Long-Term Intellectual Outcome.

J Pediatr 2020 05;220:115

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2019.11.024DOI Listing
May 2020

50 Years Ago in TheJournalofPediatrics: When the Lung Ruptures - 50 Years Ago and Today.

J Pediatr 2020 04;219:75

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2019.10.004DOI Listing
April 2020

50 Years Ago in TheJournalofPediatrics: Chromosome Studies in Full Term, Low Birth Weight, Mentally Retarded Patients.

J Pediatr 2020 03;218:56

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2019.09.032DOI Listing
March 2020

Transcriptome analysis reveals dysregulation of genes involved in oxidative phosphorylation in a murine model of retinopathy of prematurity.

Pediatr Res 2020 09 13;88(3):391-397. Epub 2020 Feb 13.

Department of Paediatric Research, Oslo University Hospital Rikshospitalet, Oslo, Norway.

Background: Retinal gene expression pattern is severely altered after exposition to hyperoxia in mice with oxygen-induced retinopathy (OIR), a common model of retinopathy of prematurity. Gene ontology and signaling pathway analyses may add new insights into a better understanding of the pathogenesis of this disease.

Methods: Seven-day-old C57BL/6J mice (n = 60) were exposed to 75% oxygen for 5 days and then recovered in room air. The controls (n = 60) were kept in the normoxic conditions. Retinas were harvested immediately following hyperoxia, during the phase of maximal neovascularization, and at the time of neovascularization regression. The retinal RNA samples were evaluated for gene expression using mouse gene expression microarrays. DAVID annotation tools were used for gene ontology and pathway analyses.

Results: The most significantly enriched signaling pathways during the neovascularization phase of OIR were: focal adhesion; ECM-receptor interaction; PI3K-Akt; oxidative phosphorylation; and Alzheimer's, Parkinson's and Huntington's disease signaling pathways. Genes involved in apoptosis, cell proliferation, cell differentiation, and immune responses were associated with neovascularization regression.

Conclusions: Performed analyses revealed the possible involvement of various signaling pathways in OIR pathomechanism, mostly specific to the OIR phase. Dysregulation of genes involved in oxidative phosphorylation may have an impact on neovascularization development.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41390-020-0793-xDOI Listing
September 2020

50 Years Ago in TheJournal ofPediatrics: Positive Pressure Ventilation in the Newborn Infant: The Use of a Face Mask.

J Pediatr 2020 02;217:97

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2019.08.054DOI Listing
February 2020

Oxygen metabolism and oxygenation of the newborn.

Semin Fetal Neonatal Med 2020 04 17;25(2):101078. Epub 2020 Jan 17.

Department of Pediatric Research, University of Oslo & Ann and Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Norway. Electronic address:

The premature infant is to some extent protected from hypoxia, however defense against hyperoxia is poorly developed. The optimal assessment of oxygenation is to measure oxygen delivery and extraction. At the bedside PaO and SpO are approximations of oxygenation at the tissue level. After birth asphyxia it is crucial to know whether or not to give oxygen supplementation, when, how much, and for how long. Oxygen saturation targets in the delivery room have been studied, but the optimal targets might still be unknown because factors like gender and delayed cord clamping influence saturation levels. However, SpO > 80% at 5 min of age is associated with favorable long term outcome in preterm babies. Immature infants most often need oxygen supplementation beyond the delivery room. Predefined saturation levels, and narrow alarm limits together with the total oxygen exposure may impact on development of oxygen related diseases like ROP and BPD. Hyperoxia is a strong trigger for genetic and epigenetic changes, contributing to the development of these conditions and perhaps lifelong changes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.siny.2020.101078DOI Listing
April 2020

What did I learn as a neonatologist over 40 years and what impact did Napoleon have on modern newborn medicine?

Acta Paediatr 2020 05 24;109(5):877-879. Epub 2020 Jan 24.

Department of Pediatric Research, University of Oslo, Oslo University Hospital, Oslo, Norway.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/apa.15170DOI Listing
May 2020

Quantification of circulating cell-free DNA (cfDNA) in urine using a newborn piglet model of asphyxia.

PLoS One 2019 31;14(12):e0227066. Epub 2019 Dec 31.

Department of Pediatric Research, Division of Pediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.

Cell free DNA (cfDNA) in plasma has been described as a potential diagnostic indicator for a variety of clinical conditions, including neonatal hypoxia. Neonatal hypoxia or perinatal asphyxia is a severe medical condition caused by a temporary interruption in oxygen availability during birth. Previously, we have reported temporal changes of cfDNA detected in blood in a newborn piglet model of perinatal asphyxia. However, cfDNA can also be found in other body liquids, opening for a less invasive diagnostic prospective. The objective of this study was to test and establish a reliable method for the isolation and quantification of cfDNA from urine and to explore changes in the quantities of cfDNA using a newborn piglet model of asphyxia. Animals were exposed to hypoxia-reoxygenation (n = 6), hypoxia-reoxygenation + hypothermia (n = 6) or were part of the sham-operated control group (n = 6) and urine samples (n = 18) were collected at 570 minutes post-intervention. Two alternative applications of cfDNA measurement were tested, an indirect method comprising a centrifugation step together with DNA extraction with magnetic beads versus a direct assessment based on two centrifugation steps. CfDNA concentrations were determined by a fluorescent assay using PicoGreen and by qRT-PCR. Genomic (gDNA) and mitochondrial DNA (mtDNA) cfDNA were determined in parallel, taking into account potential differences in the rates of damages caused by oxidative stress. In contrast to previous publications, our results indicate that the direct method is insufficient. Application of the indirect method obtained with the fluorescence assay revealed mean cfDNA levels (SD) of 1.23 (1.76) ng/ml for the hypoxia samples, 4.47 (6.15) ng/ml for the samples exposed to hypoxia + hypothermia and 2.75 (3.62) ng/ml for the control animals. The mean cfDNA levels in piglets exposed to hypoxia + hypothermia revealed significantly higher cfDNA amounts compared to mean cfDNA levels in the samples purely exposed to hypoxia (p < 0.05); however, no significant difference could be determined when compared to the control group (p = 0.09). Application of the indirect method by qRT-PCR revealed mean cfDNA levels of mtDNA and gDNA at the detection limit of the technique and thus no reliable statistics could be performed between the observed cfDNA levels in the investigated groups. The methodology for detection and monitoring of cfDNA in urine has to be further optimized before it can be applied in a clinical setting in the future.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227066PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938324PMC
April 2020

Myalgic Encephalomyelitis (ME) in the Young. Time to Repent.

Acta Paediatr 2020 04 18;109(4):645-646. Epub 2019 Dec 18.

Department of Pediatric Research, University of Oslo, Oslo, Norway.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/apa.15084DOI Listing
April 2020

50 Years Ago in TheJournal ofPediatrics: Human Chromosomal Deletion: Two Patients with the 4p-Syndrome.

J Pediatr 2020 01;216:72

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2019.07.020DOI Listing
January 2020