Ofer Spiegelstein

Ofer Spiegelstein

UNVERIFIED PROFILE

Are you Ofer Spiegelstein?   Register this Author

Register author
Ofer Spiegelstein

Ofer Spiegelstein

Publications by authors named "Ofer Spiegelstein"

Are you Ofer Spiegelstein?   Register this Author

39Publications

626Reads

45Profile Views

The Effect of CYP3A Induction and Inhibition on the Pharmacokinetics of Laquinimod, a Novel Neuroimmunomodulator.

Clin Pharmacol Drug Dev 2020 Apr 1. Epub 2020 Apr 1.

Teva Pharmaceutical Industries Ltd, Netanya, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpdd.785DOI Listing
April 2020

Pharmacokinetics and safety of single and multiple doses of rasagiline in healthy Japanese and caucasian subjects.

Basic Clin Pharmacol Toxicol 2019 Mar 21;124(3):273-284. Epub 2018 Oct 21.

Teva Pharmaceuticals Ltd., Netanya, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcpt.13131DOI Listing
March 2019

A Thorough QT/QTc Study With Laquinimod, a Novel Immunomodulator in Development for Multiple Sclerosis and Huntington Disease.

Clin Pharmacol Drug Dev 2019 01 22;8(1):49-59. Epub 2018 May 22.

eResearch Technology, Inc, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpdd.442DOI Listing
January 2019

Metoprolol-pridopidine drug-drug interaction and food effect assessments of pridopidine, a new drug for treatment of Huntington's disease.

Br J Clin Pharmacol 2017 Oct 21;83(10):2214-2224. Epub 2017 Jun 21.

Clinical Pharmacology & Pharmacometrics, Teva Pharmaceutical Industries Ltd, Netanya, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.13317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595947PMC
October 2017

Pharmacokinetics and excretion of (14)C-omacetaxine in patients with advanced solid tumors.

Invest New Drugs 2016 10 25;34(5):565-74. Epub 2016 May 25.

Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10637-016-0360-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007276PMC
October 2016

Is it possible to achieve bio-equivalence between an oral solid immediate-release and an analogue enteric-coated formulation?

J Pharm Pharmacol 2016 Oct 27;68(10):1278-89. Epub 2016 Jul 27.

Discovery and Product Development, Global Research and Development, Teva Pharmaceutical Industries, Ltd, Netanya, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.12597DOI Listing
October 2016

A thorough QT study to assess the effects of tbo-filgrastim on cardiac repolarization in healthy subjects.

Drug Des Devel Ther 2015 15;9:2653-62. Epub 2015 May 15.

R&D, Teva Pharmaceutical Industries Ltd, Netanya, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/DDDT.S81799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440426PMC
February 2016

Safety, pharmacokinetic and pharmacodynamic properties of TV-1106, a long-acting GH treatment for GH deficiency.

Eur J Endocrinol 2015 Nov 18;173(5):541-51. Epub 2015 Aug 18.

Teva Pharmaceuticals Inc.12 Hatrufa Street, Netanya 42504, IsraelTeva Biopharmaceuticals Inc.Rockville, Maryland, USATeva Pharmaceuticals Inc.Frazer, Pennsylvania, USACardiac Safety Consultants LtdLondon, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/EJE-15-0554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584421PMC
November 2015

Assessment of Pharmacokinetic and Pharmacodynamic Interactions Between Albumin-Fused Mutated Butyrylcholinesterase and Intravenously Administered Cocaine in Recreational Cocaine Users.

J Clin Psychopharmacol 2015 Aug;35(4):396-405

From the *Altreos Research Partners, Inc and †Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada; ‡Research and Development, Teva Pharmaceuticals, Netanya, Israel; and §Algorithme Pharma, Laval, Québec; and ∥DL Global Partners Inc and ¶Biopharma Services Inc, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JCP.0000000000000347DOI Listing
August 2015

Arsenic urinary speciation in Mthfr deficient mice injected with sodium arsenate.

Toxicol Lett 2012 Dec 30;215(3):214-8. Epub 2012 Oct 30.

Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2012.10.014DOI Listing
December 2012

Renal tubular reabsorption of folate mediated by folate binding protein 1.

J Am Soc Nephrol 2005 Mar 9;16(3):608-15. Epub 2005 Feb 9.

Department of Cell Biology, Institute of Anatomy, University of Aarhus, University Park, Building 234, DK-8000 Aarhus C, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2004080711DOI Listing
March 2005

Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies.

Toxicol Appl Pharmacol 2005 Feb;203(1):18-26

Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.taap.2004.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938173PMC
February 2005

Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis.

Cancer Res 2005 Feb;65(3):887-97

Molecular and Cell Biology Section, Faculty of Nutrition, Texas A&M University, Kleberg Center, College Station, TX 77843-2471, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938162PMC
February 2005

Effects of dietary folate intake and folate binding protein-2 (Folbp2) on urinary speciation of sodium arsenate in mice.

Environ Toxicol Pharmacol 2005 Jan;19(1):1-7

Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.etap.2004.01.007DOI Listing
January 2005

Embryonic development of folate binding protein-1 (Folbp1) knockout mice: Effects of the chemical form, dose, and timing of maternal folate supplementation.

Dev Dyn 2004 Sep;231(1):221-31

Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/dvdy.20107
Publisher Site
http://dx.doi.org/10.1002/dvdy.20107DOI Listing
September 2004

Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos.

Neurochem Res 2004 Jun;29(6):1105-12

Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1023/b:nere.0000023597.37698.13DOI Listing
June 2004

Valproate-induced neural tube defects in folate-binding protein-2 (Folbp2) knockout mice.

Birth Defects Res A Clin Mol Teratol 2003 Dec;67(12):974-8

Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bdra.10128DOI Listing
December 2003

Teratogenicity of valproate conjugates with anticonvulsant activity in mice.

Epilepsy Res 2003 Dec;57(2-3):145-52

Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2003.10.015DOI Listing
December 2003

Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice.

Toxicol Lett 2003 Nov;145(2):167-74

Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, 77030, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0378-4274(03)00307-2DOI Listing
November 2003

Pathobiology and genetics of neural tube defects.

Epilepsia 2003 ;44 Suppl 3:14-23

Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston 77030-3303, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1528-1157.44.s3.5.xDOI Listing
July 2003

Gas chromatographic determination of novel valproyl taurinamide derivatives in mouse and dog plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2003 May;788(1):125-36

Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, P.O. Box 12065 Ein Karem, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1570-0232(02)01034-6DOI Listing
May 2003

DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation.

J Nutr 2002 08;132(8 Suppl):2457S-2461S

Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jn/132.8.2457SDOI Listing
August 2002