Norman J Maitland

Norman J Maitland

UNVERIFIED PROFILE

Are you Norman J Maitland?   Register this Author

Register author
Norman J Maitland

Norman J Maitland

Publications by authors named "Norman J Maitland"

Are you Norman J Maitland?   Register this Author

78Publications

662Reads

11Profile Views

Resolution of Cellular Heterogeneity in Human Prostate Cancers: Implications for Diagnosis and Treatment.

Adv Exp Med Biol 2019 ;1164:207-224

Cancer Research Unit, Department of Biology, University of York, York, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-030-22254-3_16DOI Listing
October 2019

Epigenetic Control of Gene Expression in the Normal and Malignant Human Prostate: A Rapid Response Which Promotes Therapeutic Resistance.

Int J Mol Sci 2019 May 17;20(10). Epub 2019 May 17.

The Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20102437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566891PMC
May 2019

Phenotype-independent DNA methylation changes in prostate cancer.

Br J Cancer 2018 10 15;119(9):1133-1143. Epub 2018 Oct 15.

Cancer Research Unit, Department of Biology, University of York, Wentworth Way, York, YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41416-018-0236-1
Publisher Site
http://dx.doi.org/10.1038/s41416-018-0236-1DOI Listing
October 2018

Phospholipase D inhibitors reduce human prostate cancer cell proliferation and colony formation.

Br J Cancer 2018 01 14;118(2):189-199. Epub 2017 Nov 14.

Department of Biology, Cancer Research Unit, University of York, York YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/bjc.2017.391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785744PMC
January 2018

Harvesting Human Prostate Tissue Material and Culturing Primary Prostate Epithelial Cells.

Methods Mol Biol 2016 ;1443:181-201

YCR Cancer Research Unit, Department of Biology, University of York, Heslington, North Yorkshire, YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-3724-0_12DOI Listing
November 2017

A Detailed Analysis of Gene Expression in Human Basal, Luminal, and Stromal Cell Populations from Benign Prostatic Hyperplasia Tissues and Comparisons with Cultured Basal Cells.

Eur Urol 2017 07 3;72(1):157-159. Epub 2017 Apr 3.

Cancer Research Unit, Department of Biology, University of York, York, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2017.03.024DOI Listing
July 2017

Stem cells and the role of ETS transcription factors in the differentiation hierarchy of normal and malignant prostate epithelium.

J Steroid Biochem Mol Biol 2017 02 14;166:68-83. Epub 2016 May 14.

Cancer Research Unit, Department of Biology, University of York, York, YO10 5DD, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsbmb.2016.05.006DOI Listing
February 2017

Re: The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer.

Eur Urol 2017 02 13;71(2):302-303. Epub 2016 Sep 13.

Department of Biology, Cancer Research Unit, University of York, York, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2016.08.062DOI Listing
February 2017

Can Decellularised Prostate Tissue Be Used to Model Tumour Malignancy?

Eur Urol Focus 2016 Oct 18;2(4):409-411. Epub 2016 May 18.

Cancer Research Unit, University of York, York, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euf.2016.05.001DOI Listing
October 2016

Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future.

Tumour Biol 2016 Jun 18;37(6):7021-31. Epub 2016 Feb 18.

Department of Physics, York Plasma Institute, University of York, Heslington, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13277-016-4911-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875936PMC
June 2016

The molecular and cellular origin of human prostate cancer.

Biochim Biophys Acta 2016 Jun 26;1863(6 Pt A):1238-60. Epub 2016 Feb 26.

YCR Cancer Research Unit, Department of Biology, University of York, Wentworth Way, York YO10 5DD, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01674889163004
Publisher Site
http://dx.doi.org/10.1016/j.bbamcr.2016.02.016DOI Listing
June 2016

An Epigenetic Reprogramming Strategy to Resensitize Radioresistant Prostate Cancer Cells.

Cancer Res 2016 05 16;76(9):2637-51. Epub 2016 Mar 16.

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany. German Cancer Consortium (DKTK), Dresden, Germany. German Cancer Research Center (DKFZ), Heidelberg, Germany. Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiation Oncology, Dresden, Germany.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/content/early/2016/03/16/0
Web Search
http://cancerres.aacrjournals.org/content/early/2016/03/16/0
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-15-2116DOI Listing
May 2016

Prominin-1 (CD133) Expression in the Prostate and Prostate Cancer: A Marker for Quiescent Stem Cells.

Adv Exp Med Biol 2013 ;777:167-84

YCR Cancer Research Unit, Department of Biology, University of York, Wentworth Way, YO10 5DD, York, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4614-5894-4_11DOI Listing
April 2016

Telomerase Activity and Telomere Length in Human Benign Prostatic Hyperplasia Stem-like Cells and Their Progeny Implies the Existence of Distinct Basal and Luminal Cell Lineages.

Eur Urol 2016 Apr 9;69(4):551-554. Epub 2015 Oct 9.

YCR Cancer Research Unit, Department of Biology, University of York, York, North Yorkshire, UK; Hull York Medical School, University of Hull, Hull, East Yorkshire, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2015.09.039DOI Listing
April 2016

CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations.

Oncotarget 2015 Aug;6(23):19661-70

Prostate Cancer Research Center (PCRC), Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere and Tampere University Hospital, Tampere, Finland.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637312PMC
http://dx.doi.org/10.18632/oncotarget.3875DOI Listing
August 2015

Construction of therapeutically relevant human prostate epithelial fate map by utilising miRNA and mRNA microarray expression data.

Br J Cancer 2015 Aug 23;113(4):611-5. Epub 2015 Jul 23.

1] Department of Biology, YCR Cancer Research Unit, University of York, York YO10 5DD, North Yorkshire, UK [2] Department of Urology, Castle Hill Hospital, Cottingham HU16 5JQ, East Yorkshire, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/bjc.2015.262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647689PMC
August 2015

Differential regulation of TROP2 release by PKC isoforms through vesicles and ADAM17.

Cell Signal 2015 Jul 26;27(7):1325-35. Epub 2015 Mar 26.

College of Biomedical and Life Sciences, Cardiff University, Dental School, Cardiff CF14 4XY, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2015.03.017DOI Listing
July 2015

MicroRNA expression profile of primary prostate cancer stem cells as a source of biomarkers and therapeutic targets.

Eur Urol 2015 Jan 16;67(1):7-10. Epub 2014 Sep 16.

YCR Cancer Research Unit, Department of Biology, University of York, York, North Yorkshire, UK; Hull York Medical School, University of Hull, Hull, East Yorkshire, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2014.09.005DOI Listing
January 2015

Carcinoma-derived exosomes modify microenvironment.

Oncotarget 2015 Jan;6(3):1344-5

YCR Cancer Research Unit, Department of Biology, University of York, York, United Kingdom.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359297PMC
http://dx.doi.org/10.18632/oncotarget.3182DOI Listing
January 2015

Low temperature plasma: a novel focal therapy for localized prostate cancer?

Biomed Res Int 2014 13;2014:878319. Epub 2014 Mar 13.

Department of Physics, York Plasma Institute, University of York, Heslington, York YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2014/878319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971493PMC
December 2014

Low Temperature Plasma Causes Double-Strand Break DNA Damage in Primary Epithelial Cells Cultured from a Human Prostate Tumour.

IEEE Trans Plasma Sci IEEE Nucl Plasma Sci Soc 2014 Sep;42(10):2740-2741

University of York, Departments of Physics and Biology, Heslington, York, YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/TPS.2014.2351453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724888PMC
September 2014

Preclinical safety assessment of Ad[I/PPT-E1A], a novel oncolytic adenovirus for prostate cancer.

Hum Gene Ther Clin Dev 2014 Mar;25(1):7-15

1 Department of Urology, Erasmus MC , 3000 CA Rotterdam, The Netherlands .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/humc.2013.181DOI Listing
March 2014

Conserved two-step regulatory mechanism of human epithelial differentiation.

Stem Cell Reports 2014 Feb 6;2(2):180-8. Epub 2014 Feb 6.

YCR Cancer Research Unit, Department of Biology, University of York, York, North Yorkshire YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2014.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923223PMC
February 2014

Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells.

Nat Commun 2013 ;4:1623

YCR Cancer Research Unit, Department of Biology, University of York, York, North Yorkshire, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms2627DOI Listing
October 2013

A fusion at the root of prostate cancer.

Asian J Androl 2013 Sep 10;15(5):592-3. Epub 2013 Jun 10.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/aja.2013.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881632PMC
September 2013

Words of wisdom: re: prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study.

Eur Urol 2013 Aug;64(2):341-2

YCR Cancer Research Unit, Department of Biology, University of York, York, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2013.05.014DOI Listing
August 2013

A preclinical xenograft model of prostate cancer using human tumors.

Nat Protoc 2013 May 4;8(5):836-48. Epub 2013 Apr 4.

Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2013.043DOI Listing
May 2013

Advanced prostate cancer--a case for adjuvant differentiation therapy.

Nat Rev Urol 2012 10 14;9(10):595-602. Epub 2012 Aug 14.

Yorkshire Cancer Research Unit, Department of Biology (Area 13), University of York, York YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrurol.2012.157DOI Listing
October 2012

Prostate cancer stem cells: are they androgen-responsive?

Mol Cell Endocrinol 2012 Sep 23;360(1-2):14-24. Epub 2011 Jul 23.

YCR Cancer Research Unit, Department of Biology, University of York, Wentworth Way, York, YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2011.07.008DOI Listing
September 2012

Human epithelial basal cells are cells of origin of prostate cancer, independent of CD133 status.

Stem Cells 2012 06;30(6):1087-96

Prostate and Breast Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, [corrected] Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.1094DOI Listing
June 2012

Cancer stem cells, models of study and implications of therapy resistance mechanisms.

Adv Exp Med Biol 2011 ;720:105-18

Department of Biology, University of York, Heslington, North Yorkshire, YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4614-0254-1_9DOI Listing
March 2012

The calcium sensor STIM1 is regulated by androgens in prostate stromal cells.

Prostate 2011 Nov 22;71(15):1646-55. Epub 2011 Mar 22.

YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pros.21384DOI Listing
November 2011

Baculoviruses as gene therapy vectors for human prostate cancer.

J Invertebr Pathol 2011 Jul;107 Suppl:S59-70

Yorkshire Cancer Research Unit, Dept of Biology, University of York, York YO10 5DD, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jip.2011.05.006DOI Listing
July 2011

Prostate cancer stem cells: do they have a basal or luminal phenotype?

Horm Cancer 2011 Feb;2(1):47-61

YCR Cancer Research Unit, Department of Biology (Area 13), University of York, Heslington, York YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12672-010-0058-yDOI Listing
February 2011

Cancer stem cells - A therapeutic target?

Curr Opin Mol Ther 2010 Dec;12(6):662-73

University of York, YCR Cancer Research Unit, Department of Biology, York YO1 5YW, UK.

View Article

Download full-text PDF

Source
December 2010

Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells.

Exp Cell Res 2010 Nov 19;316(19):3161-71. Epub 2010 Aug 19.

YCR Cancer Research Unit, Department of Biology, University of York, Heslington, North Yorkshire, YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexcr.2010.08.004DOI Listing
November 2010

Phenotypic effects of HPV-16 E2 protein expression in human keratinocytes.

Virology 2010 Jun 27;401(2):314-21. Epub 2010 Mar 27.

YCR Cancer Research Unit, Department of Biology (Area 13), University of York, PO Box 373, YORK YO105YW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2010.03.002DOI Listing
June 2010

Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer.

Cancer Res 2010 Jan;70(1):347-56

YCR Cancer Research Unit, Department of Biology, University of York, Heslington, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-09-1252DOI Listing
January 2010

Prostate cancer: regeneration of interest in the prostate.

Nat Rev Urol 2009 Apr;6(4):184-6

Yorkshire Cancer Research Cancer Research Unit, University of York, York, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrurol.2009.48
Publisher Site
http://dx.doi.org/10.1038/nrurol.2009.48DOI Listing
April 2009

Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection?

J Cell Biochem 2008 Nov;105(4):931-9

YCR Cancer Research Unit, Deparment of Biology, University of York, York YO10 5YW, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.21843DOI Listing
November 2008

An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner.

Hum Gene Ther 2008 Aug;19(8):840-50

YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/hum.2007.165DOI Listing
August 2008

Androgen receptor signalling in prostate: effects of stromal factors on normal and cancer stem cells.

Mol Cell Endocrinol 2008 Jun 2;288(1-2):30-7. Epub 2008 Mar 2.

YCR Cancer Research Unit, Department of Biology, University of York, Wentworth Way, York, YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2008.02.024DOI Listing
June 2008

Prostate cancer stem cells: a new target for therapy.

J Clin Oncol 2008 Jun;26(17):2862-70

YCR Cancer Research Unit, Department of Biology, University of York, Heslinton, York, YO10 5YW, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2007.15.1472DOI Listing
June 2008

Dimerization of the human papillomavirus type 16 E2 N terminus results in DNA looping within the upstream regulatory region.

J Virol 2008 May 12;82(10):4853-61. Epub 2008 Mar 12.

YCR Cancer Research Unit, Department of Biology (Area 13), University of York, Heslington, York, YO10 5DD United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02388-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2346762PMC
May 2008

Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells.

Drug Discov Today 2007 Aug 27;12(15-16):611-21. Epub 2007 Jul 27.

Centre for Oncology and Applied Pharmacology, University of Glasgow, Cancer Research UK Beatson Laboratories, Alexander Stone Building, Garscube Estate, Switchback Road, Bearsden, Glasgow, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2007.06.009DOI Listing
August 2007

Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines.

Cell Signal 2007 Jan 7;19(1):129-38. Epub 2006 Jun 7.

YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2006.05.029DOI Listing
January 2007

Differentiation of prostate epithelial cell cultures by matrigel/ stromal cell glandular reconstruction.

In Vitro Cell Dev Biol Anim 2006 Sep-Oct;42(8-9):273-80

YCR Cancer Research Unit, University of York, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1290/0511080.1DOI Listing
January 2007

Prostate cancer stem cells.

Eur J Cancer 2006 Jun 2;42(9):1213-8. Epub 2006 May 2.

University of York, YCR Cancer Research Unit, Department of Biology, Heslington, York YO10 5DD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2006.01.037DOI Listing
June 2006

Expression and localization of endothelin-converting enzyme-1 in human prostate cancer.

Exp Biol Med (Maywood) 2006 Jun;231(6):1106-10

Proteolysis Research Group, School of Biochemistry & Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom.

View Article

Download full-text PDF

Source
June 2006

A tumour stem cell hypothesis for the origins of prostate cancer.

BJU Int 2005 Dec;96(9):1219-23

YCR Cancer Research Unit, Department of Biology, University of York, York, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1464-410X.2005.05744.xDOI Listing
December 2005

Prospective identification of tumorigenic prostate cancer stem cells.

Cancer Res 2005 Dec;65(23):10946-51

Yorkshire Cancer Research Unit, Department of Biology, University of York, York, United Kingdom.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-05-2018DOI Listing
December 2005

CD133, a novel marker for human prostatic epithelial stem cells.

J Cell Sci 2004 Jul 29;117(Pt 16):3539-45. Epub 2004 Jun 29.

Prostate Research Group, Surgical Oncology, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK.

View Article

Download full-text PDF

Source
http://jcs.biologists.org/cgi/doi/10.1242/jcs.01222
Publisher Site
http://dx.doi.org/10.1242/jcs.01222DOI Listing
July 2004

Immortalization of human prostate cells with the human papillomavirus type 16 E6 gene.

Methods Mol Med 2004 ;88:275-85

YCR Cancer Research Unit, Department of Biology, University of York, UK.

View Article

Download full-text PDF

Source
March 2004

Coculture of prostate cancer cells.

Methods Mol Med 2004 ;88:295-302

YCR Cancer Research Unit, Department of Biology, University of York, UK.

View Article

Download full-text PDF

Source
March 2004

Exploitation of prostate gene expression to develop targeted therapies.

Acta Biomed 2003 Aug;74(2):105-6

YCR Cancer Research Unit, Department of Biology, University of York, PO Box 373, York YO1 5YW, U.K.

View Article

Download full-text PDF

Source
August 2003

Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines.

Clin Sci (Lond) 2002 Aug;103 Suppl 48:314S-317S

School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/CS103S314SDOI Listing
August 2002

Primary prostate stromal cells modulate the morphology and migration of primary prostate epithelial cells in type 1 collagen gels.

Cancer Res 2002 Jan;62(1):58-62

YCR Cancer Research Unit, Department of Biology, University of York, York YO10 5YW, United Kingdom.

View Article

Download full-text PDF

Source
January 2002