Publications by authors named "Nuria Casals"

55Publications

CPT1C negatively regulates the endocannabinoid hydrolase ABHD6 depending on nutritional status.

Br J Pharmacol 2021 Jan 14. Epub 2021 Jan 14.

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, 08195, Sant Cugat del Vallès, Spain.

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January 2021

The return of malonyl-CoA to the brain: Cognition and other stories.

Prog Lipid Res 2020 Nov 10;81:101071. Epub 2020 Nov 10.

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, E-08195 Sant Cugat del Vallès, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, E-28029 Madrid, Spain. Electronic address:

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November 2020

Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty.

Cell Metab 2020 Dec 19;32(6):951-966.e8. Epub 2020 Oct 19.

Instituto Maimónides de Investigation Biomédica de Córdoba (IMIBIC), Department of Cell Biology, Physiology and Immunology, University of Córdoba and Hospital Universitario Reina Sofia, 14004 Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 14004 Córdoba, Spain; Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine and Turku Center for Disease Modeling, University of Turku, Turku, Finland. Electronic address:

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December 2020

An overview of nanomedicines for neuron targeting.

Nanomedicine (Lond) 2020 07 3;15(16):1617-1636. Epub 2020 Jul 3.

Department of Basic Sciences, Faculty of Medicine & Health Sciences, Universitat Internacional de Catalunya, 08195, Sant Cugat del Vallès, Spain.

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July 2020

Drug uptake-based chemoresistance in breast cancer treatment.

Biochem Pharmacol 2020 07 7;177:113959. Epub 2020 Apr 7.

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, E-08195 Sant Cugat del Vallès, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, E-28029 Madrid, Spain. Electronic address:

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July 2020

Proteasomal-Mediated Degradation of AKAP150 Accompanies AMPAR Endocytosis during cLTD.

eNeuro 2020 Mar/Apr;7(2). Epub 2020 Apr 16.

Institut de Neurociències and Dpt. Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallès 08193, Spain

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April 2020

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth.

Elife 2019 12 23;8. Epub 2019 Dec 23.

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain.

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December 2019

Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice.

J Lipid Res 2019 07 28;60(7):1260-1269. Epub 2019 May 28.

Basic Sciences Department, Faculty of Medicine and Health Sciences Universitat Internacional de Catalunya, 08195 Sant Cugat del Vallès, Spain

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July 2019

Blood-brain barrier dysfunction underlying Alzheimer's disease is induced by an SSAO/VAP-1-dependent cerebrovascular activation with enhanced Aβ deposition.

Biochim Biophys Acta Mol Basis Dis 2019 09 30;1865(9):2189-2202. Epub 2019 Apr 30.

Biochemistry and Molecular Biology Department, Institute of Neurosciences (INc), Universitat Autònoma de Barcelona (UAB), Bellaterra, Barcelona, Spain. Electronic address:

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September 2019

CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity.

Mol Metab 2019 01 2;19:75-85. Epub 2018 Nov 2.

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, 08195, Sant Cugat del Vallès, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, E-28029, Madrid, Spain. Electronic address:

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January 2019

Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement.

Front Mol Neurosci 2018 8;11:275. Epub 2018 Aug 8.

Laboratori de Neurofisiologia, Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.

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August 2018

CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy.

Sci Rep 2018 05 3;8(1):6997. Epub 2018 May 3.

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya (UIC), 08195, Sant Cugat del Vallès, Spain.

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May 2018

Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex.

Mol Neurobiol 2018 Sep 2;55(9):7216-7228. Epub 2018 Feb 2.

Department of Biochemistry and Physiology, Facultat de Farmàcia i Ciències de l'Alimentació and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-30, E-08028, Barcelona, Spain.

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September 2018

Uridine-5'-Triphosphate Partially Blocks Differentiation Signals and Favors a more Repair State in Cultured rat Schwann Cells.

Neuroscience 2018 02 11;372:255-265. Epub 2018 Jan 11.

Department of Basic Sciences, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain. Electronic address:

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February 2018

Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice.

Sci Rep 2017 11 22;7(1):16082. Epub 2017 Nov 22.

Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, E-08028, Barcelona, Spain.

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November 2017

Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids.

Sci Rep 2017 09 7;7(1):10779. Epub 2017 Sep 7.

Life and Medical Sciences Institute (LIMES), University of Bonn, Carl-Troll-Straße 31, D-53115, Bonn, Germany.

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September 2017

Hypothalamic Regulation of Liver and Muscle Nutrient Partitioning by Brain-Specific Carnitine Palmitoyltransferase 1C in Male Mice.

Endocrinology 2017 07;158(7):2226-2238

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, 08195 Sant Cugat del Vallès, Barcelona, Spain.

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July 2017

Ceramides and mitochondrial fatty acid oxidation in obesity.

FASEB J 2017 04 21;31(4):1263-1272. Epub 2016 Dec 21.

Department of Biochemistry and Physiology, School of Pharmacy, Institut de Biomedicina, Universitat de Barcelona, Barcelona, Spain;

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April 2017

Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity.

Diabetes 2017 Jan 15;66(1):87-99. Epub 2016 Sep 15.

Department of Physiology, Centro Singular de Investigación en Medicina Molecular e Enfermidades Crónicas, University of Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain

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January 2017

Carnitine palmitoyltransferase 1C: From cognition to cancer.

Prog Lipid Res 2016 Jan 18;61:134-48. Epub 2015 Dec 18.

CIBER Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Biochemistry and Molecular Biology, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, E-08028 Barcelona, Spain.

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January 2016

Novel Regulation of the Synthesis of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus.

J Biol Chem 2015 Oct 3;290(42):25548-60. Epub 2015 Sep 3.

From the Basic Sciences Department, Facultat de Medicina i Ciències de la Salut, Universitat Internacional de Catalunya, Sant Cugat del Vallès 08195, Spain, the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), 15706 Santiago de Compostela, Spain

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October 2015

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation.

Am J Physiol Endocrinol Metab 2015 May 24;308(9):E756-69. Epub 2015 Feb 24.

Department of Biochemistry and Molecular Biology, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona Fisiopatología de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid, Spain;

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May 2015

Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance.

Cell Rep 2014 Oct 2;9(1):366-377. Epub 2014 Oct 2.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain. Electronic address:

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October 2014

Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation.

PLoS One 2014 6;9(6):e98998. Epub 2014 Jun 6.

Department of Basic Sciences, Facultat de Medicina, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.

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January 2015

Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin.

Diabetes 2014 Oct 21;63(10):3242-52. Epub 2014 May 21.

Department of Metabolism and Aging, Scripps Research Institute, Jupiter, FL Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO

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October 2014

Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity.

Behav Brain Res 2013 Nov 21;256:291-7. Epub 2013 Aug 21.

Department of Basic Sciences, Facultat de Medicina i Ciències de la Salut, Universitat Internacional de Catalunya (UIC), 08195 Sant Cugat del Vallés, Spain; Centro de Investigación Biomédica en Red (CIBER)-Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.

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November 2013

Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei.

Physiol Behav 2013 Jun 13;118:165-70. Epub 2013 May 13.

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB T6G 2S2, Canada.

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June 2013

Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin.

Diabetes 2013 Jul 14;62(7):2329-37. Epub 2013 Mar 14.

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain.

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July 2013

N-cadherin expression is regulated by UTP in schwannoma cells.

Purinergic Signal 2013 Jun 28;9(2):259-70. Epub 2012 Dec 28.

Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat International de Catalunya, Sant Cugat del Vallès, Spain.

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June 2013

Defective in mitotic arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation.

J Biol Chem 2013 Feb 21;288(7):4704-14. Epub 2012 Dec 21.

Departament de Ciències Bàsiques, Universitat Internacional de Catalunya, 08017 Barcelona, Spain.

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February 2013

Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol.

J Lipid Res 2012 Oct 30;53(10):2046-56. Epub 2012 Jul 30.

Unit of Clinical Genetics and Functional Genomics, Department of Pharmacology and Physiology, School of Medicine, University of Zaragoza, Spain.

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October 2012

Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition.

J Biol Chem 2012 Jun 26;287(25):21224-32. Epub 2012 Apr 26.

From the Department of Basic Sciences, Facultat de Medicina i Ciències de la Salut, Universitat Internacional de Catalunya, E-08195 Sant Cugat del Vallès, Spain.

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June 2012

Dental pulp of the third molar: a new source of pluripotent-like stem cells.

J Cell Sci 2012 Jul 30;125(Pt 14):3343-56. Epub 2012 Mar 30.

Laboratory for Regenerative Medicine, College of Dentistry, Universitat Internacional de Catalunya, Barcelona 08009, Spain.

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July 2012

Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding.

Proc Natl Acad Sci U S A 2011 Jun 18;108(23):9691-6. Epub 2011 May 18.

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada T6G 2S2.

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June 2011

Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a.

Am J Physiol Regul Integr Comp Physiol 2011 Jul 20;301(1):R209-17. Epub 2011 Apr 20.

Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

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July 2011

Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria.

J Inherit Metab Dis 2010 Aug 8;33(4):405-10. Epub 2010 Jun 8.

Laboratory of Clinical Genetics and Functional Genomics, Department of Pharmacology and Physiology, School of Medicine, University of Zaragoza, C/ Domingo Miral s/n, 50009, Zaragoza, Spain.

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August 2010

Buccal fat pad, an oral access source of human adipose stem cells with potential for osteochondral tissue engineering: an in vitro study.

Tissue Eng Part C Methods 2010 Oct;16(5):1083-94

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, International University of Catalonia, Barcelona, Spain.

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October 2010

CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity.

J Biol Chem 2008 Mar 11;283(11):6878-85. Epub 2008 Jan 11.

Molecular and Cellular Unit, School of Health Sciences, Universitat Internacional de Catalunya, Josep Trueta s/n, Sant Cugat del Vallés, Barcelona 08195, Spain.

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March 2008

A new LC-ESI-MS/MS method to measure long-chain acylcarnitine levels in cultured cells.

Anal Chim Acta 2007 Sep 3;599(1):1-6. Epub 2007 Aug 3.

Scientific & Technical Services, University of Barcelona, Spain.

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September 2007

Molecular genetics of HMG-CoA lyase deficiency.

Mol Genet Metab 2007 Nov 9;92(3):198-209. Epub 2007 Aug 9.

Laboratory of Clinical Genetics and Functional Genomics, University of Zaragoza Medical School, E-50009 Zaragoza, Spain.

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November 2007

C-terminal end and aminoacid Lys48 in HMG-CoA lyase are involved in substrate binding and enzyme activity.

Mol Genet Metab 2007 Jun 24;91(2):120-7. Epub 2007 Apr 24.

Department of Biochemistry and Molecular Biology, School of Health Sciences, Universitat Internacional de Catalunya, E-08195 Sant Cugat, Barcelona, Spain.

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June 2007

CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons.

J Mol Neurosci 2003 Feb;20(1):53-60

Unit of Molecular and Cellular Biology, Faculty of Health Sciences, International University of Catalonia, Barcelona, Spain.

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February 2003

Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae.

Yeast 2003 Jan;20(2):157-69

Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra 08193, Barcelona.

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January 2003

The diagnosis of mitochondrial HMG-CoA synthase deficiency.

J Pediatr 2002 Jun;140(6):778-80

Division of Metabolic and Endocrine Diseases, University Children's Hospital, Heidelberg, Germany.

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June 2002