Publications

RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation.
Ann Rheum Dis 2016 Jun 29;75(6):1187-95. Epub 2015 May 29.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan Explorative Research for Advanced Technology (ERATO) Program, Japan Science and Technology Agency (JST), Takayanagi Osteonetwork Project, Tokyo, Japan.

Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
Immunity 2015 Dec 8;43(6):1174-85. Epub 2015 Dec 8.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan. Electronic address:

Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance.
Cell 2015 Nov;163(4):975-87
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Takayanagi Osteonetwork Project, Exploratory Research for Advanced Technology Program, Japan Science and Technology Agency (JST), Tokyo 113-0033, Japan. Electronic address:

Regulatory T cells in Arthritis.
Prog Mol Biol Transl Sci 2015 28;136:207-15. Epub 2015 Aug 28.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; Japan Science and Technology Agency, Exploratory Research for Advanced Technology Program, Takayanagi Osteonetwork Project, Bunkyo-ku, Tokyo, Japan. Electronic address:

Immune complexes regulate bone metabolism through FcRγ signalling.
Nat Commun 2015 Mar 31;6:6637. Epub 2015 Mar 31.
1] Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan [2] Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan [3] Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia.

Arthritogenic T cells in autoimmune arthritis.
Int J Biochem Cell Biol 2015 Jan 28;58:92-6. Epub 2014 Nov 28.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.
Nat Med 2014 Jan 22;20(1):62-8. Epub 2013 Dec 22.
1] Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. [2] Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Bunkyo-ku, Tokyo, Japan. [3] Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Nedlands, Western Australia, Australia.

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