Nunzio Bottini

Nunzio Bottini

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Nunzio Bottini

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Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy.

ACS Nano 2019 May 25;13(5):5036-5048. Epub 2019 Apr 25.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience , National Center for Nanoscience and Technology of China , Beijing 100190 , People's Republic of China.

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http://dx.doi.org/10.1021/acsnano.9b01710DOI Listing
May 2019

The Contribution of PTPN22 to Rheumatic Disease.

Arthritis Rheumatol 2019 Apr 2;71(4):486-495. Epub 2019 Mar 2.

University of California at San Diego, La Jolla.

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http://dx.doi.org/10.1002/art.40790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438733PMC
April 2019

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.

Nat Commun 2018 07 6;9(1):2627. Epub 2018 Jul 6.

Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1038/s41467-018-05095-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035278PMC
July 2018

Nitric Oxide Dependent Degradation of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes: Implications for Intra-Articular Delivery.

Adv Healthc Mater 2018 03 15;7(6):e1700916. Epub 2018 Jan 15.

Nanosafety & Nanomedicine Laboratory-NNL, Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1002/adhm.201700916DOI Listing
March 2018

Targeting Tyrosine Phosphatases: Time to End the Stigma.

Trends Pharmacol Sci 2017 06 12;38(6):524-540. Epub 2017 Apr 12.

Department of Medicine, University of California, San Diego, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2017.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494996PMC
June 2017

Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets.

Curr Rheumatol Rep 2017 May;19(5):28

Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California, San Diego, 9500 Gilman Drive MC #0656, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1007/s11926-017-0655-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703857PMC
May 2017

Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes.

Epigenomics 2017 04 21;9(4):479-492. Epub 2017 Mar 21.

Division of Rheumatology, Allergy & Immunology, University of California, San Diego School of Medicine, La Jolla, CA, USA.

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http://dx.doi.org/10.2217/epi-2016-0151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549652PMC
April 2017

CD45-mediated control of TCR tuning in naïve and memory CD8 T cells.

Nat Commun 2016 11 14;7:13373. Epub 2016 Nov 14.

Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang 790-784, Korea.

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http://dx.doi.org/10.1038/ncomms13373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114568PMC
November 2016

T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity.

J Allergy Clin Immunol 2016 09 4;138(3):839-851.e8. Epub 2016 Apr 4.

Centre for Immune Regulation, Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1016/j.jaci.2016.01.035DOI Listing
September 2016

Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy.

Nanomedicine 2016 Feb 18;12(2):255-68. Epub 2015 Dec 18.

Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.

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http://dx.doi.org/10.1016/j.nano.2015.09.013DOI Listing
February 2016

Decade in review-translational rheumatology: Ten years after: rheumatology research from bench to bedside.

Nat Rev Rheumatol 2015 Nov 22;11(11):623-4. Epub 2015 Sep 22.

UC San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1038/nrrheum.2015.126DOI Listing
November 2015

Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.

J Immunol 2015 Nov 5;195(10):4841-52. Epub 2015 Oct 5.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1402654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635565PMC
November 2015

Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.

PLoS One 2014 3;9(2):e86677. Epub 2014 Feb 3.

Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America ; Institute for Genetic Medicine, University of Southern California, Los Angeles, California, United States of America.

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http://www.lupusresearch.org/lupus-research/scientific-publi
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http://dx.plos.org/10.1371/journal.pone.0086677
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086677PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911918PMC
December 2014

Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes.

ACS Nano 2014 Dec 26;8(12):12280-91. Epub 2014 Nov 26.

Inflammatory and Infectious Disease Center, Sanford Burnham Medical Research Institute , La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/nn504537bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373402PMC
December 2014

Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.

Annu Rev Immunol 2014 18;32:83-119. Epub 2013 Dec 18.

Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037; email:

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http://dx.doi.org/10.1146/annurev-immunol-032713-120249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402334PMC
November 2014

PTPN22: the archetypal non-HLA autoimmunity gene.

Nat Rev Rheumatol 2014 Oct 8;10(10):602-11. Epub 2014 Jul 8.

Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/nrrheum.2014.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375551PMC
October 2014

"PEST control": regulation of molecular barcodes by tyrosine phosphatases.

Cell Res 2014 Sep 1;24(9):1027-8. Epub 2014 Aug 1.

Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/cr.2014.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152731PMC
September 2014

Cellular biochemistry methods for investigating protein tyrosine phosphatases.

Antioxid Redox Signal 2014 May 25;20(14):2160-78. Epub 2014 Feb 25.

1 Division of Cellular Biology, La Jolla Institute for Allergy and Immunology , La Jolla, California.

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http://dx.doi.org/10.1089/ars.2013.5731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995294PMC
May 2014

Covalent inhibition of the lymphoid tyrosine phosphatase.

ChemMedChem 2014 Feb 8;9(2):296-9. Epub 2014 Jan 8.

Department of Medicinal Chemistry, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112 (USA).

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http://dx.doi.org/10.1002/cmdc.201300404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096870PMC
February 2014

Epigenetics in rheumatoid arthritis: a primer for rheumatologists.

Curr Rheumatol Rep 2013 Nov;15(11):372

La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA,

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http://dx.doi.org/10.1007/s11926-013-0372-9DOI Listing
November 2013

Thiuram disulfides as pseudo-irreversible inhibitors of lymphoid tyrosine phosphatase.

ChemMedChem 2013 Sep 19;8(9):1561-8. Epub 2013 Jul 19.

Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1002/cmdc.201300215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863632PMC
September 2013

Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors.

Chembiochem 2013 Sep 16;14(13):1640-7. Epub 2013 Aug 16.

Department of Medicinal Chemistry, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112 (USA).

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http://dx.doi.org/10.1002/cbic.201300273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874405PMC
September 2013

In vivo targeting of intratumor regulatory T cells using PEG-modified single-walled carbon nanotubes.

Bioconjug Chem 2013 Jun 22;24(6):852-8. Epub 2013 May 22.

Inflammatory and Infectious Disease Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/bc400070qDOI Listing
June 2013

A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.

J Med Chem 2013 Jun 6;56(12):4990-5008. Epub 2013 Jun 6.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1021/jm400248cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711248PMC
June 2013

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors.

Nat Rev Rheumatol 2013 Jan 13;9(1):24-33. Epub 2012 Nov 13.

Division of Cellular Biology, La Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/nrrheum.2012.190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970924PMC
January 2013

Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.

Immunology 2012 Sep;137(1):1-19

Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1111/j.1365-2567.2012.03591.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449242PMC
September 2012

PTPN22 alters the development of regulatory T cells in the thymus.

J Immunol 2012 Jun 25;188(11):5267-75. Epub 2012 Apr 25.

Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.1200150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358490PMC
June 2012

PEG-modified carbon nanotubes in biomedicine: current status and challenges ahead.

Biomacromolecules 2011 Oct 21;12(10):3381-93. Epub 2011 Sep 21.

Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/bm201020hDOI Listing
October 2011

Carbon nanotube-based nanocarriers: the importance of keeping it clean.

J Nanosci Nanotechnol 2010 Aug;10(8):5293-301

Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Suite 240, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1166/jnn.2010.3083DOI Listing
August 2010

Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.

Semin Immunopathol 2010 Jun 4;32(2):127-36. Epub 2010 Mar 4.

Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1007/s00281-010-0201-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881161PMC
June 2010

Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase.

J Inorg Biochem 2010 Mar 28;104(3):268-73. Epub 2009 Dec 28.

University of Utah Department of Medicinal Chemistry, Salt Lake City, UT 84112, United States.

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http://dx.doi.org/10.1016/j.jinorgbio.2009.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873867PMC
March 2010

Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes.

J Med Chem 2009 Nov;52(21):6912-8

Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.

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http://dx.doi.org/10.1021/jm901220mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801581PMC
November 2009

Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans.

J Clin Endocrinol Metab 2009 Oct 21;94(10):4094-102. Epub 2009 Jul 21.

Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1210/jc.2008-2751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758733PMC
October 2009

Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms.

Med Sci Monit 2009 Oct;15(10):CR511-517

Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy.

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October 2009

Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain.

Biochemistry 2009 Aug;48(31):7525-32

Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1021/bi900332fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113683PMC
August 2009

Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes.

Bioconjug Chem 2009 Mar;20(3):427-31

Department of Biochemistry and Molecular Biology and Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1021/bc800540jDOI Listing
March 2009

Less air pollution leads to rapid reduction of airway inflammation and improved airway function in asthmatic children.

Pediatrics 2009 Mar;123(3):1051-8

West Virginia University School of Medicine, Department of Pediatrics, Robert C. Byrd Health Sciences Center, 1 Medical Center Dr, PO Box 9214, Morgantown, WV 26506-9214, USA.

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http://dx.doi.org/10.1542/peds.2008-1153DOI Listing
March 2009

Gold(I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study.

J Med Chem 2008 Aug 8;51(15):4790-5. Epub 2008 Jul 8.

Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.

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http://dx.doi.org/10.1021/jm800101wDOI Listing
August 2008

The effects of genetic and seasonal factors on reproductive success.

Fertil Steril 2008 May 6;89(5):1090-4. Epub 2007 Aug 6.

Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome, Tor Vergata, Rome, Italy.

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http://dx.doi.org/10.1016/j.fertnstert.2007.04.030DOI Listing
May 2008

Association between PTPN22 and endometriosis.

Fertil Steril 2008 Apr 10;89(4):993-4. Epub 2007 Jul 10.

Division of Gynecology and Obstetrics, Department of Surgery, Hospital University of Rome Tor Vergata, School of Medicine, Rome, Italy.

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http://dx.doi.org/10.1016/j.fertnstert.2007.04.008DOI Listing
April 2008

Low birth weight and allergy: possible pleiotropic effect of ACP1.

Hum Biol 2008 Feb;80(1):65-72

Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Ver- gata, Via Montpellier 1, 00133 Rome, Italy.

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http://dx.doi.org/10.3378/1534-6617(2008)80[65:LBWAAP]2.0.CO;2DOI Listing
February 2008

Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes.

Diabetes 2008 Jan 12;57(1):229-34. Epub 2007 Oct 12.

Dipartimento di Scienze Biomediche, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.2337/db07-0289DOI Listing
January 2008

Protein tyrosine phosphatase PTPN22 in human autoimmunity.

Autoimmunity 2007 Sep;40(6):453-61

The Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1080/08916930701464897DOI Listing
September 2007

Role of PTPN22 in type 1 diabetes and other autoimmune diseases.

Semin Immunol 2006 Aug 11;18(4):207-13. Epub 2006 May 11.

Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, United States.

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http://dx.doi.org/10.1016/j.smim.2006.03.008DOI Listing
August 2006

Adenosine deaminase polymorphism and the relationship of total immunoglobulin E with skin prick test: a study on school children.

Allergy Asthma Proc 2006 Mar-Apr;27(2):115-8

Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Italy.

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August 2006

Protein-tyrosine phosphorylation in Bacillus subtilis.

J Mol Microbiol Biotechnol 2005 ;9(3-4):189-97

Microbial Physiology and Genetics Group, BioCentrum, Technical University of Denmark, Lyngby, Denmark.

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http://dx.doi.org/10.1159/000089647DOI Listing
March 2006

Multi-walled carbon nanotubes induce T lymphocyte apoptosis.

Toxicol Lett 2006 Jan 25;160(2):121-6. Epub 2005 Aug 25.

Infectious and Inflammatory Disease Center, The Burnham Institute, La Jolla, CA 92037, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S037842740500190
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http://dx.doi.org/10.1016/j.toxlet.2005.06.020DOI Listing
January 2006

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.

Nat Genet 2005 Dec 6;37(12):1317-9. Epub 2005 Nov 6.

Program on Inflammatory Disease Research, Infectious and Inflammatory Disease Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/ng1673DOI Listing
December 2005

Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function.

J Exp Med 2005 Dec;202(11):1587-97

Division of Respirology, Department of Medicine, and the McLaughlin Center for Molecular Medicine, University of Toronto and Toronto General Hospital Research Institute of the University Health Network, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1084/jem.20051108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213338PMC
December 2005

Serum glucose concentration and ACP1 genotype in healthy adult subjects.

Metabolism 2005 Jul;54(7):891-4

Division of Occupational Health Medicine, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, 00123 Rome Italy.

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http://dx.doi.org/10.1016/j.metabol.2005.02.002DOI Listing
July 2005

Low-molecular-weight protein tyrosine phosphatases of Bacillus subtilis.

J Bacteriol 2005 Jul;187(14):4945-56

The Institute for Genetic Medicine, University of Southern California, Los Angeles, 90033, USA.

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http://dx.doi.org/10.1128/JB.187.14.4945-4956.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1169535PMC
July 2005

Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds.

J Biol Chem 2005 Mar 22;280(10):9400-8. Epub 2004 Dec 22.

Infectious and Inflammatory Disease Center, The Burnham Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M413122200DOI Listing
March 2005

Covalent decoration of multi-walled carbon nanotubes with silica nanoparticles.

Chem Commun (Camb) 2005 Feb 15(6):758-60. Epub 2004 Dec 15.

Burnham Institute, 10901 North, Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1039/b412876aDOI Listing
February 2005

Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes.

Hum Immunol 2005 Jan;66(1):60-4

Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA.

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http://dx.doi.org/10.1016/j.humimm.2004.09.016DOI Listing
January 2005

Protein tyrosine phosphatases and the immune response.

Nat Rev Immunol 2005 Jan;5(1):43-57

Program of Inflammation, Inflammatory and Infectious Disease Center, and Program of Signal Transduction, Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nri1530DOI Listing
January 2005

Control of vesicle fusion by a tyrosine phosphatase.

Nat Cell Biol 2004 Sep 22;6(9):831-9. Epub 2004 Aug 22.

Program of Inflammation, Infectious and Inflammatory Disease Center, and Program of Signal Transduction, Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/ncb1164DOI Listing
September 2004

Protein tyrosine phosphatases in T cell physiology.

Mol Immunol 2004 Jul;41(6-7):687-700

Program of Signal Transduction, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016158900400132
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http://dx.doi.org/10.1016/j.molimm.2004.04.015DOI Listing
July 2004

Protein tyrosine phosphatases in the human genome.

Cell 2004 Jun;117(6):699-711

Program of Signal Transduction, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.cell.2004.05.018DOI Listing
June 2004

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.

Nat Genet 2004 Apr 7;36(4):337-8. Epub 2004 Mar 7.

Program of Signal Transduction, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/ng1323DOI Listing
April 2004

Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location.

Biochem J 2004 Mar;378(Pt 2):335-42

Program of Signal Transduction, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1042/BJ20031244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223964PMC
March 2004

Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH.

J Biol Chem 2004 Feb 17;279(6):4922-8. Epub 2003 Nov 17.

Program of Signal Transduction, Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M308978200DOI Listing
February 2004

Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells.

J Immunol 2003 Dec;171(12):6661-71

Program of Signal Transduction, Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.171.12.6661DOI Listing
December 2003

Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes.

Med Sci Monit 2003 Mar;9(3):CR105-8

Department of Pediatrics, University of Sassari, Italy.

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March 2003

Role of protein tyrosine phosphatases in T cell activation.

Immunol Rev 2003 Feb;191:139-47

Program of Signal Transduction, Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1034/j.1600-065x.2003.00014.xDOI Listing
February 2003

Association of the acid phosphatase (ACP1) gene with triglyceride levels in obese women.

Mol Genet Metab 2002 Nov;77(3):226-9

The Burnham Institute, La Jolla, CA, USA.

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November 2002