Oksana Gavrilova

Oksana Gavrilova

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Oksana Gavrilova

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Macrophage derived TNFα promotes hepatic reprogramming to Warburg-like metabolism.

J Mol Med (Berl) 2019 Sep 3;97(9):1231-1243. Epub 2019 May 3.

Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Room 4A62, Bethesda, MD, 20892, USA.

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http://link.springer.com/10.1007/s00109-019-01786-w
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http://dx.doi.org/10.1007/s00109-019-01786-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715514PMC
September 2019

Selective activation of G signaling in adipocytes causes striking metabolic improvements in mice.

Mol Metab 2019 09 20;27:83-91. Epub 2019 Jun 20.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778193045
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http://dx.doi.org/10.1016/j.molmet.2019.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717953PMC
September 2019

Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis.

Nat Commun 2019 07 3;10(1):2936. Epub 2019 Jul 3.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, NIH-20892, USA.

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http://dx.doi.org/10.1038/s41467-019-11003-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610117PMC
July 2019

The Catalytic Subunit of PKA Affects Energy Balance and Catecholaminergic Activity.

J Endocr Soc 2019 May 28;3(5):1062-1078. Epub 2019 Mar 28.

Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

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https://academic.oup.com/jes/article/3/5/1062/5421012
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http://dx.doi.org/10.1210/js.2019-00029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503631PMC
May 2019

Physiology and effects of nucleosides in mice lacking all four adenosine receptors.

PLoS Biol 2019 03 1;17(3):e3000161. Epub 2019 Mar 1.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415873PMC
March 2019

Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure, and heart rate, but not food intake.

Nat Neurosci 2018 11 22;21(11):1530-1540. Epub 2018 Oct 22.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://www.nature.com/articles/s41593-018-0249-3
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http://dx.doi.org/10.1038/s41593-018-0249-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203600PMC
November 2018

Activation of adenosine A or A receptors causes hypothermia in mice.

Neuropharmacology 2018 09 13;139:268-278. Epub 2018 Mar 13.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2018.02.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067974PMC
September 2018

Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.

Am J Physiol Endocrinol Metab 2018 09 29;315(3):E357-E366. Epub 2018 May 29.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1152/ajpendo.00024.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171009PMC
September 2018

Olfactomedin 4 Deletion Improves Male Mouse Glucose Intolerance and Insulin Resistance Induced by a High-Fat Diet.

Endocrinology 2018 09;159(9):3235-3244

Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.

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https://academic.oup.com/endo/article/159/9/3235/5055754
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http://dx.doi.org/10.1210/en.2018-00451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098226PMC
September 2018

Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function.

Nat Commun 2018 05 4;9(1):1796. Epub 2018 May 4.

Adipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-04127-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935725PMC
May 2018

Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline.

Aging Cell 2018 04 31;17(2). Epub 2018 Jan 31.

Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/acel.12721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847881PMC
April 2018

Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice.

Cell Metab 2017 Nov 5;26(5):764-777.e5. Epub 2017 Oct 5.

Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA; Center for Molecular and Translational Medicine, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905336PMC
November 2017

Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism.

Mol Metab 2017 11 15;6(11):1540-1550. Epub 2017 Sep 15.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778173057
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http://dx.doi.org/10.1016/j.molmet.2017.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681273PMC
November 2017

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Cell Metab 2017 Oct 14;26(4):672-685.e4. Epub 2017 Sep 14.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131173050
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http://dx.doi.org/10.1016/j.cmet.2017.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668683PMC
October 2017

Hypothermia in mouse is caused by adenosine A and A receptor agonists and AMP via three distinct mechanisms.

Neuropharmacology 2017 03 30;114:101-113. Epub 2016 Nov 30.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.11.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183552PMC
March 2017

Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.

J Pharmacol Exp Ther 2016 Feb 25;356(2):474-82. Epub 2015 Nov 25.

Diabetes, Endocrinology, and Obesity Branch (J.L.C., C.X., R.A.P., M.L.R.), Molecular Recognition Section, Laboratory of Bioorganic Chemistry (D.K.T., K.A.J.), and Mouse Metabolism Core (O.G.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland; and Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri (Z.C., D.S.)

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http://dx.doi.org/10.1124/jpet.115.229872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746492PMC
February 2016

Gsα deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight.

Proc Natl Acad Sci U S A 2016 Jan 28;113(2):446-51. Epub 2015 Dec 28.

Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1517142113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720348PMC
January 2016

A mouse model for a partially inactive obesity-associated human MC3R variant.

Nat Commun 2016 Jan 28;7:10522. Epub 2016 Jan 28.

Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms10522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738366PMC
January 2016

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.

Nat Commun 2015 Dec 15;6:10166. Epub 2015 Dec 15.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms10166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682112PMC
December 2015

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis.

Cell Metab 2015 Oct 3;22(4):695-708. Epub 2015 Sep 3.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.08.005DOI Listing
October 2015

Anti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C.

Obesity (Silver Spring) 2015 Jul 5;23(7):1450-9. Epub 2015 Jun 5.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA.

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http://doi.wiley.com/10.1002/oby.21124
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http://dx.doi.org/10.1002/oby.21124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482793PMC
July 2015

A neural basis for melanocortin-4 receptor-regulated appetite.

Nat Neurosci 2015 Jun 27;18(6):863-71. Epub 2015 Apr 27.

1] Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. [2] Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nn.4011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446192PMC
June 2015

Integration of body temperature into the analysis of energy expenditure in the mouse.

Mol Metab 2015 Jun 10;4(6):461-70. Epub 2015 Mar 10.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22128778150005
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http://dx.doi.org/10.1016/j.molmet.2015.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443293PMC
June 2015

Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion.

Proc Natl Acad Sci U S A 2014 Nov 10;111(47):16760-5. Epub 2014 Nov 10.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892

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http://dx.doi.org/10.1073/pnas.1419240111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250121PMC
November 2014

Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice.

PLoS One 2014 17;9(1):e85876. Epub 2014 Jan 17.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085876PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895006PMC
September 2014

Differentially regulated protein kinase A (PKA) activity in adipose tissue and liver is associated with resistance to diet-induced obesity and glucose intolerance in mice that lack PKA regulatory subunit type IIα.

Endocrinology 2014 Sep 10;155(9):3397-408. Epub 2014 Jun 10.

Section on Endocrinology and Genetics (E.L., M.N., E.S., S.A.M., C.A.S.), Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Biostatistics and Clinical Epidemiology Service (N.S.), CC, National Institutes of Health, Mouse Metabolism Core Laboratory (T.C., O.G.), National Institute of Diabetes and Digestive and Kidney Diseases, and Eunice Kennedy Shriver National Institute of Child Health and Human Development intramural Summer Student Program (S.A.M.), Bethesda, Maryland 20892.

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http://dx.doi.org/10.1210/en.2014-1122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138573PMC
September 2014

Role of forkhead box protein A3 in age-associated metabolic decline.

Proc Natl Acad Sci U S A 2014 Sep 15;111(39):14289-94. Epub 2014 Sep 15.

Genetic of Development and Disease Branch and

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http://www.pnas.org/lookup/doi/10.1073/pnas.1407640111
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http://dx.doi.org/10.1073/pnas.1407640111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191794PMC
September 2014

Biphasic effect of melanocortin agonists on metabolic rate and body temperature.

Cell Metab 2014 Aug 26;20(2):333-45. Epub 2014 Jun 26.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126889PMC
August 2014

Erythropoietin signaling: a novel regulator of white adipose tissue inflammation during diet-induced obesity.

Diabetes 2014 Jul 19;63(7):2415-31. Epub 2014 Mar 19.

Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD

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http://dx.doi.org/10.2337/db13-0883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066343PMC
July 2014

A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo.

Endocrinology 2013 Oct 16;154(10):3539-51. Epub 2013 Jul 16.

PhD, Chief, Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Building 8A, Room B1A-05, 8 Center Drive MSC 0810, Bethesda, Maryland 20892-0810. or Jianhua Li, PhD, Center for Molecular Medicine, National Institutes of Health, National Heart, Lung, and Blood Institute, Building 10-CRC, Room 5-3216, 10 Center Drive MSC 1454, Bethesda, Maryland 20892-1454. E-mail:

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http://dx.doi.org/10.1210/en.2012-2127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776870PMC
October 2013

The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion.

Mol Cell Biol 2013 Sep 24;33(17):3392-9. Epub 2013 Jun 24.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/MCB.00244-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753856PMC
September 2013

Increasing muscle mass to improve metabolism.

Adipocyte 2013 Apr;2(2):92-8

Genetics of Development and Disease Branch; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Bethesda, MD USA.

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http://www.tandfonline.com/doi/abs/10.4161/adip.22500
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http://dx.doi.org/10.4161/adip.22500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661116PMC
April 2013

Hypoxia-inducible factor 1α regulates a SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes.

J Biol Chem 2013 Feb 19;288(6):3844-57. Epub 2012 Dec 19.

Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M112.426338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567639PMC
February 2013

Myostatin inhibition prevents diabetes and hyperphagia in a mouse model of lipodystrophy.

Diabetes 2012 Oct 17;61(10):2414-23. Epub 2012 May 17.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.2337/db11-0915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447905PMC
October 2012

Spinophilin as a novel regulator of M3 muscarinic receptor-mediated insulin release in vitro and in vivo.

FASEB J 2012 Oct 22;26(10):4275-86. Epub 2012 Jun 22.

Molecular Signaling Section, Mouse Metabolic Core Facility, Laboratory of Bioorganic Chemistry, NIH-NIDDK, Bldg. 8A, Rm. B1A-05, 8 Center Dr. MSC 0810 Bethesda, MD 20892-0810, USA.

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http://www.fasebj.org/doi/10.1096/fj.12-204644
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http://dx.doi.org/10.1096/fj.12-204644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448777PMC
October 2012

Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations.

Endocrinology 2012 Sep 25;153(9):4256-65. Epub 2012 Jun 25.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health, Bethesda, Maryland 20892-1752, USA.

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http://dx.doi.org/10.1210/en.2012-1113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423628PMC
September 2012

Insulin stimulates fusion, but not tethering, of GLUT4 vesicles in skeletal muscle of HA-GLUT4-GFP transgenic mice.

Am J Physiol Endocrinol Metab 2012 Apr 31;302(8):E950-60. Epub 2012 Jan 31.

Program in Physical Biology, National Institute of Child Health and Human Development/National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1152/ajpendo.00466.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330721PMC
April 2012

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.

J Clin Invest 2011 Nov 3;121(11):4477-90. Epub 2011 Oct 3.

Genetics of Development and Disease Branch, NIH, 10/9N105, 10 Center Drive, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1172/JCI46243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204833PMC
November 2011

Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut.

Nat Med 2011 Nov 20;17(12):1585-93. Epub 2011 Nov 20.

'Ghost Lab', T Cell Tolerance and Memory Section, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases (NIAID), US National Institutes of Health (NIH), Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/nm.2505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902046PMC
November 2011

Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).

Proc Natl Acad Sci U S A 2011 Oct 10;108(42):17462-7. Epub 2011 Oct 10.

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1107474108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198316PMC
October 2011

Absence of the glucagon-like peptide-1 receptor does not affect the metabolic phenotype of mice with liver-specific G(s)α deficiency.

Endocrinology 2011 Sep 19;152(9):3343-50. Epub 2011 Jul 19.

Metabolic Diseases Branch, Building 10 Room 8C101, National Institute for Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1752, USA.

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http://dx.doi.org/10.1210/en.2011-0012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159780PMC
September 2011

A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice.

PLoS Genet 2011 Sep 29;7(9):e1002307. Epub 2011 Sep 29.

Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183090PMC
September 2011

Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling.

Cell Metab 2011 Jul;14(1):67-79

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Clinical Research Center, South Drive and Old Georgetown Road, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cmet.2011.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169298PMC
July 2011

Suppression of the C/EBP family of transcription factors in adipose tissue causes lipodystrophy.

J Mol Endocrinol 2011 Jun 15;46(3):175-92. Epub 2011 Apr 15.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3128, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1530/JME-10-0172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159190PMC
June 2011

Wnt signaling regulates hepatic metabolism.

Sci Signal 2011 Feb 1;4(158):ra6. Epub 2011 Feb 1.

Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/scisignal.2001249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147298PMC
February 2011

Beneficial metabolic effects caused by persistent activation of beta-cell M3 muscarinic acetylcholine receptors in transgenic mice.

Endocrinology 2010 Nov 15;151(11):5185-94. Epub 2010 Sep 15.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 8 Center Drive MSC 0810, Bethesda, MD 20892-0810, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2010-0519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954720PMC
November 2010

SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.

J Biol Chem 2010 Nov 16;285(47):36776-84. Epub 2010 Sep 16.

Genetics of Development and Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.168039
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http://dx.doi.org/10.1074/jbc.M110.168039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978606PMC
November 2010

RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo.

Proc Natl Acad Sci U S A 2010 Apr 12;107(17):7999-8004. Epub 2010 Apr 12.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1003655107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867926PMC
April 2010

Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice.

Diabetes 2009 Dec 14;58(12):2776-87. Epub 2009 Sep 14.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://diabetes.diabetesjournals.org/content/early/2009/09/1
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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db09-05
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http://dx.doi.org/10.2337/db09-0522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780871PMC
December 2009

Persistent diet-induced obesity in male C57BL/6 mice resulting from temporary obesigenic diets.

PLoS One 2009 29;4(4):e5370. Epub 2009 Apr 29.

Laboratory of Biological Modeling, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005370PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670508PMC
July 2009

Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis.

Cell Metab 2009 Jul;10(1):27-39

Nuclear Receptor Biology Section, CEB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cmet.2009.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732027PMC
July 2009

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice.

Proc Natl Acad Sci U S A 2009 Jul 10;106(30):12471-6. Epub 2009 Jul 10.

Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0904506106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708975PMC
July 2009

Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation.

Cell Metab 2009 Jun;9(6):548-55

Signal Transduction Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cmet.2009.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698878PMC
June 2009

Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes.

Diabetes 2009 May 19;58(5):1175-84. Epub 2009 Feb 19.

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db08-06
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http://dx.doi.org/10.2337/db08-0616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671059PMC
May 2009

Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity.

PLoS One 2009 19;4(3):e4937. Epub 2009 Mar 19.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654157PMC
May 2009

Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors.

Virol J 2009 May 18;6:61. Epub 2009 May 18.

Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1186/1743-422X-6-61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687429PMC
May 2009

G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency.

Am J Physiol Cell Physiol 2009 Apr 21;296(4):C930-40. Epub 2009 Jan 21.

Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1752, USA.

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http://dx.doi.org/10.1152/ajpcell.00443.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670650PMC
April 2009

Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth.

Proc Natl Acad Sci U S A 2009 Apr 30;106(15):6398-403. Epub 2009 Mar 30.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0900977106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662962PMC
April 2009

Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth.

PLoS Comput Biol 2009 Mar 27;5(3):e1000324. Epub 2009 Mar 27.

Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, USA.

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http://dx.doi.org/10.1371/journal.pcbi.1000324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653640PMC
March 2009

Metabolic roles of the M3 muscarinic acetylcholine receptor studied with M3 receptor mutant mice: a review.

J Recept Signal Transduct Res 2008 ;28(1-2):93-108

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892-0810, USA.

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http://www.tandfonline.com/doi/full/10.1080/1079989080194200
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http://dx.doi.org/10.1080/10799890801942002DOI Listing
August 2008

Severe obesity and insulin resistance due to deletion of the maternal Gsalpha allele is reversed by paternal deletion of the Gsalpha imprint control region.

Endocrinology 2008 May 17;149(5):2443-50. Epub 2008 Jan 17.

Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health, Building 10, Room 8C101, Bethesda, Maryland 20892-1752, USA.

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http://dx.doi.org/10.1210/en.2007-1458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2329281PMC
May 2008

A model for obesity and gigantism due to disruption of the Ankrd26 gene.

Proc Natl Acad Sci U S A 2008 Jan 27;105(1):270-5. Epub 2007 Dec 27.

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA.

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http://dx.doi.org/10.1073/pnas.0710978105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224199PMC
January 2008

The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging.

Biochim Biophys Acta 2007 Sep 29;1773(9):1455-61. Epub 2007 May 29.

Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 8 Center Drive, Room 101, Bethesda, MD 20892-0822, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016748890700117
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http://dx.doi.org/10.1016/j.bbamcr.2007.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695665PMC
September 2007

Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration.

Hepatology 2007 Aug;46(2):504-13

Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892-0822, USA.

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http://dx.doi.org/10.1002/hep.21713DOI Listing
August 2007

Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.

Cell Metab 2007 Feb;5(2):115-28

Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.cmet.2007.01.005DOI Listing
February 2007

Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency.

Cell Metab 2006 Nov;4(5):363-75

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1016/j.cmet.2006.09.008DOI Listing
November 2006

Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus.

Endocrinology 2006 Jun 2;147(6):2619-30. Epub 2006 Mar 2.

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Betheda, MD 20892, USA.

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http://dx.doi.org/10.1210/en.2005-1556DOI Listing
June 2006

Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice.

Am J Physiol Endocrinol Metab 2006 Jun;290(6):E1227-36

Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1152/ajpendo.00344.2005DOI Listing
June 2006

p53 regulates mitochondrial respiration.

Science 2006 Jun 25;312(5780):1650-3. Epub 2006 May 25.

Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/science.1126863DOI Listing
June 2006