Norman L Lehman

Norman L Lehman

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Norman L Lehman

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Pituitary carcinomas: review of the current literature and report of atypical case.

Br J Neurosurg 2019 Mar 5:1-6. Epub 2019 Mar 5.

a Department of Neurological Surgery, Wexner Medical Center , The Ohio State University College of Medicine , Columbus , OH , USA.

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http://dx.doi.org/10.1080/02688697.2019.1582750DOI Listing
March 2019

IgG4-Related Disease: A New Etiology Underlying Diffuse Intracranial Dilating Vasculopathy.

World Neurosurg 2017 Nov 10;107:1048.e15-1048.e20. Epub 2017 Aug 10.

Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.1016/j.wneu.2017.08.012DOI Listing
November 2017

Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults.

Neuro Oncol 2017 01 14;19(1):31-42. Epub 2016 Jul 14.

Department of Pathology, The Ohio State University, Columbus, Ohio (N.L.L., A.U., C.R.P., K.K., K.Z., N.M., G.Z., W.Z.); Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana (E.M.H., J.M.B.); Department of Pathology, Vanderbilt University, Nashville, Tennessee (B.C.M.); Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia (M.J.S.); Department of Pathology, Duke University, Durham, North Carolina (R.E.M., E.S.L.); Institute of Neuropathology, University Hospital Münster, Germany (W.P.); Institute for Neuropathology, University Hospital of Zurich, Switzerland (E.J.R.); Department of Pathology, The University of Texas Southwestern, Dallas, Texas (M.-M.G., J.M.R.); Department of Pathology, Case Western Reserve University, Cleveland, Ohio (M.C., M.L.C.); Department of Anatomic Pathology, Beaumont Hospital, Royal Oak, Michigan (M.S.D.); Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio (C.R.P.); Department of Pathology, University of Illinois, Peoria, Illinois (S.E.M.); Department of Pathology, Sheikh Khalifa Medical City, Abu Dhabi, UAE (M.A.A.-A.); Department of Family and Community Medicine, Contra Costa Regional Medical Center, Martinez, California (T.D.L.).

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http://dx.doi.org/10.1093/neuonc/now118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193018PMC
January 2017

Firm, non-tender mass in right breast · worsening, nonproductive cough · pleuritic pain · Dx?

J Fam Pract 2017 01;66(1):38-41

Department of Pathology, Stanford University School of Medicine, CA, USA.

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January 2017

NHERF1/EBP50 and NF2 as diagnostic markers for choroid plexus tumors.

Acta Neuropathol Commun 2016 05 27;4(1):55. Epub 2016 May 27.

Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1186/s40478-016-0329-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882843PMC
May 2016

Surgical Neuropathology of Focal Epilepsies: Textbook and Atlas.

Authors:
Norman L Lehman

J Neuropathol Exp Neurol 2016 Mar 24;75(3):291. Epub 2016 Feb 24.

The Ohio State University College of Medicine Columbus, Ohio.

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http://dx.doi.org/10.1093/jnen/nlw006DOI Listing
March 2016

A 59-Year-Old Man with History of Renal Transplantation.

Brain Pathol 2015 Nov;25(6):788-9

Division of Neuropathology, The Ohio State University Wexner Medical Center, Columbus, OH.

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http://dx.doi.org/10.1111/bpa.12321DOI Listing
November 2015

Primary Meningeal Pleomorphic Xanthoastrocytoma With Anaplastic Features: A Report of 2 Cases, One With BRAF(V600E) Mutation and Clinical Response to the BRAF Inhibitor Dabrafenib.

J Neuropathol Exp Neurol 2015 Oct;74(10):960-9

From the Departments of Pathology (AU, CRP, CAK, WZ, NLL), Anatomy (CRP), Neurosurgery (KH, MA), and Neuroscience (NLL), and Division of Neuro-oncology (VKP), The Ohio State University; and Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital (CRP), Columbus Ohio; and Departments of Pathology (ONK, TGM, NLL) and Neurosurgery (JR), Henry Ford Hospital, Detroit, Michigan.

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http://dx.doi.org/10.1097/NEN.0000000000000240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777522PMC
October 2015

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Changes in BAI1 and nestin expression are prognostic indicators for survival and metastases in breast cancer and provide opportunities for dual targeted therapies.

Mol Cancer Ther 2015 Jan 5;14(1):307-14. Epub 2014 Nov 5.

Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio. Department of Radiation Oncology, James Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297221PMC
January 2015

Aurora-A inhibition offers a novel therapy effective against intracranial glioblastoma.

Cancer Res 2014 Oct 8;74(19):5364-70. Epub 2014 Aug 8.

Department of Pathology, The Ohio State University, Columbus Ohio. Department of Neuroscience, The Ohio State University, Columbus Ohio.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528677PMC
October 2014

Characterizing brain structures and remodeling after TBI based on information content, diffusion entropy.

PLoS One 2013 15;8(10):e76343. Epub 2013 Oct 15.

Department of Neurology, Henry Ford Hospital, Detroit, Michigan, United States of America ; Department of Physics, Oakland University, Rochester, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076343PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797055PMC
June 2014

Radiation necrosis mimicking rapid intracranial progression of melanoma metastasis in two patients treated with vemurafenib.

Melanoma Res 2014 Apr;24(2):172-6

aDepartment of Internal Medicine, Division of Medical Oncology Departments of bBiomedical Informatics cRadiation Oncology dNeurology eNeurologic Surgery fPathology, The Ohio State University gDepartment of Radiology, Division of Diagnostic Radiology, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1097/CMR.0000000000000044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372136PMC
April 2014

A pilocytic astrocytoma mimicking a clinoidal meningioma.

Case Rep Radiol 2014 13;2014:524574. Epub 2014 Mar 13.

Department of Neurological Surgery, The Ohio State University Wexner Medical Center, 410 W. 10th Avenue, N1022 Doan Hall, Columbus, OH 43210, USA.

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http://www.hindawi.com/journals/crira/2014/524574/
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http://dx.doi.org/10.1155/2014/524574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972933PMC
April 2014

Glioblastoma cell enrichment is critical for analysis of phosphorylated drug targets and proteomic-genomic correlations.

Cancer Res 2014 Feb 17;74(3):818-28. Epub 2013 Dec 17.

Authors' Affiliations: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia; Departments of Neurosurgery, Henry Ford Hospital, Detroit; and Pathology, Henry Ford Hospital, Detroit, Michigan.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-2172DOI Listing
February 2014

Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class.

Clin Cancer Res 2013 Sep 17;19(18):4951-60. Epub 2013 Jul 17.

Authors' Affiliations: Emory University School of Medicine, Departments of Biomedical Informatics and Pathology and Laboratory Medicine,Center for Comprehensive Informatics, Winship Cancer Institute, Emory University; Department of Pathology, Children's Healthcare of Atlanta, Atlanta, Georgia; Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan; Department of Pathology, Case Western Reserve University, Cleveland, Ohio; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Pathology, Duke University Medical Center, Durham, North Carolina; Department of Pathology, Ohio State University, Columbus, Ohio; Department of Pathology, University of North Carolina, Chapel Hill, North Carolina; and Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865611PMC
September 2013

Differential expression of aurora-A kinase in T-cell lymphomas.

Mod Pathol 2013 May 15;26(5):640-7. Epub 2013 Feb 15.

Department of Pathology and Laboratory Medicine, Henry Ford Hospital, Detroit, MI 48202, USA.

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http://dx.doi.org/10.1038/modpathol.2012.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007132PMC
May 2013

Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.

Cell Cycle 2012 Feb 1;11(3):489-502. Epub 2012 Feb 1.

Department of Pathology and Laboratory Medicine, The Hermelin Brain Tumor Center, Henry Ford Hospital, and Department of Pathology, Wayne State University, Detroit, MI, USA.

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http://dx.doi.org/10.4161/cc.11.3.18996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315093PMC
February 2012

Synoptic reporting for central nervous system tumors: has its time come?

Authors:
Norman L Lehman

Arch Pathol Lab Med 2011 Jun;135(6):691-2

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http://dx.doi.org/10.1043/2010-0673-EDI.1DOI Listing
June 2011

Predicting survival in glioblastomas using diffusion tensor imaging metrics.

J Magn Reson Imaging 2010 Oct;32(4):788-95

Department of Radiology, Henry Ford Health System, Detroit, Michigan 48202, USA.

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http://dx.doi.org/10.1002/jmri.22304DOI Listing
October 2010

Can permeability measurements add to blood volume measurements in differentiating tumefactive demyelinating lesions from high grade gliomas using perfusion CT?

J Neurooncol 2010 May 15;97(3):383-8. Epub 2009 Oct 15.

Division of Neuroradiology, Department of Radiology, Henry Ford Health System, 2799 West Grand Blvd, Detroit, MI 48202, USA.

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http://dx.doi.org/10.1007/s11060-009-0030-2DOI Listing
May 2010

Intramedullary papillary ependymoma with choroid plexus differentiation and cerebrospinal fluid dissemination to the brain.

J Neurosurg Pediatr 2010 May;5(5):511-7

Department of Pathology, Stanford University Medical Center, Stanford, California, USA.

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http://dx.doi.org/10.3171/2009.12.PEDS09130DOI Listing
May 2010

Gliosarcoma stem cells undergo glial and mesenchymal differentiation in vivo.

Stem Cells 2010 Feb;28(2):181-90

Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202-2689, USA.

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http://dx.doi.org/10.1002/stem.264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873790PMC
February 2010

The ubiquitin proteasome system in neuropathology.

Authors:
Norman L Lehman

Acta Neuropathol 2009 Sep 14;118(3):329-47. Epub 2009 Jul 14.

Department of Pathology and Laboratory Medicine, Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI 48202, USA.

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http://dx.doi.org/10.1007/s00401-009-0560-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716447PMC
September 2009

Patterns of brain infiltration and secondary structure formation in supratentorial ependymal tumors.

Authors:
Norman L Lehman

J Neuropathol Exp Neurol 2008 Sep;67(9):900-10

Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1097/NEN.0b013e31818521cdDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805172PMC
September 2008

GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis.

Neuro Oncol 2008 Jun 10;10(3):236-43. Epub 2008 Apr 10.

Department of Neurosurgery and Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI 48202, USA.

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http://dx.doi.org/10.1215/15228517-2008-006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563046PMC
June 2008

Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma.

Mod Pathol 2008 Apr 18;21(4):445-54. Epub 2008 Jan 18.

Department of Pathology, Stanford University, Stanford, CA, USA.

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http://www.nature.com/articles/3801022
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http://dx.doi.org/10.1038/modpathol.3801022DOI Listing
April 2008

Gliosarcoma with melanocytic differentiation.

Acta Neuropathol 2008 Mar 20;115(3):357-61. Epub 2007 Jul 20.

Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1007/s00401-007-0232-7DOI Listing
March 2008

Central nervous system tumors with ependymal features: a broadened spectrum of primarily ependymal differentiation?

Authors:
Norman L Lehman

J Neuropathol Exp Neurol 2008 Mar;67(3):177-88

Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI 48202, USA.

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http://dx.doi.org/10.1097/NEN.0b013e31816543a6DOI Listing
March 2008

Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence.

Mol Cell Biol 2007 Nov 17;27(22):7955-65. Epub 2007 Sep 17.

Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1128/MCB.00908-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169152PMC
November 2007

Screening of tissue microarrays for ubiquitin proteasome system components in tumors.

Methods Enzymol 2005 ;399:334-55

Department of Pathology, Stanford University School of Medicine, Palo Alto, California, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S007668790599023
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http://dx.doi.org/10.1016/S0076-6879(05)99023-XDOI Listing
May 2007

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.

Genes Dev 2006 Sep 18;20(17):2410-20. Epub 2006 Aug 18.

Program in Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1454006
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http://dx.doi.org/10.1101/gad.1454006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560415PMC
September 2006

Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells.

Cell Cycle 2006 Jul 17;5(14):1569-73. Epub 2006 Jul 17.

Department of Pathology, Stanford University, Stanford, California 94305, USA.

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https://www.tandfonline.com/doi/full/10.4161/cc.5.14.2925
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http://dx.doi.org/10.4161/cc.5.14.2925DOI Listing
July 2006

Malignant PEComa of the skull base.

Authors:
Norman L Lehman

Am J Surg Pathol 2004 Sep;28(9):1230-2

Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1097/01.pas.0000128668.34934.81DOI Listing
September 2004

Histologic findings of disc, end plate and neural elements after coblation of nucleus pulposus: an experimental nucleoplasty study.

Spine J 2003 Nov-Dec;3(6):466-70

Spinal Diagnostics and Treatment Center, Daly City, CA 94015, USA.

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http://dx.doi.org/10.1016/s1529-9430(03)00143-8DOI Listing
March 2004

Cortical ependymoma. A case report and review.

Pediatr Neurosurg 2003 Jul;39(1):50-4

Department of Pathology, Stanford University Medical Center, Calif 94305, USA.

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http://dx.doi.org/10.1159/000070881DOI Listing
July 2003

Synchronous subarachnoid drop metastases from a pituitary adenoma with multiple recurrences. Case report.

J Neurosurg 2003 May;98(5):1120-3

Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA.

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http://dx.doi.org/10.3171/jns.2003.98.5.1120DOI Listing
May 2003

Future potential of thymidylate synthase inhibitors in cancer therapy.

Authors:
Norman L Lehman

Expert Opin Investig Drugs 2002 Dec;11(12):1775-87

Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1517/13543784.11.12.1775DOI Listing
December 2002