Nynke Hofman

Nynke Hofman

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Nynke Hofman

Publications by authors named "Nynke Hofman"

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Determination and Interpretation of the QT Interval.

Circulation 2018 11;138(21):2345-2358

Heart Center, Department of Clinical and Experimental Cardiology (A.S.V., K.V.V.L., N.H., S.e.K., M.H.A.S., H.M.J.S., A.A.M.W., P.G.P.), Amsterdam UMC, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.033943DOI Listing
November 2018

Gain-of-function mutation in SCN5A causes ventricular arrhythmias and early onset atrial fibrillation.

Int J Cardiol 2017 Jun 29;236:187-193. Epub 2017 Jan 29.

Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.01.113DOI Listing
June 2017

Effect of Age and Sex on the QTc Interval in Children and Adolescents With Type 1 and 2 Long-QT Syndrome.

Circ Arrhythm Electrophysiol 2017 Apr;10(4)

From the Department of Cardiology, Heart Centre (A.S.V., N.H., A.A.M.W.), Department of Pediatric Cardiology, Emma Children's Hospital (A.S.V., S.-A.B.C., N.A.B.), and Department of Clinical Epidemiology, Biostatistics and Bioinformatics (R.B.G.), Academic Medical Centre, Amsterdam, The Netherlands; Department of Pediatric Cardiology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, The Netherlands (A.C.B.); Department of Pediatrics, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands (C.C.A.D.K.); Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Japan (M.Y.); and Department of Pediatric Cardiology, Willem-Alexander Children's Hospital, University Medical Centre Leiden, The Netherlands (N.A.B.).

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http://dx.doi.org/10.1161/CIRCEP.116.004645DOI Listing
April 2017

Role of Genetic Testing in Patients with Ventricular Arrhythmias in Apparently Normal Hearts.

Card Electrophysiol Clin 2016 Sep 9;8(3):515-23. Epub 2016 Jun 9.

Department of Cardiology, Academic Medical Center, B2-239, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ccep.2016.04.002DOI Listing
September 2016

Clinical Aspects of Type 3 Long-QT Syndrome: An International Multicenter Study.

Circulation 2016 Sep 26;134(12):872-82. Epub 2016 Aug 26.

From AMC Heart Centre, Department of Clinical and Experimental Cardiology (A.A.M.W., C.R.B.) and Department of Clinical Genetics (N.H., M.A.), Academic Medical Center, Amsterdam, The Netherlands; Cardiology Division of the Department of Medicine (A.J.M., C.L., W.Z., I.G., J.L.R., M.L.A., S.M., B.P.), the Department of Biostatistics (D.R.P.), and the Department of Pathology (M.Q.), University of Rochester School of Medicine and Dentistry, Rochester, NY; Heart and Vascular Research Center, MetroHealth Campus of Case Western Reserve University, Cleveland, OH (E.S.K.); Department of Cardiovascular Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (W.S.); Department of Cardiology Bikur Cholim Hospital, Jerusalem, Israel (J.B.); Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.A.T.); IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy (C.P. L.C., P.J.S.); Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark (J.K.K.); Departments of Medicine, Pediatrics, and Molecular Pharmacology & Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN (D.J.T., M.J.A.); Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine (W.S.) and Department of Preventive Cardiology (Y.M.), National Cerebral and Cardiovascular Center, Suita, Japan; Department of Molecular Medicine, University of Pavia, Italy (L.C.); Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Kingdom of Saudi Arabia (A.A.M.W.); and Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital IRCCS Istituto Auxologico Italiano, Milan, Italy (L.C., P.J.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.021823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030177PMC
September 2016

Analysis for Genetic Modifiers of Disease Severity in Patients With Long-QT Syndrome Type 2.

Circ Cardiovasc Genet 2015 Jun 3;8(3):447-456. Epub 2015 Mar 3.

Department of Clinical and Experimental Cardiology (I.C.R.M.K., P.G.P., J.B., T.T.K., A.A.M.W., C.R.B.), Department of Clinical Epidemiology, Biostatistics and Bioinformatics (I.C.R.M.K., M.W.T.T.), and Department of Clinical Genetics (N.H.), Academic Medical Center, Amsterdam, the Netherlands; ICIN (Netherlands Heart Institute) (J.B., A.A.M.W., C.R.B.), Utrecht, the Netherlands; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR) 1087, L'Institut du Thorax, Nantes, France (J.B., J.-J.S.); Centre National de la Recherche Scientifique (CNRS) UMR 6291, Nantes, France (J.B., J.-J.S.); Université de Nantes, Nantes, France (J.B., J.-J.S.); Department of Medicine I, University Hospital Munich, Campus Grosshadern and Innenstadt, Ludwig-Maximilians University, Munich, Germany (M.F.S., B.M.B., S.K.); German Center for Cardiovascular Research (DZHK), Munich Heart Alliance, Munich, Germany (S.K.T.M.); Institute for Genetics of Heart Diseases, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany (S.Z., A.H., B.S., E.S.-B.); Interdisciplinary Centre for Clinical Research (IZKF) of the University of Münster, Münster, Germany (S.Z., A.H., B.S., E.S.-B.); Institute of Bioinformatics and Systems Biology (A.P.), and Institute of Human Genetics (A.P., P.L., T.M.), Helmholtz Zentrum München, Neuherberg, Germany; Institute of Human Genetics, Technische Universität München, Munich, Germany (A.P., P.L., T.M.); Department of Medicine (R.J.M., N.H.B.), Department of Molecular and Cellular Pharmacology (R.J.M., N.H.B.), and Hussmann Institute of Human Genomics (R.J.M., N.H.B.), University of Miami Miller School of Medicine, FL; Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (D.M.R.); Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Kingdom of Saudi Arabia (A.A.M.W.); and Centre Hospitalier Universitaire (CHU) Nantes, L'Institut du Thorax, Service de Cardiologie, Nantes, France (J.-J.S.).

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770255PMC
June 2015

Low rate of cardiac events in first-degree relatives of diagnosis-negative young sudden unexplained death syndrome victims during follow-up.

Heart Rhythm 2014 Oct 29;11(10):1728-32. Epub 2014 May 29.

Heart Center, Department of Cardiology; Princess Al-Jawhara Albrahim Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://dx.doi.org/10.1016/j.hrthm.2014.05.028DOI Listing
October 2014

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

Authors:
Dan E Arking Sara L Pulit Lia Crotti Pim van der Harst Patricia B Munroe Tamara T Koopmann Nona Sotoodehnia Elizabeth J Rossin Michael Morley Xinchen Wang Andrew D Johnson Alicia Lundby Daníel F Gudbjartsson Peter A Noseworthy Mark Eijgelsheim Yuki Bradford Kirill V Tarasov Marcus Dörr Martina Müller-Nurasyid Annukka M Lahtinen Ilja M Nolte Albert Vernon Smith Joshua C Bis Aaron Isaacs Stephen J Newhouse Daniel S Evans Wendy S Post Daryl Waggott Leo-Pekka Lyytikäinen Andrew A Hicks Lewin Eisele David Ellinghaus Caroline Hayward Pau Navarro Sheila Ulivi Toshiko Tanaka David J Tester Stéphanie Chatel Stefan Gustafsson Meena Kumari Richard W Morris Åsa T Naluai Sandosh Padmanabhan Alexander Kluttig Bernhard Strohmer Andrie G Panayiotou Maria Torres Michael Knoflach Jaroslav A Hubacek Kamil Slowikowski Soumya Raychaudhuri Runjun D Kumar Tamara B Harris Lenore J Launer Alan R Shuldiner Alvaro Alonso Joel S Bader Georg Ehret Hailiang Huang W H Linda Kao James B Strait Peter W Macfarlane Morris Brown Mark J Caulfield Nilesh J Samani Florian Kronenberg Johann Willeit J Gustav Smith Karin H Greiser Henriette Meyer Zu Schwabedissen Karl Werdan Massimo Carella Leopoldo Zelante Susan R Heckbert Bruce M Psaty Jerome I Rotter Ivana Kolcic Ozren Polašek Alan F Wright Maura Griffin Mark J Daly David O Arnar Hilma Hólm Unnur Thorsteinsdottir Joshua C Denny Dan M Roden Rebecca L Zuvich Valur Emilsson Andrew S Plump Martin G Larson Christopher J O'Donnell Xiaoyan Yin Marco Bobbo Adamo P D'Adamo Annamaria Iorio Gianfranco Sinagra Angel Carracedo Steven R Cummings Michael A Nalls Antti Jula Kimmo K Kontula Annukka Marjamaa Lasse Oikarinen Markus Perola Kimmo Porthan Raimund Erbel Per Hoffmann Karl-Heinz Jöckel Hagen Kälsch Markus M Nöthen Marcel den Hoed Ruth J F Loos Dag S Thelle Christian Gieger Thomas Meitinger Siegfried Perz Annette Peters Hanna Prucha Moritz F Sinner Melanie Waldenberger Rudolf A de Boer Lude Franke Pieter A van der Vleuten Britt Maria Beckmann Eimo Martens Abdennasser Bardai Nynke Hofman Arthur A M Wilde Elijah R Behr Chrysoula Dalageorgou John R Giudicessi Argelia Medeiros-Domingo Julien Barc Florence Kyndt Vincent Probst Alice Ghidoni Roberto Insolia Robert M Hamilton Stephen W Scherer Jeffrey Brandimarto Kenneth Margulies Christine E Moravec Fabiola del Greco M Christian Fuchsberger Jeffrey R O'Connell Wai K Lee Graham C M Watt Harry Campbell Sarah H Wild Nour E El Mokhtari Norbert Frey Folkert W Asselbergs Irene Mateo Leach Gerjan Navis Maarten P van den Berg Dirk J van Veldhuisen Manolis Kellis Bouwe P Krijthe Oscar H Franco Albert Hofman Jan A Kors André G Uitterlinden Jacqueline C M Witteman Lyudmyla Kedenko Claudia Lamina Ben A Oostra Gonçalo R Abecasis Edward G Lakatta Antonella Mulas Marco Orrú David Schlessinger Manuela Uda Marcello R P Markus Uwe Völker Harold Snieder Timothy D Spector Johan Ärnlöv Lars Lind Johan Sundström Ann-Christine Syvänen Mika Kivimaki Mika Kähönen Nina Mononen Olli T Raitakari Jorma S Viikari Vera Adamkova Stefan Kiechl Maria Brion Andrew N Nicolaides Bernhard Paulweber Johannes Haerting Anna F Dominiczak Fredrik Nyberg Peter H Whincup Aroon D Hingorani Jean-Jacques Schott Connie R Bezzina Erik Ingelsson Luigi Ferrucci Paolo Gasparini James F Wilson Igor Rudan Andre Franke Thomas W Mühleisen Peter P Pramstaller Terho J Lehtimäki Andrew D Paterson Afshin Parsa Yongmei Liu Cornelia M van Duijn David S Siscovick Vilmundur Gudnason Yalda Jamshidi Veikko Salomaa Stephan B Felix Serena Sanna Marylyn D Ritchie Bruno H Stricker Kari Stefansson Laurie A Boyer Thomas P Cappola Jesper V Olsen Kasper Lage Peter J Schwartz Stefan Kääb Aravinda Chakravarti Michael J Ackerman Arne Pfeufer Paul I W de Bakker Christopher Newton-Cheh

Nat Genet 2014 Aug 22;46(8):826-36. Epub 2014 Jun 22.

1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. [5].

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http://dx.doi.org/10.1038/ng.3014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124521PMC
August 2014

Yield of molecular and clinical testing for arrhythmia syndromes: report of 15 years' experience.

Circulation 2013 Oct 20;128(14):1513-21. Epub 2013 Aug 20.

Department of Clinical Genetics (N.H., M.A., S.d.H., M.M.A.M.M., M.P.L., R.H.L.d.D., I.v.L.), Department of Cardiology (H.L.T., A.A.M.W.), and Department of Epidemiology, Biostatistics, and Bioinformatics (I.K.), Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.000091DOI Listing
October 2013

[Premature sudden death--consider serious familial heart rhythm disturbances].

Ned Tijdschr Geneeskd 2011 ;155(39):A3391

Academisch Medisch Centrum, Afd. Cardiologie, Hartfaal Centrum, Amsterdam, the Netherlands.

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December 2011

Sodium channelopathies: do we really understand what's going on?

J Cardiovasc Electrophysiol 2011 May 31;22(5):590-3. Epub 2010 Aug 31.

Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/j.1540-8167.2010.01892.xDOI Listing
May 2011

Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients.

Sci Transl Med 2011 Mar;3(76):76ra28

Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1126/scitranslmed.3001551DOI Listing
March 2011

Diagnostic yield in sudden unexplained death and aborted cardiac arrest in the young: the experience of a tertiary referral center in The Netherlands.

Heart Rhythm 2010 Oct 31;7(10):1383-9. Epub 2010 May 31.

Heart Failure Research Center, Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S15475271100056
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http://dx.doi.org/10.1016/j.hrthm.2010.05.036DOI Listing
October 2010

Active cascade screening in primary inherited arrhythmia syndromes: does it lead to prophylactic treatment?

J Am Coll Cardiol 2010 Jun;55(23):2570-6

Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2009.12.063DOI Listing
June 2010

The role of the epinephrine test in the diagnosis and management of children suspected of having congenital long QT syndrome.

Pediatr Cardiol 2010 May 3;31(4):462-8. Epub 2009 Dec 3.

Department of Pediatric Cardiology, Emma Children's Hospital, Academic Medical Centre, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.

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http://dx.doi.org/10.1007/s00246-009-9603-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858806PMC
May 2010

Genetic testing in cardiovascular diseases.

Curr Opin Cardiol 2010 May;25(3):243-8

Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/HCO.0b013e3283374d69DOI Listing
May 2010

Genetic basis of malignant channelopathies and ventricular fibrillation in the structurally normal heart.

Future Cardiol 2010 May;6(3):395-408

Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.2217/fca.10.11DOI Listing
May 2010

Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations.

Ann Noninvasive Electrocardiol 2008 Jul;13(3):234-41

Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY14642, USA.

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http://dx.doi.org/10.1111/j.1542-474X.2008.00226.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538575PMC
July 2008

Contribution of inherited heart disease to sudden cardiac death in childhood.

Pediatrics 2007 Oct;120(4):e967-73

Department of Clinical Genetics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1542/peds.2006-3751DOI Listing
October 2007

Diagnostic criteria for congenital long QT syndrome in the era of molecular genetics: do we need a scoring system?

Eur Heart J 2007 Mar 7;28(5):575-80. Epub 2006 Nov 7.

Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/eurheartj/ehl355DOI Listing
March 2007

Diagnostic value of flecainide testing in unmasking SCN5A-related Brugada syndrome.

J Cardiovasc Electrophysiol 2006 Aug 9;17(8):857-64. Epub 2006 Jun 9.

Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/j.1540-8167.2006.00531.xDOI Listing
August 2006

Sudden unexplained death: heritability and diagnostic yield of cardiological and genetic examination in surviving relatives.

Circulation 2005 Jul 5;112(2):207-13. Epub 2005 Jul 5.

Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.104.5
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.104.522581DOI Listing
July 2005