Norman Arnheim

Norman Arnheim

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Norman Arnheim

Norman Arnheim

Publications by authors named "Norman Arnheim"

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28Publications

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Estimating Exceptionally Rare Germline and Somatic Mutation Frequencies via Next Generation Sequencing.

PLoS One 2016 24;11(6):e0158340. Epub 2016 Jun 24.

Molecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089-2910, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158340PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920415PMC
July 2017

Germline Stem Cell Competition, Mutation Hot Spots, Genetic Disorders, and Older Fathers.

Annu Rev Genomics Hum Genet 2016 08 8;17:219-43. Epub 2016 Apr 8.

Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089-2910; email: ,

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http://dx.doi.org/10.1146/annurev-genom-083115-022656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007215PMC
August 2016

New evidence for positive selection helps explain the paternal age effect observed in achondroplasia.

Hum Mol Genet 2013 Oct 4;22(20):4117-26. Epub 2013 Jun 4.

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.

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http://dx.doi.org/10.1093/hmg/ddt260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781639PMC
October 2013

Age-dependent germline mosaicism of the most common noonan syndrome mutation shows the signature of germline selection.

Am J Hum Genet 2013 Jun 30;92(6):917-26. Epub 2013 May 30.

Molecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089-2910, USA.

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http://dx.doi.org/10.1016/j.ajhg.2013.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682763PMC
June 2013

Positive selection for new disease mutations in the human germline: evidence from the heritable cancer syndrome multiple endocrine neoplasia type 2B.

PLoS Genet 2012 16;8(2):e1002420. Epub 2012 Feb 16.

Molecular and Computational Biology Program, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1371/journal.pgen.1002420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280958PMC
February 2013

Detection of meiotic DNA breaks in mouse testicular germ cells.

Methods Mol Biol 2009 ;557:165-81

Fluidigm Corporation, South San Francisco, CA, USA.

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http://dx.doi.org/10.1007/978-1-59745-527-5_11DOI Listing
November 2009

Understanding what determines the frequency and pattern of human germline mutations.

Nat Rev Genet 2009 Jul;10(7):478-88

Molecular and Computational Biology Program, University of Southern California, 1050 Childs Way, Los Angeles, California 90089-2910, USA.

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http://dx.doi.org/10.1038/nrg2529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744436PMC
July 2009

The ups and downs of mutation frequencies during aging can account for the Apert syndrome paternal age effect.

PLoS Genet 2009 Jul 10;5(7):e1000558. Epub 2009 Jul 10.

Molecular and Computational Biology Program, University of Southern California, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700275PMC
July 2009

A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations.

Proc Natl Acad Sci U S A 2008 Jul 16;105(29):10143-8. Epub 2008 Jul 16.

Molecular and Computational Biology Program, University of Southern California, 1050 Childs Way, Los Angeles, CA 90089-2910, USA.

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http://dx.doi.org/10.1073/pnas.0801267105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474563PMC
July 2008

Mammalian meiotic recombination hot spots.

Annu Rev Genet 2007 ;41:369-99

Molecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089-2910, USA.

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http://dx.doi.org/10.1146/annurev.genet.41.110306.130301DOI Listing
May 2008

The molecular anatomy of spontaneous germline mutations in human testes.

PLoS Biol 2007 Sep;5(9):e224

Molecular and Computational Biology Program, University of Southern California, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.0050224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951783PMC
September 2007

High-resolution recombination patterns in a region of human chromosome 21 measured by sperm typing.

PLoS Genet 2006 May 5;2(5):e70. Epub 2006 May 5.

Molecular and Computational Biology Program, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1371/journal.pgen.0020070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456319PMC
May 2006

Genetic instability induced by overexpression of DNA ligase I in budding yeast.

Genetics 2005 Oct 18;171(2):427-41. Epub 2005 Jun 18.

Molecular and Computational Biology Program, University of Southern California, Los Angeles, 90089-2910, USA.

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http://dx.doi.org/10.1534/genetics.105.042861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456761PMC
October 2005

Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.

Cancer Res 2005 Oct;65(19):8662-70

Department of Medicine and Biological Chemistry, University of California, Irvine, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0742DOI Listing
October 2005

Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells.

Mol Cell Biol 2004 Feb;24(4):1655-66

Program in Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089-1340, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC344187PMC
http://dx.doi.org/10.1128/mcb.24.4.1655-1666.2004DOI Listing
February 2004

Single-molecule analysis of the hypermutable tetranucleotide repeat locus D21S1245 through sperm genotyping: a heterogeneous pattern of mutation but no clear male age effect.

Mol Biol Evol 2004 Jan 6;21(1):58-64. Epub 2003 Oct 6.

Department of Evolutionary Biology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1093/molbev/msg242DOI Listing
January 2004

Hot and cold spots of recombination in the human genome: the reason we should find them and how this can be achieved.

Am J Hum Genet 2003 Jul 22;73(1):5-16. Epub 2003 May 22.

Molecular and Computational Biology Program, University of Southern California, 835 West 37th Street, SHS 172, Los Angeles, CA 90089-1340, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180590PMC
http://dx.doi.org/10.1086/376419DOI Listing
July 2003

The mutation process of microsatellites during the polymerase chain reaction.

J Comput Biol 2003 ;10(2):143-55

Department of Mathematics, University of Southern California, Los Angeles, CA 90089-1113, USA.

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http://dx.doi.org/10.1089/106652703321825937DOI Listing
July 2003

Huntington disease expansion mutations in humans can occur before meiosis is completed.

Proc Natl Acad Sci U S A 2003 Jul 11;100(15):8834-8. Epub 2003 Jul 11.

Molecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089-1340, USA.

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http://dx.doi.org/10.1073/pnas.1331390100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166399PMC
July 2003

Candidate DNA replication initiation regions at human trinucleotide repeat disease loci.

Hum Mol Genet 2003 May;12(9):1021-8

Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089-1340, USA.

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http://dx.doi.org/10.1093/hmg/ddg111DOI Listing
May 2003

Taq DNA polymerase slippage mutation rates measured by PCR and quasi-likelihood analysis: (CA/GT)n and (A/T)n microsatellites.

Nucleic Acids Res 2003 Feb;31(3):974-80

Program in Molecular and Computational Biology and Department of Mathematics, University of Southern California, Los Angeles, CA 90089, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149199PMC
http://dx.doi.org/10.1093/nar/gkg178DOI Listing
February 2003

The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect.

Proc Natl Acad Sci U S A 2002 Nov 23;99(23):14952-7. Epub 2002 Oct 23.

Molecular and Computational Biology Program, University of Southern California, Los Angeles 90089-1340, USA.

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http://dx.doi.org/10.1073/pnas.232568699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137526PMC
November 2002

Single-sperm typing.

Curr Protoc Hum Genet 2002 May;Chapter 1:Unit 1.6

Agricultural University of Norway, Aas, Norway.

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http://dx.doi.org/10.1002/0471142905.hg0106s32DOI Listing
May 2002