Publications by authors named "O M Khardzeishvili"

9 Publications

DISTRIBUTION AND DEMOGRAPHIC CHARACTERISTICS OF DUCTAL INVASIVE BREAST CARCINOMA SUBTYPES IN GEORGIAN POPULATION.

Georgian Med News 2018 Oct(283):129-133

David Tvildiani Medical University; Iv. Javakhishvili Tbilisi State University, A. Natishvili Institute of Morphology; Pathology Research Center; Tbilisi State Medical University, Georgia.

The analysis of prevalence of each specific subtypes of the ductal invasive breast carcinoma according to age group categories showed that Luminal A subtype is observed in every age group as dominant subtype, although in different intensity: two peaks were demonstrated in group III and group IV, and in relatively less amount, in V group as well. Its considerable that Her2(+)/ER subtype was second most prevalent subtype in almost all age groups. It also must be noted that there was no direct correlation found between pre- or post-menopausal period and HER2+ state, except for group IV (60-69 year old range), where it was almost 2 times less frequently found than Basal-like subtype. The frequency of Her2(+)/ER tumor subtype was identical to Luminal A subtype frequency. In age group I (30-39 year old) and all others its frequency was found to be markedly decreasing along with the frequency of Luminal A subtype (if in age group I their frequency was 1.2, in the age group IV it accounted for 9.4, which means that Her2(+)/ER subtype prevalence decreases with increasing age until the age group V (70-79 year old), after which it increases again (age group V and VI demonstrated the frequency of 2.0 and 5.0 respectively). Basal-like tumor was not found in age groups I and VI, and its frequency was gradually increasing except for age group II, where it was approximately 1.5 less frequent than in other age group categories. Triple-negative subtype was not found in age groups I and VI, however, its frequency was gradually increasing with increasing age. The prevalence of triple-negative tumor in age group V was 4.5 times higher than in age group II. The frequency of Luminal B subtype tumor was almost 2 times decreased in age group III, while in age group V it was almost 3 times increased. However, it disappeared in age group VI completely. Consideration of the age-related specificities of ductal invasive breast carcinoma subtypes (phenotypes) is important both for diagnostic aspect and treatment strategy selection, as well as adequate planning of breast cancer screening programs. Thus, in all age groups of the studied population, IIIA and B stages of tumor were identified, with tumor sizes ranging between 2.8-4.7mm. There was no stable direct correlation between breast cancer and family history, as the presence of such data requires additional research with more focus on anamnesis details.
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October 2018

MOLECULAR BASIS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND CYCLIN E EXPRESSION INTERDEPENDENCE IN BASAL-LIKE SUBTYPE OF INVASIVE BREAST CARCINOMA.

Georgian Med News 2018 Mar(276):101-107

David Tvildiani Medical University; Iv. Javakhishvili Tbilisi State University, A. Natishvili Institute of Morphology; Pathology Research Center; Tbilisi State Medical University, Georgia.

Aim of the study was the simultaneous assessment of EGFR and Cyclin E in "basal-like" carcinoma group, in order to establish their interactivity in the aspect of the age and grade of the tumor, taking into account the common parallel HER2+ samples. The study involved postoperative and/or biopsy material (paraffin blocks) of 237 patients from archived data, who were operated due to breast cancer (National Cancer Center of Tbilisi, 2008-2012 years). In TNBC group and "basal-like" tumor subgroup expression of ESFR, Cyclin E and Cytokeratins 5/6 and 17 were shown advanced activity of processes and high dependence to patients age. Taking into account all above mentioned, the immunohistochemical profile of "basal-like" type of breast cancer is defined mostly by sensitivity to cytokeratins CK5,6/17 and EGFR. In addition, the defected synthesis and activity of the latter, which is actually observed in "basal-like" carcinoma, leads to increased malignancy grade and mitotic activity, which creates the phenotypic and group characteristics for this type of carcinomas overall.
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March 2018

EXPRESSION OF CYCLIN E IN BASAL-LIKE BREAST CARCINOMA.

Georgian Med News 2017 Dec(273):104-108

Davit Tvildiani Medical University; I. Javakhishvili Tbilisi State University; Tbilisi State Medical University, Georgia.

Results of study under 362 patients biopsy materials in Tbilisi National Cancer Center were shown that basal-like type breast carcinoma is characterizes by different reaction on Cyclin E, CK5/17 and ER/PR immunoreactivities. Basal-like tumor immunoreactivity on Cyclin E differs based they clinical stage and seen maximum correlation with III-IV stage and poor prognosis.
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December 2017

Immunohistochemical expression of BRCA1 protein in invasive ductal carcinoma of the breast.

Georgian Med News 2010 Jul-Aug(184-185):51-60

Immunohistochemically detected BRCA1 positivity has been reported to indicate the presence of full-length functional protein, while immunohistochemical negativity may be a result of sporadic BRCA1 mutation. We set out to study the immunohistochemical expression of BRCA1 protein in breast cancer and assess associations with lymph node status, histologic grade and expression of other biomarkers. We examined 100 patients aged from 21 to 71 years diagnosed with invasive ductal carcinoma. Immunohistochemistry was performed using anti-BRCA1, ER, PR, HER2/neu, and Ki-67 (MIB-1) antibodies. Cytoplasmic or nuclear-cytoplasmic BRCA1 expression was identified in a total of 64 breast cancer patients. None of the breast cancer tissue samples showed solely nuclear BRCA1 immunoreactivity. BRCA1 expression was associated with higher histologic grade, and majority of BRCA1-positive patients were below 50 years of age. Most BRCA1-negative patients had intermediate grade tumors. BRCA1 expression was positively associated with ER and PR positivity, and negatively associated with HER2/neu overexpression. Although immunohistochemistry can be an inexpensive and valuable preliminary method for detecting the BRCA1 status, BRCA1 protein localization is a complex issue. Well designed studies are needed to further investigate the performance of various anti-BRCA1 antibodies in formalin- fixed paraffin-embedded tissue samples, assess their association with BRCA1 gene mutations and determine clinical usefulness of BRCA1 immunohistochemistry.
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February 2011

[Etiologic factors in development of inflammatory diseases (cheilitis) of the lips].

Georgian Med News 2009 Mar(168):27-31

Last years the number of patients affected with lips' pathologies has been significantly increased that could be caused by different exogenic (chemical, biological, pharmacological and toxic substances etc.) and endogenic factors. Therefore, considering the above-mentioned etiologic factors, the aim of our study was identification and differentiation of different types of Cheilitis and basing on the study of their pathogenesis, to perform differential diagnostics and to systematize them. In certain cases, cheilitis appeared to be the early manifestations of diseases of different organs or organ systems on lips, laying the great responsibility on the Doctor-Stomatologists, who together with the other appropriate specialists is obliged to perform diagnostics of general (background) diseases in time; to make differential diagnostics and to plan the further and target therapy.
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March 2009
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