Publications by authors named "Norman J Haughey"

94Publications

Inhibition of neutral sphingomyelinase 2 promotes remyelination.

Sci Adv 2020 Oct 2;6(40). Epub 2020 Oct 2.

Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1126/sciadv.aba5210DOI Listing
October 2020

Influence of species and processing parameters on recovery and content of brain tissue-derived extracellular vesicles.

J Extracell Vesicles 2020 Jun 30;9(1):1785746. Epub 2020 Jun 30.

Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1080/20013078.2020.1785746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480582PMC
June 2020

Bioenergetic adaptations to HIV infection. Could modulation of energy substrate utilization improve brain health in people living with HIV-1?

Exp Neurol 2020 05 11;327:113181. Epub 2020 Jan 11.

The Johns Hopkins University School of Medicine, Department of Neurology, United States; The Johns Hopkins University School of Medicine, Department of Psychiatry, United States. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2020.113181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233457PMC
May 2020

Lipid accumulation and oxidation in glioblastoma multiforme.

Sci Rep 2019 12 20;9(1):19593. Epub 2019 Dec 20.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/s41598-019-55985-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925201PMC
December 2019

Proteome characterization of small extracellular vesicles from spared nerve injury model of neuropathic pain.

J Proteomics 2020 01 24;211:103540. Epub 2019 Oct 24.

Department of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2019.103540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916715PMC
January 2020

Lipidomic characterization of extracellular vesicles in human serum.

J Circ Biomark 2019 Jan-Dec;8:1849454419879848. Epub 2019 Sep 30.

Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1177/1849454419879848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769212PMC
September 2019

Stimulus-dependent modifications in astrocyte-derived extracellular vesicle cargo regulate neuronal excitability.

Glia 2020 01 30;68(1):128-144. Epub 2019 Aug 30.

Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/glia.23708DOI Listing
January 2020

Involvement of organelles and inter-organellar signaling in the pathogenesis of HIV-1 associated neurocognitive disorder and Alzheimer's disease.

Brain Res 2019 11 16;1722:146389. Epub 2019 Aug 16.

Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, United States. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2019.146389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755067PMC
November 2019

Acetylcholinesterase is not a generic marker of extracellular vesicles.

J Extracell Vesicles 2019 3;8(1):1628592. Epub 2019 Jul 3.

Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1080/20013078.2019.1628592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609367PMC
July 2019

A novel and potent brain penetrant inhibitor of extracellular vesicle release.

Br J Pharmacol 2019 10 4;176(19):3857-3870. Epub 2019 Sep 4.

Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1111/bph.14789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780992PMC
October 2019

MEAnalyzer - a Spike Train Analysis Tool for Multi Electrode Arrays.

Neuroinformatics 2020 01;18(1):163-179

Department of Neurology, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1007/s12021-019-09431-0DOI Listing
January 2020

Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients.

Neurology 2019 03 20;92(12):e1344-e1353. Epub 2019 Feb 20.

From the Departments of Neurology (S.S.K., S.C., L.H.R., N.S., J.C.M., N.J.H.) and Psychiatry (N.J.H.), Johns Hopkins University School of Medicine, Baltimore, MD; HIV Neurobehavioral Research Program and Department of Psychiatry (S.L., T.M., I.G., D.F.), School of Medicine, University of California, San Diego, La Jolla; Department of Epidemiology (J.B.M., L.P.J., G.D.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Medicine (V.S.), Division of Infectious Diseases, and Department of Surgery (V.S.), Division of Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL; University of Texas Health Sciences Center (J.E.L.), Houston; Infectious Disease and Microbiology (G.R.), University of Pittsburg, PA; and Turku Centre for Biotechnology (A.M.D.), Turku University, Finland.

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http://dx.doi.org/10.1212/WNL.0000000000007125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511093PMC
March 2019

Dimethyl fumarate treatment induces lipid metabolism alterations that are linked to immunological changes.

Ann Clin Transl Neurol 2019 01 30;6(1):33-45. Epub 2018 Oct 30.

Department of Neurology Johns Hopkins University School of Medicine Baltimore Maryland.

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http://dx.doi.org/10.1002/acn3.676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331509PMC
January 2019

Intravenous Triacylglycerol Infusion Promotes Ceramide Accumulation and Hepatic Steatosis in Dairy Cows.

J Nutr 2018 10;148(10):1529-1535

Department of Animal Science, Cornell University, Ithaca, NY.

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http://dx.doi.org/10.1093/jn/nxy155DOI Listing
October 2018

TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons.

Cell Death Dis 2018 03 5;9(3):363. Epub 2018 Mar 5.

Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41419-018-0369-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838212PMC
March 2018

Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse.

ACS Chem Neurosci 2018 04 4;9(4):809-816. Epub 2018 Jan 4.

Department of Medicine , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.

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http://dx.doi.org/10.1021/acschemneuro.7b00434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906198PMC
April 2018

Plasma sphingolipids and depressive symptoms in coronary artery disease.

Brain Behav 2017 11 26;7(11):e00836. Epub 2017 Sep 26.

Neuropsychopharmacology Research Group Hurvitz Brain Sciences Program Sunnybrook Research Institute Toronto ON Canada.

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http://dx.doi.org/10.1002/brb3.836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698859PMC
November 2017

Internal grant review to increase grant funding for junior investigators.

Ann Neurol 2017 10 4;82(4):497-502. Epub 2017 Oct 4.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1002/ana.25040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761667PMC
October 2017

Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging.

Sci Rep 2017 08 10;7(1):7748. Epub 2017 Aug 10.

Johns Hopkins University School of Medicine Departments of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, 600N, Wolfe Street, Baltimore, MS, 21287, USA.

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http://dx.doi.org/10.1038/s41598-017-07570-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552766PMC
August 2017

Modifications in acute phase and complement systems predict shifts in cognitive status of HIV-infected patients.

AIDS 2017 06;31(10):1365-1378

aIntramural Research Program, National Institute on Aging, Baltimore, Maryland bDepartment of Pharmacology and Experimental Neuroscience, The University of Nebraska Medical Center, Omaha, Nebraska cDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland dDivision of Epidemiology, Department of Health Sciences Research eDepartment of Neurology College of Medicine, Mayo Clinic, Rochester, Minnesota fHIV Neurobehavioral Research Program and Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California gDepartment of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501712PMC
June 2017

The Psychiatric Impact of HIV.

ACS Chem Neurosci 2017 07 24;8(7):1432-1434. Epub 2017 May 24.

Department of Psychiatry, University of California San Diego , La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acschemneuro.7b00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769465PMC
July 2017

Temporal changes in sphingolipids and systemic insulin sensitivity during the transition from gestation to lactation.

PLoS One 2017 9;12(5):e0176787. Epub 2017 May 9.

Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, West Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176787PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423608PMC
September 2017

Peripheral sphingolipids are associated with variation in white matter microstructure in older adults.

Neurobiol Aging 2016 07 21;43:156-63. Epub 2016 Apr 21.

Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894643PMC
July 2016

Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species.

Aging Cell 2015 Dec 20;14(6):1014-23. Epub 2015 Jul 20.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1111/acel.12369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693456PMC
December 2015

Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties.

PLoS One 2015 26;10(5):e0124481. Epub 2015 May 26.

Brain Science Institute Drug Discovery Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124481PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444023PMC
February 2016

Cerebrospinal fluid metabolomics implicate bioenergetic adaptation as a neural mechanism regulating shifts in cognitive states of HIV-infected patients.

AIDS 2015 Mar;29(5):559-69

aDepartment of Pharmacology, University of Oxford, Oxford, UK bDepartment of Neurology cPsychiatry, Johns Hopkins University, Baltimore, Maryland dHIV Neurobehavioral Research Program and Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California eDivision of Epidemiology, Department of Health Sciences Research and Department of Neurology College of Medicine, Mayo Clinic, Rochester, Minnesota, USA fDepartment of Chemistry, University of Oxford, UK.

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http://pdfs.journals.lww.com/aidsonline/2015/03130/Cerebrosp
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/QAD.0000000000000580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340743PMC
March 2015

Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation.

PLoS One 2014 26;9(12):e115642. Epub 2014 Dec 26.

Center for Metabolism and Obesity Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Brain Science, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115642PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277346PMC
August 2015

Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum.

BMC Neurosci 2014 Dec 24;15:137. Epub 2014 Dec 24.

Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Carnegie 616A, 600 North Wolfe Street, Baltimore, 21287, MD, USA.

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http://dx.doi.org/10.1186/s12868-014-0137-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304132PMC
December 2014

Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging.

Aging Cell 2015 Feb 24;14(1):112-21. Epub 2014 Oct 24.

Department of Health Science Research and Neurology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1111/acel.12275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310757PMC
February 2015

Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection.

J Neurosci 2014 Aug;34(34):11485-503

Johns Hopkins University School of Medicine, Department of Neurology, Division of Neuroimmunology and Neurological Infections, Baltimore, Maryland 21287,

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http://dx.doi.org/10.1523/JNEUROSCI.0210-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138351PMC
August 2014

Ceramide metabolism analysis in a model of binge drinking reveals both neuroprotective and toxic effects of ethanol.

J Neurochem 2014 Dec 21;131(5):645-54. Epub 2014 Aug 21.

Richard T. Johnson Division of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1111/jnc.12834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405906PMC
December 2014

Spinal cord injury causes chronic liver pathology in rats.

J Neurotrauma 2015 Feb 21;32(3):159-69. Epub 2014 Oct 21.

1 Department of Neuroscience, The Ohio State University , Columbus, Ohio.

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http://dx.doi.org/10.1089/neu.2014.3497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298754PMC
February 2015

Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease.

Neurobiol Aging 2014 Nov 27;35(11):2486-2494. Epub 2014 May 27.

Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Madison VA Geriatric Research, Education and Clinical Center (GRECC), Madison, WI, USA; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170854PMC
November 2014

Polyamines: Predictive Biomarker for HIV-Associated Neurocognitive Disorders.

J AIDS Clin Res 2014;5(6):1000312

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.4172/2155-6113.1000312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397651PMC
January 2014

A biological perspective of CSF lipids as surrogate markers for cognitive status in HIV.

J Neuroimmune Pharmacol 2013 Dec 8;8(5):1136-46. Epub 2013 Nov 8.

Department of Neurology, Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Pathology 517, 600 North Wolfe Street, Baltimore, MD, 21287, USA,

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http://link.springer.com/10.1007/s11481-013-9506-0
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http://dx.doi.org/10.1007/s11481-013-9506-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909934PMC
December 2013

A lipid storage-like disorder contributes to cognitive decline in HIV-infected subjects.

Neurology 2013 Oct 11;81(17):1492-9. Epub 2013 Sep 11.

From the Department of Neurology, Division of Neuroimmunology and Neurological Infections (V.V.R.B., N.S., J.C.M., C.P., P.C., N.J.H.), and the Department of Psychiatry (N.J.H.), The Johns Hopkins University, School of Medicine, Baltimore, MD; the Department of Health Sciences Research (M.M.M.), Division of Epidemiology, The Mayo Clinic, Rochester, MN; HIV Neurobehavioral Research Program and Department of Psychiatry (I.G., S.L.), School of Medicine, University of California, San Diego, La Jolla; the Department of Psychiatry (L.C., S.M.), University of Hawaii, John A. Burns School of Medicine, Honolulu; and the Department of Neurology (V.W.), Specialized Neurosciences Research Program, University of Puerto Rico Medical Sciences Campus, San Juan.

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http://dx.doi.org/10.1212/WNL.0b013e3182a9565eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888167PMC
October 2013

Adenosine triphosphate released from HIV-infected macrophages regulates glutamatergic tone and dendritic spine density on neurons.

J Neuroimmune Pharmacol 2013 Sep 18;8(4):998-1009. Epub 2013 May 18.

Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, Johns Hopkins University School of Medicine, Pathology 517, 600 North Wolfe Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1007/s11481-013-9471-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740066PMC
September 2013

Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production.

Neurobiol Aging 2013 Oct 11;34(10):2370-8. Epub 2013 May 11.

Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706576PMC
October 2013

Use of a glycolipid inhibitor to ameliorate renal cancer in a mouse model.

PLoS One 2013 9;8(5):e63726. Epub 2013 May 9.

Department of Pediatrics, Division of Pediatric Cardiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063726PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650082PMC
December 2013

Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer's disease?

Clin Lipidol 2012 Oct;7(5):525-536

Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.

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http://dx.doi.org/10.2217/clp.12.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627378PMC
October 2012

Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz.

J Pharmacol Exp Ther 2012 Dec 13;343(3):696-703. Epub 2012 Sep 13.

Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1124/jpet.112.195701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500535PMC
December 2012

Selected statins produce rapid spinal motor neuron loss in vitro.

BMC Musculoskelet Disord 2012 Jun 15;13:100. Epub 2012 Jun 15.

Department of Neurology, Johns Hopkins School of Medicine, Baltimore, USA.

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http://dx.doi.org/10.1186/1471-2474-13-100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487793PMC
June 2012

Role of endolysosomes in HIV-1 Tat-induced neurotoxicity.

ASN Neuro 2012 Jun 20;4(4):243-52. Epub 2012 Jun 20.

Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA.

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http://journals.sagepub.com/doi/10.1042/AN20120017
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http://dx.doi.org/10.1042/AN20120017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379000PMC
June 2012

The Role of ATP-Binding Cassette Transporters in Neuro-Inflammation: Relevance for Bioactive Lipids.

Front Pharmacol 2012 30;3:74. Epub 2012 Apr 30.

Blood-Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fphar.2012.00074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339339PMC
October 2012

Ketone bodies protection against HIV-1 Tat-induced neurotoxicity.

J Neurochem 2012 Jul 17;122(2):382-91. Epub 2012 May 17.

Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2012.07764.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419790PMC
July 2012

Deficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity.

PLoS Pathog 2011 Dec 8;7(12):e1002410. Epub 2011 Dec 8.

Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234224PMC
December 2011

The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.

J Neurosci 2011 Nov;31(47):17074-90

Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4072-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254245PMC
November 2011

Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease.

J Alzheimers Dis 2011 ;27(2):259-69

Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.3233/JAD-2011-110405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218198PMC
August 2012

A failure to normalize biochemical and metabolic insults during morphine withdrawal disrupts synaptic repair in mice transgenic for HIV-gp120.

J Neuroimmune Pharmacol 2011 Dec 12;6(4):640-9. Epub 2011 Jul 12.

Department of Neurology, Division of Neuroimmunology, Johns Hopkins University School of Medicine, Meyer 6-109, 600 North Wolfe Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1007/s11481-011-9289-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422763PMC
December 2011

Elevated plasma ceramides in depression.

J Neuropsychiatry Clin Neurosci 2011 ;23(2):215-8

Drs. Gracia-Garcia and Lobo are affiliated with the Department of Psychiatry Hospital Clínico Universitario, University of Zaragoza, Instituto Aragonés de Ciencias de la Salud, Zaragoza.

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http://dx.doi.org/10.1176/jnp.23.2.jnp215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121176PMC
September 2011

Roles for biological membranes in regulating human immunodeficiency virus replication and progress in the development of HIV therapeutics that target lipid metabolism.

J Neuroimmune Pharmacol 2011 Jun 29;6(2):284-95. Epub 2011 Mar 29.

Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Meyer 6-109, 600N. Wolfe Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1007/s11481-011-9274-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417146PMC
June 2011

Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus.

J Neurovirol 2010 Nov 18;16(6):445-56. Epub 2010 Nov 18.

Department of Psychiatry, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.3109/13550284.2010.525599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144420PMC
November 2010

Sphingolipids in neurodegeneration.

Authors:
Norman J Haughey

Neuromolecular Med 2010 Dec 25;12(4):301-5. Epub 2010 Aug 25.

Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Meyer 6-109, 600 North Wolfe Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1007/s12017-010-8135-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083244PMC
December 2010

Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice.

J Neurosci Res 2010 Oct;88(13):2940-51

Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://doi.wiley.com/10.1002/jnr.22438
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919585PMC
October 2010

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis.

Biochim Biophys Acta 2010 Aug 7;1801(8):878-86. Epub 2010 May 7.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.bbalip.2010.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907186PMC
August 2010

GPI-1046 protects dorsal root ganglia from gp120-induced axonal injury by modulating store-operated calcium entry.

J Peripher Nerv Syst 2009 Mar;14(1):27-35

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://doi.wiley.com/10.1111/j.1529-8027.2009.00203.x
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http://dx.doi.org/10.1111/j.1529-8027.2009.00203.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728770PMC
March 2009

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis.

Brain 2008 Nov 4;131(Pt 11):3092-102. Epub 2008 Sep 4.

Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1093/brain/awn190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577809PMC
November 2008

Converging roles for sphingolipids and cell stress in the progression of neuro-AIDS.

Front Biosci 2008 May 1;13:5120-30. Epub 2008 May 1.

Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739118PMC
http://dx.doi.org/10.2741/3068DOI Listing
May 2008

Serum sphingomyelins and ceramides are early predictors of memory impairment.

Neurobiol Aging 2010 Jan 5;31(1):17-24. Epub 2008 May 5.

Department of Psychiatry,Division of Geriatric Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Suite 308, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2008.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783210PMC
January 2010

Neuroprotective and antiretroviral effects of the immunophilin ligand GPI 1046.

J Neuroimmune Pharmacol 2007 Mar 3;2(1):49-57. Epub 2007 Jan 3.

Department of Neurology, The Johns Hopkins University School of Medicine Pathology 509, 600 North Wolfe Street, Baltimore, MD 21287, USA.

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http://link.springer.com/10.1007/s11481-006-9060-0
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March 2007

ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain.

Neurobiol Aging 2009 Apr 20;30(4):591-9. Epub 2007 Sep 20.

Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758772PMC
April 2009

Dual effects of ATP on rat hippocampal synaptic plasticity.

Neuroreport 2004 Mar;15(4):633-6

Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1097/00001756-200403220-00012DOI Listing
March 2004

Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia.

Ann Neurol 2004 Feb;55(2):257-67

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://doi.wiley.com/10.1002/ana.10828
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February 2004

Alzheimer's amyloid beta-peptide enhances ATP/gap junction-mediated calcium-wave propagation in astrocytes.

Neuromolecular Med 2003 ;3(3):173-80

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1385/NMM:3:3:173DOI Listing
September 2003

Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease.

J Neurochem 2002 Dec;83(6):1509-24

Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2002.01267.xDOI Listing
December 2002

Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120.

J Acquir Immune Defic Syndr 2002 Oct;31 Suppl 2:S55-61

Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1097/00126334-200210012-00005DOI Listing
October 2002

Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.

J Pharmacol Exp Ther 2002 Sep;302(3):881-8

Section of Drug Design and Development, Laboratory of Neuroscience, Gerontology Research Center, National Institute on Aging/NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1124/jpet.102.037481DOI Listing
September 2002

Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid beta-peptide: implications for the pathogenesis of Alzheimer's disease.

Neuromolecular Med 2002 ;1(2):125-35

Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1385/NMM:1:2:125DOI Listing
June 2002