Publications by authors named "O Ersoy"

196 Publications

Myxoma complicated acute intestinal obstruction: A rare case with diagnostic challenges.

Authors:
O Ersoy U Sekmen A B Balmuk A Girit

Niger J Clin Pract 2021 Feb;24(2):292-294

School of Medicine-Medical School Student, Acibadem Mehmet Ali Aydınlar University, Istanbul, Turkey.

Myxomas are slowly growing mesenchymal tumors and are considered as extremely rare benign tumors of small intestine. This is the case of a young woman presenting with acute bowel obstruction due to ileo-ileal intussusception caused by an intraluminal 4- cm solitary nodule, found to be a myxoma upon pathologic examination, after resection by surgery.
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http://dx.doi.org/10.4103/njcp.njcp_676_19DOI Listing
February 2021

Borate mineral loading into acrylic bone cements to gain cost-effectivity, enhanced antibacterial resistivity, and better cellular integration properties.

Authors:
Mesut Kaplan Erdoğan Özgür Orkun Ersoy Lokman Kehribar Neslihan İdil Lokman Uzun

J Biomater Sci Polym Ed 2021 Feb 11:1-14. Epub 2021 Feb 11.

Institute of Science, Division of Bioengineering, Hacettepe University, Ankara, Turkey.

Polymethyl methacrylate (PMMA), called as bone cement, has been used in implant surgery, initially in dental practices, then in arthroplasty surgery for decades. Bone cement is a highly preferred chemical in the field of orthopedics due to its bone-like hardness and mechanical strength. Meanwhile, antibiotic-loaded cements are used in joints and similar surgeries are generally due to the risk of infection. In this study, we aimed to demonstrate the effects of borate mineral loading into bone cement on enhancing the antibacterial resistivity and cell integration as well as retaining mechanical properties. Moreover, the incorporation of minerals into bone cements makes them much more cost-friendly biomaterials for surgical operations. Herein, antibacterial properties were evaluated by using vancomycin- and gentamycin-susceptible strains of and whereas cell viability tests were performed by osteoblast cell lines. Three sets of the bone cements, plain, calcium borate-, and sodium borate-loaded, were prepared through commercial procedures and subjected to mechanical, antibacterial and cell viability tests. Percentage deformation determined by compression tests under 0.100 MPa pressure was determined in the range of 12.58%-10.67% in respect to the amount of sodium borate mineral loaded whereas that was determined in the range of 12.54%-9.87% in respect to the amount of calcium borate mineral loaded. Micro-CT results also supported good mineral integration and structural features of the composite bone cements. Furthermore, mineral incorporation enhanced the cell viability, in other words, cellular integrity, up to 101.28% for sodium borate-loaded (NB75, 7.5 g mineral) and 72.04% for calcium borate-loaded (CB75, 7.5 g mineral) bone cement according to the negative control group, fresh culture medium. As a conclusion, both of these minerals could be classified as promising alternatives for developing bone cements with better antibacterial resistivity and cellular integration properties.
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http://dx.doi.org/10.1080/09205063.2021.1880169DOI Listing
February 2021

Sitagliptin and fucoidan prevent apoptosis and reducing ER stress in diabetic rat testes.

Authors:
Gulnur Kizilay Onur Ersoy Aysegul Cerkezkayabekir Yeter Topcu-Tarladacalisir

Andrologia 2021 Apr 21;53(3):e13858. Epub 2021 Jan 21.

Department of Histology and Embryology, School of Medicine, Trakya University, Edirne, Turkey.

Sitagliptin increases the levels of incretin hormones and stimulates a decrease in blood glucose levels, by blocking the DPP4 enzyme. We have very limited information about impact of sitagliptin on male genital system and relationship between sitagliptin/diabetes/ER. Fucoidan can be effective in blood glucose homeostasis. We goal to explain of the effect of sitagliptin and introduce an approach of fucoidan treatment in experimental diabetes in male rats. Fifty-eight Wistar albino rats were divided into C-control group and D-diabetes group: 60 mg/kg streptozotocin intraperitoneal (i.p.); DS group: STZ + 10 mg/kg sitagliptin intragastric (i.g.); DF group: STZ + 100 mg/kg fucoidan i.p.; and DSF group: STZ + 10 mg/kg sitagliptin + 100 mg/kg fucoidan. A significant decrease was detected when DS, DF and DSF groups compared to group D in blood glucose levels, basement membrane thickness and also apoptotic cell/tubule index, pJNK, caspase 3, caspase 12, GRP78, CHOP and DPP4. Sitagliptin and fucoidan have been found to be effective in blood glucose homeostasis and reducing the expression of certain proteins that lead to apoptosis and especially the proteins in the ER stress pathway. Therefore, we think that both sitagliptin and fucoidan can be effective in preventing or eliminating histopathological damages in diabetic testicular tissues, and their treatment effects can be used more.
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http://dx.doi.org/10.1111/and.13858DOI Listing
April 2021

Risk factors for post-ERCP pancreatitis: it depends on the ERCP indication.

Authors:
H Köseoğlu T Solakoğlu M Başaran S Özer Sarı M Tahtacı S Yaman E Selvi O Ersoy

Acta Gastroenterol Belg 2020 Oct-Dec;83(4):598-602

Department of Gastroenterology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.

Background And Aims: Endoscopic retrograde cholangiopancreatography (ERCP) is an invasive modality, and has a high risk of causing post-ERCP pancreatitis (PEP). Risk factors of PEP have been investigated and conflicting results are present for most risk factors. The aim of this study was to evaluate the risk factors for PEP and to determine whether the risk factors differ due to the ERCP indication.

Patients And Methods: A retrospective study was conducted which included 666 patients with 968 ERCP procedures. Some risk factors were evaluated for PEP, and they were also evaluated separately for patients with bile duct stones and patients who underwent ERCP for other reasons than bile duct stones.

Results: In patients with bile duct stones detected on ERCP ; female gender, lower diameter of the common bile duct, placing a biliary plastic stent and not having a cholecystectomy history were risk factors for PEP, whereas in patients without bile duct stones the only risk factor for PEP was not having a prior endoscopic sphincterotomy.

Conclusions: Our study revealed that PEP risk factors depend on the indication of ERCP. To the best of our knowledge our study is the first study defining cholecystectomy as a protective factor for PEP in patients with bile duct stones and endoscopic sphincterotomy history as a protective factor for PEP in patients without bile duct stones. Our study also showed that female gender, lower diameter of the common bile duct and placing a plastic biliary stent were risk factors for PEP in patients with bile duct stones.
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December 2020

Successful Liver And Kidney Transplantations From A Donor With Left Ventricular Assist Device.

Authors:
Helin Sahinturk Deniz Kaya Ozgur Ersoy Pinar Zeyneloglu Mehmet Haberal

Exp Clin Transplant 2020 Aug 7. Epub 2020 Aug 7.

From the Anesthesiology and ICM Department, Baskent University Faculty of Medicine, Ankara, Turkey.

Organ transplant from donors with ventricular assist devices is not common. Here, we report organ retrieval from a donor with a left ventricular assist device who had been on the heart transplant wait list before a brain death diagnosis. The organ donor was diagnosed with dilated cardiomyopathy and underwent left ventricular assist device surgery for bridging to heart transplant in 2016. Brain death occurred 22 months after implantation of the device at the age of 39 years due to widespread intraparenchymal and subarachnoid hemorrhage. Brain death diagnosis was confirmed with brain perfusion single-photon emission computed tomography. In accordance with the donor's will, the relatives approved organ donation. The donor's organ reserve was assessed to be suitable for liver and kidney transplants, and proper donor care was given. During recovery of organs, the organ transplant team was accompanied by cardiovascular surgeons to control flow of the left ventricular assist device and to ensure optimum organ perfusion. After a successful operation, the liver was transplanted to a patient with primary sclerosing cholangitis who had been on the wait list for liver transplant for 13 years. The kidneys were transplanted to patients awaiting kidney transplant for 31 and 14 years with diagnoses of nephrolithiasis and polycystic kidney disease, respectively. No complications occurred among the liver and kidney transplant recipients. There are few reports of donors with assist devices. This is the first case of an organ donor with an assist device waiting for an organ transplant who became an actual donor in our country.
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http://dx.doi.org/10.6002/ect.2019.0152DOI Listing
August 2020

Awareness, treatment rates, and compliance to treatment in patients with serum LDL cholesterol higher than 250 mg/dL, and possible, probable, or definite familial hypercholesterolemia.

Authors:
Samet Yaman Didem Ozdemir Busra Tugce Akman Bekir Cakir Osman Ersoy

Postgrad Med 2021 Mar 23;133(2):146-153. Epub 2020 Sep 23.

Department of Gastroenterology, Ankara Yildirim Beyazit University, Ankara, Turkey.

Purpose: Familial hypercholesterolemia (FH) is a genetic disease characterized by increased levels of low-density lipoprotein cholesterol (LDL-C). It is underdiagnosed and undertreated despite relatively high prevalance and significant association with increased mortality. We aimed to determine treatment status and compliance in patients with LDL-C ≥ 250 mg/dL and FH.

Design: Patients older than 18 years old and have a serum LDL-C ≥ 250 mg/dL between January 2010 to December 2016 were identified from the hospital database. A phone survey was performed. Demographic features, smoking status, alcohol use, exercise, cardiovascular disease (CVD), use of medication for dyslipidemia, and CVD and high cholesterol levels in the family were questioned. Dutch Lipid Clinical Network Criteria was used to classify patients. The study was registered to Clinicaltrials.gov in July 2020 (NCT04494464).

Results: 1365 patients with a LDL-C ≥ 250 mg/dL were identified. Patients that could not be reached and who refused to interview were excluded and the data of 367 patients were analyzed. There were 248 (67.6%) female and 119 (32.4%) male patients and mean age was 50.52 ± 11.66. LDL-C was ≥330 mg/dL in 50 (13.6%) and 250-329 mg/dL in 317 (86.4%) patients. Forty (10.9%) patients were classified as definite, 181 (49.3%) as probable and 146 (39.8%) as possible FH. 213 (58.0%) patients were not receiving lipid-lowering treatment, and 162 (76.1%) stated that medication was never recommended previously, 30 (14.1%) had stopped medication him/herself and 21 (9.8%) had stopped medication with the advice of the physician. Among patients with definite/probable FH, 84 (38.0%) had CVD and the rate of lipid-lowering drug use in these patients was 58.3%.

Conclusion: A significant proportion of patients with LDL-C ≥ 250 mg/dL were not taking lipid-lowering drugs. Similar with many other studies, diagnosis, and treatment rates of FH patients were very low in our study. Further national studies are required to increase awareness of the disease in both physicians and patients.
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http://dx.doi.org/10.1080/00325481.2020.1805212DOI Listing
March 2021

An Improved Real-Coded Genetic Algorithm Using the Heuristical Normal Distribution and Direction-Based Crossover.

Authors:
Jiquan Wang Mingxin Zhang Okan K Ersoy Kexin Sun Yusheng Bi

Comput Intell Neurosci 2019 14;2019:4243853. Epub 2019 Nov 14.

College of Engineering, Northeast Agricultural University, Harbin, Heilongjiang 150030, China.

A multi-offspring improved real-coded genetic algorithm (MOIRCGA) using the heuristical normal distribution and direction-based crossover (HNDDBX) is proposed to solve constrained optimization problems. Firstly, a HNDDBX operator is proposed. It guarantees the cross-generated offsprings are located near the better individuals in the population. In this way, the HNDDBX operator ensures that there is a great chance of generating better offsprings. Secondly, as iterations increase, the same individuals are likely to appear in the population. Therefore, it is possible that the two parents of participation crossover are the same. Under these circumstances, the crossover operation does not generate new individuals, and therefore does not work. To avoid this problem, the substitution operation is added after the crossover so that there is no duplication of the same individuals in the population. This improves the computational efficiency of MOIRCGA by leading it to quickly converge to the global optimal solution. Finally, aiming at the shortcoming of a single mutation operator which cannot simultaneously take into account local search and global search, a Combinational Mutation method is proposed with both local search and global search. The experimental results with sixteen examples show that the multi-offspring improved real-coded genetic algorithm (MOIRCGA) has fast convergence speed. As an example, the optimization model of the cantilevered beam structure is formulated, and the proposed MOIRCGA is compared to the RCGA in optimizing the parameters of the cantilevered beam structure. The optimization results show that the function value obtained with the proposed MOIRCGA is superior to that of RCGA.
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http://dx.doi.org/10.1155/2019/4243853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925694PMC
May 2020

A Comparative Study Evaluating the Incidence of Colorectal Neoplasia(s) in Candidates for Bariatric Surgery by Screening Colonoscopy, 40-49 Versus 50-65 Years Old: a Preliminary Study.

Authors:
Toygar Toydemir Görkem Özgen İsmail Çalıkoğlu Özdal Ersoy Mehmet Ali Yerdel

Obes Surg 2019 08;29(8):2430-2435

İstanbul Bariatrics, Obesity and Advanced Laparoscopy Center, Hakkı Yeten Cad, Yeşil Çimen sok, Polat Tower, Şişli, 34394, İstanbul, Turkey.

Introduction: Obesity and metabolic syndrome (MetS) are associated with colorectal neoplasia (CRN) and carcinoma (CRC). Whether such subjects must undergo screening colonoscopy (SC) earlier, is unknown. Incidences of CRNs in 40-49- versus 50-65-year-old bariatric patients were compared by SC. No prospective data on SC is available in morbidly obese/MetS.

Material And Methods: Surgical weight loss candidates over 39 years of age, asymptomatic, and average-risk for CRC offered SC. Those giving written informed consent were enrolled. Colonoscopies were done by the same surgeon. Smoking/drinking history, fasting blood glucose (FBG), insulin, C-peptide, triglyceride, high density lipoprotein, vitamin D, HbA1c, and insulin resistance parameters were recorded. CRN rate and the distribution of variables in patients 40-49 years of age were compared with 50-65. Student's t and Chi-square tests were used as appropriate. P < 0.05 was regarded as statistically significant.

Results: Among 168 SCs, 47 had CRNs (27.9%). Including carcinoma, 15 had an advanced CRN (aCRN) (8.9% aCRN and 0.6% CRC). CRN rate was 35.6% in ≥ 50 years old whereas 22.1% in 40-49 (p = 0.053). aCRN rates (8.4% in 40-49 versus 9.6% in 50-65) were similar (p = 0.792). Metabolic parameters and smoking-drinking history were equally distributed between the groups except FBG and HbA1c as their mean levels were slightly higher in the 50-65 age group (p < 0.05).

Conclusions: Presented results warrant routine SC in the 40-49-year-old morbidly obese and/or MetS patient population with average risk, and in aged > 50, it certainly must be enforced and included in the preoperative check-list if not done before.
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http://dx.doi.org/10.1007/s11695-019-03819-2DOI Listing
August 2019

Validity and reliability of the measure yourself medical outcome profile 2 (MYMOP2) questionnaire among Turkish patients having anorectal disorders.

Authors:
Özdal Ersoy Yasemin Ecem Temel Hasan Kerem Alptekin

Turk J Gastroenterol 2019 01;30(1):28-32

Department of Physiotherapy and Rehabilitation, Bahçesehir University School of Health Sciences, İstanbul, Turkey.

Background/aims: Measure Yourself Medical Outcome Profile 2 (MYMOP2) is a patient-generated outcome measure allowing patients to select the problems that are the most important to them and that they want to address, and it measures the effects of the problem from a wide range of health care interventions. This study aimed to translate the questionnaire into Turkish language (Turkish MYMOP-TMYMOP) and add this clinically useful measure to Turkish medical practice by assessing its validity and reliability.

Materials And Methods: Fifty volunteers with anorectal disorders were prospectively included into the study. Each patient was enrolled into a pelvic floor training biofeedback program, specific to their anorectal symptomatology. The subjects were administered both the Nottingham Health Profile and the TMYMOP2 questionnaires before the treatment session (initial visit) and at the control follow-up visits (the first and second months, via e-mail or telephone calls).

Results: The TMYMOP2 questionnaire was shown to be moderately valid (the Pearson correlation coefficient score between the total scores of the subgroups of the two questionnaires were 0.335 and 0.642, respectively, p<0.05) and highly reliable (the Cronbach's alfa coefficient score between the total scores of the subgroups of the two questionnaires were 0.77, 0.82, and 0.88 in the beginning and at the first and second month follow-up visits, respectively).

Conclusion: The TMYMOP2 was shown to be a low-to-moderately valid and a highly reliable scale. Because it is brief and short to complete, it might be an important and free-to-use tool to measure the diseases, and it can enhance the patient-centered care within the Turkish health care context.
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http://dx.doi.org/10.5152/tjg.2018.17859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389304PMC
January 2019

The Effect of Preoperative Oral Carbohydrate Administration on Insulin Resistance and Comfort Level in Patients Undergoing Surgery.

Authors:
Emine Onalan Isil I Andsoy Omer F Ersoy

J Perianesth Nurs 2019 Jun 3;34(3):539-550. Epub 2018 Nov 3.

Purpose: The aim of this study was to evaluate the effect of preoperative oral carbohydrate solution (OCS) administration on postoperative insulin resistance and patient comfort in elective laparoscopic cholecystectomy.

Design: Randomized controlled clinical study.

Methods: The experimental group received OCS. The control group did not eat or drink before surgery. Glucose and insulin level were measured at baseline, 2 hours before surgery, and at the first and third hour after surgery. Insulin resistance was assessed by the homeostasis model assessment of insulin resistance (HOMA-IR). The visual analogue scale (VAS) and general comfort scale (GCS) were used to assess postoperative comfort level.

Findings: A significant increase in the glucose level was observed in both groups (P < 0.05). A change in glucose level was significantly higher in the control group (P = .014). HOMA-IR values did not change significantly in the OCS group (P = .160). In the OCS group VAS scores were significantly lower (P < .0001). The OCS group had significantly higher relief (P = .014), ease (P = .001), and transcendence (P < .0001) scores.

Conclusions: OCS decreases insulin resistance and increases comfort.
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http://dx.doi.org/10.1016/j.jopan.2018.07.007DOI Listing
June 2019

Fault detection in dynamic plant-wide process by multi-block slow feature analysis and support vector data description.

Authors:
Jian Huang Okan K Ersoy Xuefeng Yan

ISA Trans 2019 Feb 24;85:119-128. Epub 2018 Oct 24.

Key Laboratory of Advanced Control and Optimization for Chemical Processes of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

This study describes a dynamic large-scale process fault detection algorithm based on multi-block slow feature analysis by taking advantages of both multi-block algorithms in highlighting the local information and slow feature analysis in extracting the different dynamics of process data. A mutual information-based relevance matrix is first calculated to measure the correlation between any two variables, and then K-means clustering is used to cluster the original variables into several blocks by gathering the variables with similar relevance vectors into the same block. Slow feature analysis is applied in each block. A support vector data description is utilized to give a final decision. The proposed algorithm is tested with a well-known Tennessee Eastman (TE) process. The fault detection results show the efficiency and the superiority of the proposed method as compared to other related methods.
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http://dx.doi.org/10.1016/j.isatra.2018.10.016DOI Listing
February 2019

Can pancreatic steatosis affect exocrine functions of pancreas?

Authors:
Mustafa Tahtacı Oktay Algın Tarkan Karakan Öykü Tayfur Yürekli Murat Alışık Hüseyin Köseoğlu Melike Ruşen Metin Aylin Demirezer Bolat Özcan Erel Osman Ersoy

Turk J Gastroenterol 2018 09;29(5):588-594

Department of Gastroenterology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.

Background/aims: Pancreatic steatosis (PS) is a generally used term to define accumulation of fat in the pancreas. In theory PS may be able to affect the exocrine function of pancreas. In this study we aimed to determine the effect of PS on exocrine pancreas function.

Materials And Methods: Forty-three patients with PS determined by 3 tesla magnetic resonance imaging (MRI) and 48 patients without PS were included in this study. Patients with PS were classified as group 1 and control patients were classified as group 2. Fecal elastase-1 levels were determined. Fecal elastase-1 levels <200 μg/g were defined as exocrine pancreatic insufficiency (EPI). Patients with PS were further grouped according to severity and anatomic distribution of steatosis based on findings of 3 tesla MRI.

Results: Fecal elastase-1 levels was significantly lower in group 1 compared to group 2 (319.76±45.7 vs 549.31±69.4, respectively, p=0.003). Proportion of patients with EPI was significantly higher in group 1 than group 2 (35.5% vs 12% p=0.042). There were no significant differences in terms of severity or the anatomic distribution of PS in patients with PS with EPI based on MRI (p=0.052, p=0.198, p=0.405) Conclusion: Current study demonstrates that PS can cause EPI.
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http://dx.doi.org/10.5152/tjg.2018.17696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284608PMC
September 2018

The relationship between severity of ulcerative colitis and thiol-disulphide homeostasis.

Authors:
S Neselioglu P B Keske A Aydin Senat O T Yurekli S Erdogan M Alisik M S Ergin H Koseoglu O Ersoy O Erel

Bratisl Lek Listy 2018;119(8):498-502

Objectives: The aim of the study was to determine dynamic thiol-disulphide homeostasis in patients with ulcerative colitis, compare it with those of healthy control and to investigate the relationship between the severity of the disease and homeostasisMETHODS: A total of 78 patients and 58 healthy subjects were included in the study. Serum native thiol, total thiol and disulphide amounts were measured by using a novel automated method. Obtained results were compared and relationships were determined by correlation analysis.

Results: Serum native thiol, total thiol, disulphide amounts and disulphide/native thiol percent ratio (index) were significantly lower (p = 0.003 for index ratio and p < 0.001 for other parameters) in patients with ulcerative colitis than in healthy controls. Native thiol, total thiol and disulphide amounts were significantly higher (p < 0.001) in patients with ulcerative colitis in remission than in patients with active ulcerative colitis and near to those of healthy control. There were significant negative correlations between the severity of the disease and thiol-disulphide homeostasis parameters (r = -0.55, p < 0.001 for native thiol; r = -0.64, p < 0.0001 for total thiol; r = -0.65, p < 0.001 for disulphide and r = -0.33, p = 0.011 for index).

Conclusion: The thiol-disulphide homeostasis was weakened in ulcerative colitis. Strong correlations between the activity of the disease and thiol-disulfide homeostasis indicate that homeostasis may play a role in the pathogenesis of the disease (Tab. 3, Fig. 3, Ref. 30).
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http://dx.doi.org/10.4149/BLL_2018_091DOI Listing
January 2019

Collodion baby case series: the success of oral retinoic acid.

Authors:
Banu Mutlu Özyurt Özge Sürmeli Onay Özlem Ersoy

Turk Pediatri Ars 2018 Mar 1;53(1):51-56. Epub 2018 Mar 1.

Mersin Women's and Children's Hospital, Neonatal Intensive Care Unit, Mersin, Turkey.

Ichthyosis is a clinical skin cornification disorder characterized by hyperkeratosis. Lamellar ichthyosis is a rare form of ichthyosis (collodion baby), which is autosomal recessive. Diagnostic clinical findings can be confirmed with skin biopsy and genetic analysis. The principles of treatment are moistening the skin, prevention of dehydration, and use of keratolytic agents. Systemic retinoic acid (0.5-1 mg/kg/day) is reported to provide dramatic benefits in the treatment of lamellar ichthyosis and congenital ichthyosiform erythroderma. In this study, the efficiency of oral retinoic acid treatment is presented to show a dramatic improvement in five patients who were diagnosed as collodion babies and admitted to The Neonatal Intensive Care Unit after birth. None had other congenital problems. Only two patients were diagnosed as having sepsis. Hair loss was the only adverse effect of treatment in all five patients. With this series of collodion baby, we wanted to the draw the attention of physicians to the promising efficacy of retinoic acid.
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http://dx.doi.org/10.5152/TurkPediatriArs.2018.3704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070221PMC
March 2018

Effect of sildenafil citrate on the liver structure and function in obstructive jaundice: An experimental study.

Authors:
Tamer Şimşek Ömer Faik Ersoy Zeki Özsoy Erdinç Yenidoğan Hüseyin Ayhan Kayaoğlu Namık Özkan Mustafa Şahin

Turk J Surg 2018 1;34(2):111-116. Epub 2018 Jul 1.

Department of General Surgery, Gaziosmanpaşa University School of Medicine, Tokat, Turkey.

Objective: We aimed to investigate the effect of 10 mg/kg sildenafil on the structure and function of the liver in a rat model of obstructive jaundice.

Material And Methods: Sixty-two male Wistar albino rats were distributed into six different groups. Obstructive jaundice was performed by legating the common bile duct. 10 mg/kg sildenafil citrate in drinking water was delivered orally after the operation before sacrificing them. Rats were sacrificed either after 10 or 28 days according to the study design. The blood and tissue samples from the liver were obtained to perform a biochemical and histopathological analysis to study functional and structural changes in the liver.

Results: At the 10th day, there was no difference between the sildenafil-treated and control groups with regard to the aspartate aminotransferase and alanine aminotransferase levels (p=0.423, p=0.661). The alkaline phosphatase total bilirubin levels among the groups were statistically different (p<0.001). At the 28th day, liver function tests except alanine aminotransferase showed significant differences among the groups (p<0.001). Liver function tests did not changed significantly between the 10th and 28th day in sildenafil-treated rats (p>0.05). Significant differences were observed among the groups with regard to cholestasis, fibrosis, inflammation, and necrosis (p<0.001). However, edema increased in the sildenafil-treated group (p<0.001). On the 28th day, the severity of structural changes in the liver after obstructive jaundice, except edema, reduced significantly (p<0.001). The sildenafil-treated groups at different time points didn't show any statistical difference in histopathological changes (p>0.05).

Conclusion: Oral administration of 10 mg/kg sildenafil citrate dramatically reverses the biochemical and histopathological liver changes induced by obstructive jaundice in rats.
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http://dx.doi.org/10.5152/turkjsurg.2018.3771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048637PMC
July 2018

Association of Low Fecal Elastase-1 and Non-Ulcer Dyspepsia.

Authors:
Mustafa Tahtaci Huseyin Koseoglu Murat Alisik Oyku Tayfur Yurekli Gozde Tahtaci Ozcan Erel Osman Ersoy

J Clin Med 2018 Jun 16;7(6). Epub 2018 Jun 16.

Department of Gastroenterology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara 06800, Turkey.

Non-ulcer dyspepsia (NUD) is a term used to define a set of symptoms that are believed to originate from the gastroduodenal region, and no underlying organic, systemic, or metabolic reason can be found. The majority of patients suffer from chronic symptoms although half of the patients report improvement in symptoms with time. The potential role exocrine pancreatic insufficiency in NUD patients has not been clarified yet. We aimed to identify exocrine pancreas function with pancreatic fecal elastase-1 in patients diagnosed with non-ulcer dyspepsia and no typical exocrine pancreatic insufficiency (EPI) symptoms. Thirty-five patients referred to gastroenterology clinics with NUD and 35 people with no dyspeptic symptoms as a control group were included in this prospective study. Non-ulcer dyspepsia patients were classified as group 1 and control subjects classified as group 2. Upper gastrointestinal endoscopies were performed in both groups. Assessment of exocrine pancreatic function was performed by measuring fecal elastase-1 concentration with a commercial ELISA kit using polyclonal antibodies (BioServ Diagnostics) in NUD patients compared to control subjects. Mean fecal elastase-1 levels were significantly lower in group 1 patients compared with group 2 (367.47 ± 43.27; 502.48 ± 50.94 respectively; = 0.04). The percentage of the patients with EPI was significantly higher in group 1 ( = 0.02). Patients with NUD should be re-evaluated if they do not show satisfactory improvement with treatment. Exocrine pancreatic insufficiency was significantly higher in patients with NUD in our study. Evaluation for the presence of EPI can be a cost effective approach in management of refractory patients during the process of ruling out organic reasons.
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http://dx.doi.org/10.3390/jcm7060155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025585PMC
June 2018

Dynamic thiol/disulphide homeostasis in acute pancreatitis.

Authors:
Hüseyin Köseoğlu Murat Alışık Murat Başaran Öykü Tayfur Yürekli Tevfik Solakoğlu Mustafa Tahtacı Osman Ersoy Özcan Erel

Turk J Gastroenterol 2018 05;29(3):348-353

Department of Clinical Biochemistry, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.

Background/aims: The dynamic thiol/disulfide homeostasis plays pivotal roles in many physiological mechanisms in an organism. We aimed to investigate whether dynamic thiol/disulfide homeostasis changes among patients with acute pancreatitis.

Materials And Methods: This prospective trial contained 45 patients with acute pancreatitis and 45 sex-and age-matched healthy volunteers as control group. Thiol/disulfide homeostasis parameters were measured by a novel and automated assay, and detected results were compared between the two groups.

Results: Disulfide/total thiol percent ratio and disulfide/native thiol percent ratios were significantly higher in acute pancreatitis group; besides the native thiol, total thiol levels and native thiol/total thiol percent ratios were significantly lower (for all p < 0.001).

Conclusion: The thiol/disulfide homeostasis is impaired in acute pancreatitis with a shift toward the oxidative status, and this deficiency might be a pathogenic factor in acute pancreatitis. The correction of this thiol/disulfide imbalance may be a new target in the management of acute pancreatitis.
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http://dx.doi.org/10.5152/tjg.2018.17499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284655PMC
May 2018

Marginal Fit of All-Ceramic Crowns Before and After Cementation: An In Vitro Study.

Authors:
Saniye Eren Halıcı Canan Hekimoğlu Orkun Ersoy

Int J Periodontics Restorative Dent 2018 May/Jun;38(3):e41-e48

The marginal integrity of all-ceramic crowns for anterior and posterior teeth were evaluated. A total of 60 ceramic crowns (In-Ceram Alumina, IPS e.max Press, and Lava) were fabricated for the epoxy resin maxillary first central incisor and first molar and divided into three groups (n = 20). The crowns were measured at the facial, lingual, mesial, and distal finish lines (52 points) before and after cementation using scanning electron microscopy. The results were analyzed using one-way analysis of variance, paired samples t test, and independent t test. The mean values of marginal gaps were within acceptable clinical limits before and after cementation. The values of the anterior crowns at the buccal finish line were higher than those at the proximal finish line areas (P < .05). However, these were insignificant at four measurement areas for posterior crowns (P > .05). Marginal gaps of crowns at the anterior teeth were higher than at the posterior teeth for all groups.
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http://dx.doi.org/10.11607/prd.3169DOI Listing
November 2018

Treatment of Left Ventricular Assist Device Thrombosis: Single-Center Experience.

Authors:
D Sarp Beyazpınar Özgür Ersoy Bahadır Gültekin Anar Aliyev Mert Avsever H Tankut Akay Murat Özkan Atilla Sezgin Sait Aşlamacı

Exp Clin Transplant 2018 Mar;16 Suppl 1(Suppl 1):165-167

From the Department of Family Medicine, Baskent University Faculty of Medicine, Ankara, Turkey.

Heart failure is the one of the biggest health problem in the world. Because of limited donors for heart transplant procedures, the ventricular assist device has become a solution for heart failure therapy. With the increase in number of ventricular assist devices, the incidence of complications has also increased. One of the most important life-threatening complications is ventricular assist device thrombosis. Medical therapy and changes in the ventricular assist device are the main therapy methods for ventricular assist device thrombosis. In this study, we showed our clinical experience with treatment of ventricular assist device thrombosis.
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http://dx.doi.org/10.6002/ect.TOND-TDTD2017.P47DOI Listing
March 2018

Effects of fucoidan on diabetic rat testicular tissue.

Authors:
O Ersoy G Kizilay

Biotech Histochem 2018 7;93(4):277-285. Epub 2018 Mar 7.

a Department of Histology and Embryology, Faculty of Medicine , Trakya University , Edirne , Turkey.

Increased reactive oxygen species (ROS) resulting from hyperglycemia and inadequate endogenous antioxidant systems are responsible for the complications of diabetes. ROS accumulate in the cell and stimulate apoptosis, which compromises sperm quality and function. We investigated the possible effects of fucoidan, a potent antioxidant with a regulatory effect on blood glucose homeostasis, on the testicular tissues of rats with experimental diabetes. Diabetes was induced by administering 40 mg/kg streptozotocin (STZ) on five consecutive days. Twenty-four Wistar albino male rats were divided into four groups: group 1, control group (CG); group 2, diabetes group (DG); group 3, early fucoidan group (EFG) treated with 50 mg/kg fucoidan after diabetes induction; group 4, late fucoidan group (LFG) treated with the same dose of fucoidan 15 days after diabetes induction. Fucoidan was administered intraperitoneally every two days for four weeks. Basement membrane thickness and Johnsen scores were higher in the DG than in the CG; no difference was found for either the EFG or LFG compared to the CG. Seminiferous tubule diameters of EFG were significantly greater than for the DG. Apoptotic tubule and apoptotic cell indexes were significantly greater in the DG and significantly less in the EFG and LFG groups compared to the CG. Early use of fucoidan in diabetic individuals may minimize damage to testicular tissue.
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http://dx.doi.org/10.1080/10520295.2018.1434679DOI Listing
November 2018

Melatonin exhibits supportive effects on oxidants and anastomotic healing during intestinal ischemia/reperfusion injury.

Authors:
Namık Özkan Ömer Faik Ersoy Zeki Özsoy Ebru Çakır

Ulus Travma Acil Cerrahi Derg 2018 Jan;24(1):1-8

Department of General Surgery, Gaziosmanpaşa University Faculty of Medicine, Tokat-Turkey.

Background: The aim of this study was to investigate the effects of melatonin on intestinal anastomosis after intestinal ischemia/ reperfusion injury (IRI).

Methods: Thirty Wistar albino rats of both sexes were divided into 3 groups: sham, control, and treatment. IRI was performed by clamping the superior mesenteric artery (SMA) for 30 minutes, followed by reperfusion. The sham rats received only manipulation of the SMA. Melatonin (10 mg/kg) was administered to the treatment group, and the control group was given a vehicle injection. Both the treatment group and the control group further underwent ileal resection of a 1-cm segment and anastomosis. On the postoperative seventh day, the anastomotic burst pressure, hydroxyproline level, histological indices of wound healing, and oxidative parameters of catalase (CAT), superoxide dismutase (SOD), total glutathione (T-GSH), and glutathione peroxidase (GSH-Px) levels were measured. A one-way analysis of variance and chi-square test were used for the categorical data.

Results: Melatonin treatment led to a significantly higher burst pressure (p=0.027 and p<0.001, respectively). The 2 antioxidant enzymes, CAT and SOD, were at the highest level in the sham and melatonin groups and the lowest level in the control group (p=0.001 and p=0.002, respectively). Melatonin treatment resulted in a significantly higher level of both enzymes compared with the control group (p=0.026 and 0.003, respectively). The GSHpx and total GSH levels were slightly elevated in the treated rats, but the difference was not statistically significant (p=0.205 and 0.216, respectively). Fibroblast infiltration, capillary formation, and epithelialization were significantly better in the melatonin-treated animals. The granulocyte and mononuclear infiltration scores were similar between all groups.

Conclusion: It was concluded that melatonin had marked effects on intestinal anastomotic healing during intestinal IRI.
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http://dx.doi.org/10.5505/tjtes.2017.23539DOI Listing
January 2018

Association between antioxidants and mild acute pancreatitis.

Authors:
Tevfik Solakoglu Huseyin Koseoglu Semra Isikoglu Ozcan Erel Osman Ersoy

Arab J Gastroenterol 2017 Dec 21;18(4):201-205. Epub 2017 Dec 21.

Department of Gastroenterology, Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey.

Background And Study Aims: The mechanisms underlying acute pancreatitis have not been well elucidated. Over the last 20 years, there has been increasing awareness regarding the role played by oxidative stress in acute pancreatitis, but it is less well defined in human clinical trials. The aim of this study was to identify the relationship between antioxidants and acute pancreatitis.

Patients And Methods: We performed a cross-sectional trial on patients with mild acute pancreatitis. The study population consisted of 53 patients with mild acute pancreatitis and 55 healthy controls. Serum paraoxonase, arylesterase activity, total antioxidant status, total oxidant status and thiol levels were measured, and oxidative stress index was calculated.

Results: Paraoxonase, arylesterase activity, thiol and total antioxidant status levels were significantly lower in the acute pancreatitis group than in the control group (p = .024, p < .001, p < .001, p = .010, respectively). Oxidative stress index and total oxidant status levels were higher in the acute pancreatitis group than in the control group, but the difference was not statistically significant (p = .135, p = .253, respectively).

Conclusions: This study demonstrates that decreased antioxidant levels are associated with mild acute pancreatitis. No association was observed between mild acute pancreatitis and total oxidant status.
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http://dx.doi.org/10.1016/j.ajg.2017.11.008DOI Listing
December 2017

Role of baseline adenoma characteristics for adenoma recurrencein patients with high-risk adenoma

Authors:
Tevfik Solakoğlu Hüseyin Köseoğlu Sevil Özer Sarı Fatma Ebru Akın Aylin Demirezer Bolat Öykü Tayfur Yürekli Naciye Şemnur Büyükaşık Osman Ersoy

Turk J Med Sci 2017 11 13;47(5):1416-1424. Epub 2017 Nov 13.

Background/aim: The present observational study aimed to determine the predictive value of 3-year recurrence adenoma characteristics at baseline conventional colonoscopy in patients with high-risk adenoma.Materials and methods: A total of 47 patients with high-risk adenoma at baseline colonoscopy were followed up and underwent a surveillance colonoscopy at 3 years. Correlations between adenoma recurrence and baseline adenoma characteristics (size, number, histological features, and location) were analyzed.Results: Among 135 patients with high-risk adenoma, 47 patients (35%) who underwent surveillance colonoscopy at 3 years following baseline colonoscopy were included in the study. In these 47 patients, at least one new adenoma was detected in 19 (40.4%) patients, and new advanced adenomas were detected in 5 (10.6%) patients during the surveillance colonoscopy. No significant difference was found in patients who had adenoma recurrence versus those who did not in terms of size of adenomas (P = 0.143), number of adenomas (P = 0.562), histological properties of adenomas (P = 0.658), or locations of adenomas (P = 0.567).Conclusion: Baseline adenoma characteristics were not associated with the recurrence of adenomas or advanced adenomas in patients with high-risk adenoma.
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http://dx.doi.org/10.3906/sag-1502-105DOI Listing
November 2017

Determination of the knowledge level, attitudes, and behaviors of islamic religious officials toward blood donation.

Authors:
Hamit Sirri Keten Oguz Isik Celal Kus Ozgur Ersoy Soner Olmez Fatis Yildirim Mustafa Celik

Transfus Apher Sci 2017 Dec 2;56(6):875-879. Epub 2017 Nov 2.

Department of Family Medicine, Medical Faculty, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.

The aim of the present study was to determine knowledge level, attitudes, and behaviors of Islamic religious officials toward blood donation. This study included 334 religious officials rendering service in the province of Kahramanmaras, located in the Mediterranean region of Turkey. A questionnaire was administered to gather sociodemographic data of the participants and their knowledge levels, attitudes, and behaviors toward blood donation. The questionnaire consisted of 11 questions that yielded a total of 11 points. The religious officials in the study included 206 imams (61.7%, males) and 128 Quran course instructors (38.3%, females). Of study participants, 134 (40.1%) reported a previous experience of blood donation and 200 (59.9%) denied previous experience of blood donation. The mean knowledge score was 7.09±2.54 points for males and 6.89±2.18 points for females. Male and female participants achieved comparable scores (p=0.476). Of the participants, 291 (87.1%) agreed and nine (2.7%) disagreed with the expression, "Blood donation is permissible in Islam;" 34 (10.2%) participants had no idea. The present study revealed considerable deficiencies in knowledge about blood donation among religious officials. In addition, the rate of blood donation and willingness to donate blood were low among religious officials. Although the level of knowledge about blood donation was similar in males and females, it was an interesting finding that the blood donation rate was significantly higher in males than in females.
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http://dx.doi.org/10.1016/j.transci.2017.10.006DOI Listing
December 2017

Is glycogenic acanthosis a predictor of insulin resistance and metabolic syndrome?

Authors:
Mustafa Tahtacı Aylin Demirezer Bolat Öykü Tayfur Yürekli Hüseyin Köseoğlu Murat Başaran Sevil Özer Sarı Osman Ersoy

Turk J Gastroenterol 2017 Sep 4;28(5):337-341. Epub 2017 Aug 4.

Department of Gastroenterology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.

Background/aims: To evaluate the incidence of insulin resistance and metabolic syndrome (MetS) in patients with glycogenic acanthosis (GA).

Materials And Methods: Thirty patients with GA, detected upon endoscopy, and 30 age- and sex-matched control patients without GA were included in this case-control study. Patients with GA were considered group 1 and control group was considered group 2. Anthropometric measurements [height, weight, and waist circumference (WC)], biochemical parameters [fasting plasma glucose (FPG), triglyceride, high-density lipoprotein (HDL), and low-density lipoprotein (LDL)], and serum fasting insulin levels were evaluated. Insulin resistance (IR) was estimated by the homeostatic model assessment of IR. MetS was diagnosed using the criteria of the National Cholesterol Education Program Adult Treatment Panel III. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to evaluate associations with GA.

Results: There were no differences in terms of FPG, triglyceride, HDL, and LDL between groups (p-values 0.118, 0.114, 0.192, 0.086, respectively). WC was significantly higher in group 1 than in group 2 (103.77 vs 97.03, p=0.032). The number of patients with IR and MetS were significantly higher in group 1 than in group 2 (53.3% vs 13.3%, p=0.003 and 53.3% vs 23.3%, p=0.034). ORs [95% CI] of WC, IR, and MetS for GA were 0.68 [0.17-2.62], 7.12 [1.89-26.72], and 4.11 [1.04-16.21], respectively.

Conclusion: These findings showed that IR and MetS were significantly associated with the presence of GA.
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http://dx.doi.org/10.5152/tjg.2017.17159DOI Listing
September 2017

Unusual Treatment of Unusual Complication: Stenting of Left Ventricular Assist Device Outflow Graft Stenosis.

Authors:
Bahadır Gültekin Ali Harman Özgür Ersoy Hakkı Tankut Akay Atilla Sezgin Sait Aşlamacı

Exp Clin Transplant 2017 May 3. Epub 2017 May 3.

From the Department of Cardiovascular Surgery, Başkent University Faculty of Medicine, Ankara, Turkey.

Due to the increase in the number of patients waiting for heart transplantation and shortage of heart donors, both the use of mechanical assist devices and their associated complications increase. Here we present the case of a stenosis occurring in a patient at aortic outflow graft anastomosis for whom we applied a left ventricular assist device, followed by a discussion of the diagnosis, approach, and the treatment we offer in our clinic.
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http://dx.doi.org/10.6002/ect.2016.0356DOI Listing
May 2017

Steroid-induced ischemic pancolitis.

Authors:
Mustafa Akar Huseyin Koseoglu Tevfik Solakoglu Tugba Kosker Naciye Buyukasik Osman Ersoy

J Gastrointestin Liver Dis 2017 03;26(1)

Department of Gastroenterology, Yildirim Beyazit University, Faculty of Medicine, Turkey.

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http://dx.doi.org/10.15403/jgld.2014.1121.261.sipDOI Listing
March 2017

Analyzing esophageal squamous cell papillomas for the presence of human papilloma virüs.

Authors:
Arzu Tiftikçi Eser Kutsal Ender Altıok Ümit İnce Bahattin Çicek Murat Saruç Nurten Türkel Özdal Ersoy Güven Yenmiş Nurdan Tözün

Turk J Gastroenterol 2017 May 17;28(3):176-178. Epub 2017 Mar 17.

Department of Gastroenterology, Acıbadem University School of Medicine, İstanbul, Turkey.

Background/aims: Human Papilloma Virus (HPV) infection can be a predisposing condition for the development of squamous cell papilloma (SCP) of the esophagus, which can progress to dysplasia and to carcinoma as a result of chronic infection. The aim of the present study was to search for the presence of HPV in the esophageal SCP, and to genotype the detected HPV.

Materials And Methods: Data from patients with definite diagnosis of SCP of the esophagus were identified from pathology records for two years period at different Hospitals. Slides from each patient were reviewed and samples with satisfactory papilloma tissues were submitted to molecular analysis. DNA has been isolated. DNA sequencing has been performed for genotyping HPV for all types.

Results: Our study group consisted of 21 women and 17 men (a total of 38 patients), mean age was 41 years (range 17-67 years). Most of the papillomas were located at mid-esophagus (68%). Eight out of 38 patients (21%) had associated erosive esophagitis, and fourteen patients (36.8%) had Helicobacter Pylori (H. pylori). Of the 38 SCP analyzed, seven (19%) were positive for HPV DNA. Three of them were of genotype 6, whereas four were of genotype 16, 18, 31, 81 that are known as highly oncogenic. There were no correlations between the presence of HPV and the patient's age, the presence of reflux esophagitis or H. pylori, smoking habit and the location of the papillomas.

Conclusion: The presence of high-risk type HPV in esophageal SCP may implicate a role of the virus in the pathogenesis of the esophageal tumor.
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http://dx.doi.org/10.5152/tjg.2017.16636DOI Listing
May 2017

Spectroscopic super-resolution fluorescence cell imaging using ultra-small Ge quantum dots.

Authors:
Mingying Song Ali Karatutlu Isma Ali Osman Ersoy Yun Zhou Yongxin Yang Yuanpeng Zhang William R Little Ann P Wheeler Andrei V Sapelkin

Opt Express 2017 Feb;25(4):4240-4253

We demonstrate a spectroscopic imaging based super-resolution approach by separating the overlapping diffraction spots into several detectors during a single scanning period and taking advantage of the size-dependent emission wavelength in nanoparticles. This approach has been tested using off-the-shelf quantum dots (Invitrogen Qdot) and in-house novel ultra-small (~3 nm) Ge QDs. Furthermore, we developed a method-specific Gaussian fitting and maximum likelihood estimation based on a Matlab algorithm for fast QD localisation. This methodology results in a three-fold improvement in the number of localised QDs compared to non-spectroscopic images. With the addition of advanced ultra-small Ge probes, the number can be improved even further, giving at least 1.5 times improvement when compared to Qdots. Using a standard scanning confocal microscope we achieved a data acquisition rate of 200 ms per image frame. This is an improvement on single molecule localisation super-resolution microscopy where repeated image capture limits the imaging speed, and the size of fluorescence probes limits the possible theoretical localisation resolution. We show that our spectral deconvolution approach has a potential to deliver data acquisition rates on the ms scale thus providing super-resolution in live systems.
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http://dx.doi.org/10.1364/OE.25.004240DOI Listing
February 2017

Space debris detection in optical image sequences.

Authors:
Jiangbo Xi Desheng Wen Okan K Ersoy Hongwei Yi Dalei Yao Zongxi Song Shaobo Xi

Appl Opt 2016 Oct;55(28):7929-7940

We present a high-accuracy, low false-alarm rate, and low computational-cost methodology for removing stars and noise and detecting space debris with low signal-to-noise ratio (SNR) in optical image sequences. First, time-index filtering and bright star intensity enhancement are implemented to remove stars and noise effectively. Then, a multistage quasi-hypothesis-testing method is proposed to detect the pieces of space debris with continuous and discontinuous trajectories. For this purpose, a time-index image is defined and generated. Experimental results show that the proposed method can detect space debris effectively without any false alarms. When the SNR is higher than or equal to 1.5, the detection probability can reach 100%, and when the SNR is as low as 1.3, 1.2, and 1, it can still achieve 99%, 97%, and 85% detection probabilities, respectively. Additionally, two large sets of image sequences are tested to show that the proposed method performs stably and effectively.
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http://dx.doi.org/10.1364/AO.55.007929DOI Listing
October 2016