Oksana Berezovska

Oksana Berezovska

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Oksana Berezovska

Publications by authors named "Oksana Berezovska"

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Synapsin 1 promotes Aβ generation via BACE1 modulation.

PLoS One 2019 12;14(12):e0226368. Epub 2019 Dec 12.

MassGeneral Institute for Neurodegenerative Disease, Alzheimer's Disease Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226368PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907790PMC
December 2019

Presenilin 1 increases association with synaptotagmin 1 during normal aging.

Neurobiol Aging 2019 Nov 15. Epub 2019 Nov 15.

Alzheimer's Disease Research Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.10.006DOI Listing
November 2019

Novel interaction between Alzheimer's disease-related protein presenilin 1 and glutamate transporter 1.

Sci Rep 2018 06 7;8(1):8718. Epub 2018 Jun 7.

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Department of Neurology, 114 16th Street, 02129, Charlestown, MA, USA.

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http://dx.doi.org/10.1038/s41598-018-26888-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992168PMC
June 2018

Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer's Disease Pathogenesis.

Mol Neurobiol 2018 03 22;55(3):2275-2284. Epub 2017 Mar 22.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1007/s12035-017-0487-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610083PMC
March 2018

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1.

EBioMedicine 2017 Oct 4;24:93-101. Epub 2017 Sep 4.

Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129-2060, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.08.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652037PMC
October 2017

Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay.

J Biol Chem 2017 09 6;292(36):14720-14729. Epub 2017 Jul 6.

From the Alzheimer's Disease Research Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 and

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http://dx.doi.org/10.1074/jbc.M117.784264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592654PMC
September 2017

Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production.

Mol Neurodegener 2017 02 13;12(1):15. Epub 2017 Feb 13.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Rm. 2006, 02129, Charlestown, MA, USA.

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http://dx.doi.org/10.1186/s13024-017-0159-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307796PMC
February 2017

Pathogenic PS1 phosphorylation at Ser367.

Elife 2017 01 30;6. Epub 2017 Jan 30.

Alzheimer's Disease Research Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States.

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http://dx.doi.org/10.7554/eLife.19720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279945PMC
January 2017

Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation.

Mol Med 2016 Sep 5;22:329-337. Epub 2016 Jul 5.

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Department of Neurology, Charlestown, Massachusetts, United States of America.

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http://dx.doi.org/10.2119/molmed.2016.00127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023509PMC
September 2016

Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta.

BMC Biol 2016 Mar 31;14:25. Epub 2016 Mar 31.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1186/s12915-016-0248-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818459PMC
March 2016

Oxidative stress and lipid peroxidation are upstream of amyloid pathology.

Neurobiol Dis 2015 Dec 21;84:109-19. Epub 2015 Jun 21.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, CNY 114, 16th Street, Charlestown 02129, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684986PMC
December 2015

Synaptotagmins interact with APP and promote Aβ generation.

Mol Neurodegener 2015 Jul 23;10:31. Epub 2015 Jul 23.

Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1186/s13024-015-0028-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511450PMC
July 2015

MeCP2: a novel Huntingtin interactor.

Hum Mol Genet 2014 Feb 8;23(4):1036-44. Epub 2013 Oct 8.

Department of Neurology and The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1093/hmg/ddt499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900110PMC
February 2014

Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.

Structure 2014 Jan 7;22(1):125-35. Epub 2013 Nov 7.

Department of Clinical Neurosciences, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK; Tanz Centre for Research in Neurodegenerative Diseases, and Departments of Medicine, Laboratory Medicine and Pathobiology, and Medical Biophysics, University of Toronto, Toronto, ON M5S 3H2, Canada. Electronic address:

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http://www.cell.com/structure/pdf/S0969-2126(13)00369-9.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S096921261300369
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http://dx.doi.org/10.1016/j.str.2013.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887256PMC
January 2014

Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease.

Acta Neuropathol 2013 Feb 9;125(2):187-99. Epub 2012 Nov 9.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital, Harvard Medical School, CNY 114, 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1007/s00401-012-1065-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552123PMC
February 2013

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.

EMBO J 2011 Oct 14;30(23):4815-24. Epub 2011 Oct 14.

Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1038/emboj.2011.372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243616PMC
October 2011

Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation.

Mol Neurodegener 2011 Feb 10;6(1):15. Epub 2011 Feb 10.

Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1186/1750-1326-6-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046905PMC
February 2011

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site.

Nat Commun 2010 Nov 30;1:130. Epub 2010 Nov 30.

1] Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. [2].

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http://www.nature.com/doifinder/10.1038/ncomms1129
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http://dx.doi.org/10.1038/ncomms1129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060602PMC
November 2010

Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway.

FASEB J 2009 Nov 22;23(11):3819-28. Epub 2009 Jul 22.

Neurobiology of Disease Laboratory, Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1096/fj.09-134999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775008PMC
November 2009

Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.

PLoS One 2009 Nov 18;4(11):e7893. Epub 2009 Nov 18.

Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007893PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773935PMC
November 2009

Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase.

Mol Cell Neurosci 2009 Jun 9;41(2):166-74. Epub 2009 Mar 9.

Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative, Diseases, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.mcn.2009.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732195PMC
June 2009

Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy.

J Biomed Opt 2008 Jan-Feb;13(1):014008

Harvard Medical School, Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Disorders, 114 16th Street, Charlestown, Massachusetts 02129, USA.

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http://biomedicaloptics.spiedigitallibrary.org/article.aspx?
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http://dx.doi.org/10.1117/1.2837169DOI Listing
June 2008

CHIP targets toxic alpha-Synuclein oligomers for degradation.

J Biol Chem 2008 Jun 24;283(26):17962-8. Epub 2008 Apr 24.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1074/jbc.M802283200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936239PMC
June 2008

Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays.

J Biomed Opt 2006 Sep-Oct;11(5):054024

Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA.

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http://biomedicaloptics.spiedigitallibrary.org/article.aspx?
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http://dx.doi.org/10.1117/1.2363367DOI Listing
January 2007

Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.

Mol Neurodegener 2006 Nov 14;1:16. Epub 2006 Nov 14.

Department of Neuroscience, Mayo Clinic Jacksonville, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA.

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http://dx.doi.org/10.1186/1750-1326-1-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1654158PMC
November 2006

Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.

J Biol Chem 2006 Oct 31;281(43):32240-53. Epub 2006 Aug 31.

Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1074/jbc.M603106200DOI Listing
October 2006

Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader.

J Biol Chem 2006 Sep 30;281(36):26400-7. Epub 2006 Jun 30.

Alzheimer's Disease Research Laboratory, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1074/jbc.M601085200DOI Listing
September 2006

Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy.

Biochem Biophys Res Commun 2006 Feb 20;340(2):668-74. Epub 2005 Dec 20.

Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.bbrc.2005.12.063DOI Listing
February 2006

APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation.

J Neurochem 2005 Oct 8;95(2):446-56. Epub 2005 Aug 8.

Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129-4404, USA.

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http://doi.wiley.com/10.1111/j.1471-4159.2005.03381.x
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http://dx.doi.org/10.1111/j.1471-4159.2005.03381.xDOI Listing
October 2005

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.

J Biol Chem 2005 Jul 25;280(29):27303-9. Epub 2005 May 25.

Alzheimer Research Unit, Massachusetts Institute for Neurodegenerative Disorders, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1074/jbc.M413969200DOI Listing
July 2005

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.

Nat Med 2004 Oct 26;10(10):1065-6. Epub 2004 Sep 26.

Alzheimer Research Unit, Massachusetts General Hospital, 114 16th St, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nm1112DOI Listing
October 2004

Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.

J Neurochem 2004 Sep;90(5):1132-43

Alzheimer Disease Research Unit, Massachusetts General Hospital-East, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02581.xDOI Listing
September 2004

Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations.

Am J Geriatr Psychiatry 2004 Mar-Apr;12(2):146-56

Massachusetts General Hospital, Alzheimer Research Unit, Charleston, MA 02129, USA.

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http://dx.doi.org/10.1097/00019442-200403000-00006DOI Listing
June 2004

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.

J Biol Chem 2003 Nov 5;278(48):47370-5. Epub 2003 Sep 5.

Alzheimer Research Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02114, USA.

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http://dx.doi.org/10.1074/jbc.M308480200DOI Listing
November 2003

Activated Notch1 associates with a presenilin-1/gamma-secretase docking site.

J Neurochem 2003 Nov;87(4):843-50

Alzheimer's Research Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2003.02030.xDOI Listing
November 2003

Designed helical peptides inhibit an intramembrane protease.

J Am Chem Soc 2003 Oct;125(39):11794-5

Center for Neurologic Diseases, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/ja037131vDOI Listing
October 2003

Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.

J Neurosci 2003 Jun;23(11):4560-6

Alzheimer's Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740808PMC
June 2003

Monitoring proteins in intact cells.

Sci Aging Knowledge Environ 2003 Jun 11;2003(23):PE14. Epub 2003 Jun 11.

Alzheimer's Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1126/sageke.2003.23.pe14DOI Listing
June 2003

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

FASEB J 2003 Jan 1;17(1):79-81. Epub 2002 Nov 1.

Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1096/fj.02-0394fjeDOI Listing
January 2003

The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells.

J Biol Chem 2002 Aug 24;277(32):28530-6. Epub 2002 May 24.

Alzheimer's Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M203372200
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http://dx.doi.org/10.1074/jbc.M203372200DOI Listing
August 2002