Publications

Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis.
J Steroid Biochem Mol Biol 2017 May 4;169:69-76. Epub 2016 Mar 4.
Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan. Electronic address:


Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47(phox).
Sci Rep 2017 Feb 27;7:43441. Epub 2017 Feb 27.
Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.


Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene.
J Lipid Res 2015 Nov 27;56(11):2172-82. Epub 2015 Sep 27.
Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan.

Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells.
J Biochem 2015 Oct 21;158(4):331-8. Epub 2015 May 21.
Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto 610-0321, Japan; and

Immunostaining of oxidized DJ-1 in human and mouse brains.
J Neuropathol Exp Neurol 2014 Jul;73(7):714-28
From the Systems Life Sciences (YS, KH, YM, NN) and Neuropathology (TM, YI), Department of Medical Life Systems, Faculty of Medical and Life Sciences, Doshisha University, Kyotanabe, Kyoto; Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology (HH, SM); Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo (OK-A, HI, TH); and Institute of Immunology Co Ltd (OK-A), Tokyo; Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka (YY, EN); and Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo (KT-N, HA), Japan.

Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death.
Redox Biol 2013 4;2:28-35. Epub 2013 Dec 4.
Systems Life Sciences, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan.

Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain.
J Neurosci 2013 Sep;33(37):14767-77
Majors of Medical Sciences, University of Tsukuba, Ibaraki 305-8575, Japan, Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan, Center for Behavioral Molecular Genetics, University of Tsukuba, Ibaraki 305-8575, Japan, Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8504, Japan, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan, and Cardiovascular Division, British Heart Foundation Centre of Research Excellence, School of Medicine, King's College London, London SE1 9NH, United Kingdom.

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation.
Free Radic Biol Med 2012 Dec 7;53(12):2256-62. Epub 2012 Oct 7.
Department of Stress Response Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan. Electronic address:

Actual ratios of triacylglycerol positional isomers consisting of saturated and highly unsaturated fatty acids in fishes and marine mammals.
Food Chem 2011 Jul 9;127(2):467-72. Epub 2011 Jan 9.
Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan.

α-Tocopheryl phosphate: uptake, hydrolysis, and antioxidant action in cultured cells and mouse.
Free Radic Biol Med 2011 Jun 26;50(12):1794-800. Epub 2011 Mar 26.
Health Research Institute, National Institute of Advanced Industrial Science & Technology, Ikeda, Osaka 563-8577, Japan.

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.
Genes Cells 2011 Jun 10;16(6):692-703. Epub 2011 May 10.
Department of Genetic Cord, Graduate School of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe 610-0394, Japan.

Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function.
Free Radic Biol Med 2010 Nov 22;49(10):1542-9. Epub 2010 Aug 22.
Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563-8577, Japan.

Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals.
Neurosci Lett 2010 Oct 11;483(3):201-5. Epub 2010 Aug 11.
Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka, Japan.

Enhanced neointimal hyperplasia and carotid artery remodelling in sequestosome 1 deficient mice.
J Cell Mol Med 2010 Jun 24;14(6B):1546-54. Epub 2009 Sep 24.
Majors of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.



Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress.
J Exp Ther Oncol 2007 ;6(4):335-48
Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B-60 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.


Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species.
Free Radic Biol Med 2007 Jan 20;42(2):260-9. Epub 2006 Oct 20.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (LSBM), University of Tokyo, 4-6-1, Komaba, Meguro, Tokyo 153-8904, Japan.

Alpha-tocopherol induces calnexin in renal tubular cells: another protective mechanism against free radical-induced cellular damage.
Arch Biochem Biophys 2006 Sep 28;453(2):168-78. Epub 2006 Jul 28.
Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

Induction of adaptive response and enhancement of PC12 cell tolerance by 7-hydroxycholesterol and 15-deoxy-delta(12,14)-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms.
J Biol Chem 2006 May 24;281(20):14440-5. Epub 2006 Mar 24.
Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1-8-31, Midorigaoka, Ikeda, Osaka, 563-8577, Japan.


Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells.
J Biol Chem 2005 Jul 25;280(29):27244-50. Epub 2005 May 25.
Environmental Response Project ERATO-Japan Science and Technology Agency, Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan.


Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion molecules.
Atherosclerosis 2005 May 12;180(1):19-25. Epub 2005 Jan 12.
Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

Expression of the LXRalpha protein in human atherosclerotic lesions.
Arterioscler Thromb Vasc Biol 2005 Mar 29;25(3):622-7. Epub 2004 Dec 29.
Department of Systems Biology and Medicine, Research Center for Advanced Science and Technology, the University of Tokyo, Japan.


Lysophosphatidylcholine enhances cytokine production of endothelial cells via induction of L-type amino acid transporter 1 and cell surface antigen 4F2.
Arterioscler Thromb Vasc Biol 2004 Sep 3;24(9):1640-5. Epub 2004 Jun 3.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo, 153-8904, Japan.

Effect on endothelial cell gene expression of shear stress, oxygen concentration, and low-density lipoprotein as studied by a novel flow cell culture system.
Free Radic Biol Med 2004 Sep;37(5):682-94
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8906, Japan.


Antioxidant action of 2,2,4,6-tetra-substituted 2,3-dihydro-5-hydroxybenzofuran against lipid peroxidation: effects of substituents and side chain.
Free Radic Res 2002 Nov;36(11):1171-8
Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Midorigaoaka, Ikeda, Osaka 563-8577, Japan.


Oxidized low density lipoprotein-induced LFA-1-dependent adhesion and transendothelial migration of monocytes via the protein kinase C pathway.
Atherosclerosis 2002 Feb;160(2):281-8
First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis.
J Biol Chem 2002 Jan 19;277(4):2687-94. Epub 2001 Nov 19.
Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464-8601, Japan.

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