Norman Lacayo

Engineered type 1 regulatory T cells designed for clinical use kill primary pediatric acute myeloid leukemia cells.

Authors:

Brandon Cieniewicz Molly Javier Uyeda Ping Pauline Chen Ece Canan Sayitoglu Jeffrey Mao-Hwa Liu Grazia Andolfi Katharine Greenthal Alice Bertaina Silvia Gregori Rosa Bacchetta Norman James Lacayo Alma-Martina Cepika Maria Grazia Roncarolo

Haematologica 2020 Sep 28;Online ahead of print. Epub 2020 Sep 28.

Department of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford.

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September 2020

Safety, pharmacokinetics, and pharmacodynamics of panobinostat in children, adolescents, and young adults with relapsed acute myeloid leukemia.

Authors:

Seth E Karol Todd M Cooper Paul E Mead Kristine R Crews John C Panetta Thomas B Alexander Jeffrey W Taub Norman J Lacayo Kenneth M Heym Dennis J Kuo Deborah E Schiff Deepa Bhojwani Yubin Ge Jeffery M Klco Raul C Ribeiro Hiroto Inaba Ching-Hon Pui Jeffrey E Rubnitz

Cancer 2020 Nov 18;126(21):4800-4805. Epub 2020 Aug 18.

St. Jude Children's Research Hospital, Memphis, Tennessee.

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November 2020

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.

Authors:

Ayuko Hoshino Han Sang Kim Linda Bojmar Kofi Ennu Gyan Michele Cioffi Jonathan Hernandez Constantinos P Zambirinis Gonçalo Rodrigues Henrik Molina Søren Heissel Milica Tesic Mark Loïc Steiner Alberto Benito-Martin Serena Lucotti Angela Di Giannatale Katharine Offer Miho Nakajima Caitlin Williams Laura Nogués Fanny A Pelissier Vatter Ayako Hashimoto Alexander E Davies Daniela Freitas Candia M Kenific Yonathan Ararso Weston Buehring Pernille Lauritzen Yusuke Ogitani Kei Sugiura Naoko Takahashi Maša Alečković Kayleen A Bailey Joshua S Jolissant Huajuan Wang Ashton Harris L Miles Schaeffer Guillermo García-Santos Zoe Posner Vinod P Balachandran Yasmin Khakoo G Praveen Raju Avigdor Scherz Irit Sagi Ruth Scherz-Shouval Yosef Yarden Moshe Oren Mahathi Malladi Mary Petriccione Kevin C De Braganca Maria Donzelli Cheryl Fischer Stephanie Vitolano Geraldine P Wright Lee Ganshaw Mariel Marrano Amina Ahmed Joe DeStefano Enrico Danzer Michael H A Roehrl Norman J Lacayo Theresa C Vincent Martin R Weiser Mary S Brady Paul A Meyers Leonard H Wexler Srikanth R Ambati Alexander J Chou Emily K Slotkin Shakeel Modak Stephen S Roberts Ellen M Basu Daniel Diolaiti Benjamin A Krantz Fatima Cardoso Amber L Simpson Michael Berger Charles M Rudin Diane M Simeone Maneesh Jain Cyrus M Ghajar Surinder K Batra Ben Z Stanger Jack Bui Kristy A Brown Vinagolu K Rajasekhar John H Healey Maria de Sousa Kim Kramer Sujit Sheth Jeanine Baisch Virginia Pascual Todd E Heaton Michael P La Quaglia David J Pisapia Robert Schwartz Haiying Zhang Yuan Liu Arti Shukla Laurence Blavier Yves A DeClerck Mark LaBarge Mina J Bissell Thomas C Caffrey Paul M Grandgenett Michael A Hollingsworth Jacqueline Bromberg Bruno Costa-Silva Hector Peinado Yibin Kang Benjamin A Garcia Eileen M O'Reilly David Kelsen Tanya M Trippett David R Jones Irina R Matei William R Jarnagin David Lyden

Cell 2020 Aug 13;182(4):1044-1061.e18. Epub 2020 Aug 13.

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. Electronic address:

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August 2020

RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit.

Authors:

Hee-Don Chae Ritika Dutta Bruce Tiu Fieke W Hoff Benedetta Accordi Valentina Serafin Minyoung Youn Min Huang Nathan Sumarsono Kara L Davis Norman J Lacayo Martina Pigazzi Terzah M Horton Steven M Kornblau Kathleen M Sakamoto

Oncotarget 2020 Jun 23;11(25):2387-2403. Epub 2020 Jun 23.

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

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June 2020

Delayed cancer diagnoses and high mortality in children during the COVID-19 pandemic.

Authors:

Yang-Yang Ding Sneha Ramakrishna Adrienne H Long Charles A Phillips Raul Montiel-Esparza Caroline J Diorio L Charles Bailey Shannon L Maude Richard Aplenc Vandana Batra Anne F Reilly Susan R Rheingold Norman J Lacayo Kathleen M Sakamoto Stephen P Hunger

Pediatr Blood Cancer 2020 09 26;67(9):e28427. Epub 2020 Jun 26.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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September 2020

Metabolomics in acute myeloid leukemia.

Authors:

Anna V Wojcicki Maya M Kasowski Kathleen M Sakamoto Norman Lacayo

Mol Genet Metab 2020 08 18;130(4):230-238. Epub 2020 May 18.

Division of Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

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August 2020

Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study.

Authors:

Seth E Karol Thomas B Alexander Amit Budhraja Stanley B Pounds Kristin Canavera Lei Wang Joshua Wolf Jeffery M Klco Paul E Mead Soumyasri Das Gupta Su Y Kim Ahmed Hamed Salem Tammy Palenski Norman J Lacayo Ching-Hon Pui Joseph T Opferman Jeffrey E Rubnitz

Lancet Oncol 2020 04 11;21(4):551-560. Epub 2020 Mar 11.

Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA. Electronic address:

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April 2020

Repurposing Drugs for Acute Myeloid Leukemia: A Worthy Cause or a Futile Pursuit?

Authors:

Anna V Wojcicki Meena Kadapakkam Adam Frymoyer Norman Lacayo Hee-Don Chae Kathleen M Sakamoto

Cancers (Basel) 2020 Feb 13;12(2). Epub 2020 Feb 13.

Division of Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

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February 2020

Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2020 01;18(1):81-112

National Comprehensive Cancer Network.

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January 2020

Epigenetic Targeting of -Associated Gene Expression Signature in Human Neuroblastoma with Overexpression.

Authors:

Min Huang Jasmine Zeki Nathan Sumarsono Garry L Coles Jordan S Taylor Enrico Danzer Matias Bruzoni Florette K Hazard Norman J Lacayo Kathleen M Sakamoto James C Y Dunn Sheri L Spunt Bill Chiu

Cancer Res 2020 03 3;80(5):1024-1035. Epub 2020 Jan 3.

Department of Surgery, Stanford University School of Medicine, Stanford, California.

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March 2020

Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer.

JAMA Netw Open 2019 10 2;2(10):e1913968. Epub 2019 Oct 2.

University of California, Santa Cruz Genomics Institute, Santa Cruz.

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October 2019

Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor.

Cold Spring Harb Mol Case Stud 2019 10 23;5(5). Epub 2019 Oct 23.

Department of Molecular, Cell and Developmental Biology, UC Santa Cruz Genomics Institute, Santa Cruz, California 95064, USA.

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October 2019

Clofarabine Can Replace Anthracyclines and Etoposide in Remission Induction Therapy for Childhood Acute Myeloid Leukemia: The AML08 Multicenter, Randomized Phase III Trial.

Authors:

Jeffrey E Rubnitz Norman J Lacayo Hiroto Inaba Kenneth Heym Raul C Ribeiro Jeffrey Taub Jennifer McNeer Barbara Degar Deborah Schiff Allen Eng-Juh Yeoh Elaine Coustan-Smith Lei Wang Brandon Triplett Susana C Raimondi Jeffery Klco John Choi Stanley Pounds Ching-Hon Pui

J Clin Oncol 2019 08 27;37(23):2072-2081. Epub 2019 Jun 27.

1St Jude Children's Research Hospital and the University of Tennessee Health Science Center, College of Medicine, Memphis, TN.

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August 2019

A phase II clinical trial of adoptive transfer of haploidentical natural killer cells for consolidation therapy of pediatric acute myeloid leukemia.

Authors:

Rosa Nguyen Huiyun Wu Stanley Pounds Hiroto Inaba Raul C Ribeiro David Cullins Barbara Rooney Teresa Bell Norman J Lacayo Kenneth Heym Barbara Degar Deborah Schiff William E Janssen Brandon Triplett Ching-Hon Pui Wing Leung Jeffrey E Rubnitz

J Immunother Cancer 2019 03 20;7(1):81. Epub 2019 Mar 20.

Department of Oncology, St. Jude Children's Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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March 2019

Tracking Cell Transplants in Femoral Osteonecrosis with Magnetic Resonance Imaging: A Proof-of-Concept Study in Patients.

Authors:

Ashok J Theruvath Hossein Nejadnik Anne M Muehe Felix Gassert Norman J Lacayo Stuart B Goodman Heike E Daldrup-Link

Clin Cancer Res 2018 12 17;24(24):6223-6229. Epub 2018 Sep 17.

Department of Radiology, Pediatric Radiology, Lucile Packard Children's Hospital, Stanford University, Stanford, California.

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December 2018

Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse.

Authors:

Zinaida Good Jolanda Sarno Astraea Jager Nikolay Samusik Nima Aghaeepour Erin F Simonds Leah White Norman J Lacayo Wendy J Fantl Grazia Fazio Giuseppe Gaipa Andrea Biondi Robert Tibshirani Sean C Bendall Garry P Nolan Kara L Davis

Nat Med 2018 05 5;24(4):474-483. Epub 2018 Mar 5.

Baxter Laboratory in Stem Cell Biology, Stanford University, Stanford, California, USA.

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May 2018

Niclosamide suppresses acute myeloid leukemia cell proliferation through inhibition of CREB-dependent signaling pathways.

Authors:

Hee-Don Chae Nick Cox Gary V Dahl Norman J Lacayo Kara L Davis Samanta Capolicchio Mark Smith Kathleen M Sakamoto

Oncotarget 2018 Jan 31;9(4):4301-4317. Epub 2017 Dec 31.

Division of Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

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January 2018

Improved outcomes for myeloid leukemia of Down syndrome: a report from the Children's Oncology Group AAML0431 trial.

Authors:

Jeffrey W Taub Jason N Berman Johann K Hitzler April D Sorrell Norman J Lacayo Kelley Mast David Head Susana Raimondi Betsy Hirsch Yubin Ge Robert B Gerbing Yi-Cheng Wang Todd A Alonzo Dario Campana Elaine Coustan-Smith Prasad Mathew Alan S Gamis

Blood 2017 06 7;129(25):3304-3313. Epub 2017 Apr 7.

Division of Hematology/Oncology, Children's Mercy Hospitals and Clinics, Kansas City, MO.

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June 2017

Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Combination With Fludarabine and Cytarabine, in Pediatric Relapsed or Refractory Acute Leukemia.

Authors:

Thomas B Alexander Norman J Lacayo John K Choi Raul C Ribeiro Ching-Hon Pui Jeffrey E Rubnitz

J Clin Oncol 2016 12 31;34(34):4094-4101. Epub 2016 Oct 31.

Thomas B. Alexander, John K. Choi, Raul C. Ribeiro, Ching-Hon Pui, and Jeffrey E. Rubnitz, St Jude Children's Research Hospital; Raul C. Ribeiro, Ching-Hon Pui, and Jeffrey E. Rubnitz, University of Tennessee College of Medicine, Memphis, TN; and Norman J. Lacayo, Lucile Packard Children's Hospital Stanford, Stanford, CA.

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December 2016

Altered resting state functional connectivity in young survivors of acute lymphoblastic leukemia.

Authors:

Shelli R Kesler Meike Gugel Mika Pritchard-Berman Clement Lee Emily Kutner S M Hadi Hosseini Gary Dahl Norman Lacayo

Pediatr Blood Cancer 2014 Jul 12;61(7):1295-9. Epub 2014 Mar 12.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.

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July 2014

Development and validation of a single-cell network profiling assay-based classifier to predict response to induction therapy in paediatric patients with de novo acute myeloid leukaemia: a report from the Children's Oncology Group.

Authors:

Norman J Lacayo Todd A Alonzo Urte Gayko David B Rosen Matt Westfall Norman Purvis Santosh Putta Brent Louie James Hackett Aileen Cleary Cohen Alessandra Cesano Robert Gerbing Yaddanapudi Ravindranath Gary V Dahl Alan Gamis Soheil Meshinchi

Br J Haematol 2013 Jul 20;162(2):250-62. Epub 2013 May 20.

Children's Oncology Group, Arcadia, CA, USA.

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July 2013

AKT signaling as a novel factor associated with in vitro resistance of human AML to gemtuzumab ozogamicin.

Authors:

David B Rosen Kimberly H Harrington James A Cordeiro Ling Y Leung Santosh Putta Norman Lacayo George S Laszlo Chelsea J Gudgeon Donna E Hogge Rachael E Hawtin Alessandra Cesano Roland B Walter

PLoS One 2013 8;8(1):e53518. Epub 2013 Jan 8.

Nodality Inc., South San Francisco, California, United States of America.

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August 2013

Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia.

Authors:

Charles Gawad Francois Pepin Victoria E H Carlton Mark Klinger Aaron C Logan David B Miklos Malek Faham Gary Dahl Norman Lacayo

Blood 2012 Nov 28;120(22):4407-17. Epub 2012 Aug 28.

Division of Hematology-Oncology-Stem Cell Transplantation and Cancer Biology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

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November 2012

Assessing signaling pathways associated with in vitro resistance to cytotoxic agents in AML.

Authors:

David B Rosen James A Cordeiro Aileen Cohen Norman Lacayo Donna Hogge Rachael E Hawtin Alessandra Cesano

Leuk Res 2012 Jul 21;36(7):900-4. Epub 2012 Apr 21.

Department of Research, Nodality Inc, South San Francisco, CA, United States.

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July 2012

Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types.

Authors:

Julia Salzman Charles Gawad Peter Lincoln Wang Norman Lacayo Patrick O Brown

PLoS One 2012 1;7(2):e30733. Epub 2012 Feb 1.

Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America.

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September 2012

A pilot study of an online cognitive rehabilitation program for executive function skills in children with cancer-related brain injury.

Authors:

Shelli R Kesler Norman J Lacayo Booil Jo

Brain Inj 2011 ;25(1):101-12

Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.

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April 2011

Dorsolateral midbrain MRI abnormalities and ocular motor deficits following cytarabine-based chemotherapy for acute myelogenous leukemia.

Authors:

Thuy Doan Norman Lacayo Paul G Fisher Yaping Joyce Liao

J Neuroophthalmol 2011 Mar;31(1):52-3

Department of Ophthalmology, Stanford University School of Medicine, Stanford, California 94304-5353, USA.

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March 2011

Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial.

Lancet Oncol 2010 Jun 5;11(6):543-52. Epub 2010 May 5.

Department of Oncology, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN 38105-2794, USA.

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June 2010

Phase I study of valspodar (PSC-833) with mitoxantrone and etoposide in refractory and relapsed pediatric acute leukemia: a report from the Children's Oncology Group.

Authors:

Maureen M O'Brien Norman J Lacayo Bert L Lum Smita Kshirsagar Steven Buck Yaddanapudi Ravindranath Mark Bernstein Howard Weinstein Myron N Chang Robert J Arceci Branimir I Sikic Gary V Dahl

Pediatr Blood Cancer 2010 May;54(5):694-702

Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.

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May 2010

Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML.

Blood 2010 Mar 7;115(12):2372-9. Epub 2010 Jan 7.

Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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March 2010

Speeding the flow toward personalized therapy in childhood acute leukemia.

Authors:

Erin F Simonds Kara L Davis Norman J Lacayo

Pediatr Blood Cancer 2009 Oct;53(4):525-6

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.

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October 2009

WT1 expression at diagnosis does not predict survival in pediatric AML: a report from the Children's Oncology Group.

Authors:

Suzie A Noronha Jason E Farrar Todd A Alonzo Robert B Gerbing Norman J Lacayo Gary V Dahl Yaddanapudi Ravindranath Robert J Arceci David M Loeb

Pediatr Blood Cancer 2009 Dec;53(6):1136-9

Division of Pediatric Oncology, Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA.

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December 2009

Molecular inversion probes reveal patterns of 9p21 deletion and copy number aberrations in childhood leukemia.

Authors:

Joshua D Schiffman Yuker Wang Lisa A McPherson Katrina Welch Nancy Zhang Ronald Davis Norman J Lacayo Gary V Dahl Malek Faham James M Ford Hanlee P Ji

Cancer Genet Cytogenet 2009 Aug;193(1):9-18

Pediatric Hematology/Oncology and Oncological Sciences, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Room 4343, Salt Lake City, UT 84112.

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August 2009