Publications by authors named "O Dammann"

216 Publications

Visuopathy of prematurity: is retinopathy just the tip of the iceberg?

Pediatr Res 2021 Jun 24. Epub 2021 Jun 24.

Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.

Research on retinopathy of prematurity (ROP) focuses mainly on the abnormal vascularization patterns that are directly visible for ophthalmologists. However, recent findings indicate that children born prematurely also exhibit changes in the retinal cellular architecture and along the dorsal visual stream, such as structural changes between and within cortical areas. Moreover, perinatal sustained systemic inflammation (SSI) is associated with an increased risk for ROP and the visual deficits that follow. In this paper, we propose that ROP might just be the tip of an iceberg we call visuopathy of prematurity (VOP). The VOP paradigm comprises abnormal vascularization of the retina, alterations in retinal cellular architecture, choroidal degeneration, and abnormalities in the visual pathway, including cortical areas. Furthermore, VOP itself might influence the developmental trajectories of cerebral structures and functions deemed responsible for visual processing, thereby explaining visual deficits among children born preterm.
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http://dx.doi.org/10.1038/s41390-021-01625-0DOI Listing
June 2021

The prenatal phase of retinopathy of prematurity.

Acta Paediatr 2021 May 24. Epub 2021 May 24.

Departments of Pediatrics, Ophthalmology, and Pharmacology, Hôpital Maisonneuve-Rosemont Research Center, Montreal, QC, Canada.

Aim: To explore the current literature on prenatal inflammation-associated risk factors for retinopathy of prematurity (ROP).

Methods: Subjective summary of selected experimental and epidemiological publications that support the authors' central hypothesis that the aetiology of ROP begins before birth.

Results: Based on current evidence we suggest that, contrary to current aetiological models, the process of ROP development begins with a prephase in utero. This beginning is likely initiated by inflammatory responses that are associated with intrauterine infection.

Conclusion: We propose a novel aetio-pathogenetic model of ROP and suggest that the effects of postnatal exposure to inflammatory stressors (resulting from infection or hyperoxia or both) as well as those of other pre- and postnatal contributors to the complex pathogenesis of ROP might be modified by the prenatal phase of the disease.
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http://dx.doi.org/10.1111/apa.15945DOI Listing
May 2021

Evidence Mapping to Justify Health Interventions.

Authors:
Olaf Dammann

Perspect Biol Med 2021 ;64(2):155-172

In order to support health interventions, biomedical and population health researchers need to collect solid evidence. This article asks what type of evidence this should be and expands on previous work that focused on etiological explanations, or causal-mechanical explanations of why and how illness occurs. The article proposes adding predictive evidence to the explanatory evidence, in order to form a joint evidence set, or JES = [A,B,C,D], which consists of four different types of evidence: association [A], biology [B], confirmation [C], and difference-making [D]. The article discusses explanatory coherence as a backbone for this proposal, suggests criteria for each type of evidence, and offers a rubric for multi-evidence mapping.
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http://dx.doi.org/10.1353/pbm.2021.0018DOI Listing
January 2021

The Essence of Authenticity.

Front Psychol 2020 21;11:629654. Epub 2021 Jan 21.

Liesenfeld Research Institute, Boston, MA, United States.

In this paper, we build upon the model of authenticity proposed by Lehman and colleagues, which includes the dimensions consistency, conformity, and connection. We expand this "3C-view" by adding a fourth dimension, continuity, which results in what we have come to call "4C-view of authenticity." We discuss our proposal from a process perspective and emphasize that congruence might be a reasonable candidate for a concept that unifies the four dimensions of authenticity.
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http://dx.doi.org/10.3389/fpsyg.2020.629654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859617PMC
January 2021

Maternal Overweight, Inflammation and Neurological Consequences for the Preterm Child: Results of the ELGAN Study.

Geburtshilfe Frauenheilkd 2019 Nov 11;79(11):1176-1182. Epub 2019 Nov 11.

Frauenklinik, Medizinische Hochschule Hannover, Hannover, Germany.

Maternal overweight and obesity are prenatal risk factors for obstetrical complications, preterm birth, neonatal morbidity as well as cognitive and behavioural developmental disorders in children. Paediatric morbidity and mortality as well as child development disorders are significantly associated with maternal obesity. Particularly in the neurodevelopmental and psychiatric area, it is becoming increasingly clear that, in children of mothers with an increased body mass index (BMI), there is a high correlation with childhood cognitive disabilities, attention disorders, and diseases on the autistic spectrum. The ELGAN (Extremely Low Gestational Age Newborn) study is a multicentre study which has been supported since 2000 by the National Institutes of Health (NIH) and whose objective is to research predictors for neonatal brain damage and neurological-cognitive sequelae in premature infants. The areas of focus are the connection between maternal overweight and obesity and pregnancy complications, APGAR scores and systemic inflammatory markers. In this overview, our aim is to summarise the work in this area and discuss it critically on the basis of current literature. We will examine the hypothesis whether maternal overweight and obesity in terms of a chronic inflammatory state is associated with neonatal inflammation which in turn is associated with an unfavourable development prognosis.
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http://dx.doi.org/10.1055/a-0960-0939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846733PMC
November 2019
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